Grantee Research Project Results
Research Centers
University of Washington
University of Washington
The theme of the University of Washington based Center for Child Environmental Health Risks Research (CHC) is understanding the biochemical, molecular and exposure mechanisms that define children''''s susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning. The CHC is a multi-disciplinary research center that takes advantage of the established landscape of risk research at the University of Washington; it is administratively housed within the Institute for Risk Analysis and Risk Communication that is in the UW''''s School of Public Health and Community Medicine..
To facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures, center participants include members from multiple institutions, schools, and varied departments and clinics. To achieve tangible effects on the community, the CHC includes a partnership with an eastern Washington community within the Yakima Valley agricultural center of our state, to jointly accomplish pesticide intervention with reduced childhood pesticide exposures.
The CHC is comprised of two laboratory based research projects, two field based projects, and four facility cores. The specific objectives of the laboratory based research projects are to:
- identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides and
- identify the impact of genetic polymorphisms for paraoxonase on the developmental neurotoxicity of organophosphate pesticides.
The specific objectives of the two field based projects-a pesticide exposure pathways research project plus the related community based intervention study are to:
- identify critical pathways of pesticide exposure for children and
- to develop a culturally-appropriate intervention to break the take-home pathway that will ultimately result in reducing children''''s exposure to pesticides.
The four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) are designed to support the research agenda and to put the research into a child specific risk assessment context. Thus the scientific findings on pesticide toxicity and exposure can be directly incorporated into risk assessment models that are designed to protect child health.
Laboratory Based Projects
The laboratory based projects in this proposal will specifically address two aspects of children''''s susceptibility to pesticides. They will investigate molecular mechanisms of neurotoxicity for pesticides and evaluate the role of paraoxonase in defining sensitivity of children to organophosphate pesticides. Functional assessments for both studies will be performed in the Neurobehavioral Assessment Facility Core. These projects will be closely linked as common organophosphate pesticides will be examined in all projects, animals, and tissues and research results will be readily shared among these researchers.
View Projects in Tabular Format
Main Center Abstract and Reports:
Development of Environmental Indicators of Condition,Integrity, and Sustainability in the Coastal Regions of the US Great Lakes Basin
Atlantic Coast Environmental Indicators Consortium
Research Center for Particulate Air Pollution and Health
- Original Abstract
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- Final Report
Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM)
- Original Abstract
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- Final Report
FRIENDS Children's Environmental Health Center
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
Center for Hazardous Substances in Urban Environments (CHSUE)
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
- Final Report
Western Region Hazardous Substance Research Center for Developing In-Situ Processes for VOC Remediation in Groundwater and Soil
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
- Final Report
Urban Waste Management & Research Center (University of New Orleans)
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
- Final Report
Hazardous Substance Research Center–South and Southwest
Western Region Hazardous Substance Research Center
The Johns Hopkins University Center For The Asthmatic Child in the Urban Environment
Center for Child Environmental Health Risks Research
CECEHDPR - University of Michigan
HSRC (1989) - South and Southwest HSRC
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
Midwest Hazardous Substance Research Center
Hazardous Substance Research Center/South and Southwest
Center for Hazardous Substances in Urban Environments (CHSUE)
Technical Outreach Services for Communities Support
FDP - Center for Environmental Science
Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States
National Environmental Respiratory Center: Health Hazards of Inhaled Gasoline Engine Emissions and Street Dust
Johns Hopkins Particulate Matter Research Center
Harvard Particle Center
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- Final Report
Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
Texas Joint Center for Air Quality
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- 2011 Progress Report
- Final Report
The Center for Advancing Microbial Risk Assessment (CAMRA)
Applying Spatial and Temporal Modeling of Statistical Surveys to Aquatic Resources
Center for Integrating Statistical and Environmental Science
National Research Program on Design-Based/Model-Assisted Survey Methodology for Aquatic Resources
Center for Science and Policy Applications for Coastal Environments (SPACE)
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
Inner City Toxicants, Child Growth and Development
Center for Child Environmental Health Risks Research
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
- Final Report
Johns Hopkins Center for Childhood Asthma in the Urban Environment
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
Center for the Study of Metals in the Environment
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
- Final Report
Carolina Center for Computational Toxicology
Center for the Study of Metals in the Environment
The Center for Environmental Implications of Nanotechnology (CEINT)
The Texas-Indiana Virtual STAR Center; Data-Generating in vitro and in silico Models of Developmental Toxicity in Embryonic Stem Cells and Zebrafish
Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
- Original Abstract
- 2010 Progress Report
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- Final Report
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
- Original Abstract
- 2010 Progress Report
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- Final Report
Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
- Original Abstract
- 2010 Progress Report
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- Final Report
Center for Child Environmental Health Risks Research
Berkeley/Stanford Children’s Environmental Health Center
- Original Abstract
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2015 Progress Report
- Final Report
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
University of Washington Center for Clean Air Research (UW CCAR)
- Original Abstract
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- Final Report
Air Pollution Mixtures: Health Effects Across Life Stages
- Original Abstract
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- Final Report
National Environmental Respiratory Center
- Original Abstract
- 2010 Progress Report
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- Final Report
Environmental Research and Technology Transfer Program of The Consortium for Plant Biotechnology Research, Inc.
Center for Reinventing Aging Infrastructure for Nutrient Management (RAINmgt)
Center for Comprehensive, optimaL, and Effective Abatement of Nutrients
- Original Abstract
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
- Original Abstract
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
- Original Abstract
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
- Original Abstract
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Novel Methods to Assess the Effects of Chemicals on Child Development
- Original Abstract
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- Final Report
Water Innovation Network for Sustainable Small Systems (WINSSS)
- Original Abstract
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Predictive Toxicology Center for Organotypic Cultures and Assessment ofAOPs for Engineered Nanomaterials
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- Final Report
Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- Final Report
SEARCH: Solutions to Energy, AiR, Climate, and Health
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- Final Report
Comparing Urban and Rural Effects of Poverty on COPD (CURE COPD)
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- 2021 Progress Report
- Final Report
Center for Native American Environmental Health Equity Research
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- 2021 Progress Report
- Final Report
Center for Research on Early Childhood Exposure and Development in Puerto Rico
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- Final Report
Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- 2021 Progress Report
- Final Report
A Sustainable Center for Crowd-Sourced Water Infrastructure Modeling
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- Final Report
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.