Grantee Research Project Results
2013 Progress Report: University of Washington Center for Clean Air Research (UW CCAR)
EPA Grant Number: R834796Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: University of Washington Center for Clean Air Research (UW CCAR)
Investigators: Vedal, Sverre
Current Investigators: Vedal, Sverre , Sheppard, Lianne (Elizabeth) A. , McDonald, Jacob D. , Kaufman, Joel D. , Campen, Matthew J. , VanReken, Timothy M. , Larson, Timothy V. , Szpiro, Adam , Simpson, Christopher , Rosenfeld, Michael , Yost, Michael , Sampson, Paul , Jobson, Thomas
Institution: University of Washington , Washington University , Lovelace Biomedical & Environmental Research Institute , University of New Mexico
Current Institution: University of Washington , Lovelace Biomedical & Environmental Research Institute , University of New Mexico , Washington University
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
Project Period Covered by this Report: December 1, 2012 through November 30,2013
Project Amount: $8,000,000
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
The UW CCAR is focused on the cardiovascular health effects of near-roadway pollution, a complex mixture of particle, vapor and gas phase components that vary by vehicle emission source, road surface, extent of physical aging, and the type and degree of atmospheric processing and photochemical reactions. This exposure scenario is not only known to be of considerable health importance, but also serves as a prototypical case for developing research approaches to dealing with multi-pollutant exposure-effect relationships. Our aim is to integrate exposure, epidemiological, toxicological, clinical, and statistical sciences to study cardiovascular hazards of fresh and aged roadway emissions and significantly advance our understanding of the components and reaction products that cause these effects.
The Center consists of five highly integrated research projects and two facility cores that together are pursuing the following six aims:
- To characterize real-world near-roadway pollutant concentrations, particle size distributions and chemical composition
- To simulate realistic contrasting near-roadway multi-pollutant exposure atmospheres for laboratory animal and human studies
- To identify cardiovascular and immunologic effects and the pathogenic mechanisms of near-roadway exposures using animal models
- To identify cardiovascular and immunologic effects of near-roadway exposures in human clinical studies
- To identify effects of long-term exposure to traffic-derived particles and gases on subclinical measures of cardiovascular disease and DNA methylation in a multi-ethnic population
- To develop a statistical and methodological framework for studying health effects of multi-pollutant mixtures
Progress Summary:
Committees and Meetings
- Investigators Committee – The Investigators Committee is comprised of key members from all five research projects, as well as representatives from the Biostatistics and Administrative Cores. This group continues to meet every 4 weeks for status reports and to discuss the day-to-day scientific activities of the Center and its individual projects. As the research and data become more developed and integrated across projects, the presentations from rotating investigators have become more valuable for examining preliminary results and shaping progress and direction.
- Internal Steering Committee – The Internal Steering Committee (ISC) is comprised of the Center Director, Deputy Directors, project and core PIs, the Center Quality Assurance Manager (QAM), and the Center Manager. This group has met quarterly to discuss finances, budgets, resource allocation, and collaborations. The ISC also serves as the Cross Collaboration Committee and convened recently to discuss the progress and direction of the inter-Center collaboration projects. Additionally, during this meeting, the ISC discussed potential chamber facility modifications and the associated funding sources in support of the planned Projects 1 and 2 November 2013 chamber characterizations and for the start of Project 4, scheduled to begin in the late fall of 2013 or early winter of 2014.
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Scientific Advisory Committee – The Scientific Advisory Committee (SAC) is comprised of 10 scientists representing varying specialties and institutions, including the U.S. EPA and members from the other CLARC Centers. A list of the committee members with their associated institutions appears in Table 1.
- The Year 2 SAC meeting was held on September 27 and 28, 2012. All SAC committee members, as well our EPA program and project officers, were present and offered constructive advice on the Center’s progress, direction, focus, and future.
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The Year 3 SAC meeting was held on July 23 and 24, 2013. This small change in timeframe from previous CCAR SAC meetings was the result of the University of Washington’s Center also hosting the EPA CLARC Annual Program Meeting on July 25 and 26. By having these meetings back to back, travel expenses for SAC and CLARC program participants were minimized.
- The Year 3 SAC meeting was chaired by Sanjay Rajagopalan, instead of John Balmes, who had a scheduling conflict.
- Both Barbara Turpin and C. Arden Pope were late cancellations due to family concerns and could not attend.
- Jake Lusis asked to be removed from the CCAR Advisory Committee citing a lack of specific background to the research now being conducted within the CCAR Center. Dr. Jesus Araujo from the University of California Los Angeles was suggested as his replacement by the Center’s Director and subsequently approved by the CCAR EPA Project Officer Michael Hiscock.
Dr. Michael Hiscock was introduced as the new CCAR EPA Project Officer, effective July 23, 2013. Dr. Hiscock replaces Mel Peffers who is moving to a new position within EPA. We would like to thank Mel Peffers for her guidance and leadership during her tenure as the CCAR EPA Project Officer.
We thank the committee for evaluating our Center’s progress and for sharing their ideas. The insight and suggestions provided during these meetings, and in their follow up SAC comments, are always greatly appreciated and are strongly considered by our investigators.
Table 1 - CCAR Scientific Advisory Committee Members
This year’s Annual Meeting focused less on general overviews from each Center, as the research has progressed significantly into year 3 of the 5-year Center program, and more on targeted highlights from individual projects and research activities. An additional focus was also directed towards further developing the five cross-center collaboration projects through individual breakout sessions. Results, progress, and future direction from those sessions were reported back for general discussion. A lively and productive group discussion was moderated by Dr. Sverre Vedal on the topic of “Effects of Different Air Pollutant Mixtures.” Questions such as air pollution mixture toxicity and particle mass component and source toxicity were debated and considered for future research directions. Dr. Brent Coull, from the Harvard Center, gave a presentation on “Statistical Approaches for Multipollutant Data,” to conclude the Annual Meeting.
Future Activities:
The individual project and Biostatistics Core summaries will address planned and future activities.
Administrative Core
- Quality Management – The Center will continue to follow up with each individual project, and associated QAO, to review, revise, and archive all relevant SOPs, and their respective QAPPs. Additionally, Project 4 will be responsible for submitting for approval their individual QAPP before any data is collected.
- Quality Management – To supplement the formal QAPP for each Project, the Center’s Quality Assurance Manager has requested that each project collecting research data create a separate QC Report. This report will need to be “customized” to each individual project and data collection method but should contain such items such as, but not limited to:
- Summary of sampler type and use/deployment characteristics
- Summary of collection media planning, deployment, capture, and validity results
- Criteria for usable data or for flagging or voiding suspect data
- Information on comparison to existing or available AQS data
- Summary statistics in relation to Data Quality Objectives [DQOs]
- Laboratory Analysis QC
- Method limit of detection results
- Method QC results i.e. duplicate and blank samples, standard curves, etc.
- Quality Management - With the Center well into Year 3 and research activities seeing significant progress across almost all projects, a comprehensive quality review of all Center projects and activities is being planned by the QAM. Because of the substantial distances between institutions, the significant differences in types of data collected, the sheer volume of information involved, and the time and effort this undertaking could require, the design and execution of this review will be a continuing topic of discussion in the investigators meetings, as well as between the QAM, the Center’s Director, and the Center’s Manager.
- Data Use Requests – As the projects collect, process, and analyze data, discussion has been raised about creating a more formal method for handling data use requests. This idea concerns internal to the Center requests, but also in the longer term, external requests from a wide variety of interested collaborators. This item will be progressively addressed in upcoming Investigators Meetings as well as among the Internal Steering Committee members.
- Manuscript Review – As data become available to Center end-users, a formal manuscript review process will be needed to evaluate topics and publication content. This item will also be addressed in upcoming Investigators Meetings and a process will be defined and implemented.
Journal Articles: 96 Displayed | Download in RIS Format
| Other center views: | All 197 publications | 94 publications in selected types | All 93 journal articles |
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Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV. Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives 2015;123(6):541-548. |
R834796 (2014) R831697 (Final) R833741 (Final) |
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Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ. Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology 2016;16(2):163-171. |
R834796 (2015) R834796 (Final) R834796C003 (2015) R834796C003 (Final) |
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Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environmental Health Perspectives 2013;121(9):1017-1025. |
R834796 (2013) R834796 (2014) R834796 (Final) R834796C005 (2013) R831697 (2013) R831697 (Final) R833864 (2011) |
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Bergen S, Szpiro AA. Mitigating the impact of measurement error when using penalized regression to model exposure in two-stage air pollution epidemiology studies. Environmental and Ecological Statistics 2015;22(3):601-631. |
R834796 (2014) R834796 (Final) R831697 (Final) |
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Bergen S, Sheppard L, Kaufman JD, Szpiro AA. Multipollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. Journal of the Royal Statistical Society Series C-Applied Statistics 2016;65(5):731-753. |
R834796 (Final) R831697 (Final) |
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Brower JB, Doyle-Eisele M, Moeller B, Stirdivant S, McDonald JD, Campen MJ. Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions. Inhalation Toxicology 2016;28(5):241-250. |
R834796 (2016) R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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Campen MJ, Lund A, Rosenfeld M. Mechanisms linking traffic-related air pollution and atherosclerosis. Current Opinion in Pulmonary Medicine 2012;18(2):155-160. |
R834796 (2012) R834796 (2013) R834796 (2015) R834796 (Final) R834796C003 (2012) R834796C003 (2013) R834796C003 (Final) R833990 (2010) R833990 (2011) |
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Campen M, Robertson S, Lund A, Lucero J, McDonald J. Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology 2014;26(6):353-360. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
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Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. Long-term air pollution exposure and blood pressure in the Sister Study. Environmental Health Perspectives 2015;123(10):951-958. |
R834796 (2015) R834796 (Final) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
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Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health 2016;15(1):119 (12 pp.). |
R834796 (2016) R834796 (Final) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
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Chi GC, Hajat A, Bird CE, Cullen MR, Griffin BA, Miller KA, Shih RA, Stefanick ML, Vedal S, Whitsel EA, Kaufman JD. Individual and neighborhood socioeconomic status and the association between air pollution and cardiovascular disease. Environmental Health Perspectives 2016;124(12):1840-1847. |
R834796 (Final) R834796C005 (Final) R831697 (Final) |
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Chi GC, Hajat A, Bird CE, Cullen MR, Griffin BA, Miller KA, Shih RA, Stefanick ML, Vedal S, Whitsel EA, Kaufman JD. Individual and neighborhood socioeconomic status and the association between air pollution and cardiovascular disease. Environmental Health Perspectives 2016; doi:10.1289/EHP199 (Epub ahead of print]. |
R834796C005 (2015) R834796C005 (2016) |
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Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD. Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 2012;59(5):943-948. |
R834796C004 (Final) R827355 (Final) R830954 (Final) |
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Cosselman KE, Navas-Acien A, Kaufman JD. Environmental factors in cardiovascular disease. Nature Reviews Cardiology 2015;12(11):627-642. |
R834796 (2015) R834796 (Final) R834796C004 (2015) R834796C004 (2016) R834796C004 (Final) |
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Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques. 2014;7(1):225-239. |
R834796 (2013) R834796 (Final) R834796C001 (2013) |
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Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques 2014;7(1):225-239. |
R834796 (2014) R834796 (2015) R834796C001 (2015) R834796C001 (Final) |
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Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques. 2014;7(1):225-239. |
R834796 (2013) R834796 (Final) R834796C001 (2013) |
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Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques 2014;7(1):225-239. |
R834796 (2014) R834796 (2015) R834796C001 (2015) R834796C001 (Final) |
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Fann N, Kim S-Y, Olives C, Sheppard L. Estimated changes in life expectancy and adult mortality resulting from declining PM2.5 exposures in the contiguous United States:1980-2010. Environmental Health Perspectives 2017;125(9):097003 (8 pp.). |
R834796 (2016) R834796 (Final) R831697 (Final) |
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Fox JR, Cox DP, Drury BE, Gould TR, Kavanagh TJ, Paulsen MH, Sheppard L, Simpson CD, Stewart JA, Larson TV, Kaufman JD. Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions. Air Quality, Atmosphere & Health 2015;8(5):507-519. |
R834796 (2014) |
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Galaviz VE, Yost MG, Simpson CD, Camp JE, Paulsen MH, Elder JP, Hoffman L, Flores D, Quintana PJE. Traffic pollutant exposures experienced by pedestrians waiting to enter the U.S. at a major U.S.-Mexico border crossing. Atmospheric Environment 2014;88:362-369. |
R834796 (2014) R834796 (2015) R834796 (2016) R834796 (Final) R834796C001 (2015) R834796C001 (Final) |
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Galaviz VE, Quintana PJE, Yost MG, Sheppard L, Paulsen MH, Camp JE, Simpson CD. Urinary metabolites of 1-nitropyrene in US-Mexico border residents who frequently cross the San Ysidro Port of Entry. Journal of Exposure Science and Environmental Epidemiology 2017;27(1):84-89. |
R834796 (2016) R834796 (Final) R834796C001 (2016) R834796C001 (Final) |
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Gueneron M, Erickson MH, VanderSchelden GS, Jobson BT. PTR-MS fragmentation patterns of gasoline hydrocarbons. International Journal of Mass Spectrometry 2015;379:97-109. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C001 (2015) R834796C001 (Final) |
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Hazelhurst M, Dearborn L, Sherris A, Loftus C, Adgent M, Szpiro A, Ni Y, Day D, Kaufman J, Thakur N, Wright R, Sathyanarayana S, Carroll K, Moore P, Karr C. Long-term ozone exposure and lung function in middle childhood. ENVIRONMENTAL RESEARCH 2024;421(117632) |
R834796 (Final) R831697 (Final) R833741 (Final) |
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Hazlehurst MF, Spalt EW, Curl CL, Davey ME, Vedal S, Burke GL, Kaufman JD. Integrating data from multiple time-location measurement methods for use in exposure assessment: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science and Environmental Epidemiology 2017;27(6):569-574. |
R834796 (2016) R834796 (Final) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
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Hazlehurst MF, Spalt EW, Nicholas TP, Curl CL, Davey ME, Burke GL, Watson KE, Vedal S, Kaufman JD. Contribution of the in-vehicle microenvironment to individual ambient-source nitrogen dioxide exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Journal of Exposure Science & Environmental Epidemiology 2018;28(4):371-380. |
R834796 (Final) R834796C005 (Final) R831697 (Final) |
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Herring CL, Faiola CL, Massoli P, Sueper D, Erickson MH, McDonald JD, Simpson CD, Yost MG, Jobson BT, VanReken TM. New methodology for quantifying polycyclic aromatic hydrocarbons (PAHs) using high-resolution aerosol mass spectrometry. Aerosol Science and Technology 2015;49(11):1131-1148. |
R834796 (2015) R834796 (Final) R834796C001 (2015) R834796C001 (Final) |
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Hooper LG, Young MT, Keller JP, Szpiro A, O’Brien K M, Sandler DP, Vedal S, Kaufman J, London S. Ambient air pollution exposure and chronic bronchitis in a cohort of U.S. women. Environmental Health Perspectives 2018;126(2):027005 (9 pp.). |
R834796 (Final) |
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Hudda N, Gould T, Hartin K, Larson TV, Fruin SA. Emissions from an international airport increase particle number concentrations 4-fold at 10 km downwind. Environmental Science & Technology 2014;48(12):6628-6635. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C001 (2015) R834796C001 (Final) |
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Jandarov RA, Sheppard LA, Sampson PD, Szpiro AA. A novel principal component analysis for spatially misaligned air pollution data. Journal of the Royal Statistical Society: Series C, Applied Statistics 2017,66(1):3-28. |
R834796 (Final) |
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Keller JP, Olives C, Kim S-Y, Sheppard L, Sampson PD, Szpiro AA, Oron AP, Lindstrom J, Vedal S, Kaufman JD. A unified spatiotemporal modeling approach for predicting concentrations of multiple air pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Environmental Health Perspectives 2015;123(4):301-309. |
R834796 (2014) R834796 (2015) R834796 (Final) R831697 (Final) |
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Keller JP, Drton M, Larson T, Kaufman JD, Sandler DP, Szpiro AA. Covariate-adaptive clustering of exposures for air pollution epidemiology cohorts. Annals of Applied Statistics 2017;11(1):93-113. |
R834796 (Final) R831697 (Final) |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834796 (2016) R834796 (Final) R834799 (2016) R834799 (Final) R834799C003 (Final) |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834796 (Final) R834799 (Final) |
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Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. |
R834796 (2016) R834796 (Final) R834799 (2016) R834799 (Final) R834799C003 (Final) |
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Keller JP, Larson TV, Austin E, Barr RG, Sheppard L, Vedal S, Kaufman JD, Szpiro AA. Pollutant composition modification of the effect of air pollution on progression of coronary artery calcium:the Multi-Ethnic Study of Atherosclerosis. Environmental Epidemiology 2018;2:e024. |
R834796 (Final) R834796C005 (Final) R838300 (2018) R838300 (2020) |
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Kelp M, Gould T, Austin E, Marshall JD, Yost M, Simpson C, Larson T. Sensitivity analysis of area-wide, mobile source emission factors to high-emitter vehicles in Los Angeles. Atmospheric Environment 2020;223:117212 |
R834796 (Final) R835873 (2019) R835873 (Final) |
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Kim SY, Dutton SJ, Sheppard L, Hannigan MP, Miller SL, Milford JB, Peel JL, Vedal S. Erratum to: The short-term association of selected components of fine particulate matter and mortality in the Denver Aerosol Sources and Health (DASH) study. Environmental Health 2016;15(1):85. |
R834796 (Final) |
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Kim S-Y, Dutton SJ, Sheppard L, Hannigan MP, Miller SL, Milford JB, Peel JL, Vedal S. The short-term association of selected components of fine particulate matter and mortality in the Denver Aerosol Sources and Health (DASH) study. Environmental Health 2015;14:49 (11 pp.). |
R834796 (2014) R834796 (2015) R834796 (Final) |
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Kim S-Y, Sheppard L, Bergen S, Szpiro AA, Sampson PD, Kaufman JD, Vedal S. Prediction of fine particulate matter chemical components with a spatio-temporal model for the Multi-Ethnic Study of Atherosclerosis cohort. Journal of Exposure Science & Environmental Epidemiology 2016;26(5):520-528. |
R834796 (2016) R834796 (Final) R831697 (Final) |
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Kim S-Y, Olives C, Sheppard L, Sampson PD, Larson TV, Kaufman JD. Historical prediction modeling approach for estimating long-term concentrations of PM2.5 in cohort studies before 1999 implementation of widespread monitoring. Environmental Health Perspectives 2017;125(1):38-46. |
R834796 (2016) R834796 (Final) R831697 (Final) |
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Kim S-Y, Sheppard L, Kaufman JD, Bergen S, Szpiro AA, Larson TV, Adar SD, Diez Roux AV, Polak JF, Vedal S. Individual-level concentrations of fine particulate matter chemical components and subclinical atherosclerosis: a cross-sectional analysis based on 2 advanced exposure prediction models in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2014;180(7):718-728. |
R834796 (2014) R834796 (2015) R834796 (Final) R831697 (Final) |
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Kim S-Y, Sheppard L, Larson TV, Kaufman JD, Vedal S. Combining PM2.5 component data from multiple sources: data consistency and characteristics relevant to epidemiological analyses of predicted long-term exposures. Environmental Health Perspectives 2015;123(7):651-658. |
R834796 (2014) R834796 (2015) R834796 (Final) R831697 (Final) |
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Kioumourtzoglou MA, Spiegelman D, Szpiro AA, Sheppard L, Kaufman JD, Yanosky JD, Williams R, Laden F, Hong B, Suh H. Exposure measurement error in PM2.5 health effects studies: a pooled analysis of eight personal exposure validation studies. Environmental Health 2014;13(1):2. |
R834796 (2014) |
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Larson T, Gould T, Riley EA, Austin E, Fintzi J, Sheppard L, Yost M, Simpson C. Ambient air quality measurements from a continuously moving mobile platform: estimation of area-wide, fuel-based, mobile source emission factors using absolute principal component scores. Atmospheric Environment 2017;152:201-211. |
R834796 (2016) R834796 (Final) R834796C001 (2016) R834796C001 (Final) |
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Lee A, Szpiro A, Kim SY, Sheppard L. Impact of preferential sampling on exposure prediction and health effect inference in the context of air pollution epidemiology. Environmetrics 2015;26(4):255-267. |
R834796 (2015) R834796 (Final) |
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Lindstrom J, Szpiro AA, Sampson PD, Oron AP, Richards M, Larson TV, Sheppard L. A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics 2014;21(3):411-433. |
R834796 (2013) R834796 (2014) R834796 (2015) R831697 (2013) R831697 (Final) |
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Lucero J, Suwannasual U, Herbert L, McDonald J, Lund A. The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice. INHALATION TOXICOLOGY 2017;29(6):266-281. |
R834796 (Final) |
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Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhalation Toxicology 2013;25(6):309-324. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2015) R834796C002 (Final) R834796C003 (2013) R833990 (2011) |
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Mauderly JL, Kracko D, Brower J, Doyle-Eisele M, McDonald JD, Lund AK, Seilkop SK. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhalation Toxicology 2014;26(11):691-696. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2015) R834796C002 (2016) R834796C002 (Final) |
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McDonald JD, Chow JC, Peccia J, Liu Y, Chand R, Hidy GM, Mauderly JL. Influence of collection region and site type on the composition of paved road dust. Air Quality, Atmosphere and Health 2013;6(3):615-628. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2013) R834796C002 (2016) R834796C002 (Final) |
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Miller KA, Spalt EW, Gassett AJ, Curl CL, Larson TV, Avol E, Allen RW, Vedal S, Szpiro AA, Kaufman JD. Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. Journal of Exposure Science and Environmental Epidemiology 2019;29(2):227-237. |
R834796 (Final) R831697 (Final) R838300 (2018) R838300 (2020) |
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Ni Y, Sullivan A, Szpiro A, Peng J, Loftus C, Hazelhurst M, Sherris A, Wallace E, Murphy L, Nguyen R, Swan S, Sathysnarayana S, Barrett E, Mason W, Bush N, Karr C, Lewinn K. Ambient Air Pollution Exposures and Child Executive Function: A US Multicohort Study. EPIDEMIOLOGY 2024;93335(5):676-688 |
R834796 (Final) R831697 (Final) R838300 (Final) |
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Olives C, Sheppard L, Lindstrom J, Sampson PD, Kaufman JD, Szpiro AA. Reduced-rank spatio-temporal modeling of air pollution concentrations in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Annals of Applied Statistics 2014;8(4):2509-2537. |
R834796 (2014) R834796 (2015) R834796 (Final) R831697 (Final) |
Exit Exit |
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Oppenheim HA, Lucero J, Guyot A-C, Herbert LM, McDonald JD, Mabondzo A, Lund AK. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Particle and Fibre Toxicology 2013;10:62. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2015) R834796C002 (2016) R834796C002 (Final) |
Exit Exit Exit |
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Paffett ML, Zychowski KE, Sheppard L, Robertson S, Weaver JM, Lucas SN, Campen MJ. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences 2015;146(2):244-253. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
Exit Exit Exit |
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Riley EA, Banks L, Fintzi J, Gould TR, Hartin K, Schaal L, Davey M, Sheppard L, Larson T, Yost MG, Simpson CD. Multi-pollutant mobile platform measurements of air pollutants adjacent to a major roadway. Atmospheric Environment 2014;98:492-499. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C001 (2015) R834796C001 (2016) R834796C001 (Final) |
Exit Exit Exit |
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Riley EA, Gould T, Hartin K, Fruin SA, Simpson CD, Yost MG, Larson T. Ultrafine particle size as a tracer for aircraft turbine emissions. Atmospheric Environment 2016;139:20-29. |
R834796 (2016) R834796 (Final) R834796C001 (2016) R834796C001 (Final) |
Exit Exit Exit |
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Riley EA, Schaal L, Sasakura M, Crampton R, Gould TR, Hartin K, Sheppard L, Larson T, Simpson CD, Yost MG. Correlations between short-term mobile monitoring and long-term passive sampler measurements of traffic-related air pollution. Atmospheric Environment 2016;132:229-239. |
R834796 (2016) R834796 (Final) R834796C001 (2016) R834796C001 (Final) |
Exit Exit Exit |
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Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicological Sciences 2013;134(2):304-311. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) R833990 (2011) R833990 (Final) |
Exit Exit Exit |
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Sampson PD, Richards M, Szpiro AA, Bergen S, Sheppard L, Larson TV, Kaufman JD. A regionalized national universal kriging model using Partial Least Squares regression for estimating annual PM2.5 concentrations in epidemiology. Atmospheric Environment 2013;75:383-392. |
R834796 (2013) R834796 (2014) R834796 (2015) R831697 (2013) R831697 (Final) R833864 (2012) R833864 (2013) R833864 (Final) |
Exit Exit Exit |
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Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhalation Toxicology 2015;27(5):272-280. |
R834796 (2015) R834796 (Final) R834796C003 (Final) |
Exit Exit |
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Schisler J, Campen MJ, Madden M, and Willis MS. Transcriptional Endothelial Biosensor Response to Diesel-Induced Plasma Compositional Changes. Inhalation Toxicology. 2015, 27(5):272–280. |
R834796C003 (2016) |
not available |
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Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope III CA, Brunekreef B. Confounding and exposure measurement error in air pollution epidemiology. Air Quality, Atmosphere & Health 2012;5(2):203-216. |
R834796 (2012) R834796 (2013) R834796 (2015) R834796 (Final) R831697 (2013) R831697 (Final) |
Exit Exit |
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Spalt EW, Curl CL, Allen RW, Cohen M, Williams K, Hirsh JA, Adar SD, Kaufman JD. Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science & Environmental Epidemiology 2016;26(4):341-348. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
Exit Exit Exit |
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Spalt EW, Curl CL, Allen RW, Cohen M, Adar SD, Stukovsky KH, Avol E, Castro-Diehl C, Nunn C, Mancera-Cuevas K, Kaufman JD. Time-location patterns of a diverse population of older adults:the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science & Environmental Epidemiology 2016;26(4):349-355. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
Exit Exit |
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Sun M, Kaufman JD, Kim S-Y, Larson TV, Gould TR, Polak JF, Budoff MJ, Diez Roux AV, Vedal S. Particulate matter components and subclinical atherosclerosis:common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environmental Health 2013;12:39. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2013) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (2013) R831697 (Final) |
Exit Exit |
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Suwannasual U, Lucero J, McDonald JD, Lund AK. Exposure to traffic-generated air pollutants mediates alterations in brain microvascular integrity in wildtype mice on a high-fat diet. Environmental Research 2018;160:449-461. |
R834796 (Final) |
Exit Exit Exit |
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Szpiro AA, Sheppard L, Lumley T. Efficient measurement error correction with spatially misaligned data. Biostatistics 2011;12(4):610-623. |
R834796 (2012) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R831697 (2013) R831697 (Final) |
Exit Exit Exit |
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Szpiro AA, Paciorek CJ, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 2011;22(5):680-685. |
R834796 (2012) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R831697 (2013) R831697 (Final) |
Exit Exit Exit |
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Szpiro AA, Paciorek CJ. Measurement error in two-stage analyses, with application to air pollution epidemiology. Environmetrics 2013;24(8):501-517. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R831697 (2013) R831697 (Final) |
Exit |
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Szpiro AA, Sheppard L, Adar SD, Kaufman JD. Estimating acute air pollution health effects from cohort study data. Biometrics 2014;70(1):164-174. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2013) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (2013) R831697 (Final) |
Exit |
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Tessum MW, Larson T, Gould TR, Simpson CD, Yost MG, Vedal S. Mobile and fixed-site measurements to identify spatial distributions of traffic-related pollution sources in Los Angeles. Environmental Science & Technology 2018;52(5):2844-2853. |
R834796 (Final) R834796C001 (Final) |
Exit Exit Exit |
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Tyler CR, Zychowski KE, Sanchez BN, Rivero V, Lucas S, Herbert G, Liu J, Irshad H, McDonald JD, Bleske BE, Campen MJ. Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes. Particle and Fibre Toxicology 2016;13(1):64 (18 pp.). |
R834796 (2016) R834796 (Final) R834796C003 (Final) |
Exit Exit |
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Vedal S, Kaufman JD. What does multi-pollutant air pollution research mean? American Journal of Respiratory and Critical Care Medicine 2011;183(1):4-6. |
R834796 (2012) R834796 (2013) R834796 (2014) R834796 (Final) R834796C005 (2013) R834796C005 (2016) R834796C005 (Final) |
Exit Exit Exit |
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Wang M, Keller JP, Adar SD, Kim S-Y, Larson TV, Olives C, Sampson PD, Sheppard L, Szpiro AA, Vedal S, Kaufman JD. Development of long-term spatiotemporal models for ambient ozone in six metropolitan regions of the United States: the MESA Air Study. Atmospheric Environment 2015;123(A):79-87. |
R834796 (2016) R834796 (Final) R831697 (Final) R833741 (Final) |
Exit Exit Exit |
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Wang M, Brunekreef B, Gehring U, Szpiro A, Hoek G, Beelen R. A new technique for evaluating land-use regression models and their impact on health effect estimates. Epidemiology 2016;27(1):51-56. |
R834796 (2015) R834796 (Final) |
Exit |
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Wang M, Sampson PD, Hu J, Kleeman M, Keller JP, Olives C, Szpiro AA, Vedal S, Kaufman JD. Combining land-use regression and chemical transport modeling in a spatiotemporal geostatistical model for ozone and PM2.5. Environmental Science & Technology 2016;50(10):5111-5118. |
R834796 (2016) R834796 (Final) R831697 (Final) R833741 (Final) R833864 (Final) |
Exit Exit Exit |
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Weuve J, Kaufman JD, Szpiro AA, Curl C, Puett RC, Beck T, Evans DA, Mendes de Leon CF. Exposure to traffic-related air pollution in relation to progression in physical disability among older adults. Environmental Health Perspectives 2016;124(7):1000-1008. |
R834796 (Final) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
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Xu W, Riley EA, Austin E, Sasakura M, Schaal L, Gould TR, Hartin K, Simpson CD, Sampson PD, Yost MG, Larson TV, Xiu G, Vedal S. Use of mobile and passive badge air monitoring data for NOx and ozone air pollution spatial exposure prediction models. Journal of Exposure Science and Environmental Epidemiology 2017;27(2):184-192. |
R834796 (Final) R834796C001 (2015) R834796C001 (2016) R834796C001 (Final) |
Exit Exit |
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Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33(6):1153-1161. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) |
Exit Exit Exit |
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Young MT, Sandler DP, DeRoo LA, Vedal S, Kaufman JD, London SJ. Ambient air pollution exposure and incident adult asthma in a nationwide cohort of U.S. women. American Journal of Respiratory and Critical Care Medicine 2014;190(8):914-921. |
R834796 (2015) R834796 (Final) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (Final) |
Exit Exit Exit |
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Young M, Jansen K, Cosselman K, Gould T, Stewart J, Larson T, Sack C, Vedal S, Szpiro A, Kaufman J. Blood Pressure Effect of Traffic-Related Air Pollution A Crossover Trial of In-Vehicle Filtration. ANNALS OF INTERNAL MEDICINE 2023;. |
R834796 (Final) |
Exit |
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Zychowski KE, Lucas SN, Sanchez B, Herbert G, Campen MJ. Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure. Toxicology and Applied Pharmacology 2016;305:40-45. |
R834796 (2016) R834796 (Final) |
Exit Exit Exit |
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Wang M, Sampson PD, Sheppard LE, Stein JH, Vedal S, Kaufman JD. Long-term exposure to ambient ozone and progression of subclinical arterial disease:the multi-ethnic study of atherosclerosis and air pollution. Environmental Health Perspectives 2019;127(5):057001. |
R834796 (Final) R838300 (2019) R838300 (2020) |
Exit |
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Herring CL, Faiola CL, Massoli P, Sueper D, Erickson MH, McDonald JD, Simpson CD, Yost MG, Jobson BT, VanReken TM:New Methodology for Quantifying Polycyclic Aromatic Hydrocarbons (PAHs) Using High-Resolution Aerosol Mass Spectrometry. Aerosol Science and Technology. 2015, 49(11):1131-1148. |
R834796C001 (2016) |
not available |
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Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 2013, 33(6):1153-61. |
R834796C003 (2016) |
not available |
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Galaviz V, Yost M, Simpson C, Camp J, Paulsen M, Elder J, Hoffman L, Flores D, Quintana P:Traffic pollutant exposures experienced by pedestrians waiting to enter the US at a major USMexico border crossing. Atmospheric Environment. 2014, 88:362-369. |
R834796C001 (2016) |
not available |
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Erickson M, Gueneron M, Jobson B:Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques. 2014, 7(1):225-239. |
R834796C001 (2016) |
not available |
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Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ:Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures. Cardiovascular toxicology. 2016, 16(2):163-171. |
R834796C003 (2016) |
not available |
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Campen MJ, Lund A, Rosenfeld M:Mechanisms linking traffic-related air pollution and atherosclerosis. Current opinion in pulmonary medicine. 2012, 18(2):155. |
R834796C003 (2016) |
not available |
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Hudda N, Gould T, Hartin K, Larson TV, Fruin SA:Emissions from an international airport increase particle number concentrations 4-fold at 10 km downwind. Environmental science & technology. 2014, 48(12):6628-6635. |
R834796C001 (2016) |
not available |
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Campen M, Robertson S, Lund A, Lucero J, McDonald J:Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation toxicology. 2014, 26(6):353-360. |
R834796C003 (2016) |
not available |
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Gueneron M, Erickson MH, VanderSchelden GS, Jobson BT:PTR-MS fragmentation patterns of gasoline hydrocarbons. International Journal of Mass Spectrometry. 2015, 379:97-109. |
R834796C001 (2016) |
not available |
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Paffett ML, Sheppard L, Robertson S, Weaver J, Lucas SN, Campen MJ. Ozone inhalation enhances coronary artery constriction and impairs dilation via superoxide-dependent mechanisms. Toxicol Appl Pharmacol. 2015, In press. |
R834796C003 (2016) |
not available |
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Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The Effects of α-Pinene-vs. Toluene-Derived Secondary Organic Aerosol Exposure on the Expression of Markers Associated with Vascular Disease. Inhalation Toxicology. 2013, 25(6):309-324. |
R834796C002 (2016) |
not available |
Supplemental Keywords:
Environmental policy, exposure modeling, epidemiologic inference, health effects, air pollution exposure, atherosclerosis, epidemiology, toxicology, transportation, cardiovascular disease, cardiotoxicity, particle exposure, ambient particle health effects, air pollution, airway disease, particulate matter, Scientific Discipline, Health, Health Risk Assessment, Risk Assessments, Environmental Monitoring, Biochemistry, Atmospheric Sciences, particulate matter, airway disease, bioavailability, air pollution, particle exposure, ambient particle health effects, vascular dysfunction, cardiotoxicityRelevant Websites:
UW Center for Clean Air Research (CCAR) | University of Washington, DEOHS ExitProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.