2020 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage

EPA Grant Number: RD838300
Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Period Covered by this Report: September 1, 2019 through August 31,2020
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text |  Recipients Lists
Research Category: Air , Human Health , Airborne Particulate Matter Health Effects , Environmental Justice

Objective:

The aims for this project are unchanged from the original application. Our aims are: 1. To evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical CVD disease in the entire MESA Air cohort; 2. To characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium (CAC) measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation; and 3. To quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.

Progress Summary:

Progress in year 3 was as anticipated with continued events follow-up, air pollution modeling updates, and progress on health analyses. In year 3, follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air continued at all six MESA field centers. Field centers made contact with nearly all participants (>99%) and completed interviews for 77% of participants. Significant work has been done to adjudicate identified events from these follow-up calls, prioritizing older events first. In addition to the events surveillance and adjudication work, we have updated our air pollutant models through 2017 for use with exam 6 data and recent events. This process involves completely refitting the exposure models in every city over the entire modeling period (i.e., since 1999 for PM2.5 and earlier for gaseous pollutants). Our efforts to more accurately model fine near-roadway concentration gradients for traffic-related air pollutants continued, including testing covariate selection strategies that prioritize near-roadway variables identified in our previous studies as potentially providing improvements in model results. We have made updates to our database and modeling infrastructure, which significantly boosted computational performance of our models and provide measures to enhance efficiency, reliability, and reproducibility of our methods. We have finalized the primary results of the cardiac events analysis and are in the process of preparing a manuscript for that key health analysis. A number of additional epidemiological analyses are underway including a submitted manuscript on the relationship between exposure to air pollution and respiratory infections in the MESA cohort. Finally, we are also continuing our work on data sharing by refining our plans to release additional de-identified data as part of the NIH/NHLBI BioLINCC.

Future Activities:

Throughout the next year, events ascertainment and adjudication in four of the six MESA cities will continue. The University of Washington team will continue to work on improvements to our exposure model with a focus on improving near-road exposure prediction. Our team will continue to work on health analyses, including finalizing the events analysis and an analysis of the relationship between exposure to air pollution and left ventricular structure and function.  We will also continue to address the data sharing aspects of the project.


Journal Articles on this Report : 37 Displayed | Download in RIS Format

Other project views: All 37 publications 37 publications in selected types All 37 journal articles
Type Citation Project Document Sources
Journal Article Adar SD, Chen YH, D'Souza JC, O'Neill MS, Szpiro AA, Auchincloss AH, Park SK, Daviglus ML, Diez Roux AV, Kaufman JD. Longitudinal analysis of long-term air pollution levels and blood pressure:a cautionary tale from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives 2018;126(10):107003 (11 pp.).
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  • Journal Article Gronlund CJ, Sheppard L, Adar SD, O'Neill MS, Auchincloss A, Madrigano J, Kaufman J, Diez Roux AV. Vulnerability to the cardiovascular effects of ambient heat in six US cities:Results from the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiology 2018;29(6):756-764.
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  • Journal Article Hayes RB, Lim C, Zhang Y, Cromar K, Shao Y, Reynolds HR, Silverman DT, Jones RR, Park Y, Jerrett M, Ahn J. PM2.5 air pollution and cause-specific cardiovascular disease mortality. International Journal of Epidemiology 2019. .
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  • Journal Article Keller JP, Larson TV, Austin E, Barr RG, Sheppard L, Vedal S, Kaufman JD, Szpiro AA. Pollutant composition modification of the effect of air pollution on progression of coronary artery calcium:the Multi-Ethnic Study of Atherosclerosis. Environmental Epidemiology 2018;2:e024.
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  • Journal Article Lim CC, Hayes RB, Ahn J, Shao Y, Silverman DT, Jones RR, Garcia C, Bell ML, Thurston GD. Long-term exposure to ozone and cause-specific mortality risk in the United States. American Journal of Respiratory and Critical Care Medicine 2019;200(8):1022-1031.
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  • Journal Article Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A. Lp-PLA2 , scavenger receptor class B type I gene (SCARB1 ) rs10846744 variant, and cardiovascular disease. PloS One 2018;13(10):e0204352.
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  • Journal Article Miller KA, Spalt EW, Gassett AJ, Curl CL, Larson TV, Avol E, Allen RW, Vedal S, Szpiro AA, Kaufman JD. Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. Journal of Exposure Science and Environmental Epidemiology 2019;29(2):227-237.
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  • Journal Article Petkus AJ, Younan D, Wang X, Beavers DP, Espeland MA, Gatz M, Gruenewald TL, Kaufman JD, Chui HC, Manson JE, Resnick SM. Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest‐Old Women. Journal of the American Geriatrics Society 2020 Nov 17.
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  • Journal Article Shea S, Stein JH, Jorgensen NW, McClelland RL, Tascau L, Shrager S, Heinecke JW, Yvan-Charvet L, Tall AR. Cholesterol mass efflux capacity, incident cardiovascular disease, and progression of carotid plaque:the Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2019;39(1):89-96.
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  • Journal Article Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, et al. A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. The American Journal of Human Genetics 2018;102(3):375-400.
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  • Journal Article Aaron CP, Schwartz JE, Hoffman EA, Angelini E, Austin JH, Cushman M, Jacobs Jr DR, Kaufman JD, Laine A, Smith LJ, Yang J. A longitudinal cohort study of aspirin use and progression of emphysema-like lung characteristics on CT imaging:the MESA Lung Study. Chest 2018;154(1):41-50.
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  • Journal Article Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs Jr DR, Kalhan R, Kaplan R, Kronmal R. Harmonization of respiratory data from 9 US population-based cohorts:the NHLBI pooled cohorts study. American Journal of Epidemiology 2018;187(11):2265-2278.
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  • Journal Article Aroner SA, Koch M, Mukamal KJ, Furtado JD, Stein JH, Tattersall MC, McClelland RL, Jensen MK. High‐density lipoprotein subspecies defined by Apolipoprotein C‐III and subclinical atherosclerosis measures:MESA (the multi‐ethnic study of atherosclerosis). Journal of the American Heart Association 2018;7(6):e007824.
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  • Journal Article Oelsner EC, Smith BM, Hoffman EA, Kalhan R, Donohue KM, Kaufman JD, Nguyen JN, Manichaikul AW, Rotter JI, Michos ED, Jacobs Jr DR. Prognostic significance of large airway dimensions on computed tomography in the general population. The multi-ethnic study of atherosclerosis (MESA) lung study. Annals of the American Thoracic Society 2018;15(6):718-727.
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  • Journal Article Oelsner EC, Ortega VE, Smith BM, Nguyen JN, Manichaikul AW, Hoffman EA, Guo X, Taylor KD, Woodruff PG, Couper DJ, Hansel NN. A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography. American Journal of Respiratory and Critical Care Medicine 2019;200(6):721-731.
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  • Journal Article Aaron CP, Hoffman EA, Kawut SM, Austin JH, Budoff M, Michos ED, Stukovsky KH, Sack C, Szpiro AA, Watson KD, Kaufman JD. Ambient air pollution and pulmonary vascular volume on computed tomography:the MESA Air Pollution and Lung cohort studies. European Respiratory Journal 2019;53(6):1802116.
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  • Journal Article Quraishi SM, Lin PC, Richter KS, Hinckley MD, Yee B, Neal-Perry G, Sheppard L, Kaufman JD, Hajat A. Ambient air pollution exposure and fecundability in women undergoing in vitro fertilization. Environmental Epidemiology 2019;3(1):e036.
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  • Journal Article Wang M, Aaron CP, Madrigano J, Hoffman EA, Angelini E, Yang J, Laine A, Vetterli TM, Kinney PL, Sampson PD, Sheppard LE. Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function. JAMA 2019;322(6):546-556.
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  • Journal Article Mitchell CC, Korcarz CE, Gepner AD, Nye R, Young RL, Matsuzaki M, Post WS, Kaufman JD, McClelland RL, Stein JH. Carotid artery echolucency, texture features, and incident cardiovascular disease events:The MESA Study. Journal of the American Heart Association 2019;8(3):e010875.
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  • Journal Article Wang M, Sampson PD, Sheppard LE, Stein JH, Vedal S, Kaufman JD. Long-term exposure to ambient ozone and progression of subclinical arterial disease:the multi-ethnic study of atherosclerosis and air pollution. Environmental Health Perspectives 2019;127(5):057001.
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  • Journal Article Hajat A, Diez Roux AV, Castro-Diehl C, Cosselman K, Golden SH, Hazlehurst MF, Szpiro A, Vedal S, Kaufman JD. The association between long-term air pollution and urinary catecholamines:evidence from the multi-ethnic study of atherosclerosis. Environmental Health Perspectives 2019;127(5):057007.
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  • Journal Article Billings ME, Gold D, Szpiro A, Aaron CP, Jorgensen N, Gassett A, Leary PJ, Kaufman JD, Redline SR. The association of ambient air pollution with sleep apnea:the multi-ethnic study of atherosclerosis. Annals of the American Thoracic Society 2019;16(3):363-370.
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  • Journal Article Karger AB, Steffen BT, Nomura SO, Guan W, Garg PK, Szklo M, Budoff MJ, Tsai MY. Association between homocysteine and vascular calcification incidence, prevalence, and progression in the MESA cohort. Journal of the American Heart Association 2020;9(3):e013934.
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  • Journal Article Smith BM, Kirby M, Hoffman EA, Kronmal RA, Aaron SD, Allen NB, Bertoni A, Coxson HO, Cooper C, Couper DJ, Criner G. Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults. Jama 2020;323(22):2268-80.
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  • Journal Article Zusman M, Schumacher CS, Gassett AJ, Spalt EW, Austin E, Larson TV, Carvlin G, Seto E, Kaufman JD, Sheppard L. Calibration of low-cost particulate matter sensors:model development for a multi-city epidemiological study. Environment International 2020;134:105329..
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  • Journal Article Loftus CT, Ni Y, Szpiro AA, Hazlehurst MF, Tylavsky FA, Bush NR, Sathyanarayana S, Carroll KN, Young M, Karr CJ, LeWinn KZ. Exposure to ambient air pollution and early childhood behavior:A longitudinal cohort study. Environmental Research 2020;183:109075.
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  • Journal Article Dzaye O, Dardari ZA, Cainzos-Achirica M, Blankstein R, Szklo M, Budoff MJ, Lima JA, Blumenthal RS, Nasir K, Blaha MJ. Incidence of new coronary calcification:time to conversion from CAC= 0. Journal of the American College of Cardiology 2020;75(13):1610-3.
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  • Journal Article Kulick ER, Wellenius GA, Boehme AK, Joyce NR, Schupf N, Kaufman JD, Mayeux R, Sacco RL, Manly JJ, Elkind MS. Long-term exposure to air pollution and trajectories of cognitive decline among older adults. Neurology 2020;94(17):e1782-92.
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  • Journal Article Kulick ER, Elkind MS, Boehme AK, Joyce NR, Schupf N, Kaufman JD, Mayeux R, Manly JJ, Wellenius GA. Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. Environment International 2020;136:105440.
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  • Journal Article Oelsner EC, Balte PP, Grams ME, Cassano PA, Jacobs DR, Barr RG, Burkart KM, Kalhan R, Kronmal R, Loehr LR, O’Connor GT. Albuminuria, lung function decline, and risk of incident chronic obstructive pulmonary disease. The NHLBI Pooled Cohorts Study. American Journal of Respiratory and Critical Care Medicine. 2019;199(3):321-332.
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  • Journal Article Costa MD, Redline S, Soliman EZ, Goldberger AL, Heckbert SR. Fragmented Sinoatrial Dynamics in the Prediction of Atrial Fibrillation:The Multi-Ethnic Study of Atherosclerosis. American Journal of Physiology-Heart and Circulatory Physiology 2020 Sep 28.
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  • Journal Article Kwon Y, Mariani S, Reid M, Jacobs Jr D, Lima J, Kapur V, Punjabi N, Redline S. Lung to Finger Circulation Time in Sleep Study and Coronary Artery Calcification:The Multi-Ethnic Study of Atherosclerosis [Brief Communication]. Sleep Medicine 2020 Jun 3.
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  • Journal Article Zusman M, Gassett AJ, Kirwa K, Barr RG, Cooper CB, Han MK, Kanner RE, Koehler K, Ortega VE, Paine R, Paulin L. Modeling Residential Indoor Concentrations of PM2. 5, NO2, NOx, and secondhand smoke in the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Study. Indoor air 2020 Oct 9.
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  • Journal Article Razavi AC, Wong N, Budoff M, Bazzano LA, Kelly TN, He J, Fernandez C, Lima J, Polak JF, Mongraw-Chaffin M, deFilippi C. Predicting Long-Term Absence of Coronary Artery Calcium in Metabolic Syndrome and Diabetes:The MESA Study. JACC:Cardiovascular Imaging 2020 Oct 28.
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  • Journal Article Inoue K, Goldwater D, Allison M, Seeman T, Kestenbaum BR, Watson KE. Serum Aldosterone Concentration, Blood Pressure, and Coronary Artery Calcium:The Multi-Ethnic Study of Atherosclerosis. Hypertension 2020 May 18:HYPERTENSIONAHA-120.
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  • Journal Article Hajat A, Hazlehurst MF, Golden SH, Merkin SS, Seeman T, Szpiro AA, Kaufman JD, Roux AD. The cross-sectional and longitudinal association between air pollution and salivary cortisol:Evidence from the Multi-Ethnic Study of Atherosclerosis. Environment international 2019 Oct 1;131:105062.
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  • Journal Article Dzaye O, Dardari ZA, Cainzos-Achirica M, Blankstein R, Agatston AS, Duebgen M, Yeboah J, Szklo M, Budoff MJ, Lima JA, Blumenthal RS. Warranty Period of a Calcium Score of Zero:Comprehensive Analysis From the Multiethnic Study of Atherosclerosis. JACC:Cardiovascular Imaging 2020 Oct 28.
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  • Supplemental Keywords:

    Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporal

    Relevant Websites:

    Multi-Ethinic Study of Atherosclerosis and Air Pollution Exit

    Progress and Final Reports:

    Original Abstract
  • 2018 Progress Report
  • 2019 Progress Report