Grantee Research Project Results
2021 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
EPA Grant Number: R838300Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Period Covered by this Report: September 1, 2020 through August 31,2021
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text | Recipients Lists
Research Category: Environmental Justice , Airborne Particulate Matter Health Effects , Human Health , Air
Objective:
The aims for this project are unchanged from the original application. Our aims are: 1. To evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical CVD disease in the entire MESA Air cohort; 2. To characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium (CAC) measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation; and 3. To quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.
Progress Summary:
Progress in year 4 was as anticipated with continued events follow-up, air pollution modeling updates, and progress on health analyses. In year 4, follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air concluded at the remaining four MESA field centers (two field centers concluded calls in year 3). Field centers made contact with 89% participants and completed interviews for 80% of participants. Significant work has been done to adjudicate identified events from these follow-up calls, prioritizing older events first. In addition to the events surveillance and adjudication work, we have made considerable progress on novel modeling approaches. A daily high-resolution spatiotemporal daily carbon monoxide (CO) model has been developed for Baltimore using both regulatory measurements at agency monitoring sites and measurements from low-cost gas monitors deployed by our team. We have also worked to improve the predictive performance of and extend our historical PM2.5 model resulting in improved predictions for the period between 1980 and 2019. Our efforts to more accurately model fine near-roadway concentration gradients for traffic-related air pollutants continued; we finalized our traffic flow estimates and began the process of inputting them into dispersion models. We have continued to make updates to our database and modeling infrastructure. We finalized the primary results of the cardiac events analysis and are in the process of finalizing a manuscript for that key health analysis. A number of additional epidemiological analyses are underway including work on air pollution and cardiac structure and function. Finally, we are also continuing our work on data sharing by refining our plans to release additional de-identified data as part of the NIH/NHLBI BioLINCC.
Future Activities:
Throughout the next year, events adjudication will continue. The University of Washington team will continue to work on modeling efforts including publishing the daily CO model, finalizing the enhancements to the national historical PM2.5 model, and continuing the improvements to our MESA city exposure models with a focus on improving near-road exposure prediction. Our team will continue to work on health analyses, including finalizing the events analysis and an analysis of the relationship between exposure to air pollution and left ventricular structure and function. We will also continue to address the data sharing aspects of the project.
Journal Articles on this Report : 16 Displayed | Download in RIS Format
| Other project views: | All 62 publications | 56 publications in selected types | All 56 journal articles |
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Bi J, Carmona N, Blanco M, Gassett A, Seto E, Szpiro A, Larson V, Sampson P, Kauffman J, Sheppard L. Publicly available low-cost sensor measurements for PM2.5 exposure modeling:Guidance for monitor deployment and data selection. ENVIRONMENTAL INTERNATIONAL 2022;158(106897). |
R838300 (2021) R831697 (Final) |
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Kirwa K, Eckert C, Vedal S, Hajat A, Kaufman J. Ambient air pollution and risk of respiratory infection among adults:evidence from the multiethnic study of atherosclerosis MESA. BMJ OPEN RESPIRATORY RESEARCH 2021;17(10):2075-2083. |
R838300 (2021) R831697 (Final) |
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Ong K, McClelland R, Allison M, Cushman M, Garg P, Tsai M, Rye K, Tabet F. Lipoprotein (a) and coronary artery calcification:prospective study assessing interactions with other risk factors. METABOLISM 2021;116. |
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Pelkus A, Younan D, Wang X, Beavers D, Espeland M, Gatz M, Gruenwald T, Kaufman J, Chui H, Millstein J, Rapp S, Manson J, Resnick S, Wellenius G, Whitsel E, Widman K, Chen J. Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women. JOURNAL OF ALZHEIMER'S DISEASE 2021;84(4):1691-1707. |
R838300 (2021) R831697 (Final) |
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Pelkus A, Resnick S, Wang X, Beavers D, Espeland M, Gatz M, Gruenwald T, Millstein J, Chui H, Kaufman J, Manson J, Wellenius G, Whitsel E, Widman K, Younan D, Chen J. Ambient air pollution exposure and in Reasing depressive symptoms in older women:The mediating Role of the prefrontal cortex and insula. SCIENCE OF THE TOTAL ENVIRONMENT 2022;823(153642). |
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Pewowaruk R, Korcarz C, Tedla Y, Mitchell C, Gepner A. CAROTID ARTERY STIFFNESS MECHANISMS IN HYPERTENSION AND THEIR ASSOCIATION WITH ECHOLUCENCY AND TEXTURE FEATURES:THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA). ULTRASOUND IN MEDICINE AND BIOLOGY 2022;48(11):2249-2257. |
R838300 (2021) R831697 (Final) |
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Pewowaruk R, KOrcarz C, Stein J, Bluemke D, Tedla Y, Gepner A. Methods of arterial stiffness calculation and cardiovascular disease events: the multiethnic study of atherosclerosis. JOURNAL OF HYPERTENSION 2023;41(3):486-493 |
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Phishgar F, Shabani M, Silva T, Bluemke D, Budoff M, Barr R, Allison M, Bertoni A, Post W, Lima J, Demehri S. Adipose tissue biomarkers and type 2 diabetes incidence in normoglycemic participants in the MESA Arthritis Ancillary Study:A cohort study. PLOS MEDICINE 2021;18(7):e1003700. |
R838300 (2021) R831697 (Final) |
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Pishgar F, Shabani M, Silva T, Blumeke D, Budoff M, Barr R, Allison M, Post W, Lima J, Demehri S. Quantitative Analysis of Adipose Depots by Using Chest CT and Associations with All-Cause Mortality in Chronic Obstructive Pulmonary Disease:Longitudinal Analysis from MESArthritis Ancillary Study. RADIOLOGY 2021;299(3):703-711. |
R838300 (2021) |
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Razavi A, Allen N, Dzaye O, Michos E, Budoff M, Lima J, Liu K, Post W, Blumenthal R. Risk Factors for Incident Coronary Artery Calcium in Younger (Age 32 to 45 Years) Versus Intermediate (46 to 64 Years) Versus Older (65 to 84 Years) Persons. AMERICAN JOURNAL OF CARDIOLOGY 2022;184:14-21. |
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Sayanthan S, Allison M, Dudoff M, Kye K, Ong K. Relationship of fibroblast growth factor 21 with the prevalence and progression of vascular and valvular calcification: Multi-ethnic study of atherosclerosis. INTERNATIONAL JOURNAL OF CARDIOLOGY 2023;370:388-395 |
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Wang X, Younan D, Petk A, Beavers D, Espeland M, Chiu H, Rsnick S, Gatz M, Kaufman J, Welleni G, Whitsel E, Manson J, Chen J. Ambient Air Pollution and Long-Term Trajectories of Episodic Memory Decline among Older Women in the WHIMS-ECHO Cohort. ENVIRONMENTAL HEALTH PERSPECTIVES 2020;129(9):97009. |
R838300 (2021) |
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Wang X, Younan D, Millstein J, Petkus A, Garcia E, Beavers D, Espland M, Chui H, Resnick S, Gatz M, Kaufman D, Wellenious G, Whitsel E, Manson J, Rapp S, Chen J. Association of improved air quality with lower dementiaRisk in older women. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES 2022;119(2):e2107833119. |
R838300 (2021) |
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Weze K, Obisean O, Dardari Z, Cainzos-Achirica M, Dzay O, Graham G, miedema M, Yeboah J, DeFilippis A, Nasir K, Blaha M, Osei A. The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism. AMERICAN JOURNAL OF PREVENTIVE MEDICINE 2022;63(1):E11-E20. |
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Younan D, Wang X, Millstein J, Petkus A, Beavers D, Espeland M, Chui H, Resnick S, Gatz M, Kauffman J, Wellenius G, Whitsel E, Manson J, Rapp S, Chen J. Air quality improvement and cognitive decline in community-dwelling older women in the United States:A longitudinal cohort study. PLOS MEDICINE 2022;19(2):e1003893. |
R838300 (2021) R831697 (Final) |
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Ni Y, Szpiro AA, Young MT, Loftus CT, Bush NR, LeWinn KZ, Sathyanarayana S, Enquobahrie DA, Davis RL, Kratz M, Fitzpatrick AL. Associations of pre-and postnatal air pollution exposures with child blood pressure and modification by maternal nutrition:a prospective study in the CANDLE cohort. Environmental health perspectives 2021;129(4):047004. |
R838300 (2021) R831697 (Final) |
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Supplemental Keywords:
Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporalRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2022 Progress Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- Original Abstract
56 journal articles for this project