Grantee Research Project Results
2013 Progress Report: Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
EPA Grant Number: R834796C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R834796
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials
Center Director: Faustman, Elaine
Title: Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
Investigators: Vedal, Sverre , Sheppard, Lianne (Elizabeth) A. , Kaufman, Joel D. , Larson, Timothy V. , Szpiro, Adam , Yost, Michael , Sampson, Paul
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
Project Period Covered by this Report: December 1, 2012 through November 30,2013
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
- Employ the small-scale gradient data acquired as part of the mobile monitoring campaign in Project 1, in conjunction with central fixed site data, regulatory monitoring data, and geographic covariates, to build a multi-pollutant exposure model for traffic-derived air pollutants. This model will incorporate complex spatial information on primary and secondary traffic-derived particles and gases.
- Develop and validate individual-level exposure estimates for traffic-derived air pollutants, integrating: i) the outdoor residential concentration estimates from the multi-pollutant model; ii) estimates of residential infiltration rates; iii) road class- and traffic condition-specific estimates of on-roadway concentrations; and iv) individual-level questionnaire-derived time location information. These individual-level exposure estimates also will utilize personal monitoring data designed to clarify the in-transit component of total exposure.
- Estimate the effect of individual-level exposure to traffic-derived air pollution on subclinical cardiovascular disease using these exposure models. Health outcomes will include left ventricular myocardial mass as ascertained by MRI, arteriolar diameters as measured by retinal photography, coronary artery calcium as ascertained by CT, intima-medial thickness as measured by ultrasound, and DNA methylation.
Progress Summary:
Future Activities:
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other subproject views: | All 29 publications | 15 publications in selected types | All 15 journal articles |
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Other center views: | All 196 publications | 93 publications in selected types | All 92 journal articles |
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Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environmental Health Perspectives 2013;121(9):1017-1025. |
R834796 (2013) R834796 (2014) R834796 (Final) R834796C005 (2013) R831697 (2013) R831697 (Final) R833864 (2011) |
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Sun M, Kaufman JD, Kim S-Y, Larson TV, Gould TR, Polak JF, Budoff MJ, Diez Roux AV, Vedal S. Particulate matter components and subclinical atherosclerosis:common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environmental Health 2013;12:39. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2013) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (2013) R831697 (Final) |
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Szpiro AA, Sheppard L, Adar SD, Kaufman JD. Estimating acute air pollution health effects from cohort study data. Biometrics 2014;70(1):164-174. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C005 (2013) R834796C005 (2015) R834796C005 (2016) R834796C005 (Final) R831697 (2013) R831697 (Final) |
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Vedal S, Kaufman JD. What does multi-pollutant air pollution research mean? American Journal of Respiratory and Critical Care Medicine 2011;183(1):4-6. |
R834796 (2012) R834796 (2013) R834796 (2014) R834796 (Final) R834796C005 (2013) R834796C005 (2016) R834796C005 (Final) |
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Supplemental Keywords:
Cardiovascular disease, subclinical, Health, Scientific Discipline, Air, ENVIRONMENTAL MANAGEMENT, Air Quality, air toxics, Health Risk Assessment, Risk Assessments, mobile sources, Risk Assessment, ambient air quality, atmospheric particulate matter, particulate matter, aerosol particles, air pollutants, motor vehicle emissions, vehicle emissions, air quality models, motor vehicle exhaust, airway disease, bioavailability, air pollution, particle exposure, atmospheric aerosols, ambient particle health effects, vascular dysfunction, cardiotoxicity, atmospheric chemistry, exposure assessmentRelevant Websites:
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834796 Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
15 journal articles for this subproject
Main Center: R834796
196 publications for this center
92 journal articles for this center