Grantee Research Project Results
2007 Progress Report: Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
EPA Grant Number: R832415Center: Rochester PM Center
Center Director: Oberdörster, Günter
Title: Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
Investigators: Oberdörster, Günter , Zareba, Wojciech , Prather, Kimberly A. , Elder, Alison C.P. , Utell, Mark J. , Hopke, Philip K. , Finkelstein, Jacob N. , Frampton, Mark W. , Henneberger, Alexandra , Peters, Annette , Oakes, David , Kittelson, David , Wichmann, Heinz-Erich , Brüske-Hohlfeld, Irene , Cyrus, Josef , Tieu, Kim , Rückerl, Regina , Phipps, Richard , Gelein, Robert , Beckett, William , Kreyling, Wolfgang
Current Investigators: Oberdörster, Günter , Hopke, Philip K. , Frampton, Mark W. , Utell, Mark J. , Finkelstein, Jacob N. , Peters, Annette
Institution: University of Rochester , University of California - San Diego , GSF-National Research Center for Environment and Health , University of Minnesota , Clarkson University
Current Institution: University of Rochester , Clarkson University , GSF-National Research Center for Environment and Health
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2012)
Project Period Covered by this Report: October 1, 2006 through September 30, 2007
Project Amount: $8,000,000
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
Studies are proposed to identify health hazards of source-specific physicochemical components of fine PM (e.g., UFP; organics) in epidemiological, controlled clinical, animal, and in vitro studies; a main focus will be on characterizing fine PM and determining pathophysiological mechanisms of effects to test the hypothesis that ambient ultrafine (UF)/fine PM cause oxidative stress and trigger cardiovascular adverse health effects, with specific emphasis on events leading to endothelial dysfunction.
Progress Summary:
Core 1: Exposure Assessment and PM Source Identification
During this year, work has continued to improve our understanding of the ambient aerosol through the development of on-the-fly particle source identification and apportionment and the identification of new chemical components that contribute to the particle-bound reactive oxygen species in the ambient aerosol. These results will lead to new approaches for providing key exposure assessment to support the toxicology and clinical studies in the Center. In addition, we have provided other critical data to other research cores. For example, particle size distribution and other pollutant concentration data support the clinical studies of heart rate variability and inflammatory markers in the blood of rehabilitation patients. We will be using our existing particle size distribution data base to initiate an epidemiological study of particle number concentrations and mortality in Rochester in conjunction with the Harvard PM and Health Center, and we are working with the in vitro core to analyze the results of their composition response data to see if we can identify relationships between composition and response.
Core 2: Epidemiological studies on extra pulmonary effects of fresh and aged urban aerosols from different sources
The objective of the epidemiological study is to determine the effect of fine and ultrafine particles on various blood markers. It is aimed to enroll 240 participants in three panels consisting of subjects with (1) type 2 diabetes, (2) impaired glucose tolerance (IGT) and (3) potential genetic susceptibility. Particles are measured at a central measurement site in Augsburg. In addition, personal measurements of temperature, humidity, noise and ultrafine particles are undertaken in a subset of 90 participants from all three panels. For this subset an endothelial function test and a 4-hour ECG are also scheduled.
A pilot phase was conducted between 19th and 23rd of February 2007. No major changes in the study protocol seemed necessary. The main phase started on the 19th of March and the recruitment is still ongoing. Up to the 25th of May 45 participants had been recruited by telephone (13 diabetics, 13 with IGT and 19 genetically susceptible participants). Sixteen agreed to take part in the personal measurements (nine diabetics, six with IGT and one of the genetically susceptible participants). In the first ten weeks of the field phase 73 examinations have been conducted with a maximum of three visits per participant. Data collection will proceed until the target of 80 participants per panel is reached.
As presented at the EPA-GSF-Rochester meeting in Montreat, NC, in spring 2007, first results from the pilot study indicate a good relation between personal exposure and the data of the central measurement site on an hourly basis
Core 3: Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles
The overall Core 3 hypothesis is that inhalation of ambient ultrafine and fine PM causes small but measurable changes in cardiac and vascular function, and coagulation, that help explain the cardiovascular effects of PM exposure. We are conducting a clinical study of healthy subjects inhaling concentrated ambient UFP. This study is co-funded by the EPA and by an NIEHS RO1 grant. Nine of a projected twenty subjects are enrolled in the study and six have completed both exposures. Exposures have been successful from a technical standpoint and no subject has experienced symptoms or problems.
We have completed a study of type 2 diabetics, age 30 to 60, inhaling filtered air and 50 μg/m3 carbon UFP for two hours, at rest. Nineteen subjects completed this study. We found evidence that UFP exposure increased markers of platelet activation, and also increased the number of circulating microparticles expressing tissue factor. These findings indicate that UFP exposure transiently activated vascular endothelium and/or platelets in people with type 2 diabetes. This supports the hypothesis that exposure to ambient UFP increases the potential for vascular thrombosis in patients with severe vascular disease.
Using in vitro studies, we have found that carbon ultrafine particles have direct effects on platelet activation. The degree of activation varied with particle size and composition. Thus one mechanism for UFP effects may be direct effects on platelets from particles that enter the circulation.
Core 4: Animal Models: Cardiovascular Disease, CNS Injury and Ultrafine Particle Biokinetics
The objective of the Core 4 studies is to correlate physicochemical particle characteristics with pulmonary and cardiovascular endpoints following exposures to ultrafine particle (UFP)-containing ambient aerosols in a rat model of type II diabetes obese, (hyperinsulinemic JCR rats). Effects measurements are coordinated with the epidemiological, clinical, and in vitro studies.
The diabetic rat model (male JCR rats) was used to study pulmonary and cardiovascular endpoints following exposure to either ambient concentrated ultrafine particles or to diesel exhaust while driving on the highway. Non-obese, nonhyperinsulinemic rats (JCR +/?) not developing atherosclerotic lesions served as controls.
After exposure for 4 weeks (6 hrs./day; 5 days/week) to concentrated Rochester ultrafine particles (count median diameter 75 nm; number concentration 0.05 – 1.3 x 106 particles/cm3) changes in the following endpoints were observed in the obese rats compared to the normal lean rats: increase in total lung lavage cell number; lavage fluid protein concentration and lavage LDH and β-glucuronidase. Blood parameters: total white blood cell number; number of blood leukocyte aggregates; and plasma fibrinogen. These changes were observed after 3 days of exposure, but not after 4 weeks of exposure, indicating an adaptive response. Likewise, after 3 days of exposure aortic mtDNA amplification was blunted, suggesting that oxidative damage had occurred. This response was not seen after 4 weeks of exposure. However, it appears that iron homeostasis was disrupted in the obese rats following 4 weeks of exposure: higher levels of iron were measured in lung lavage fluid, liver and lung tissue, as well as higher levels of transferrin and ferritin in the lavage fluid. In addition, serum and lavage fluid levels of leptin were increased in the obese rats after 4 weeks of exposure (indication of defense mechanism induction?).
The on-road exposures were designed to compare respiratory and cardiovascular effects of inhaled diesel exhaust particles from low (pre-2007) and ultralow (2007) diesel fuel, simulating real-world conditions while driving the rats on the New York State Thruway between Rochester and Buffalo for 6 hours each day in the Mobile Exposure Laboratory. Rats were implanted with radiotransmitters to continuously monitor heart rate, blood pressure, body temperature and activity. Evaluations of blood pressure, heart rate and heart rate variability are on-going. Although the lung lavage of obese rats had higher total cell numbers, PMN, as well as higher protein, LDH and β-glucuronidase levels than the lean rats, exposures to the exhaust for either 1 or 4 days did not have any consistent effects. Other endpoints related to inflammation using bead array technology did not reveal significant changes, although there was a lot of variability, with the obese rats generally having higher levels. The only exposure-induced effect was in serum leptin levels which were increased in the exhaust-exposed obese rats. Lastly, as we have found previously, UFP-containing aerosols caused a decrease in heart rate; the differences between exposure groups got larger over time.
Core 5: Ultrafine particle cell interactions in vitro: Molecular mechanisms leading to altered gene expression in relation to particle composition
The experiments proposed within this project address specific mechanistic hypotheses regarding the interactions between inhaled ultrafine particles and specific pulmonary cell populations. They attempt to provide a mechanistic link and biological plausibility for the whole animal and controlled clinical (human) exposures, described in the other programs of this Particle Center. During the current year we have focused on better characterizing the response of vascular endothelial cells to PM, as this is in keeping with our effort to understand the cardiovascular effects. We established appropriate culture conditions for the microvessel endothelial cells and compared the PM response to that of HUVEC cells.
We determined that production of IL-6 and nitric oxide (NO) were useful markers of PM response and established conditions to measure them. We also showed that cells cultured in elevated glucose demonstrated a blunted response to PM consistent with altered oxidative stress.
We also compared the production of NO and IL-6 in cells exposed to PM of varying composition collected at various sites in the US with a high volume sampler. We are attempting to correlate the cellular response to the size and composition of the PM. This remains a work in progress.
Journal Articles: 144 Displayed | Download in RIS Format
| Other center views: | All 191 publications | 157 publications in selected types | All 144 journal articles |
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Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW. Neutrophils in lung inflammation: which reactive oxygen species are being measured? Inhalation Toxicology 2001;13(6):485-495. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (2004) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
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Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang L-S, Cox C, Zareba W, Oberdorster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults:a human inhalation study. American Journal of Respiratory and Critical Care Medicine 2005;171(10):1129-1135. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Berger A, Zareba W, Schneider A, Ruckerl R, Ibald-Mulli A, Cyrys J, Wichmann HE, Peters A. Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease. Journal of Occupational and Environmental Medicine 2006;48(11):1149-1158. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. Foxp3 regulates megakaryopoiesis and platelet function. Arteriosclerosis, Thrombosis, and Vascular Biology 2009;29(11):1874-1882. |
R832415 (Final) |
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Bezemer GFG, Bauer SM, Oberdorster G, Breysse PN, Pieters RHH, Georas SN, Williams MA. Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. Journal of Innate Immunity 2011;3(2):150-166. |
R832415 (Final) R832139 (Final) |
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Breitner S, Stolzel M, Cyrys J, Pitz M, Wolke G, Kreyling W, Kuchenhoff H, Heinrich J, Wichmann H-E, Peters A. Short-term mortality rates during a decade of improved air quality in Erfurt, Germany. Environmental Health Perspectives 2009;117(3):448-454. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
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Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832415 (Final) R832413 (Final) R832414 (Final) R832416 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Bruske I, Hampel R, Socher MM, Ruckerl R, Schneider A, Heinrich J, Oberdorster G, Wichmann H-E, Peters A. Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease. Inhalation Toxicology 2010;22(3):245-252. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2010) R832415C002 (2011) R832415C004 (2010) R832415C004 (2011) R827354 (Final) |
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Bruske I, Hampel R, Baumgartner Z, Ruckerl R, Greven S, Koenig W, Peters A, Schneider A. Ambient air pollution and lipoprotein-associated phospholipase A2 in survivors of myocardial infarction. Environmental Health Perspectives 2011;119(7):921-926. |
R832415 (Final) |
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Cass GR, Hughes LA, Bhave P, Kleeman MJ, Allen JO, Salmon LG. The chemical composition of atmospheric ultrafine particles. Philosophical Transactions of the Royal Society of London Series A-Mathematical Physical & Engineering Sciences 2000;358(1775):2581-2592. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (2004) R827354 (Final) R827354C001 (1999) R827354C001 (2000) R827354C001 (Final) |
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Chalupa DC, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environmental Health Perspectives 2004;112(8):879-882. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Couderc JP, Elder ACP, Cox C, Zareba W, Oberdorster G. Limitations of power-spectrum and time-domain analysis of heart rate variability in short-term ECG recorded using telemetry in unrestrained rats. Computers in Cardiology 2002;29:589-592. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R828046 (Final) |
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Cyrys J, Heinrich J, Peters A, Kreyling WG, Wichmann H-E. Emissionen, immission und messungen feiner und ultrafeiner partikel (Immission, emissions, and measurements of fine and ultrafine particles). Umweltmedizin in Forschung und Praxis 2002;7(2):67-77. |
R832415 (2010) R832415 (Final) R832415C002 (2011) |
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Cyrys J, Peters A, Soentgen J, Wichmann HE. Low emission zones reduce PM10 mass concentrations and diesel soot in German cities. Journal of the Air & Waste Management Association 2014;64(4):481-487. |
R832415 (Final) |
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Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhalation Toxicology 2003;15(6):539-552. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (2001) R826781 (Final) R827354 (2004) R827354 (Final) R827354C003 (1999) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (2003) R827354C003 (2004) R827354C003 (Final) R827354C004 (Final) |
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Deffner V, Kuechenhoff H, Maier V, Pitz M, Cyrys J, Breitner S, Schneider A, Gu J, Geruschkat U, Peters A. Personal exposure to ultrafine particles: two-level statistical modeling of background exposure and time-activity patterns during three seasons. Journal of Exposure Science and Environmental Epidemiology 2016;26(1):17-25. |
R832415 (Final) |
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Deffner V, Keuschenoff H, Breitner S, Schneider A, Cyrys J, Peters A. Mixtures of Berkson and classical covariate measurement error in the linear mixed model: Bias analysis and application to a study on ultrafine particles. BIOMETRICAL JOURNAL 2018;60(3):480-497 |
R832415 (Final) |
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Dillner AM, Schauer JJ, Christensen WF, Cass GR. A quantitative method for clustering size distributions of elements. Atmospheric Environment 2005;39(8):1525-1537. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (2004) R827354 (Final) R827354C001 (Final) R827355 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic interactions between inhaled ultrafine particles and endotoxin. Annals of Occupational Hygiene 2002;46(Suppl 1):231-234. |
R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) R828046 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhalation Toxicology 2004;16(6-7):461-471. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder ACP, Gelein R, Oberdorster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Experimental Lung Research 2004;30(2):105-120. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) |
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Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong C-H, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdorster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhalation Toxicology 2004;16(Suppl 1):41-53. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdorster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Experimental Lung Research 2005;31(6):527-546. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives 2006;114(8):1172-1178. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C004 (Final) R827354C005 (Final) |
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Elder A, Couderc J-P, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdorster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhalation Toxicology 2007;19(1):1-12. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2006) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) R828046 (Final) |
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Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R827351 (Final) R827352 (Final) R827353 (Final) R827354 (Final) R827355 (Final) R832416 (2009) R832416C003 (2009) |
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Fensterer V, Kuchenhoff H, Maier V, Wichmann HE, Breitner S, Peters A, Gu JW, Cyrys J. Evaluation of the impact of low emission zone and heavy traffic ban in Munich (Germany) on the reduction of PM10 in ambient air. International Journal of Environmental Research and Public Health 2014;11(5):5094-5112. |
R832415 (Final) |
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Frampton MW. Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environmental Health Perspectives 2001;109(Suppl 4):529-532. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
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Frampton MW, Stewart JC, Oberdorster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang L-S, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environmental Health Perspectives 2006;114(1):51-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Frampton MW. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans? Inhalation Toxicology 2007;19(Suppl 1):75-79. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (Final) R827354 (Final) R827354C003 (Final) |
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Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ. Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes. Inhalation Toxicology 2012;24(12):831-838. |
R832415 (Final) |
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Gu J, Pitz M, Breitner S, Birmili W, von Klot S, Schneider A, Soentgen J, Reller A, Peters A, Cyrys J. Selection of key ambient particulate variables for epidemiological studies--applying cluster and heatmap analyses as tools for data reduction. Science of the Total Environment 2012;435-436:541-550. |
R832415 (Final) |
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Hampel R, Schneider A, Bruske I, Zareba W, Cyrys J, Ruckerl R, Breitner S, Korb H, Sunyer J, Wichmann HE, Peters A. Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors. Environmental Health Perspectives 2010;118(12):1755-1761. |
R832415 (Final) R827354 (Final) |
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Hampel R, Breitner S, Ruckerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A. Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season. Occupational & Environmental Medicine 2010;67(6):408-416. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C003 (2011) |
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Hampel R, Breitner S, Schneider A, Zareba W, Kraus U, Cyrys J, Geruschkat U, Belcredi P, Muller M, Wichmann HE, Peters A, Cooperative Health Research in the Region of Augsburg (KORA) Study Group. Acute air pollution effects on heart rate variability are modified by SNPs involved in cardiac rhythm in individuals with diabetes or impaired glucose tolerance. Environmental Research 2012;112:177-185. |
R832415 (Final) |
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Hampel R, Breitner S, Zareba W, Kraus U, Pitz M, Geruschkat U, Belcredi P, Peters A, Schneider A, Cooperative Health Research in the Region of Augsburg Study Group. Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals. Occupational and Environmental Medicine 2012;69(6):428-436. |
R832415 (Final) |
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Hampel R, Ruckerl R, Yli-Tuomi T, Breitner S, Lanki T, Kraus U, Cyrys J, Belcredi P, Bruske I, Laitinen TM, Timonen K, Wichmann HE, Peters A, Schneider A. Impact of personally measured pollutants on cardiac function. International Journal of Hygiene and Environmental Health 2014;217(4-5):460-464. |
R832415 (Final) |
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Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdorster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology 2011;287(1-3):99-104. |
R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
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Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdorster G. Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data. Toxicology 2012;297(1-3):1-9. |
R832415 (Final) |
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Henneberger A, Zareba W, Ibald-Mulli A, Ruckerl R, Cyrys J, Couderc J-P, Mykins B, Woelke G, Wichmann H-E, Peters A. Repolarization changes induced by air pollution in ischemic heart disease patients. Environmental Health Perspectives 2005;113(4):440-446. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2003) R827354C002 (Final) |
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Hildebrandt K, Ruckerl R, Koenig W, Schneider A, Pitz M, Heinrich J, Marder V, Frampton M, Oberdorster G, Wichmann HE, Peters A. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease. Particle and Fibre Toxicology 2009;6:25. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2009) R832415C002 (2010) R832415C002 (2011) R832415C003 (2010) R832415C003 (2011) R832415C004 (2010) R832415C004 (2011) |
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Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C017 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) |
Exit Exit Exit |
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Ibald-Mulli A, Wichmann HE, Kreyling W, Peters A. Epidemiological evidence on health effects of ultrafine particles. Journal of Aerosol Medicine 2002;15(2):189-201. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2003) R827354C002 (Final) |
Exit |
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Ito K, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Neas L, Hopke PK, Thurston GD. PM source apportionment and health effects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):300-310. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) R827997 (Final) |
Exit Exit |
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Jeong C-H, Hopke PK, Chalupa D, Utell M. Characteristics of nucleation and growth events of ultrafine particles measured in Rochester, NY. Environmental Science & Technology 2004;38(7):1933-1940. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C003 (Final) |
Exit Exit Exit |
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Jeong C-H, Lee D-W, Kim E, Hopke PK. Measurement of real-time PM2.5 mass, sulfate, and carbonaceous aerosols at the multiple monitoring sites. Atmospheric Environment 2004;38(31):5247-5256. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Jeong C-H, Hopke PK, Kim E, Lee D-W. The comparison between thermal-optical transmittance elemental carbon and Aethalometer black carbon measured at multiple monitoring sites. Atmospheric Environment 2004;38(31):5193-5204. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Jeong C-H, Evans GJ, Hopke PK, Chalupa D, Utell MJ. Influence of atmospheric dispersion and new particle formation events on ambient particle number concentration in Rochester, United States, and Toronto, Canada. Journal of the Air & Waste Management Association 2006;56(4):431-443. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) |
Exit Exit |
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Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. city by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C008 (2002) R827355C008 (Final) R827355C009 (2003) R828678C010 (2003) R828678C010 (2004) R828678C010 (2005) R828678C010 (2006) R828678C010 (2007) R828678C010 (Final) |
Exit Exit Exit |
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Kim E, Hopke PK, Larson TV, Maykut NN, Lewtas J. Factor analysis of Seattle fine particles. Aerosol Science and Technology 2004;38(7):724-738. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2003) R827355C008 (Final) |
Exit Exit Exit |
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Kim E, Hopke PK, Larson TV, Covert DS. Analysis of ambient particle size distributions using Unmix and positive matrix factorization. Environmental Science & Technology 2004;38(1):202-209. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827354C002 (2004) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2002) R827355C008 (2003) R827355C008 (Final) |
Exit Exit Exit |
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Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdorster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong C-H. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhalation Toxicology 2004;16(Suppl 1):31-39. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit |
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Kraus U, Breitner S, Schnelle-Kreis J, Cyrys J, Lanki T, Ruckerl R, Schneider A, Bruske I, Gu J, Devlin R, Wichmann H-E, Zimmermann R, Peters A. Particle-associated organic compounds and symptoms in myocardial infarction survivors. Inhalation Toxicology 2011;23(7):431-447. |
R832415 (Final) R832415C002 (2011) |
Exit |
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Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdorster G, Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health-Part A 2002;65(20):1513-1530. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
Exit |
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Lagudu UR, Raja S, Hopke PK, Chalupa DC, Utell MJ, Casuccio G, Lersch TL, West RR. Heterogeneity of coarse particles in an urban area. Environmental Science & Technology 2011;45(8):3288-3296. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Lanzinger S, Hampel R, Breitner S, Ruckerl R, Kraus U, Cyrys J, Geruschkat U, Peters A, Schneider A. Short-term effects of air temperature on blood pressure and pulse pressure in potentially susceptible individuals. International Journal of Hygiene and Environmental Health 2014;217(7):775-784. |
R832415 (Final) |
Exit Exit Exit |
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Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827351 (2002) R827351 (Final) R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827354 (Final) R827355 (Final) |
Exit |
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Ljungman P, Bellander T, Nyberg F, Lampa E, Jacquemin B, Kolz M, Lanki T, Mitropoulos J, Muller M, Picciotto S, Pistelli R, Ruckerl R, Koenig W, Peters A, AIRGENE Study Group. DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: results from the AIRGENE study. Thrombosis Research 2009;124(1):57-64. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit |
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Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Neas L, Stolzel M, Paatero P, Hopke PK, Thurston GD. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):311-320. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827353 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C002 (Final) R827355C008 (Final) |
Exit Exit Exit |
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Moffet RC, Shields LG, Berntsen J, Devlin RB, Prather KA. Characterization of an ambient coarse particle concentrator used for human exposure studies: aerosol size distributions, chemical composition, and concentration enrichment. Aerosol Science and Technology 2004;38(11):1123-1137. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit |
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Oberdorster G. Pulmonary effects of inhaled ultrafine particles. International Archives of Occupational and Environmental Health 2001;74(1):1-8. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C004 (2000) R827354C004 (2001) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Utell MJ. Ultrafine particles in the urban air:to the respiratory tract—and beyond? Environmental Health Perspectives 2002;110(8):A440-A441. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. Journal of Toxicology and Environmental Health, Part A: Current Issues 2002;65(20):1531-1543. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology 2004;16(6-7):437-445. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology:an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives 2005;113(7):823-839. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (Final) |
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Oberdorster G, Stone V, Donaldson K. Toxicology of nanoparticles: a historical perspective. Nanotoxicology 2007;1(1):2-25. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2007) R832415C004 (2010) R832415C004 (2011) |
Exit Exit |
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Oberdorster G, Elder A, Rinderknecht A. Nanoparticles and the brain: cause for concern? Journal of Nanoscience and Nanotechnology 2009;9(8):4996-5007. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) |
Exit |
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Oberdorster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. Journal of Internal Medicine 2010;267(1):89-105. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) |
Exit Exit Exit |
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Ogulei D, Hopke PK, Chalupa DC, Utell MJ. Modeling source contributions to submicron particle number concentrations measured in Rochester, New York. Aerosol Science and Technology 2007;41(2):179-201. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R831078 (Final) |
Exit Exit Exit |
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Pavlovic J, Hopke PK. Technical note: detection and identification of radical species formed from α-pinene/ozone reaction using DMPO spin trap. Atmospheric Chemistry and Physics Discussions 2009;9(6):23695-23717. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2009) R832415C001 (2010) R832415C001 (2011) |
Exit Exit |
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Pavlovic J, Hopke PK. Detection of radical species formed by the ozonolysis of α-pinene. Journal of Atmospheric Chemistry 2010;66(3):137-155. |
R832415 (2011) R832415 (Final) R832415C001 (2011) |
Exit |
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Pavlovic J, Hopke PK. Chemical nature and molecular weight distribution of the water-soluble fine and ultrafine PM fractions collected in a rural environment. Atmospheric Environment 2012;59:264-271. |
R832415 (Final) |
Exit Exit Exit |
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Pekkanen J, Peters A, Hoek G, Tiittanen P, Brunekreef B, de Hartog J, Heinrich J, Ibald-Mulli A, Kreyling WG, Lanki T, Timonen KL, Vanninen E. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease:the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 2002;106(8):933-938. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
Exit Exit Exit |
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Peters A, Heinrich J, Wichmann H-E. Gesundheitliche Wirkungen von Feinstaub: Epidemiologie der Kurzzeiteffekte (Health impact of exposure to fine particles: epidemiology of short-term effects). Umweltmedizin in Forschung und Praxis 2002;7(2):101-115. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
Exit Exit |
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Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H, Cooperative Health Research in the Region of Augsburg Study Group. Exposure to traffic and the onset of myocardial infarction. New England Journal of Medicine 2004;351(17):1721-1730. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Peters A. Particulate matter and heart disease:evidence from epidemiological studies. Toxicology and Applied Pharmacology 2005;207(2-Suppl):477-482. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Peters A, Greven S, Heid IM, Baldari F, Breitner S, Bellander T, Chrysohoou C, Illig T, Jacquemin B, Koenig W, Lanki T, Nyberg F, Pekkanen J, Pistelli R, Ruckerl R, Stefanadis C, Schneider A, Sunyer J, Wichmann HE, AIRGENE Study Group. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. American Journal of Respiratory and Critical Care Medicine 2009;179(6):484-491. |
R832415 (2009) R832415 (2010) R832415 (Final) R832415C002 (2009) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Peters A. Air quality and cardiovascular health:smoke and pollution matter. Circulation 2009;120(11):924-927. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Peters A, Hampel R, Cyrys J, Breitner S, Geruschkat U, Kraus U, Zareba W, Schneider A. Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes. Particle and Fibre Toxicology 2015;12:7 (11 pp.). |
R832415 (Final) |
Exit Exit |
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Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdorster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang L-S, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhalation Toxicology 2004;16(Suppl 1):59-72. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (Final) R827354 (Final) R827354C003 (2003) R827354C003 (Final) R827354C004 (Final) |
Exit Exit |
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Pitz M, Birmili W, Schmid O, Peters A, Wichmann HE, Cyrys J. Quality control and quality assurance for particle size distribution measurements at an urban monitoring station in Augsburg, Germany. Journal of Environmental Monitoring 2008;10(9):1017-1024. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (Final) R832415C002 (2006) R832415C002 (2008) R832415C002 (2010) R832415C002 (2011) |
Exit |
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Pui DYH, Qi C, Stanley N, Oberdorster G, Maynard A. Recirculating air filtration significantly reduces exposure to airborne nanoparticles. Environmental Health Perspectives 2008;116(7):863-866. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2010) R832415C004 (2011) |
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Reemtsma T, These A, Venkatachari P, Xia X, Hopke PK, Springer A, Linscheid M. Identification of fulvic acids and sulfated and nitrated analogues in atmospheric aerosol by electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry 2006;78(24):8299-8304. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) |
Exit Exit Exit |
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Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O’Shea K, Wang Y, Utell MJ. Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation? Environmental Health Perspectives 2012;120(8):1162-1169. |
R832415 (Final) |
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Riesenfeld E, Chalupa D, Gibb FR, Oberdo G, Gelein R, Morrow PE, Utell MJ, Frampton MW. Ultrafine particle concentrations in a hospital. Inhalation Toxicology 2000;12(Suppl 2):83-94. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (2000) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R827354C004 (2000) R827354C004 (Final) |
Exit |
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Ruckerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. American Journal of Respiratory and Critical Care Medicine 2006;173(4):432-441. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C002 (2003) R827354C002 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit Exit Exit |
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Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann HE, Peters A. Ultrafine particles and platelet activation in patients with coronary heart disease – results from a prospective panel study. Particle and Fibre Toxicology 2007;4:1. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
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Ruckerl R, Hampel R, Breitner S, Cyrys J, Kraus U, Carter J, Dailey L, Devlin RB, Diaz-Sanchez D, Koenig W, Phipps R, Silbajoris R, Soentgen J, Soukup J, Peters A, Schneider A. Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations. Environment International 2014;70:32-49. |
R832415 (Final) |
Exit Exit Exit |
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|
Ruckerl R, Schneider A, Hampel R, Breitner S, Cyrys J, Kraus U, Gu J, Soentgen J, Koenig W, Peters A. Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations--results from a panel study. Environmental Research 2016;150:337-347. |
R832415 (Final) |
Exit Exit Exit |
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Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. Journal of Toxicology and Environmental Health, Part A 2010;73(5-6):445-461. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2010) R832415C004 (2011) R832415C005 (2010) R832415C005 (2011) |
Exit |
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Schauble CL, Hampel R, Breitner S, Ruckerl R, Phipps R, Diaz-Sanchez D, Devlin RB, Carter JD, Soukup J, Silbajoris R, Dailey L, Koenig W, Cyrys J, Geruschkat U, Belcredi P, Kraus U, Peters A, Schneider AE. Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals. Occupational and Environmental Medicine 2012;69(9):670-678. |
R832415 (Final) |
Exit Exit |
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Schneider A, Neas L, Herbst MC, Case M, Williams RW, Cascio W, Hinderliter A, Holguin F, Buse JB, Dungan K, Styner M, Peters A, Devlin RB. Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environmental Health Perspectives 2008;116(12):1666-1674. |
R832415 (2008) R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
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Schneider A, Neas LM, Graff DW, Herbst MC, Cascio WE, Schmitt MT, Buse JB, Peters A, Devlin RB. Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals. Particle and Fibre Toxicology 2010;7:14. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Schneider A, Hampel R, Ibald-Mulli A, Zareba W, Schmidt G, Schneider R, Ruckerl R, Couderc JP, Mykins B, Oberdorster G, Wolke G, Pitz M, Wichmann H-E, Peters A. Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease. Particle and Fibre Toxicology 2010;7:29 (12 pp.). |
R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
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Schneider A, Alexis NE, Diaz-Sanchez D, Neas LM, Harder S, Herbst MC, Cascio WE, Buse JB, Peters A, Devlin RB. Ambient PM2.5 exposure up-regulates the expression of costimulatory receptors on circulating monocytes in diabetic individuals. Environmental Health Perspectives 2011;119(6):778-783. |
R832415 (Final) R832415C002 (2011) |
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Semmler-Behnke M, Takenaka S, Fertsch S, Wenk A, Seitz J, Mayer P, Oberdorster G, Kreyling WG. Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium. Environmental Health Perspectives 2007;115(5):728-733. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2007) R832415C004 (2010) R832415C004 (2011) |
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Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang L-S, Utell MJ, Frampton MW. Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environmental Health Perspectives 2008;116(3):375-380. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2006) R832415C003 (2010) R832415C003 (2011) |
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Silva VM, Corson N, Elder A, Oberdorster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicological Sciences 2005;85(2):983-989. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit Exit Exit |
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Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhalation Toxicology 2005;17(9):415-425. |
R832415 (2010) R832415 (Final) R832415C005 (2011) R827354 (Final) R827354C005 (Final) |
Exit |
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Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Experimental Lung Research 2005;31(6):581-597. |
R832415 (2010) R832415 (Final) R832415C005 (2011) R827354 (Final) R827354C005 (Final) |
Exit |
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Spencer MT, Prather KA. Using ATOFMS to determine OC/EC mass fractions in particles. Aerosol Science and Technology 2006;40(8):585-594. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R831083 (Final) |
Exit Exit Exit |
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Spencer MT, Shields LG, Sodeman DA, Toner SM, Prather KA. Comparison of oil and fuel particle chemical signatures with particle emissions from heavy and light duty vehicles. Atmospheric Environment 2006;40(27):5224-5235. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Spencer MT, Shields LG, Prather KA. Simultaneous measurement of the effective density and chemical composition of ambient aerosol particles. Environmental Science & Technology 2007;41(4):1303-1309. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2006) R832415C001 (2010) R832415C001 (2011) R827354 (Final) R831083 (Final) |
Exit Exit Exit |
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Stewart JC, Villasmil ML, Frampton MW. Changes in fluorescence intensity of selected leukocyte surface markers following fixation. Cytometry Part A 2007;71A(6):379-385. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2006) R832415C003 (2010) R832415C003 (2011) |
Exit Exit Exit |
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Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW. Vascular effects of ultrafine particles in persons with type 2 diabetes. Environmental Health Perspectives 2010;118(12):1692-1698. |
R832415 (2011) R832415 (Final) R832415C003 (2011) |
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Stolzel M, Breitner S, Cyrys J, Pitz M, Wolke G, Kreyling W, Heinrich J, Wichmann H-E, Peters A. Daily mortality and particulate matter in different size classes in Erfurt, Germany. Journal of Exposure Science & Environmental Epidemiology 2007;17(5):458-467. |
R832415 (2010) R832415 (Final) R832415C002 (2011) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Su Y, Sipin MF, Furutani H, Prather KA. Development and characterization of an aerosol time-of-flight mass spectrometer with increased detection efficiency. Analytical Chemistry 2004;76(3):712-719. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Su Y, Sipin MF, Prather KA, Gelein RM, Lunts A, Oberdorster G. ATOFMS characterization of individual model aerosol particles used for exposure studies. Aerosol Science and Technology 2005;39(5):400-407. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C004 (Final) |
Exit Exit |
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Su Y, Sipin MF, Spencer MT, Qin X, Moffet RC, Shields LG, Prather KA, Venkatachari P, Jeong C-H, Kim E, Hopke PK, Gelein RM, Utell MJ, Oberdorster G, Berntsen J, Devlin RB, Chen LC. Real-time characterization of the composition of individual particles emitted from ultrafine particle concentrators. Aerosol Science and Technology 2006;40(6):437-455. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit Exit Exit |
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Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Hopke PK. Workgroup report: Workshop on source apportionment of particulate matter health effects—intercomparison of results and implications. Environmental Health Perspectives 2005;113(12):1768-1774. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) |
Exit |
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Thurston GD, Bekkedal MY, Roberts EM, Ito K, Pope III CA, Glenn BS, Ozkaynak H, Utell MJ. Use of health information in air pollution health research:past successes and emerging needs. Journal of Exposure Science and Environmental Epidemiology 2009;19(1):45-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2010) R832415C003 (2011) |
Exit Exit |
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Toner SM, Shields LG, Sodeman DA, Prather KA. Using mass spectral source signatures to apportion exhaust particles from gasoline and diesel powered vehicles in a freeway study using UF-ATOFMS. Atmospheric Environment 2008;42(3):568-581. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Utell MJ, Frampton MW. Toxicologic methods: controlled human exposures. Environmental Health Perspectives 2000;108(Suppl 4):605-613. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (Final) R827354 (Final) |
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Utell MJ, Frampton MW. Acute health effects of ambient air pollution: the ultrafine particle hypothesis. Journal of Aerosol Medicine 2000;13(4):355-359. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) |
Exit |
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Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE. Cardiovascular effects associated with air pollution:potential mechanisms and methods of testing. Inhalation Toxicology 2002;14(12):1231-1247. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
Exit |
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Venkatachari P, Hopke PK, Grover BD, Eatough DJ. Measurement of particle-bound reactive oxygen species in rubidoux aerosols. Journal of Atmospheric Chemistry 2005;50(1):49-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit |
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Venkatachari P, Zhou L, Hopke PK, Felton D, Rattigan OV, Schwab JJ, Demerjian KL. Spatial and temporal variability of black carbon in New York City. Journal of Geophysical Research 2006;111(D10):D10S05 (9 pp.). |
R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Venkatachari P, Zhou L, Hopke PK, Schwab JJ, Demerjian KL, Weimer S, Hogrefe O, Felton D, Rattigan O. An intercomparison of measurement methods for carbonaceous aerosol in the ambient air in New York City. Aerosol Science and Technology 2006;40(10):788-795. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Venkatachari P, Hopke PK, Brune WH, Ren X, Lesher R, Mao J, Mitchell M. Characterization of wintertime reactive oxygen species concentrations in Flushing, New York. Aerosol Science and Technology 2007;41(2):97-111. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit Exit Exit |
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Venkatachari P, Hopke PK. Development and laboratory testing of an automated monitor for the measurement of atmospheric particle-bound reactive oxygen species (ROS). Aerosol Science and Technology 2008;42(8):629-635. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2008) R832415C001 (2010) R832415C001 (2011) |
Exit Exit Exit |
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Venkatachari P, Hopke PK. Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides. Journal of Environmental Monitoring 2008;10(8):966-974. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit |
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Venkatachari P, Hopke PK. Development and evaluation of a particle-bound reactive oxygen species generator. Journal of Aerosol Science 2008;39(2):168-174. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit Exit Exit |
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Veranth JM, Gelein R, Oberdorster G. Vaporization – condensation generation of ultrafine hydrocarbon particulate matter for inhalation toxicology studies. Aerosol Science and Technology 2003;37(7):603-609. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) |
Exit Exit |
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von Klot S, Peters A, Aalto P, Bellander T, Berglind N, D'Ippoliti D, Elosua R, Hormann A, Kulmala M, Lanki T, Lowel H, Pekkanen J, Picciotto S, Sunyer J, Forastiere F. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 2005;112(20):3073-3079. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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von Klot S, Cyrys J, Hoek G, Kuhnel B, Pitz M, Kuhn U, Kuch B, Meisinger C, Hormann A, Wichmann HE, Peters A. Estimated personal soot exposure is associated with acute myocardial infarction onset in a case-crossover study. Progress in Cardiovascular Diseases 2011;53(5):361-368. |
R832415 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Chalupa DC, Utell MJ. Long-term study of urban ultrafine particles and other pollutants. Atmospheric Environment 2011;45(40):7672-7680. |
R832415 (Final) |
Exit Exit Exit |
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Wang Y, Hopke PK, Sun L, Chalupa DC, Utell MJ. Laboratory and field testing of an automated atmospheric particle-bound reactive oxygen species sampling-analysis system. Journal of Toxicology 2011;2011:419476 (9 pp). |
R832415 (2011) R832415 (Final) R832415C003 (2011) R831078 (Final) |
Exit |
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Wang Y, Hopke PK, Chalupa DC, Utell MJ. Effect of the shutdown of a coal-fired power plant on urban ultrafine particles and other pollutants. Aerosol Science and Techology 2011;45(10):1245-1249. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Wang Y, Hopke PK, Utell MJ. Urban-scale spatial-temporal variability of black carbon and winter residential wood combustion particles. Aerosol and Air Quality Research 2011;11(5):473-481. |
R832415 (2011) R832415 (Final) R832415C003 (2011) R831078 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Rattigan OV, Xia X, Chalupa DC, Utell MJ. Characterization of residential wood combustion particles using the two-wavelength aethalometer. Environmental Science & Technology 2011;45(17):7387-7393. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Wang Y, Hopke PK, Rattigan OV, Chalupa DC, Utell MJ. Multiple-year black carbon measurements and source apportionment using Delta-C in Rochester, New York. Journal of the Air & Waste Management Association 2012;62(8):880-887. |
R832415 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Xia X, Rattigan OV, Chalupa DC, Utell MJ. Source apportionment of airborne particulate matter using inorganic and organic species as tracers. Atmospheric Environment 2012;55:525-532. |
R832415 (Final) |
Exit Exit Exit |
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Wang Y, Hopke PK, Rattigan OV. A new indicator of fireworks emissions in Rochester, New York. Environmental Monitoring and Assessment 2012;184(12):7293-7297. |
R832415 (Final) |
Exit |
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Yue W, Schneider A, Stolzel M, Ruckerl R, Cyrys J, Pan X, Zareba W, Koenig W, Wichmann H-E, Peters A. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2007;621(1-2):50-60. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
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Yue W, Schneider A, Ruckerl R, Koenig W, Marder V, Wang S, Wichmann H-E, Peters A, Zareba W. Relationship between electrocardiographic and biochemical variables in coronary artery disease. International Journal of Cardiology 2007;119(2):185-191. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit |
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Yue W, Stolzel M, Cyrys J, Pitz M, Heinrich J, Kreyling WG, Wichmann H-E, Peters A, Wang S, Hopke PK. Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany. Science of the Total Environment 2008;398(1-3):133-144. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2008) R832415C001 (2010) R832415C001 (2011) R832415C002 (2006) R832415C002 (2008) R832415C002 (2010) R832415C002 (2011) R827354 (Final) R834797 (2016) |
Exit Exit Exit |
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Zareba W, Nomura A, Couderc JP. Cardiovascular effects of air pollution:what to measure in ECG? Environmental Health Perspectives 2001;109(Suppl 4):533-538. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit |
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Zareba W, Couderc JP, Oberdorster G, Chalupa D, Cox C, Huang L-S, Peters A, Utell MJ, Frampton MW. ECG parameters and exposure to carbon ultrafine particles in young healthy subjects. Inhalation Toxicology 2009;21(3):223-233. |
R832415 (2008) R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2010) R832415C002 (2011) R832415C003 (2010) R832415C003 (2011) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) R827354 (Final) |
Exit |
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Zauscher MD, Moore MJK, Lewis GS, Hering SV, Prather KA. Approach for measuring the chemistry of individual particles in the size range critical for cloud formation. Analytical Chemistry 2011;83(6):2271-2278. |
R832415 (Final) |
Exit |
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Zauscher MD, Wang Y, Moore MJK, Gaston CJ, Prather KA. Air quality impact and physicochemical aging of biomass burning aerosols during the 2007 San Diego Wildfires. Environmental Science and Technology 2013;47(14):7633-7643. |
R832415 (Final) |
Exit Exit |
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Zhao J, Hopke PK. Concentration of reactive oxygen species (ROS) in mainstream and sidestream cigarette smoke. Aerosol Science and Technology 2012;46(2):191-197. |
R832415 (Final) |
Exit |
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Zhao W, Hopke PK, Qin X, Prather KA. Predicting bulk ambient aerosol compositions from ATOFMS data with ART-2a and multivariate analysis. Analytica Chimica Acta 2005;549(1-2):179-187. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R831083 (Final) |
Exit Exit Exit |
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Zhou L, Kim E, Hopke PK, Stanier C, Pandis SN. Mining airborne particulate size distribution data by positive matrix factorization. Journal of Geophysical Research 2005;110(D7):D07S19 (15 pp.). |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Zhou L, Hopke PK, Venkatachari P. Cluster analysis of single particle mass spectra at Flushing, NY. Analytica Chimica Acta 2006;555(1):47-56. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
Supplemental Keywords:
RFA, Scientific Discipline, Health, Air, particulate matter, Health Risk Assessment, Risk Assessments, Biochemistry, airway epithelial cells, atmospheric particles, cardiopulmonary responses, chemical characteristics, fine particles, human health effects, airborne particulate matter, animal model, airway disease, air pollution, pariculate matter, aerosol composition, human exposure, epidemiological studies, atmospheric chemistryProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832415C001 Characterization and Source Apportionment
R832415C002 Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources
R832415C003 Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles
R832415C004 Animal models: Cardiovascular Disease, CNS Injury and Ultrafine Particle Biokinetics
R832415C005 Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading To Altered Gene Expression in Relation to Particle Composition
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2011 Progress Report
- 2010 Progress Report
- 2009 Progress Report
- 2008 Progress Report
- 2006 Progress Report
- Original Abstract
144 journal articles for this center