Grantee Research Project Results
Final Report: Harvard Particle Center
EPA Grant Number: R832416Center: Harvard Particle Center
Center Director: Koutrakis, Petros
Title: Harvard Particle Center
Investigators: Koutrakis, Petros , Gonzalez-Flecha, Beatriz , Brook, Robert D. , Speizer, Frank E. , Suh, Helen H. , Godleski, John J. , Gold, Diane R. , Brook, Jeffrey R. , Dockery, Douglas W. , Coull, Brent , Silverman, Frances , Schwartz, Joel , Vokonas, Pantel , Stone, Peter , Demokritou, Philip
Institution: Harvard University , Brigham and Women’s Hospital , University of Michigan , Boston University , University of Toronto
Current Institution: Harvard University , Boston University , Brigham and Women’s Hospital , University of Michigan , University of Toronto
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2011)
Project Amount: $7,999,609
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
The overarching objective of the Center was to link inflammation, autonomic dysfunction and vascular dysfunction to specific particulate matter (PM) characteristics and sources. In addition, Center research addressed important scientific questions such as: i) What types of pathophysiological effects are produced by PM exposures and how do these effects relate to specific PM properties and sources (toxic components); ii) What is the effect of gaseous co-pollutants on the observed PM exposure-response relationships; iii) Which are the underlying biological mechanisms whereby PM exposures can induce inflammation, autonomic dysfunction and/or vascular dysfunction; and iv) Are certain individuals more susceptible to PM due to their health condition, age, genetic characteristics and nutrition habits.
Summary/Accomplishments (Outputs/Outcomes):
The Center encompassed four highly interdisciplinary and integrated projects designed to address the four scientific questions presented above. Project 1 investigated the health effects of PM in the Normative Aging Study cohort, in Eastern Massachusetts; Project 2 examined the health effects of fine and coarse CAPs in healthy adults, in Toronto; Project 3 investigated the health effects of locally emitted and transported PM in Sprague Dawley rats and spontaneously hypersensitive rats, which were exposed to fine criteria air pollutants (CAPs) in Boston; and Project 4 investigated the health effects of primary and secondary vehicular emissions from a tunnel in the northeastern United States using healthy and spontaneous hypertensive rats (SH). Finally, the above four proposed projects were supported by three Cores: the Administrative, Particle Technology and Monitoring, and Statistical Cores.
Conclusions:
Major Findings: To date 100 peer-reviewed papers have been published as a result of the research conducted by the four projects and two cores (see list of publications). This final report highlights most of the Center findings for each project. Below we present a brief summary of these findings.
Project 1: Multi-pollutant air pollution effects were investigated by examining modifications of the health effects of PM2.5 mass by various air pollutant species, gene polymorphisms (GPM), and air mass back trajectories (AMBT). The following relations were observed: 1) lead, SO42-, and O3 effects on heart rate variability (HRV); 2) GPM protection against HRV effects of PM; 3) transition metal effects modified by GPM; 4) black carbon (BC) and ozone effects on HRV modified by AMBT, and; 5) PM2.5 species effects on low frequency (LF)/high frequency (HF) ratio modified by AMBT.
Address-specific BC values, determined by the GIS-based spatial smoothing model that was developed at Harvard School of Public Health (HSPH), were used to show an inverse association of BC with telomere length. Other associations that were found between traffic related PM and/or PM2.5 include: 1) inflammatory markers; 2) elevated plasma total homocysteine; 3) effects modification by genes related to oxidative stress, and; 4) increased vascular cell adhesion, with modification by obesity and genes. Both PM2.5 and SO42-, but not BC were associated with oxidative stress-related urinary 8-OHdG.
Association was found between PM2.5 and decreased HRV. These effects were modified by genetic polymorphism in endothelial and methyl-related genes, as well as by dietary intakes levels of methyl nutrients. Obesity was a significant factor in the susceptibility to health impacts of ozone and traffic-related PM.
Project 2: Induced sputum showed a greater inflammatory response for coarse CAPs compared to fine CAPs exposures, as evidenced by a larger number of airway neutrophils 24 hours after coarse particle exposures. The observed differences were not related to exposure mass concentration as the target CAPs level was lower for the coarse vs fine CAPs (200 vs 250 µg/m3). A more robust association between β-(1,3)-D-glucan concentration and the number of sputum neutrophils for coarse vs. fine CAPs was observed, suggesting that the biologic component of PM may be important. Some interesting and exciting findings were observed in a subgroup of subjects in whom the epigenetic effects (DNA methylation) of coarse and fine CAPs exposures were observed. Fine particle exposures induced Alu and IL-12 hypomethylation, while coarse particles, endotoxin and β-(1,3)-D-glucan induced TLR-4 hypomethylation. Furthermore, these acute DNA methylation changes might be on the pathway to increased systemic white blood cells (WBCs) and elevated blood pressure.
In addition to the coarse and fine CAPs project, we observed some key findings from collaborative retrospective analyses of our controlled fine CAPs and O3 exposures in healthy subjects at rest. First, the importance of considering prior exposure to ambient pollutants (i.e., O3, PM2.5, SO2, NO2) on baseline measures prior to chamber exposures was highlighted by the observed positive associations with the inflammatory marker IL-6. Second, we observed a dose-response relationship between CAPs mass concentration and HRV measures of autonomic tone that varied depending on the addition of O3, again highlighting the importance of examining multi-pollutant exposures. Third, we observed a significant increase in cardiac repolarization time after exposure to CAP+O3; this finding supports epidemiological studies reporting sudden or arrhythmic events associated with air pollution exposures.
Overall, our findings provide important insights into the mechanisms of response to inhaled particles, highlighting the importance of considering particle size, composition/sources and multi-pollutant mixtures on respiratory and cardiovascular pathways.
Project 3: Overall, the findings were consistent with our earlier CAPs exposures studies in Boston. In general, although there were statistically significant differences in CAPs composition between early morning and mid-day exposures, the differences were modest. As expected, the differences in composition were consistent with increased contribution of local sources in the early morning.
In normal rats, both the early morning and mid-day CAPs exposures generated significant responses in several respiratory parameters and in vivo chemiluminescence of the lung. Circadian differences in respiratory parameters, which were significant in animals exposed to filtered air, were controlled for in analysis. The respiratory responses, featuring a rapid shallow breathing pattern, were consistent with an irritative response to exposure. In SH rats and their strain control (WKY) rats there was a significant circadian blood pressure response in exposure to filtered air in the early morning compared to mid-day. In the SH rats, the blood pressure levels were sufficiently high that they may have been beyond influence by CAPs exposure. However, in the WKY strain controls, when controlling for circadian effects, there was a significant response to CAPs exposure that was associated with elements related to road dust composition.
Although there are modest statistically significant differences in the composition of early and late exposures on given days, there is no significant difference in toxicity. Our studies have adequate statistical power to detect significant diurnal differences with respiratory patterns, significant strain differences, as well as CAPs vs Sham differences. Because both early morning and mid-day exposures show significant toxicity, with no significant difference in the biological outcomes between the two exposure periods, these results suggest that either (1) the modest composition differences between morning and mid-day exposure are not sufficient to generate different biological outcomes, or (2) there is little difference in the toxic potential of local and transported sources.
Project 4: Results from the Power Plant TERESA study informed us that it is very difficult to assess the comparative toxicity of particles in different exposure types that have widely different concentrations. For this reason, the mobile source TERESA study conducted exposures to primary (P), aged primary plus secondary (P+SOA), and secondary aerosols (SOA) at consistent concentrations.
All of the exposures produced respiratory changes compared to filtered air, but more prominent respiratory toxicity was found in animals exposed to P+SOA. Overall, P+SOA>P>SOA for respiratory outcomes. The effect was greater in animals with repeated exposures. Significant breathing pattern changes were associated with the different exposure types. These changes were internally consistent, with patterns that indicate an irritative response to exposure. This response is mediated by local (respiratory effort) and central (respiratory drive) components and is augmented with repeated exposure to fresh and aged vehicular emissions. Four-day exposures to P+SOA produced the most significant and complex response in breathing pattern, with decreases in volumes, flows, respiratory drive and respiratory effort. This suggests that photochemical oxidation and formation of secondary particle mass enhanced the respiratory toxicity of primary traffic derived particles.
Both primary and secondary traffic related aerosols can substantially increase systolic blood pressure (SBP) and diastolic blood pressure (DBP). Initial increases up to 15 mmHg in DBP were recorded for the P exposure. This is a greater blood pressure change than has previously been reported in the literature in animal or human studies for either similar or substantially higher PM2.5 concentrations. The responses are sustained with repeated primary aerosol exposures, but not with secondary aerosols. Animals exposed to secondary aerosols showed a gradual decrease in the magnitude of response with repeated exposures, and subsequently show compensatory decreases in both SBP and DBP after the 3-week protocol. This unexpected but significant compensatory response suggests a biological protective effect with repeated exposures that cannot be explained by simple autonomic nervous system activation. These results confirm the adverse health effects associated with inhalation of fine particles in previous studies and give insight into a potential biological adaptation to maintain blood pressure in response to repeated and anticipated pollutant exposure. Greater limitation in the BP response in animals exposed to secondary particles requires further investigation to define the interaction of this exposure with blood pressure control mechanisms.
Journal Articles: 199 Displayed | Download in RIS Format
| Other center views: | All 206 publications | 199 publications in selected types | All 199 journal articles |
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Alexeeff SE, Litonjua AA, Suh H, Sparrow D, Vokonas PS, Schwartz J. Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA Normative Aging Study. Chest 2007;132(6):1890-1897. |
R832416 (2006) R832416 (2009) R832416 (Final) R832416C001 (2008) R832416C001 (2009) R832416C001 (Final) R827353 (Final) |
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Alexeeff SE, Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. Statin use reduces decline in lung function: VA Normative Aging Study. American Journal of Respiratory and Critical Care Medicine 2007;176(8):742-747. |
R832416 (2006) R832416 (Final) R832416C001 (2008) R832416C001 (Final) R827353 (Final) |
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Alexeeff SE, Litonjua AA, Wright RO, Baccarelli A, Suh H, Sparrow D, Vokonas PS, Schwartz J. Ozone exposure, antioxidant genes, and lung function in an elderly cohort:VA Normative Aging Study. Occupational and Environmental Medicine 2008;65(11):736-742. |
R832416 (Final) R832416C001 (2008) R832416C001 (Final) R827353 (Final) |
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Alexeeff SE, Coull BA, Gyparis A, Suh H, Sparrow D, Vokonas PS, Schwartz J. Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function. Environmental Health Perspectives 2011;119(4):481-486. |
R832416 (Final) R832416C001 (Final) |
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Austin E, Coull B, Thomas D, Koutrakis P. A framework for identifying distinct multipollutant profiles in air pollution data. Environment International 2012;45:112-121. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Austin E, Coull BA, Zanobetti A, Koutrakis P. A framework to spatially cluster air pollution monitoring sites in US based on the PM2.5 composition. Environment International 2013;59:244-254. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Baccarelli A, Cassano PA, Litonjua A, Park SK, Suh H, Sparrow D, Vokonas P, Schwartz J. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation 2008;117(14):1802-1809. |
R832416 (2006) R832416 (Final) R832416C001 (2008) R832416C001 (Final) R827353 (Final) |
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Baccarelli A, Martinelli I, Zanobetti A, Grillo P, Hou L-F, Bertazzi PA, Mannucci PM, Schwartz J. Exposure to particulate air pollution and risk of deep vein thrombosis. Archives of Internal Medicine 2008;168(9):920-927. |
R832416 (2006) R832416 (Final) R832416C001 (2008) R832416C001 (Final) R827353 (Final) |
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Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Rapid DNA methylation changes after exposure to traffic particles. American Journal of Respiratory and Critical Care Medicine 2009;179(7):572-578. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
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Baccarelli A, Martinelli I, Pegoraro V, Melly S, Grillo P, Zanobetti A, Hou L, Bertazzi PA, Mannucci PM, Schwartz J. Living near major traffic roads and risk of deep vein thrombosis. Circulation 2009;119(24):3118-3124. |
R832416C001 (2010) R827353 (Final) |
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Baccarelli A, Tarantini L, Wright RO, Bollati V, Litonjua AA, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA Normative Aging Study. Epigenetics 2010;5(3):222-228. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
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Baccarelli A, Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L, Sparrow D, Vokonas P, Schwartz J. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 2010;21(6):819-828. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
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Baccarelli A, Barretta F, Dou C, Zhang X, McCracken JP, Diaz A, Bertazzi PA, Schwartz J, Wang S, Hou L. Effects of particulate air pollution on blood pressure in a highly exposed population in Beijing, China: a repeated-measure study. Environmental Health 2011;10:108 (10 pp.). |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Baja ES, Schwartz JD, Wellenius GA, Coull BA, Zanobetti A, Vokonas PS, Suh HH. Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the Normative Aging Study. Environmental Health Perspectives 2010;118(6):840-846. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
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Baja ES, Schwartz JD, Coull BA, Wellenius GA, Vokonas PS, Suh HH. Structural equation modeling of the inflammatory response to traffic air pollution. Journal of Exposure Science and Environmental Epidemiology 2013;23(3):268-274. |
R832416 (Final) R827353 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Barnett AG, Williams GM, Schwartz J, Best TL, Neller AH, Petroeschevsky AL, Simpson RW. The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities. Environmental Health Perspectives 2006;114(7):1018-1023. |
R832416 (2008) |
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Bartoli CR, Wellenius GA, Coull BA, Akiyama I, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environmental Health Perspectives 2009;117(3):333-337. |
R832416 (2009) R832416C003 (2009) R832416C003 (Final) |
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Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Okabe K, Verrier RL, Godleski JJ. Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes. Environmental Health Perspectives 2009;117(3):361-366. |
R832416 (Final) R831917 (Final) |
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Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Okabe K, Verrier RL, Godleski JJ. Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes. Environmental Health Perspectives 2009;117(3):361-366. |
R832416 (2008) R832416 (2009) R832416C003 (2009) R832416C003 (Final) R827353 (Final) |
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Bartoli CRG, Godleski JJ. Blood flow in foreign-body capsules surrounding surgically implanted subcutaneous devices. Journal of Surgical Research 2010;158(1):147-154. |
R832416 (2009) R832416C003 (2009) |
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Bartoli CR, Nadar MM, Godleski JJ. Capsule thickness correlates with vascular density and blood flow within foreign-body capsules surrounding surgically implanted subcutaneous devices. Artificial Organs 2010;34(10):857-861. |
R832416 (Final) R832416C003 (Final) R827353 (Final) R831917 (Final) |
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Bartoli CR, Godleski JJ, Verrier RL. Mechanisms mediating adverse effects of air pollution on cardiovascular hemodynamic function and vulnerability to cardiac arrhythmias. Air Quality, Atmosphere & Health 2011;4(1):53-63. |
R832416 (Final) R832416C003 (Final) R827353 (Final) R831917 (Final) |
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Bartoli CRG, Wellenius GA, Coull BA, Akiyama I, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environmental Health Perspectives 2009;117(3):333-337. |
R832416 (Final) R827353 (Final) R831917 (Final) |
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Batalha JRF, Saldiva PHN, Clarke RW, Coull BA, Stearns RC, Lawrence J, Krishna Murthy GG, Koutrakis P, Godleski JJ. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environmental Health Perspectives 2002;110(12):1191-1197. |
R832416 (2008) R825242 (Final) R827353 (Final) R827353C014 (Final) |
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Behbod B, Urch B, Speck M, Scott JA, Liu L, Poon R, Coull B, Schwartz J, Koutrakis P, Silverman F, Gold DR. Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures. Occupational and Environmental Medicine 2013;70(11):761-767. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Behbod B, Sordillo JE, Hoffman EB, Datta S, Muilenberg ML, Scott JA, Chew GL, Platts-Mills TA, Schwartz J, Burge H, Gold DR. Wheeze in infancy:protection associated with yeasts in house dust contrasts with increased risk associated with yeasts in indoor air and other fungal taxa. Allergy 2013;68(11):1410-1418. |
R832416 (Final) |
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Behbod B, Sordillo JE, Hoffman EB, Datta S, Webb TE, Kwan DL, Kamel JA, Muilenberg ML, Scott JA, Chew GL, Platts-Mills TA, Schwartz J, Coull B, Burge H, Gold DR. Asthma and allergy development: contrasting influences of yeasts and other fungal exposures. Clinical and Experimental Allergy 2015;45(1):154-163. |
R832416 (Final) |
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Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. Journal of the American Heart Association 2013;2(3):e000212 (11 pp.). |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C004 (2013) R834798C004 (2014) R834798C004 (Final) |
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Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. Air pollution and markers of coagulation, inflammation, and endothelial function:associations of epigene-environment Interactions in an elderly cohort. Epidemiology 2012;23(2):332-340. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
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Bind M-A, Zanobetti A, Gasparrini A, Peters A, Coull B, Baccarelli A, Tarantini L, Koutrakis P, Vokonas P, Schwartz J. Effects of temperature and relative humidity on DNA methylation. Epidemiology 2014;25(4):561-569. |
R832416 (Final) R827353 (Final) R834798 (2014) R834798 (Final) R834798C002 (2014) R834798C002 (Final) |
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Bind M-A, Coull B, Suh H, Wright R, Baccarelli A, Vokonas P, Schwartz J. A novel genetic score approach using instruments to investigate interactions between pathways and environment: application to air pollution. PLoS One 2014;9(4):e96000 (8 pp.). |
R832416 (Final) R827353 (Final) R834798 (2014) R834798 (Final) R834798C002 (2014) R834798C002 (Final) |
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Bind M-A, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A, Coull BA, Tarantini L, Vokonas PS, Koutrakis P, Schwartz J. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics 2014;9(3):448-458. |
R832416 (Final) R827353 (Final) R834798 (2014) R834798 (Final) R834798C002 (2014) R834798C002 (Final) |
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Bind M-AC, Coull BA, Peters A, Baccarelli AA, Tarantini L, Cantone L, Vokonas PS, Koutrakis P, Schwartz JD. Beyond the mean: quantile regression to explore the association of air pollution with gene-specific methylation in the Normative Aging Study. Environmental Health Perspectives 2015;123(8):759-765. |
R832416 (Final) R827353 (Final) R834798 (2015) R834798 (Final) R834798C002 (Final) |
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Bind M-AC, Coull BA, Baccarelli A, Tarantini L, Cantone L, Vokonas P, Schwartz J. Distributional changes in gene-specific methylation associated with temperature. Environmental Research 2016;150:38-46. |
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Bliznyuk N, Ruppert D, Shoemaker CA. Efficient interpolation of computationally expensive posterior densities with variable parameter costs. Journal of Computational and Graphical Statistics 2011;20(3):636-655. |
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Bliznyuk N, Ruppert D, Shoemaker CA. Local derivative-free approximation of computationally expensive posterior densities. Journal of Computational and Graphical Statistics 2012;21(2):676-695. |
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Bliznyuk N, Paciorek CJ, Schwartz J, Coull B. Nonlinear predictive latent process models for integrating spatio-temporal exposure data from multiple sources. Annals of Applied Statistics 2014;8(3):1538-1560. |
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Bobb JF, Dominici F, Peng RD. A Bayesian model averaging approach for estimating the relative risk of mortality associated with heat waves in 105 U.S. cities. Biometrics 2011;67(4):1605-1616. |
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Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mechanisms of Ageing and Development 2009;130(4):234-239. |
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Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832416 (Final) R832413 (Final) R832414 (Final) R832415 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Brochu PJ, Kioumourtzoglou M-A, Coull BA, Hopke PK, Suh HH. Development of a new method to estimate the regional and local contributions to black carbon. Atmospheric Environment 2011;45(40):7681-7687. |
R832416 (Final) |
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Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension 2009;54(3):659-667. |
R832416 (2009) R832416C002 (2009) R832416C002 (2010) CR830837 (Final) |
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Brown KW, Sarnat JA, Suh HH, Coull BA, Spengler JD, Koutrakis P. Ambient site, home outdoor and home indoor particulate concentrations as proxies of personal exposures. Journal of Environmental Monitoring 2008;10(9):1041-1051. |
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Brown KW, Sarnat JA, Suh HH, Coull BA, Koutrakis P. Factors influencing relationships between personal and ambient concentrations of gaseous and particulate pollutants. Science of the Total Environment 2009;407(12):3754-3765. |
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Chahine T, Baccarelli A, Litonjua A, Wright RO, Suh H, Gold DR, Sparrow D, Vokonas P, Schwartz J. Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environmental Health Perspectives 2007;115(11):1617-1622. |
R832416 (2006) R832416 (2008) R832416 (2009) R832416 (Final) R832416C001 (2008) R832416C001 (2009) R832416C001 (Final) R827353 (Final) |
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Chang HH, Peng RD, Dominici F. Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics 2011;12(4):637-652. |
R832416 (Final) R832417 (Final) R832417C001 (Final) R833622 (Final) |
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Chen J-C, Schwartz J. Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environmental Health Perspectives 2008;116(5):612-617. |
R832416 (2006) R832416 (Final) R832416C001 (Final) R827353 (Final) |
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Chen J-C, Schwartz J. Neurobehavioral effects of ambient air pollution on cognitive performance in US adults. NeuroToxicology 2009;30(2):231-239. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
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Chuang KJ, Coull BA, Zanobetti A, Suh H, Schwartz J, Stone PH, Litonjua A, Speizer FE, Gold DR. Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease. Circulation 2008;118(13):1314-1320. |
R832416 (2008) R832416 (Final) |
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Chudnovsky AA, Lee HJ, Kostinski A, Kotlov T, Koutrakis P. Prediction of daily fine particulate matter concentrations using aerosol optical depth retrievals from the Geostationary Operational Environmental Satellite (GOES). Journal of the Air & Waste Management Association 2012;62(9):1022-1031. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Clougherty JE, Rossi CA, Lawrence J, Long MS, Diaz EA, Lim RH, McEwen B, Koutrakis P, Godleski JJ. Chronic social stress and susceptibility to concentrated ambient fine particles in rats. Environmental Health Perspectives 2010;118(6):769-775. |
R832416 (Final) R832416C003 (Final) |
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Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro III A, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men:the VA Normative Aging Study. Environmental Health Perspectives 2017;125(1):76-81. |
R832416 (Final) R834798 (Final) R835872 (2016) R835872C003 (Final) |
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Coull BA, Wellenius GA, Gonzalez-Flecha B, Diaz E, Koutrakis P, Godleski JJ. The Toxicological Evaluation of Realistic Emissions of Source Aerosols study: statistical methods. Inhalation Toxicology 2011;23(Suppl 2):31-41. |
R832416 (2010) R832416C005 (2010) |
Exit |
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Diaz EA, Lemos M, Coull B, Long MS, Rohr AC, Ruiz P, Gupta T, Kang C-M, Godleski JJ. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)--power plant studies: assessment of breathing pattern. Inhalation Toxicology 2011;23(Suppl 2):42-59. |
R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (Final) |
Exit Exit |
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Diaz EA, Chung Y, Papapostolou V, Lawrence J, Long MS, Hatakeyama V, Gomes B, Calil Y, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses – pilot single vehicle study. Inhalation Toxicology 2012;24(5):288-295. |
R832416 (Final) R827353 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2014) R834798C001 (Final) |
Exit Exit |
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Diaz EA, Chung Y, Lamoureux DP, Papapostolou V, Lawrence J, Long MS, Mazzaro V, Buonfiglio H, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses, and oxidative stress. Air Quality, Atmosphere & Health 2013;6(2):431-444. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
Exit Exit |
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Dioni L, Hoxha M, Nordio F, Bonzini M, Tarantini L, Albetti B, Savarese A, Schwartz J, Bertazzi PA, Apostoli P, Hou L, Baccarelli A. Effects of short-term exposure to inhalable particulate matter on telomere length, telomerase expression, and telomerase methylation in steel workers. Environmental Health Perspectives 2011;119(5):622-627. |
R832416 (Final) R832416C001 (Final) |
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Dockery DW. Health effects of particulate air pollution. Annals of Epidemiology 2009;19(4):257-263. |
R832416 (Final) |
Exit |
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Dubowsky SD, Suh H, Schwartz J, Coull BA, Gold DR. Diabetes, obesity, and hyptertension may enhance associations between air pollution and markers of systemic inflammation. Environmental Health Perspectives 2006;114(7):992-998. |
R832416 (2008) |
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Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mittleman MA. Autonomic effects of controlled fine particulate exposure in young healthy adults:effect modification by ozone. Environmental Health Perspectives 2009;117(8):1287-1292. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R827353 (Final) |
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Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. |
R832416 (2009) R832416C003 (2009) R827351 (Final) R827352 (Final) R827353 (Final) R827354 (Final) R827355 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) |
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Franco Suglia S, Gryparis A, Schwartz J, Wright RJ. Association between traffic-related black carbon exposure and lung function among urban women. Environmental Health Perspectives 2008;116(10):1333-1337. |
R832416 (2007) R832416 (Final) R827353 (Final) |
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Franco Suglia S, Gryparis A, Wright RO, Schwartz J, Wright RJ. Association of black carbon with cognition among children in a prospective birth cohort study. American Journal of Epidemiology 2008;167(3):280-286. |
R832416 (2006) R832416 (Final) R827353 (Final) |
Exit Exit Exit |
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Franklin M, Zeka A, Schwartz J. Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. Journal of Exposure Science and Environmental Epidemiology 2007;17(3):279-287. |
R832416 (2008) R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
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Franklin M, Schwartz J. The impact of secondary particles on the association between ambient ozone and mortality. Environmental Health Perspectives 2008;116(4):453-458. |
R832416 (2006) R832416 (2008) R832416 (Final) R832416C001 (2008) |
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Franklin M, Koutrakis P, Schwartz J. The role of particle composition on the association between PM2.5 and mortality. Epidemiology 2008;19(5):680-689. |
R832416 (2006) R832416 (2008) R832416 (Final) R832416C001 (2008) |
Exit |
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Ghelfi E, Rhoden CR, Wellenius GA, Lawrence J, Gonzalez-Flecha B. Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes. Toxicological Sciences 2008;102(2):328-336. |
R832416 (2008) R832416 (2009) R832416C003 (2009) R827353 (Final) |
Exit Exit Exit |
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Ghelfi E, Wellenius GA, Lawrence J, Millet E, Gonzalez-Flecha B. Cardiac oxidative stress and dysfunction by fine concentrated ambient particles (CAPs) are mediated by angiotensin-II. Inhalation Toxicology 2010;22(11):963-972. |
R832416 (Final) R832416C003 (Final) |
Exit |
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Godleski JJ, Diaz EA, Lemos M, Long M, Ruiz P, Gupta T, Kang C-M, Coull B. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)-power plant studies: assessment of cellular responses. Inhalation Toxicology 2011;23(Suppl 2):60-74. |
R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C001 (Final) R834798C005 (Final) |
Exit Exit |
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Godleski JJ, Rohr AC, Kang CM, Diaz EA, Ruiz PA, Koutrakis P. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA): introduction and overview. Inhalation Toxicology 2011;23(Suppl 2):1-10. |
R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (Final) |
Exit Exit |
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Greven S, Dominici F, Zeger S. An approach to the estimation of chronic air pollution effects using spatio-temporal information. Journal of the American Statistical Association 2011;106(494):396-406. |
R832416 (Final) R832417 (Final) R833622 (2009) R833622 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834894 (2012) R834894 (2013) |
Exit Exit |
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Gryparis A, Coull BA, Schwartz J. Controlling for confounding in the presence of measurement error in hierarchical models: a Bayesian approach. Journal of Exposure Science & Environmental Epidemiology 2007;17(Suppl 2):S20-S28. |
R832416 (2008) R832416 (Final) R832416C001 (2008) |
Exit Exit |
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Gryparis A, Paciorek CJ, Zeka A, Schwartz J, Coull BA. Measurement error caused by spatial misalignment in environmental epidemiology. Biostatistics 2009;10(2):258-274. |
R832416 (2008) R832416 (Final) R832416C001 (2010) |
Exit Exit Exit |
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Halonen JI, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Associations between outdoor temperature and markers of inflammation:a cohort study. Environmental Health 2010;9:42 (9 pp.). |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) |
Exit Exit Exit |
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Halonen JI, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Relationship between outdoor temperature and blood pressure. Occupational and Environmental Medicine 2011;68(4):296-301. |
R832416 (Final) R832416C001 (Final) |
Exit |
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Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. |
R832416 (Final) R832416C001 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C002 (Final) R834798C004 (2012) R834798C004 (2014) R834798C004 (Final) |
Exit |
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Hoxha M, Dioni L, Bonzini M, Pesatori AC, Fustinoni S, Cavallo D, Carugno M, Albetti B, Marinelli B, Schwartz J, Bertazzi PA, Baccarelli A. Association between leukocyte telomere shortening and exposure to traffic pollution:a cross-sectional study on traffic officers and indoor office workers. Environmental Health 2009;8:41. |
R832416 (2009) R832416C001 (2009) |
Exit Exit |
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Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, Vonk JM, Williams PV, Shapiro GG, McKone EF, Hallstrand TS, Koenig JQ, Schildcrout JS, Lumley T, Fuhlbrigge AN, Koutrakis P, Schwartz J, Weiss ST, Gold DR, Childhood Asthma Management Program Research Group. Ambient air pollution, lung function, and airway responsiveness in asthmatic children. Journal of Allergy and Clinical Immunology 2016;137(2):390-399. |
R832416 (Final) R834798 (2015) R834798 (2016) R834798C004 (Final) |
Exit Exit Exit |
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|
Imrich A, Ning YY, Lawrence J, Coull B, Gitin E, Knutson M, Kobzik L. Alveolar macrophage cytokine response to air pollution particles:oxidant mechanisms. Toxicology and Applied Pharmacology 2007;218(3):256-264. |
R832416 (2008) R832416 (Final) R832416C003 (Final) |
Exit Exit Exit |
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|
Joyce BT, Gao T, Zheng Y, Liu L, Zhang W, Dai Q, Shrubsole MJ, Hibler EA, Cristofanilli M, Zhang H, Yang H, Vokonas P, Cantone L, Schwartz J, Baccarelli A, Hou L. Prospective changes in global DNA methylation and cancer incidence and mortality. British Journal of Cancer 2016;115(4):465-472. |
R832416 (Final) R834798 (Final) |
Exit Exit |
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Kang C-M, Gupta T, Ruiz PA, Wolfson JM, Ferguson ST, Lawrence JE, Rohr AC, Godleski J, Koutrakis P. Aged particles derived from emissions of coal-fired power plants: the TERESA field results. Inhalation Toxicology 2011;23(Suppl 2):11-30. |
R832416 (Final) R832416C005 (2010) R832416C005 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
Exit Exit |
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Kang C-M, Koutrakis P, Suh HH. Hourly measurements of fine particulate sulfate and carbon aerosols at the Harvard-U.S. Environmental Protection Agency Supersite in Boston. Journal of the Air & Waste Management Association 2010;60(11):1327-1334. |
R832416 (Final) |
Exit Exit |
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Kloog I, Coull BA, Zanobetti A, Koutrakis P, Schwartz JD. Acute and chronic effects of particles on hospital admissions in New-England. PLoS ONE 2012;7(4):e34664 (8 pp.). |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (2012) R834798C002 (2014) R834798C002 (Final) R834798C005 (2013) R834798C005 (Final) |
Exit Exit Exit |
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|
Kloog I, Chudnovsky A, Koutrakis P, Schwartz J. Temporal and spatial assessments of minimum air temperature using satellite surface temperature measurements in Massachusetts, USA. Science of The Total Environment 2012;432:85-92. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (Final) |
Exit Exit Exit |
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Kloog I, Melly SJ, Ridgway WL, Coull BA, Schwartz J. Using new satellite based exposure methods to study the association between pregnancy PM2.5 exposure, premature birth and birth weight in Massachusetts. Environmental Health 2012;11:40 (8 pp.). |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (2012) R834798C002 (2014) R834798C002 (Final) R834798C005 (2013) R834798C005 (2014) R834798C005 (Final) |
Exit Exit Exit |
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|
Lamoureux DP, Diaz EA, Chung Y, Coull BA, Papapostolou V, Lawrence J, Sato R, Godleski JJ. Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. Air Quality, Atmosphere & Health 2013;6(2):407-418. |
R832416 (Final) R827353 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
Exit Exit |
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Lee HJ, Liu Y, Coull BA, Schwartz J, Koutrakis P. A novel calibration approach of MODIS AOD data to predict PM2.5 concentrations. Atmospheric Chemistry and Physics 2011;11(15):7991-8002. |
R832416 (Final) |
Exit Exit |
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|
Lemos M, Diaz EA, Gupta T, Kang C-M, Ruiz P, Coull BA, Godleski JJ, Gonzalez-Flecha B. Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols. Inhalation Toxicology 2011;23(Suppl 2):75-83. |
R832416 (Final) R832416C005 (2010) R834798 (2013) R834798 (2014) R834798 (Final) R834798C001 (Final) R834798C005 (Final) |
Exit Exit |
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Lepeule J, Laden F, Dockery D, Schwartz J. Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009. Environmental Health Perspectives 2012;120(7):965-970. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (2012) R834798C002 (2014) R834798C002 (Final) |
Exit |
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Lepeule J, Litonjua AA, Coull B, Koutrakis P, Sparrow D, Vokonas PS, Schwartz J. Long-term effects of traffic particles on lung function decline in the elderly. American Journal of Respiratory and Critical Care Medicine 2014;190(5):542-548. |
R832416 (Final) R834798 (Final) R834798C002 (Final) |
Exit Exit |
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|
Lepeule J, Litonjua AA, Gasparrini A, Koutrakis P, Sparrow D, Vokonas PS, Schwartz J. Lung function association with outdoor temperature and relative humidity and Its interaction with air pollution in the elderly. Environmental Research 2018;165:110-117. |
R832416 (Final) R834798 (Final) |
Exit Exit Exit |
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|
Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. |
R832416C001 (Final) R832417 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C005 (2012) R834798C005 (Final) R834894 (2012) R834894 (2013) |
Exit Exit Exit |
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|
Liu L, Urch B, Poon R, Szyszkowicz M, Speck M, Gold DR, Wheeler AJ, Scott JA, Brook JR, Thorne PS, Silverman FS. Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers:a controlled human exposure study. Environmental Health Perspectives 2015;123(6):534-540. |
R832416 (Final) |
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Liu L, Urch B, Szyszkowicz M, Evans G, Spek M, Van Huang A, Leingartner K, Schutt R, Pelletier G, Gold D, Brook J, Pollitt K, Silverman F. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers:A controlled exposure study. ENVIRONMENTAL INTERNATIONAL 2018;121:1331-1340. |
R832416 (Final) |
Exit Exit |
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Liu Y, Koutrakis P, Kahn R. Estimating fine particulate matter component concentrations and size distributions using satellite-retrieved fractional aerosol optical depth: part 1—method development. Journal of the Air & Waste Management Association 2007;57(11):1351-1359. |
R832416 (2006) R832416 (Final) R827353 (Final) |
Exit Exit |
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Liu Y, Koutrakis P, Kahn R, Turquety S, Yantosca RM. Estimating fine particulate matter component concentrations and size distributions using satellite-retrieved fractional aerosol optical depth: part 2—a case study. Journal of the Air & Waste Management Association 2007;57(11):1360-1369. |
R832416 (2006) R832416 (Final) R827353 (Final) |
Exit Exit Exit |
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|
Liu Y, Chen D, Kahn RA, He K. Review of the applications of Multiangle Imaging SpectroRadiometer to air quality research. Science in China Series D: Earth Sciences 2009;52(1):132-144. |
R832416 (Final) R827353 (Final) |
Exit Exit |
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Liu Y, Kahn RA, Chaloulakou A, Koutrakis P. Analysis of the impact of the forest fires in August 2007 on air quality of Athens using multi-sensor aerosol remote sensing data, meteorology and surface observations. Atmospheric Environment 2009;43(21):3310-3318. |
R832416 (Final) R827353 (Final) |
Exit Exit Exit |
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Liu Y, Paciorek CJ, Koutrakis P. Estimating regional spatial and temporal variability of PM2.5 concentrations using satellite data, meteorology, and land use information. Environmental Health Perspectives 2009;117(6):886-892. |
R832416 (Final) R827353 (Final) |
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Liu Y, Schichtel BA, Koutrakis P. Estimating particle sulfate concentrations using MISR retrieved aerosol properties. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing 2009;2(3):176-184. |
R832416 (Final) R827353 (Final) |
Exit Exit |
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Luttmann-Gibson H, Suh HH, Coull BA, Dockery DW, Sarnat SE, Schwartz J, Stone PH, Gold DR. Short-term effects of air pollution on heart rate variability in senior adults in Steubenville, Ohio. Journal of Occupational and Environmental Medicine 2006;48(8):780-788. |
R832416 (2008) R826780 (Final) R827353 (Final) R827353C003 (Final) |
Exit Exit Exit |
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Madrigano J, Baccarelli A, Wright RO, Suh H, Sparrow D, Vokonas PS, Schwartz J. Air pollution, obesity, genes and cellular adhesion molecules. Occupational and Environmental Medicine 2010;67(5):312-317. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
Exit Exit |
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Madrigano J, Baccarelli A, Mittleman MA, Wright RO, Sparrow D, Vokonas PS, Tarantini L, Schwartz J. Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environmental Health Perspectives 2011;119(7):977-982. |
R832416 (Final) R832416C001 (Final) |
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Maynard D, Coull BA, Gryparis A, Schwartz J. Mortality risk associated with short-term exposure to traffic particles and sulfates. Environmental Health Perspectives 2007;115(5):751-755. |
R832416 (2008) R832416 (2009) R832416C001 (2009) R827353 (Final) R827355 (Final) |
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|
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McCracken JP, Smith KR, Diaz A, Mittleman MA, Schwartz J. Chimney stove intervention to reduce long-term wood smoke exposure lowers blood pressure among Guatemalan women. Environmental Health Perspectives 2007;115(7):996-1001. |
R832416C001 (2008) R827353 (Final) |
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McCracken J, Baccarelli A, Hoxha M, Dioni L, Melly S, Coull B, Suh H, Vokonas P, Schwartz J. Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study. Environmental Health Perspectives 2010;118(11):1564-1570. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
Exit |
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McCracken J, Smith KR, Stone P, Diaz A, Arana B, Schwartz J. Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms. Environmental Health Perspectives 2011;119(11):1562-1568. |
R832416 (Final) R832416C001 (Final) |
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Medina-Ramon M, Zanobetti A, Schwartz J. The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease:a national multicity study. American Journal of Epidemiology 2006;163(6):579-588. |
R832416 (2008) R827353 (Final) R827353C005 (Final) |
Exit Exit Exit |
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|
Medina-Ramon M, Schwartz J. Temperature, temperature extremes, and mortality:a study of acclimatisation and effect modification in 50 US cities. Occupational and Environmental Medicine 2007;64(12):827-833. |
R832416C001 (2008) R827353 (Final) |
Exit Exit Exit |
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|
Medina-Ramon M, Goldberg R, Melly S, Mittleman MA, Schwartz J. Residential exposure to traffic-related air pollution and survival after heart failure. Environmental Health Perspectives 2008;116(4):481-485. |
R832416 (2006) R832416 (2008) R832416 (Final) R832416C001 (2008) R832416C001 (Final) |
Exit |
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|
Medina-Ramon M, Schwartz J. Who is more vulnerable to die from ozone air pollution? Epidemiology 2008;19(5):672-679. |
R832416C001 (2008) R827353 (Final) |
Exit Exit Exit |
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|
Mehta AJ, Kubzansky LD, Coull BA, Kloog I, Koutrakis P, Sparrow D, Spiro III A, Vokonas P, Schwartz J. Associations between air pollution and perceived stress: the Veterans Administration Normative Aging Study. Environmental Health 2015;14:10 (10 pp.). |
R832416 (Final) R834798 (2015) R834798 (Final) |
Exit Exit |
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Mordukhovich I, Wilker E, Suh H, Wright R, Sparrow D, Vokonas PS, Schwartz J. Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study. Environmental Health Perspectives 2009;117(11):1767-1772. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) |
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Mordukhovich I, Wright RO, Amarasiriwardena C, Baja E, Baccarelli A, Suh H, Sparrow D, Vokonas P, Schwartz J. Association between low-level environmental arsenic exposure and QT interval duration in a general population study. American Journal of Epidemiology 2009;170(6):739-746. |
R832416 (Final) R827353 (Final) |
Exit Exit |
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Mordukhovich I, Wright RO, Hu H, Amarasiriwardena C, Baccarelli A, Litonjua A, Sparrow D, Vokonas P, Schwartz J. Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the Normative Aging Study. Environmental Health Perspectives 2012;120(1):98-104. |
R832416 (Final) |
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|
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Mordukhovich I, Coull B, Kloog I, Koutrakis P, Vokonas P, Schwartz J. Exposure to sub-chronic and long-term particulate air pollution and heart rate variability in an elderly cohort: the Normative Aging Study. Environmental Health 2015;14:87 (10 pp.). |
R832416 (Final) R834798 (Final) |
Exit Exit Exit |
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|
Mordukhovich I, Kloog I, Coull B, Koutrakis P, Vokonas P, Schwartz J. Association between particulate air pollution and QT interval duration in an elderly cohort. Epidemiology 2016;27(2):284-290. |
R832416 (Final) R834798 (Final) |
Exit |
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|
Mostofsky E, Schwartz J, Coull BA, Koutrakis P, Wellenius GA, Suh HH, Gold DR, Mittleman MA. Modeling the association between particle constituents of air pollution and health outcomes. American Journal of Epidemiology 2012;176(4):317-326. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C004 (2013) R834798C004 (2014) R834798C004 (Final) |
Exit Exit Exit |
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|
Mukamal KJ, Wellenius GA, Suh HH, Mittleman MA. Weather and air pollution as triggers of severe headaches. Neurology 2009;72(10):922-927. |
R832416 (Final) R827353 (Final) |
Exit |
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|
Nikolov MC, Coull BA, Catalano PJ, Diaz E, Godleski JJ. Statistical methods to evaluate health effects associated with major sources of air pollution: a case-study of breathing patterns during exposure to concentrated Boston air particles. Journal of the Royal Statistical Society Series C-Applied Statistics 2008;57(3):357-378. |
R832416 (Final) R832416C003 (Final) |
Exit |
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|
Nikolov MC, Coull BA, Catalano PJ, Godleski JJ. Multiplicative factor analysis with a latent mixed model structure for air pollution exposure assessment. Environmetrics 2011;22(2):165-178. |
R832416 (2009) R832416 (Final) R832416C003 (2009) R832416C003 (Final) |
Exit |
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Nwanaji-Enwerem JC, Colicino E, Dai L, Di Q, Just AC, Hou L, Vokonas P, De Vivo I, Lemos B, Lu Q, Weisskopf MG, Baccarelli AA, Schwartz JD. miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men. Epigenomics 2017;9(12):1529-1542. |
R832416 (Final) R835872 (2016) |
Exit |
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Nwanaji-Enwerem JC, Bind M-A, Dai L, Oulhote Y, Colicino E, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Editor’s highlight: Modifying role of endothelial function gene variants on the association of long-term PM2.5 exposure with blood DNA methylation age: the VA Normative Aging Study. Toxicological Sciences 2017;158(1):116-126. |
R832416 (Final) R835872 (2016) |
Exit Exit |
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Nwanaji-Enwerem JC, Colicino E, Dai L, Cayir A, Sanchez-Guerra M, Laue HE, Nguyen VT, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Impacts of the mitochondrial genome on the relationship of long-term ambient fine particle exposure with blood DNA methylation age. Environmental Science & Technology 2017;51(14):8185-8195. |
R832416 (Final) R835872 (2016) R835872 (2017) |
Exit Exit Exit |
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Nwanaji-Enwerem JC, Wang W, Nwanaji-Enwerem O, Vokonas P, Baccarelli A, Weisskopf M, Herndon LW, Wiggs JL, Park SK, Schwartz J. Association of long-term ambient black carbon exposure and oxidative stress allelic variants with intraocular pressure in older men. JAMA Ophthalmology 2019;137(2):129–137. |
R832416 (Final) |
Exit |
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O'Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, Horton ES, Schwartz J. Air pollution and inflammation in type 2 diabetes:a mechanism for susceptibility. Occupational and Environmental Medicine 2007;64(6):373-379. |
R832416 (2008) R827353 (Final) R827353C004 (Final) |
Exit Exit Exit |
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Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS, Godleski JJ, Koutrakis P. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhalation Toxicology 2011;23(8):495-505. |
R832416 (Final) R832416C005 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2010) R834798C001 (2011) R834798C001 (2014) R834798C001 (Final) R834798C005 (Final) |
Exit Exit |
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Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Koutrakis P. Development and evaluation of a countercurrent parallel-plate membrane diffusion denuder for the removal of gas-phase compounds from vehicular emissions. Inhalation Toxicology 2011;23(13):853-862. |
R832416 (Final) R832416C005 (Final) |
Exit |
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Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski JJ, Koutrakis P. Development and characterization of an exposure generation system to investigate the health effects of particles from fresh and aged traffic emissions. Air Quality, Atmosphere & Health 2013;6(2):419-429. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2012) R834798C001 (2013) R834798C001 (2014) R834798C001 (Final) |
Exit Exit |
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Park SK, O'Neill MS, Vokonas PS, Sparrow D, Schwartz J. Effects of air pollution on heart rate variability: the VA Normative Aging Study. Environmental Health Perspectives 2005;113(3):304-309. |
R832416 (2009) R832416C001 (2009) R827353 (Final) R827353C010 (Final) R831076 (Final) |
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Park SK, O'Neill MS, Wright RO, Hu H, Vokonas PS, Sparrow D, Suh H, Schwartz J. HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation 2006;114(25):2798-2805. |
R832416 (2009) R832416C001 (2009) R827353 (Final) R827353C010 (Final) R831076 (Final) |
Exit Exit |
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Park SK, O'Neill MS, Stunder BJ, Vokonas PS, Sparrow D, Koutrakis P, Schwartz J. Source location of air pollution and cardiac autonomic function: trajectory cluster analysis for exposure assessment. Journal of Exposure Science & Environmental Epidemiology 2007;17(5):488-497. |
R832416 (2008) R832416 (2009) R832416C001 (2009) R827353 (Final) R827353C010 (Final) R831076 (Final) |
Exit Exit Exit |
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Park SK, O’Neill MS, Vokonas PS, Sparrow D, Spiro III A, Tucker KL, Suh H, Hu H, Schwartz J. Traffic-related particles are associated with elevated homocysteine: the VA Normative Aging Study. American Journal of Respiratory and Critical Care Medicine 2008;178(3):283-289. |
R832416 (2006) R832416 (2009) R832416 (Final) R832416C001 (2008) R832416C001 (2009) R832416C001 (Final) R827353 (Final) |
Exit Exit Exit |
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Park SK, O’Neill MS, Vokonas PS, Sparrow D, Wright RO, Coull B, Nie H, Hu H, Schwartz J. Air pollution and heart rate variability: effect modification by chronic lead exposure. Epidemiology 2008;19(1):111-120. |
R832416 (2006) R832416 (2009) R832416 (Final) R832416C001 (2008) R832416C001 (2009) R832416C001 (Final) R827353 (Final) |
Exit Exit Exit |
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Park SK, Tucker KL, O'Neill MS, Sparrow D, Vokonas PS, Hu H, Schwartz J. Fruit, vegetable, and fish consumption and heart rate variability: the Veterans Administration Normative Aging Study. American Journal of Clinical Nutrition 2009;89(3):778-786. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
Exit Exit |
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Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR. Air pollution influences on exhaled nitric oxide among people with type II diabetes. Air Quality, Atmosphere & Health 2016;9(3):265-273. |
R832416 (Final) R834798 (Final) |
Exit |
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Peters JL, Kubzansky LD, Ikeda A, Spiro III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. American Journal of Epidemiology 2011;174(12):1345-1353. |
R832416 (Final) R832416C001 (Final) R834798 (2010) R834798 (2011) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) R834798C002 (2010) R834798C002 (2011) R834798C002 (2014) R834798C002 (Final) |
Exit Exit Exit |
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Peters JL, Kubzansky LD, Ikeda A, Fang SC, Sparrow D, Weisskopf MG, Wright RO, Vokonas P, Hu H, Schwartz J. Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study. Environmental Health Perspectives 2012;120(3):361-366. |
R832416 (Final) R832416C001 (Final) |
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Pope III CA, Ezzati M, Dockery DW. Fine-particulate air pollution and life expectancy in the United States. New England Journal of Medicine 2009;360(4):376-386. |
R832416 (2008) R832416 (Final) |
Exit Exit Exit |
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Power, MC, Weisskopf MG, Alexeef SE, Coull BA, Spiro III A , Schwartz J. Traffic-related air pollution and cognitive function in a cohort of older men. Environmental Health Perspectives 2011;119(5):682-687. |
R832416 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (2010) R834798C002 (2011) R834798C002 (2014) R834798C002 (Final) |
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Power MC, Weisskopf MG, Alexeeff SE, Wright RO, Coull BA, Spiro III A, Schwartz J. Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study. Environmental Health 2013;12:16 (8 pp.). |
R832416 (Final) R834798 (2014) R834798 (Final) R834798C002 (2013) R834798C002 (2014) |
Exit Exit Exit |
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Ren C, Vokonas PS, Suh H, Fang S, Christiani DC, Schwartz J. Effect modification of air pollution on urinary 8-hydroxy-2'-deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions. Environmental Health 2010;9:78 (9 pp.). |
R832416 (Final) R832416C001 (Final) |
Exit Exit Exit |
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|
Ren C, Melly S, Schwartz J. Modifiers of short-term effects of ozone on mortality in eastern Massachusetts—a case-crossover analysis at individual level. Environmental Health 2010;9:3 (10 pp.). |
R832416 (Final) R832416C001 (Final) |
Exit Exit Exit |
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Ren C, Baccarelli A, Wilker E, Suh H, Sparrow D, Vokonas P, Wright R, Schwartz J. Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability—the VA Normative Aging Study. Journal of Epidemiology and Community Health 2010;64(1):49-56. |
R832416 (2009) R832416 (Final) R832416C001 (2009) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
Exit |
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Ren C, Park SK, Vokonas PS, Sparrow D, Wilker E, Baccarelli A, Suh HH, Tucker KL, Wright RO, Schwartz J. Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution. Epidemiology 2010;21(2):198-206. |
R832416 (2009) R832416 (Final) R832416C001 (2009) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
Exit |
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Ren C, Fang S, Wright RO, Suh H, Schwartz J. Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study. Occupational and Environmental Medicine 2011;68(8):562-569. |
R832416 (2009) R832416C001 (2009) |
Exit |
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Ren C, O'Neill MS, Park SK, Sparrow D, Vokonas P, Schwartz J. Ambient temperature, air pollution, and heart rate variability in an aging population. American Journal of Epidemiology 2011;173(9):1013-1021. |
R832416 (Final) R832416C001 (Final) |
Exit Exit Exit |
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Rhoden CR, Wellenius GA, Ghelfi E, Lawrence J, Gonzalez-Flecha B. PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation. Biochimica et Biophysica Acta (BBA)-General Subjects 2005;1725(3):305-313. |
R832416 (2008) R827353 (Final) R827353C011 (2004) R827353C011 (Final) |
Exit |
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Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR, O'Connor GT, Mittleman MA. Short-term exposure to air pollution and lung function in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 2013;188(11):1351-1357. |
R832416 (Final) R834798 (Final) R834798C003 (2014) R834798C003 (Final) |
Exit Exit |
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Rice MB, Rifas-Shiman SL, Litonjua AA, Oken E, Gillman MW, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz J, Koutrakis P, Mittleman MA, Gold DR. Lifetime exposure to ambient pollution and lung function in children. American Journal of Respiratory and Critical Care Medicine 2016;193(8):881-888. |
R832416 (Final) R834798 (2015) |
Exit |
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Rice MB, Li W, Dorans KS, Wilker EH, Ljungman P, Gold DR, Schwartz J, Koutrakis P, Kloog I, Araki T, Hatabu H, San Jose Estepar R, O'Connor GT, Mittleman MA, Washko GR. Exposure to traffic emissions and fine particulate matter and computed tomography measures of the lung and airways. Epidemiology 2018;29(3):333-341. |
R832416 (Final) |
Exit |
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Sarnat JA, Brown KW, Bartell SM, Sarnat SE, Wheeler AJ, Suh HH, Koutrakis P. The relationship between averaged sulfate exposures and concentrations: results from exposure assessment panel studies in four U.S. cities. Environmental Science & Technology 2009;43(13):5028-5034. |
R832416 (Final) R827353 (Final) |
Exit Exit Exit |
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Sarnat SE, Suh HH, Coull BA, Schwartz J, Stone PH, Gold DR. Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio. Occupational and Environmental Medicine 2006;63(10):700-706. |
R832416 (2008) R826780 (Final) R827353 (Final) R827353C003 (Final) R834797 (2016) |
Exit Exit Exit |
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Schwartz J, Park SK, O'Neill MS, Vokonas PS, Sparrow D, Weiss S, Kelsey K. Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles:gene-by-drug-by-environment interaction. American Journal of Respiratory and Critical Care Medicine 2005;172(12):1529-1533. |
R832416 (2008) R827353 (Final) R827353C010 (Final) |
Exit Exit Exit |
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Schwartz J, Sarnat JA, Coull BA, Wilson WE. Effects of exposure measurement error on particle matter epidemiology:a simulation using data from a panel study in Baltimore, MD. Journal of Exposure Science and Environmental Epidemiology 2007;17(Suppl 2):S2-S10. |
R832416 (2008) R832416 (Final) R832416C001 (2008) R832416C001 (Final) |
Exit Exit |
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Schwartz J, Coull B, Laden F, Ryan L. The effect of dose and timing of dose on the association between airborne particles and survival. Environmental Health Perspectives 2008;116(1):64-69. |
R832416 (2006) R832416 (2008) R832416 (Final) R832416C001 (2008) |
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Schwartz J, Alexeeff SE, Mordukhovich I, Gryparis A, Vokonas P, Suh H, Coull BA. Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study. Occupational and Environmental Medicine 2012;69(6):422-427. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798C002 (2012) R834798C002 (2014) R834798C002 (Final) |
Exit Exit |
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Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E, Floras J, Nanthakumar K. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. Journal of the American College of Cardiology 2011;57(2):198-206. |
R832416 (Final) R832416C002 (2010) R832416C002 (Final) CR830837 (Final) R834798 (2012) R834798 (2014) R834798 (Final) R834798C002 (2014) R834798C002 (Final) R834798C004 (2012) R834798C004 (2014) R834798C004 (Final) |
Exit Exit Exit |
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Stafoggia M, Schwartz J, Forastiere F, Perucci CA, the SISTI Group. Does temperature modify the association between air pollution and mortality? A multicity case-crossover analysis in Italy. American Journal of Epidemiology 2008;167(12):1476-1485. |
R832416C001 (2008) |
Exit Exit |
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|
Suh HH, Zanobetti A. Exposure error masks the relationship between traffic-related air pollution and heart rate variability. Journal of Occupational and Environmental Medicine 2010;52(7):685-692. |
R832416 (Final) |
Exit |
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Thompson AM, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, Speck M, Brook JR, Manno M, Gold DR. Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen. Environmental Health Perspectives 2010;118(1):120-124. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R832416C002 (Final) CR830837 (Final) |
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Urch B, Speck M, Corey P, Wasserstein D, Manno M, Lukic KZ, Brook JR, Liu L, Coull B, Schwartz J, Gold DR, Silverman F. Concentrated ambient fine particles and not ozone induce a systemic interleukin-6 response in humans. Inhalation Toxicology 2010;22(3):210-218. |
R832416 (2009) R832416 (Final) R832416C002 (2009) R832416C002 (2010) R832416C002 (Final) |
Exit |
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Wang C, Parmigiani G, Dominici F. Bayesian effect estimation accounting for adjustment uncertainty. Biometrics 2012;68(3):661-671. |
R832416 (Final) R832417 (Final) R833622 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (2012) R834798C005 (2013) R834798C005 (Final) R834894 (2012) R834894 (2013) |
Exit Exit Exit |
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Wellenius GA, Schwartz J, Mittleman MA. Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities. The American Journal of Cardiology 2006;97(3):404-408. |
R832416 (2008) R827353 (Final) R827353C004 (2004) R827353C004 (Final) |
Exit Exit Exit |
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|
Wellenius GA, Yeh GY, Coull BA, Suh HH, Phillips RS, Mittleman MA. Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study. Environmental Health 2007;6:26. |
R832416 (2006) R832416 (Final) R832416C001 (Final) R827353 (Final) |
Exit Exit Exit |
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Wellenius GA, Diaz EA, Gupta T, Ruiz PA, Long M, Kang CM, Coull BA, Godleski JJ. Electrocardiographic and respiratory responses to coal-fired power plant emissions in a rat model of acute myocardial infarction: results from the Toxicological Evaluation of Realistic Emissions of Source Aerosols Study. Inhalation Toxicology 2011;23(Suppl 2):84-94. |
R832416 (Final) R832416C005 (2010) R832416C005 (Final) R827353 (Final) |
Exit |
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Wellenius GA, Burger MR, Coull BA, Schwartz J, Suh HH, Koutrakis P, Schlaug G, Gold DR, Mittleman MA. Ambient air pollution and the risk of acute ischemic stroke. Archives of Internal Medicine 2012;172(3):229-234. |
R832416 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C003 (2012) R834798C003 (2013) R834798C003 (2014) R834798C003 (Final) |
Exit Exit |
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|
Wellenius GA, Wilhelm-Benartzi CS, Wilker EH, Coull BA, Suh HH, Koutrakis P, Lipsitz LA. Ambient particulate matter and the response to orthostatic challenge in the elderly: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study. Hypertension 2012;59(3):558-563. |
R832416 (Final) R834798 (2013) R834798 (2014) |
Exit Exit |
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Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. Exposure to particulate air pollution and cognitive decline in older women. Archives of Internal Medicine 2012;172(3):219-227. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
Exit Exit Exit |
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|
Wheeler A, Zanobetti A, Gold DR, Schwartz J, Stone P, Suh HH. The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environmental Health Perspectives 2006;114(4):560-566. |
R832416 (2008) R827353 (Final) R827353C003 (Final) |
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Wilker EH, Alexeeff SE, Poon A, Litonjua AA, Sparrow D, Vokonas PS, Mittleman MA, Schwartz J. Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men. Atherosclerosis 2009;206(2):480-485. |
R832416 (2009) R832416 (Final) R832416C001 (2009) R832416C001 (2010) R832416C001 (Final) |
Exit Exit |
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Wilker EH, Baccarelli A, Suh H, Vokonas P, Wright RO, Schwartz J. Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in microRNA processing genes. Environmental Health Perspectives 2010;118(7):943-948. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) |
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Wilker EH, Alexeeff SE, Suh H, Vokonas PS, Baccarelli A, Schwartz J. Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules:the Normative Aging Study. Environmental Health 2011;10:45. |
R832416 (Final) R832416C001 (Final) |
Exit Exit Exit |
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Wilker EH, Mittleman MA, Coull BA, Gryparis A, Bots ML, Schwartz J, Sparrow D. Long-term exposure to black carbon and carotid intima-media thickness: the Normative Aging Study. Environmental Health Perspectives 2013;121(9):1061-1067. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798C002 (2013) R834798C002 (2014) R834798C002 (Final) |
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Wilker E, Mittleman MA, Litonjua AA, Poon A, Baccarelli A, Suh H, Wright RO, Sparrow D, Vokonas P, Schwartz J. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. Environmental Health Perspectives 2009;117(6):935-940. |
R832416 (Final) R832416C001 (2010) R832416C001 (Final) R827353 (Final) |
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Zanobetti A, Schwartz J. Air pollution and emergency admissions in Boston, MA. Journal of Epidemiology & Community Health 2006;60(10):890-895. |
R832416 (2008) R827353 (Final) R827353C004 (Final) R827353C005 (Final) |
Exit |
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Zanobetti A, Schwartz J. Temperature and mortality in nine US cities. Epidemiology 2008;19(4):563-570. |
R832416 (2006) R832416 (2008) R832416 (Final) |
Exit |
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|
Zanobetti A, Schwartz J. Is there adaptation in the ozone mortality relationship:a multi-city case-crossover analysis. Environmental Health 2008;7:22 (6 pp.). |
R832416 (2006) R832416 (2008) R832416 (Final) R832416C001 (2008) |
Exit Exit Exit |
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Zanobetti A, Bind MA, Schwartz J. Particulate air pollution and survival in a COPD cohort. Environmental Health 2008;7:48 (9 pp.). |
R832416 (2008) R832416 (Final) |
Exit Exit Exit |
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Zanobetti A, Franklin M, Koutrakis P, Schwartz J. Fine particulate air pollution and its components in association with cause-specific emergency admissions. Environmental Health 2009;8:58 (12 pp.). |
R832416 (Final) R832416C001 (2010) |
Exit Exit Exit |
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|
Zanobetti A, Schwartz J. The effect of fine and coarse particulate air pollution on mortality: a national analysis. Environmental Health Perspectives 2009;117(6):898-903. |
R832416 (Final) R832416C001 (2010) |
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Zanobetti A, Stone PH, Speizer FE, Schwartz JD, Coull BA, Suh HH, Nearing BD, Mittleman MA, Verrier RL, Gold DR. T-wave alternans, air pollution and traffic in high-risk subjects. American Journal of Cardiology 2009;104(5):665-670. |
R832416 (Final) R832416C001 (2010) |
Exit Exit Exit |
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Zanobetti A, Gold DR, Stone PH, Suh HH, Schwartz J, Coull BA, Speizer FE. Reduction in heart rate variability with traffic and air pollution in patients with coronary artery disease. Environmental Health Perspectives 2010;118(3):324-330. |
R832416 (Final) |
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Zanobetti A, Redline S, Schwartz J, Rosen D, Patel S, O'Connor GT, Lebowitz M, Coull BA, Gold DR. Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas. American Journal of Respiratory and Critical Care Medicine 2010;182(6):819-825. |
R832416 (Final) |
Exit Exit Exit |
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Zanobetti A, Baccarelli A, Schwartz J. Gene-air pollution interaction and cardiovascular disease: a review. Progress in Cardiovascular Diseases 2011;53(5):344-352. |
R832416 (Final) R832416C001 (Final) |
Exit Exit |
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Zanobetti A, Schwartz J. Ozone and survival in four cohorts with potentially predisposing diseases. American Journal of Respiratory and Critical Care Medicine 2011;184(7):836-841. |
R832416 (Final) R832416C001 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C001 (Final) R834798C002 (2010) R834798C002 (2011) R834798C002 (2014) R834798C002 (Final) R834798C005 (Final) |
Exit Exit Exit |
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Zanobetti A, O'Neill MS, Gronlund CJ, Schwartz JD. Summer temperature variability and long-term survival among elderly people with chronic disease. Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6608-6613. |
R832416 (Final) R832752 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (2012) R834798C002 (2014) R834798C002 (Final) R834798C005 (Final) |
Exit Exit |
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Zanobetti A, O'Neill MS, Gronlund CJ, Schwartz JD. Susceptibility to mortality in weather extremes: effect modification by personal and small-area characteristics. Epidemiology 2013;24(6):809-819. |
R832416 (Final) R832752 (Final) R834798 (Final) |
Exit |
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Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environmental Health Perspectives 2014;122(3):242-248. |
R832416 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C004 (2013) R834798C004 (2014) R834798C004 (Final) |
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Zanobetti A, Coull BA, Kloog I, Sparrow D, Vokonas PS, Gold DR, Schwartz J. Fine-scale spatial and temporal variation in temperature and arrhythmia episodes in the VA Normative Aging Study. Journal of the Air & Waste Management Association 2017;67(1):96-104. |
R832416 (Final) R834798 (Final) R834798C002 (Final) R834798C004 (Final) R834798C005 (Final) R835872 (2016) R835872C003 (Final) |
Exit Exit |
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Zeka A, Zanobetti A, Schwartz J. Short term effects of particulate matter on cause specific mortality:effects of lags and modification by city characteristics. Occupational and Environmental Medicine 2005;62(10):718-725. |
R832416 (2008) R827353 (Final) R827353C005 (Final) |
Exit Exit Exit |
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Zeka A, Zanobetti A, Schwartz J. Individual-level modifiers of the effects of particulate matter on daily mortality. American Journal of Epidemiology 2006;163(9):849-859. |
R832416 (2008) R827353 (Final) R827353C004 (Final) |
Exit Exit Exit |
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Zeka A, Sullivan JR, Vokonas PS, Sparrow D, Schwartz J. Inflammatory markers and particulate air pollution:characterizing the pathway to disease. International Journal of Epidemiology 2006;35(5):1347-1354. |
R832416 (2008) R832416 (2009) R832416C001 (2009) R827353 (Final) R827353C004 (Final) R827353C010 (Final) |
Exit Exit Exit |
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Zeka A, Melly SJ, Schwartz J. The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts. Environmental Health 2008;7:60 (12 pp.). |
R832416 (Final) R827353 (Final) |
Exit Exit |
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Zhong J, Urch B, Speck M, Coull BA, Koutrakis P, Thorne PS, Scott J, Liu L, Brook RD, Behbod B, Gibson H, Silverman F, Mittlemanm MA, Baccarelli AA, Gold DR. Endotoxin and β-1,3-d-glucan in concentrated ambient particles induce rapid increase in blood pressure in controlled human exposures. Hypertension 2015;66(3):509-516. |
R832416 (Final) R834798 (2016) R834798 (Final) R834798C004 (Final) |
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Zhong J, Trevisi L, Urch B, Lin X, Speck M, Coull BA, Liss G, Thompson A, Wu S, Wilson A, Koutrakis P, Silverman F, Gold DR, Baccarelli AA. B-vitamin supplementation mitigates effects of fine particles on cardiac autonomic dysfunction and inflammation: a pilot human intervention trial. Scientific Reports 2017;7:45322 (9 pp.). |
R832416 (Final) R834798C004 (Final) |
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Zhu ZZ, Sparrow D, Hou L, Tarantini L, Bollati V, Litonjua AA, Zanobetti A, Vokonas P, Wright RO, Baccarelli A, Schwartz J. Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes & Control 2011;22(3):437-447. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
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Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, Yang AS, Vokonas P, Lissowska J, Fustinoni S, Pesatori AC, Bonzini M, Apostoli P, Costa G, Bertazzi PA, Chow WH, Schwartz J, Baccarelli A. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. International Journal of Epidemiology 2012;41(1):126-139. |
R832416 (Final) R832416C001 (Final) R827353 (Final) |
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Bind M-A, Peters A, Koutrakis P, Coull B, Vokonas P, Schwartz J. Quantile regression analysis of the distributional effects of air pollution on blood pressure, heart rate variability, blood lipids, and biomarkers of inflammation in elderly American men: the Normative Aging Study. Environmental Health Perspectives 2016;124(8):1189-1198. |
R832416 (Final) R834798 (2016) |
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Supplemental Keywords:
RFA, Health, Scientific Discipline, Air, particulate matter, Health Risk Assessment, Risk Assessments, Biochemistry, ambient air quality, atmospheric particulate matter, chemical characteristics, human health effects, toxicology, airborne particulate matter, cardiovascular vulnerability, automobile exhaust, biological mechanisms, traffic related particulate matter, chemical composition, biological mechanism , human exposure, ambient particle health effects, autonomic dysfunction, oxidative stressProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832416C001 Cardiovascular Responses in the Normative Aging Study: Exploring the Pathways of Particle Toxicity
R832416C002 Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
R832416C003 Assessing Toxicity of Local and Transported Particles Using Animal Models Exposed to CAPs
R832416C004 Cardiovascular Effects of Mobile Source Exposures: Effects of Particles and Gaseous Co-pollutants
R832416C005 Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- 2010 Progress Report
- 2009 Progress Report
- 2008 Progress Report
- 2007 Progress Report
- 2006 Progress Report
- Original Abstract
199 journal articles for this center