Grantee Research Project Results
Final Report: Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions
EPA Grant Number: R832416C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R832416
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions
Investigators: Koutrakis, Petros , Godleski, John J.
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2011)
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
Summary/Accomplishments (Outputs/Outcomes):
Species or Diagnostic Ratio
|
EXPOSURE ATMOSPHERE TYPE
|
||||||
Aged Primary + Secondary (P+SOA)
|
Secondary Aerosol Only (SOA)
|
Primary (P)
|
|||||
Baseline
|
Plus O3
|
Lights
|
Baseline
|
Plus O3
|
Lights
|
no O3 or light
|
|
PM
|
6.50
|
5.10
|
22.60
|
0.40
|
1.69
|
50.27
|
47.00
|
EC
|
1.68
|
1.00
|
1.20
|
0.00*
|
0.00*
|
0.00*
|
12.26
|
OC
|
1.57
|
3.62
|
8.82
|
2.91
|
3.90
|
22.85
|
10.87
|
OC1
|
0.04
|
0.05
|
0.06
|
0.02
|
0.12
|
0.25
|
0.23
|
OC2
|
0.79
|
1.73
|
2.59
|
1.45
|
1.79
|
6.88
|
5.30
|
OC3
|
0.62
|
1.30
|
3.35
|
0.85
|
1.16
|
8.54
|
4.29
|
OC4
|
0.16
|
0.37
|
1.16
|
0.23
|
0.32
|
2.49
|
1.23
|
Pyrol C
|
0.00
|
0.16
|
1.66
|
0.36
|
0.51
|
4.69
|
0.19
|
NO3-
|
0.33
|
1.18
|
2.73
|
0.10
|
1.08
|
3.84
|
0.52
|
SO42-
|
0.50
|
0.41
|
4.00
|
0.11
|
0.16
|
7.15
|
2.59
|
EC/PM
|
0.26
|
0.20
|
0.05
|
0.00
|
0.00
|
0.00
|
0.26
|
OC/EC
|
0.93
|
3.62
|
7.35
|
*
|
*
|
*
|
0.89
|
OC1/OC
|
0.03
|
0.01
|
0.01
|
0.01
|
0.03
|
0.01
|
0.02
|
OC2/OC
|
0.50
|
0.48
|
0.29
|
0.50
|
0.46
|
0.30
|
0.49
|
OC3/OC
|
0.39
|
0.36
|
0.38
|
0.29
|
0.30
|
0.37
|
0.39
|
Pyrol C/OC
|
0.00
|
0.04
|
0.19
|
0.12
|
0.13
|
0.21
|
0.02
|
SO42-/EC
|
0.30
|
0.41
|
3.33
|
*
|
*
|
*
|
0.21
|
NO3-/SO42-
|
0.66
|
2.88
|
0.68
|
0.91
|
6.75
|
0.54
|
0.20
|
|
EXPOSURE ATMOSPHERE TYPE
|
||
Primary (P)
|
Aged Primary plus Secondary (P+SOA)
|
Secondary (SOA)
|
|
Particle Mass Mean ± SD (µg/m3)
|
47.4 ± 11.8
|
48.7 ± 9.3
|
50.3 ± 22.2
|
Mass Median Diameter ± GSD (nm)
|
321 ± 21
|
297 ± 6
|
367 ± 11
|
Particle Count (103/cc)
|
17.7 ± 4.4
|
9.3 ± 1.0
|
5.8 ± 2.1
|
NO Mean ± SD (ppb)
|
71 ± 25
|
27 ± 19
|
2.1 ± 0.5
|
NOx Mean ± SD (ppb)
|
93 ± 23
|
57 ± 14
|
37 ± 13
|
Number of Exposures
|
13
|
24
|
24
|
Conclusions:
References:
Ruiz PA, Lawrence JE, Ferguson S, Wolfson JM, Koutrakis P. A counter-current parallel-plate membrane denuder for the non-specific removal of trace gases. Environ Sci Technol 2006, 40:5058-5063.
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other subproject views: | All 9 publications | 9 publications in selected types | All 9 journal articles |
---|---|---|---|
Other center views: | All 206 publications | 199 publications in selected types | All 199 journal articles |
Type | Citation | ||
---|---|---|---|
|
Kang C-M, Gupta T, Ruiz PA, Wolfson JM, Ferguson ST, Lawrence JE, Rohr AC, Godleski J, Koutrakis P. Aged particles derived from emissions of coal-fired power plants: the TERESA field results. Inhalation Toxicology 2011;23(Suppl 2):11-30. |
R832416 (Final) R832416C005 (2010) R832416C005 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
Exit Exit |
|
Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS, Godleski JJ, Koutrakis P. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhalation Toxicology 2011;23(8):495-505. |
R832416 (Final) R832416C005 (Final) R834798 (2010) R834798 (2011) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2010) R834798C001 (2011) R834798C001 (2014) R834798C001 (Final) R834798C005 (Final) |
Exit Exit |
|
Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Koutrakis P. Development and evaluation of a countercurrent parallel-plate membrane diffusion denuder for the removal of gas-phase compounds from vehicular emissions. Inhalation Toxicology 2011;23(13):853-862. |
R832416 (Final) R832416C005 (Final) |
Exit |
|
Wellenius GA, Diaz EA, Gupta T, Ruiz PA, Long M, Kang CM, Coull BA, Godleski JJ. Electrocardiographic and respiratory responses to coal-fired power plant emissions in a rat model of acute myocardial infarction: results from the Toxicological Evaluation of Realistic Emissions of Source Aerosols Study. Inhalation Toxicology 2011;23(Suppl 2):84-94. |
R832416 (Final) R832416C005 (2010) R832416C005 (Final) R827353 (Final) |
Exit |
Supplemental Keywords:
RFA, Health, Scientific Discipline, Air, particulate matter, Toxicology, Environmental Chemistry, Health Risk Assessment, Risk Assessments, ambient air quality, atmospheric particulate matter, chemical characteristics, human health effects, concentrated ambient particulates (CAPs), cardiovascular vulnerability, animal model, automobile exhaust, airborne particulate matter, chemical composition, biological mechanisms, biological mechanism , traffic related particulate matter, ambient particle health effects, PM, autonomic dysfunction, human health riskProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R832416 Health Effects Institute (2015 - 2020) Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832416C001 Cardiovascular Responses in the Normative Aging Study: Exploring the Pathways of Particle Toxicity
R832416C002 Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
R832416C003 Assessing Toxicity of Local and Transported Particles Using Animal Models Exposed to CAPs
R832416C004 Cardiovascular Effects of Mobile Source Exposures: Effects of Particles and Gaseous Co-pollutants
R832416C005 Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
9 journal articles for this subproject
Main Center: R832416
206 publications for this center
199 journal articles for this center