Grantee Research Project Results
2010 Progress Report: Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
EPA Grant Number: R832415Center: Rochester PM Center
Center Director: Oberdörster, Günter
Title: Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
Investigators: Oberdörster, Günter , Utell, Mark J. , Hopke, Philip K. , Finkelstein, Jacob N. , Frampton, Mark W. , Peters, Annette
Current Investigators: Oberdörster, Günter , Hopke, Philip K. , Frampton, Mark W. , Utell, Mark J. , Finkelstein, Jacob N. , Peters, Annette
Institution: University of Rochester , GSF-National Research Center for Environment and Health , Clarkson University
Current Institution: University of Rochester , Clarkson University , GSF-National Research Center for Environment and Health
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2012)
Project Period Covered by this Report: October 1, 2009 through September 30,2010
Project Amount: $8,000,000
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
The research projects conducted by the Rochester PM Center fall under five core areas. The titles of the projects for the five Cores are:
Core 1: Exposure Assessment and PM Source Identification – Characterization and Source Apportionment
Core 2: Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources -- Effects of Fine and Ultrafine Particles from Different Sources on Cardiovascular Function in Susceptible Subgroups
Core 3: (1) Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles and (2) Ultrafine Particles and Cardiac Responses: Evaluation in a Cardiac Rehabilitation Center
Core 4: (1) Animal Models: Cardiovascular Disease, Central Nervous System (CNS) Injury and Ultrafine Particle Biokinetics and (2) Concentrated Ambient Particulate Matter and CNS Dysfunction
Core 5: Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading to Altered Gene Expression in Relation to Particle Composition
The objectives of these research projects are to:
- Characterize the nature of the particle-bound reactive oxygen species resulting from major biogenic VOC reactions with ozone.
- Examine the effect of fine and ultrafine particles on systemic responses, endothelial and cardiac function. The specific aims are to: (1) determine the effect of ambient fine and ultrafine particles on an acute phase reaction in the blood of subjects with type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT) and potential genetic susceptibility (gen. susc.); (2) determine the effect of ambient fine and ultrafine particles on pro-thrombotic states of the blood in the above subject panels; (3) determine the effect of ambient fine and ultrafine particles on endothelial dysfunction as a key element of coronary vulnerability in a subset of the above subject panels; and (4) determine the effect of ultrafine particles on cardiac function as characterized by ECG measures of autonomic function and repolarization in a subset of the above subject panels.
- Determine the pulmonary and cardiovascular effects of exposure to ultrafine and fine particulate matter (PM). The clinical studies focus on the effects of ambient ultrafine and fine particles on three major determinants of adverse cardiac events: 1) blood coagulation induced by effects on platelets and circulating microparticles; 2) cardiac output; and 3) cardiac rhythm and repolarization.
- Evaluate the association between air pollution (with particular emphasis on ultrafine particles) and several cardiovascular parameters.
- Correlate physico-chemical particle characteristics (from Core 1 measurements) with pulmonary and cardiovascular endpoints following exposure of animals to inhaled ambient concentrated ultrafine/fine particles, inhaled freshly-generated exhaust particles from low and ultralow diesel fuel, and intratracheally administered ultrafine and fine ambient particles from different sites and sources.
- Determine effects of early life exposure to ambient ultrafine particles of rats on the CNS.
- Address specific mechanistic hypotheses regarding the interactions between inhaled ultrafine particles and specific pulmonary cell populations.
Progress Summary:
The progress for the research projects of the Center are summarized below. More details on the projects are provided in separate progress reports (see the 2010 annual reports for R832415C001, R832415C002, R832415C003, R832415C004, and R832415C005.
Core 1: Exposure Assessment and PM Source Identification
Project Title: Characterization and Source Apportionment
We hypothesized that particle-bound ROS might be an important contributor to the health effects resulting from oxidative stress. Thus, understanding the nature of the ROS components, their formation and their reactivity provides a better basis for understanding their potential role in inducing adverse effects.
The formation of α-pinene/ozone first generation products involves a number of intermediate species and yields a number of reactive radicals. Based on the tandem mass spectrometry results, chemical structures of these radicals were tentatively identified and found to be species with molecular formulas C9O2H13 (153 Da), C10O3H15 (183 Da), and C10O4H15 (199 Da), respectively. Chemical structures of several organic radicals have been tentatively identified. Radicals with molecular masses 125 Da and 157 Da, detected in this study, have not been previously reported. Structures of these radicals and formation mechanisms have been elucidated.
This work provides a clearer picture of the nature of some short-lived but highly reactive species that are associated with freshly formed secondary organic aerosol. The work provides a better understanding of the mechanism of formation of SOA and ROS and the nature of the reactive species to which humans are exposed.
Core 2: Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources
Project Title: Effects of Fine and Ultrafine Particles from Different Sources on Cardiovascular Function in Susceptible Subgroups
The study was conducted in Augsburg, Germany, between March 19, 2007 and December 17, 2008. The accomplishments include:
- The completion of nearly all parts of data management. Only datasets including the information about participants’ medication and the description of activities during the personal measurement period are still being prepared.
- The performing of statistical analyses with emphasis on effects on ECG parameters.
- The preparing of manuscripts with emphasis on effects on ECG parameters.
By looking at traffic-related PM and aged aerosols characterized at an urban background site our epidemiological study contributes to the center’s goal of identifying sources with higher toxicity and pathophysiological mechanisms by which ambient ultrafine and fine PM trigger cardiovascular adverse health effects.
The study was conducted in adults with diagnosed type 2 diabetes or impaired glucose tolerance—hypothesized to be a susceptible subpopulation with respect to PM responses.
Core 3
Project Title: Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles
The following accomplishments were reported:
- Human clinical exposures to concentrated ambient ultrafine particles—Data analyses have been completed for this study, and manuscript preparation is underway.
- Ultrafine Particle Effects on Dendritic Cells in Asthma (ASTHMACON)—We have completed a pilot study that was funded in part by the Rochester EPA Center. This study examines the effects of air pollution exposure on innate immunity in susceptible subjects.
- Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects (CUSP)—We hypothesize that the acute vascular effects of UFP exposure are a consequence of reduced NO bioavailability. We have initiated a new study, jointly funded by this center and by the NIH, to test this hypothesis in healthy subjects. We have recruited 15 subjects to the study, and 6 subjects have completed both air and UFP exposures.
These studies will provide important new information about the cardiac and vascular effects of exposure to UFP, and will test specific mechanisms for these effects. In addition, we will test the hypothesis that specific genetic polymorphisms confer increased susceptibility to UFP effects.
Project Title: Ultrafine Particles and Cardiac Responses: Evaluation in a Cardiac
Rehabilitation Center
We conducted a study evaluating the association between air pollution (with particular emphasis on ultrafine particles) and several cardiovascular parameters. The study population consisted of 75 subjects undergoing cardiac rehabilitation after recent acute coronary syndrome (myocardial infarction, unstable angina).
Core 4
Project Title: Animal Models: Cardiovascular Disease, CNS Injury and Ultrafine Particle
Biokinetics
We hypothesized that inhaled Mn oxide UFP would impact the progression of pathology in a mouse AD model. Using 4 month-old 3xTg-AD mice in pilot-type studies, we undertook a 12-day exposure (4 hrs/day) to poorly soluble Mn oxide UFP alone or in combination with weekly inhalation exposures to aerosolized endotoxin (lipopolysaccharide, LPS). Groups of mice were left untreated (naïve) or received only the LPS aerosols. One day and two months following the final exposure, mice were sacrificed, perfused with 4% paraformaldehyde, and brains were progressively dehydrated in 30% sucrose and coronally sectioned at 30 µm. Free-floating sections were separately processed for microglia staining using the Iba1 antibody or astrocytes using a GFAP-specific antibody. Quantitative image analysis revealed heightened activation of Iba1-expressing microglia in the hippocampus and dentate gyrus one days following Mn oxide aerosol exposure alone or in combination with LPS. Quantitative image analysis of staining intensities for GFAP indicated that astrocyte activation was similarly enhanced. These results indicate enhanced activation of the innate immune system in brain regions that are relevant to the pathology of AD and raise the possibility that disease severity could be accelerated with inhaled pollutant exposures. Furthermore, these changes in inflammatory cell activation state persisted through 2 months post-exposure.
Project Title: Concentrated Ambient Particulate Matter and CNS Dysfunction
C57Bl6 mice were exposed to concentrated ambient particles (CAPS) or vehicle (filtered air) from postnatal days 4-7 and 10-13 for 4 hours/day between 0800 and 1200 hr. Mice received adult re-exposure starting at postnatal day 56 for an additional 4 days creating four exposure groups as follows: postnatal air/adult air, postnatal air/adult CAPS, postnatal CAPS/adult air, postnatal CAPS/Adult CAPS. Among other regions, GFAP immunoreactivity was assessed in ventral midbrain of CAPS-exposed animals (n=2-3/treatment) sacrificed 2 days following the adult re-exposure. Increased GFAP immunoreactivity in all groups exposed to CAPS was observed. Notably, animals that received only postnatal CAPS (i.e. CAPS/Air) shows astrogliosis that persisted for at least 7 weeks following the final CAPS exposure.
Preliminary data described here indicate that developmental CAPS is capable of eliciting an astroglial response in the ventral midbrain that appears to persist for at least 7 weeks, that CAPS is capable of producing behavioral toxicity that is gender-dependent as measured by changes spontaneous locomotor activity and measurement of FI performance. The hypothalamus-pituitary-adrenal (HPA) axis (the body’s stress response system) also appears to be a target of CAPS-induced toxicity, as CAPS exposure causes corticosterone changes. It is apparent that the CNS and HPA axis are both targets of CAPS-induce toxicity.
Project Title: Susceptibility of Developing Lung to UFPs via Inflammatory and ROS Mechanisms.
Four and 56 day old C57Bl/6J mice were exposed to ambient “Real World” concentrated ultrafine particles for duration of 4 hours a day for 4 consecutive days followed by 2 days of recovery and then exposed for 4 hours a day for 4 consecutive days and examined at the end of exposure or allowed to recover until 8 weeks of age. At that time mice were either sacrificed or exposed to ambient concentrated particles for 4 days and examined at the end of exposure. Our second set of studies compared particle distribution in the lung and whole-body translocation in mice exposed to ~ 10nm Au ultrafine particles, which were used as a surrogate particle. We exposed mice to Au ultrafine particles at the end of HUCAP exposures for 4 hours and examine 24 hours post exposure. Our third set of studies will focus on later life susceptibility after early life HUCAP exposures. Lavage data demonstrates that mice exposed beginning at 4 days of age to UFP then reexposed as adults induced lavagable PMNs 4 fold greater than mice that began exposure at 56 days of age going through the same exposure regiment. Lymphocytes were also induced approximately three fold greater in 4 day old mice upon re-exposure.
Core 5
Project Title: Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading to Altered Gene Expression in Relation to Particle Composition
As a means of better correlating the potential of various particles or other stimuli to induce effects in vivo and establish appropriate in vitro models we continue to examine multiple cellular endpoints, in particular those that are relevant to measurement made in other PM center projects. Our results have established that measurement of IL 6 has the best predictive value. Once we have established the appropriate end points, our plans have been to create more relevant models. Co-culture systems consisting of lung epithelial cells and lung endothelial cells have been established so that both PM-cell and cell-cell interactions can be evaluated. Cell type specific responses of cytokine induction (TNF-α; IL-6; IL-8; or homologue) and NO-production (endothelial cells) will be measured as well as uptake and PM size-specific translocation. Dose-response relationships using PM samples collected at different sites from different sources will first be established in epithelial and endothelial cell monocultures. These data will be used to select the most active fractions of the PM samples for the co-culture studies and for the in vivo instillation studies.
We initially grew endothelial cells in transwell cultures with the cell either growing on top of the transwell, similar to a classical monolayer or grew them on the underside of the membrane to be able to access the basal surface of the cell through the pores of the insert. The system was stimulated by adding particles or a soluble agent like LPS either to the insert or to the well below. After 7 days cells were incubated with particles at the concentrations shown for 24 hours and IL-6 production assayed.
A594 cells and vascular endothelial cells cultured in transwell cells were stimulated with either LPS or particles added to the upper chamber or lower. Culture media was harvested from upper and lower chamber and assayed for luciferase as a response of the epithelial cells and IL-6 measured to indicate response of the endothelium. LDH was used as a measure of cytotoxicity.
Future Activities:
Core 1: We are working to determine if the formation of the free radical species influence the formation of low volatility oligomeric SOA that contributes to increased particle mass.
Core 2: For the period of the no-cost extension for the PM Center the following activities are planned: (1) further statistical analyses using the innovative particle characterization at the central measurement site including particle number, surface and mass concentrations of all particles and the non-volatile fraction as well as source indicators. In addition to EGG measures, blood biomarker of inflammation, coagulation and endothelial dysfunction will be analyzed to further characterize the pathomechanisms. While the current report focuses on subjects with metabolic disorders, the final year of the study will in particular assess the effects of particles in the panel of genetic susceptible individuals and will test the potential for genetic susceptibility in all participants. (2) Further preparation of publication manuscripts.
Core 3: Future activities for the UPCON study include: (1) complete measurements of soluble markers of inflammation and coagulation markers, and prepare manuscripts. Future activities for the UPASTHMA study (genetically susceptible asthmatic subjects inhaling CUFP) include: (1) complete data analysis, and (2) prepare manuscript. The future activities for the CUSP study (Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects) are to complete subject recruitment and exposures.
For the Ultrafine Particles and Cardiac Responses: Evaluation in a Cardiac Rehabilitation Center project, data analyses are ongoing and a manuscript describing the cardiac findings is planned.
Core 5: We plan to continue to use the transwell and co-culture systems to measure cell type specific responses of cytokine induction (TNF-α; IL-6; IL-8; or homologue) and NO-production (endothelial cells) as well as uptake and PM size-specific translocation. Dose-response relationships using PM samples collected at different sites from different sources first will be established in epithelial and endothelial cell monocultures. These data will be used to select the most active fractions of the PM samples.
Journal Articles: 144 Displayed | Download in RIS Format
Other center views: | All 191 publications | 157 publications in selected types | All 144 journal articles |
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Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW. Neutrophils in lung inflammation: which reactive oxygen species are being measured? Inhalation Toxicology 2001;13(6):485-495. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (2004) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
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Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang L-S, Cox C, Zareba W, Oberdorster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults:a human inhalation study. American Journal of Respiratory and Critical Care Medicine 2005;171(10):1129-1135. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Berger A, Zareba W, Schneider A, Ruckerl R, Ibald-Mulli A, Cyrys J, Wichmann HE, Peters A. Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease. Journal of Occupational and Environmental Medicine 2006;48(11):1149-1158. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. Foxp3 regulates megakaryopoiesis and platelet function. Arteriosclerosis, Thrombosis, and Vascular Biology 2009;29(11):1874-1882. |
R832415 (Final) |
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Bezemer GFG, Bauer SM, Oberdorster G, Breysse PN, Pieters RHH, Georas SN, Williams MA. Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. Journal of Innate Immunity 2011;3(2):150-166. |
R832415 (Final) R832139 (Final) |
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Breitner S, Stolzel M, Cyrys J, Pitz M, Wolke G, Kreyling W, Kuchenhoff H, Heinrich J, Wichmann H-E, Peters A. Short-term mortality rates during a decade of improved air quality in Erfurt, Germany. Environmental Health Perspectives 2009;117(3):448-454. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
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Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832415 (Final) R832413 (Final) R832414 (Final) R832416 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Bruske I, Hampel R, Socher MM, Ruckerl R, Schneider A, Heinrich J, Oberdorster G, Wichmann H-E, Peters A. Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease. Inhalation Toxicology 2010;22(3):245-252. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2010) R832415C002 (2011) R832415C004 (2010) R832415C004 (2011) R827354 (Final) |
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Bruske I, Hampel R, Baumgartner Z, Ruckerl R, Greven S, Koenig W, Peters A, Schneider A. Ambient air pollution and lipoprotein-associated phospholipase A2 in survivors of myocardial infarction. Environmental Health Perspectives 2011;119(7):921-926. |
R832415 (Final) |
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Cass GR, Hughes LA, Bhave P, Kleeman MJ, Allen JO, Salmon LG. The chemical composition of atmospheric ultrafine particles. Philosophical Transactions of the Royal Society of London Series A-Mathematical Physical & Engineering Sciences 2000;358(1775):2581-2592. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (2004) R827354 (Final) R827354C001 (1999) R827354C001 (2000) R827354C001 (Final) |
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Chalupa DC, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environmental Health Perspectives 2004;112(8):879-882. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Couderc JP, Elder ACP, Cox C, Zareba W, Oberdorster G. Limitations of power-spectrum and time-domain analysis of heart rate variability in short-term ECG recorded using telemetry in unrestrained rats. Computers in Cardiology 2002;29:589-592. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R828046 (Final) |
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Cyrys J, Heinrich J, Peters A, Kreyling WG, Wichmann H-E. Emissionen, immission und messungen feiner und ultrafeiner partikel (Immission, emissions, and measurements of fine and ultrafine particles). Umweltmedizin in Forschung und Praxis 2002;7(2):67-77. |
R832415 (2010) R832415 (Final) R832415C002 (2011) |
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Cyrys J, Peters A, Soentgen J, Wichmann HE. Low emission zones reduce PM10 mass concentrations and diesel soot in German cities. Journal of the Air & Waste Management Association 2014;64(4):481-487. |
R832415 (Final) |
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Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhalation Toxicology 2003;15(6):539-552. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (2001) R826781 (Final) R827354 (2004) R827354 (Final) R827354C003 (1999) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (2003) R827354C003 (2004) R827354C003 (Final) R827354C004 (Final) |
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Deffner V, Kuechenhoff H, Maier V, Pitz M, Cyrys J, Breitner S, Schneider A, Gu J, Geruschkat U, Peters A. Personal exposure to ultrafine particles: two-level statistical modeling of background exposure and time-activity patterns during three seasons. Journal of Exposure Science and Environmental Epidemiology 2016;26(1):17-25. |
R832415 (Final) |
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Deffner V, Keuschenoff H, Breitner S, Schneider A, Cyrys J, Peters A. Mixtures of Berkson and classical covariate measurement error in the linear mixed model: Bias analysis and application to a study on ultrafine particles. BIOMETRICAL JOURNAL 2018;60(3):480-497 |
R832415 (Final) |
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Dillner AM, Schauer JJ, Christensen WF, Cass GR. A quantitative method for clustering size distributions of elements. Atmospheric Environment 2005;39(8):1525-1537. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (2004) R827354 (Final) R827354C001 (Final) R827355 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic interactions between inhaled ultrafine particles and endotoxin. Annals of Occupational Hygiene 2002;46(Suppl 1):231-234. |
R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) R828046 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhalation Toxicology 2004;16(6-7):461-471. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder ACP, Gelein R, Oberdorster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Experimental Lung Research 2004;30(2):105-120. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) |
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Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong C-H, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdorster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhalation Toxicology 2004;16(Suppl 1):41-53. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdorster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Experimental Lung Research 2005;31(6):527-546. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives 2006;114(8):1172-1178. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) R827354 (Final) R827354C004 (Final) R827354C005 (Final) |
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Elder A, Couderc J-P, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdorster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhalation Toxicology 2007;19(1):1-12. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2006) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) R828046 (Final) |
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Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R827351 (Final) R827352 (Final) R827353 (Final) R827354 (Final) R827355 (Final) R832416 (2009) R832416C003 (2009) |
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Fensterer V, Kuchenhoff H, Maier V, Wichmann HE, Breitner S, Peters A, Gu JW, Cyrys J. Evaluation of the impact of low emission zone and heavy traffic ban in Munich (Germany) on the reduction of PM10 in ambient air. International Journal of Environmental Research and Public Health 2014;11(5):5094-5112. |
R832415 (Final) |
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Frampton MW. Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environmental Health Perspectives 2001;109(Suppl 4):529-532. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
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Frampton MW, Stewart JC, Oberdorster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang L-S, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environmental Health Perspectives 2006;114(1):51-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Frampton MW. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans? Inhalation Toxicology 2007;19(Suppl 1):75-79. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (Final) R827354 (Final) R827354C003 (Final) |
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Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ. Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes. Inhalation Toxicology 2012;24(12):831-838. |
R832415 (Final) |
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Gu J, Pitz M, Breitner S, Birmili W, von Klot S, Schneider A, Soentgen J, Reller A, Peters A, Cyrys J. Selection of key ambient particulate variables for epidemiological studies--applying cluster and heatmap analyses as tools for data reduction. Science of the Total Environment 2012;435-436:541-550. |
R832415 (Final) |
Exit Exit Exit |
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Hampel R, Schneider A, Bruske I, Zareba W, Cyrys J, Ruckerl R, Breitner S, Korb H, Sunyer J, Wichmann HE, Peters A. Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors. Environmental Health Perspectives 2010;118(12):1755-1761. |
R832415 (Final) R827354 (Final) |
|
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Hampel R, Breitner S, Ruckerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A. Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season. Occupational & Environmental Medicine 2010;67(6):408-416. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C003 (2011) |
Exit |
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Hampel R, Breitner S, Schneider A, Zareba W, Kraus U, Cyrys J, Geruschkat U, Belcredi P, Muller M, Wichmann HE, Peters A, Cooperative Health Research in the Region of Augsburg (KORA) Study Group. Acute air pollution effects on heart rate variability are modified by SNPs involved in cardiac rhythm in individuals with diabetes or impaired glucose tolerance. Environmental Research 2012;112:177-185. |
R832415 (Final) |
Exit Exit Exit |
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Hampel R, Breitner S, Zareba W, Kraus U, Pitz M, Geruschkat U, Belcredi P, Peters A, Schneider A, Cooperative Health Research in the Region of Augsburg Study Group. Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals. Occupational and Environmental Medicine 2012;69(6):428-436. |
R832415 (Final) |
Exit |
|
Hampel R, Ruckerl R, Yli-Tuomi T, Breitner S, Lanki T, Kraus U, Cyrys J, Belcredi P, Bruske I, Laitinen TM, Timonen K, Wichmann HE, Peters A, Schneider A. Impact of personally measured pollutants on cardiac function. International Journal of Hygiene and Environmental Health 2014;217(4-5):460-464. |
R832415 (Final) |
Exit Exit Exit |
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Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdorster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology 2011;287(1-3):99-104. |
R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
Exit Exit Exit |
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Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdorster G. Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data. Toxicology 2012;297(1-3):1-9. |
R832415 (Final) |
Exit Exit Exit |
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Henneberger A, Zareba W, Ibald-Mulli A, Ruckerl R, Cyrys J, Couderc J-P, Mykins B, Woelke G, Wichmann H-E, Peters A. Repolarization changes induced by air pollution in ischemic heart disease patients. Environmental Health Perspectives 2005;113(4):440-446. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2003) R827354C002 (Final) |
|
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Hildebrandt K, Ruckerl R, Koenig W, Schneider A, Pitz M, Heinrich J, Marder V, Frampton M, Oberdorster G, Wichmann HE, Peters A. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease. Particle and Fibre Toxicology 2009;6:25. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2009) R832415C002 (2010) R832415C002 (2011) R832415C003 (2010) R832415C003 (2011) R832415C004 (2010) R832415C004 (2011) |
Exit Exit Exit |
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Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C017 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) |
Exit Exit Exit |
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Ibald-Mulli A, Wichmann HE, Kreyling W, Peters A. Epidemiological evidence on health effects of ultrafine particles. Journal of Aerosol Medicine 2002;15(2):189-201. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2003) R827354C002 (Final) |
Exit |
|
Ito K, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Neas L, Hopke PK, Thurston GD. PM source apportionment and health effects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):300-310. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) R827997 (Final) |
Exit Exit |
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Jeong C-H, Hopke PK, Chalupa D, Utell M. Characteristics of nucleation and growth events of ultrafine particles measured in Rochester, NY. Environmental Science & Technology 2004;38(7):1933-1940. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C003 (Final) |
Exit Exit Exit |
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Jeong C-H, Lee D-W, Kim E, Hopke PK. Measurement of real-time PM2.5 mass, sulfate, and carbonaceous aerosols at the multiple monitoring sites. Atmospheric Environment 2004;38(31):5247-5256. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Jeong C-H, Hopke PK, Kim E, Lee D-W. The comparison between thermal-optical transmittance elemental carbon and Aethalometer black carbon measured at multiple monitoring sites. Atmospheric Environment 2004;38(31):5193-5204. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Jeong C-H, Evans GJ, Hopke PK, Chalupa D, Utell MJ. Influence of atmospheric dispersion and new particle formation events on ambient particle number concentration in Rochester, United States, and Toronto, Canada. Journal of the Air & Waste Management Association 2006;56(4):431-443. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) |
Exit Exit |
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Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. city by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C008 (2002) R827355C008 (Final) R827355C009 (2003) R828678C010 (2003) R828678C010 (2004) R828678C010 (2005) R828678C010 (2006) R828678C010 (2007) R828678C010 (Final) |
Exit Exit Exit |
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Kim E, Hopke PK, Larson TV, Maykut NN, Lewtas J. Factor analysis of Seattle fine particles. Aerosol Science and Technology 2004;38(7):724-738. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2003) R827355C008 (Final) |
Exit Exit Exit |
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Kim E, Hopke PK, Larson TV, Covert DS. Analysis of ambient particle size distributions using Unmix and positive matrix factorization. Environmental Science & Technology 2004;38(1):202-209. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R827354C002 (2004) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2002) R827355C008 (2003) R827355C008 (Final) |
Exit Exit Exit |
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Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdorster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong C-H. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhalation Toxicology 2004;16(Suppl 1):31-39. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit |
|
Kraus U, Breitner S, Schnelle-Kreis J, Cyrys J, Lanki T, Ruckerl R, Schneider A, Bruske I, Gu J, Devlin R, Wichmann H-E, Zimmermann R, Peters A. Particle-associated organic compounds and symptoms in myocardial infarction survivors. Inhalation Toxicology 2011;23(7):431-447. |
R832415 (Final) R832415C002 (2011) |
Exit |
|
Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdorster G, Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health-Part A 2002;65(20):1513-1530. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
Exit |
|
Lagudu UR, Raja S, Hopke PK, Chalupa DC, Utell MJ, Casuccio G, Lersch TL, West RR. Heterogeneity of coarse particles in an urban area. Environmental Science & Technology 2011;45(8):3288-3296. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Lanzinger S, Hampel R, Breitner S, Ruckerl R, Kraus U, Cyrys J, Geruschkat U, Peters A, Schneider A. Short-term effects of air temperature on blood pressure and pulse pressure in potentially susceptible individuals. International Journal of Hygiene and Environmental Health 2014;217(7):775-784. |
R832415 (Final) |
Exit Exit Exit |
|
Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827351 (2002) R827351 (Final) R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827354 (Final) R827355 (Final) |
Exit |
|
Ljungman P, Bellander T, Nyberg F, Lampa E, Jacquemin B, Kolz M, Lanki T, Mitropoulos J, Muller M, Picciotto S, Pistelli R, Ruckerl R, Koenig W, Peters A, AIRGENE Study Group. DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: results from the AIRGENE study. Thrombosis Research 2009;124(1):57-64. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit |
|
Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Neas L, Stolzel M, Paatero P, Hopke PK, Thurston GD. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):311-320. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827353 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C002 (Final) R827355C008 (Final) |
Exit Exit Exit |
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Moffet RC, Shields LG, Berntsen J, Devlin RB, Prather KA. Characterization of an ambient coarse particle concentrator used for human exposure studies: aerosol size distributions, chemical composition, and concentration enrichment. Aerosol Science and Technology 2004;38(11):1123-1137. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit |
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Oberdorster G. Pulmonary effects of inhaled ultrafine particles. International Archives of Occupational and Environmental Health 2001;74(1):1-8. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C004 (2000) R827354C004 (2001) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Utell MJ. Ultrafine particles in the urban air:to the respiratory tract—and beyond? Environmental Health Perspectives 2002;110(8):A440-A441. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
|
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. Journal of Toxicology and Environmental Health, Part A: Current Issues 2002;65(20):1531-1543. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R826784 (Final) R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology 2004;16(6-7):437-445. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit Exit |
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Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology:an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives 2005;113(7):823-839. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (Final) |
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Oberdorster G, Stone V, Donaldson K. Toxicology of nanoparticles: a historical perspective. Nanotoxicology 2007;1(1):2-25. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2007) R832415C004 (2010) R832415C004 (2011) |
Exit Exit |
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Oberdorster G, Elder A, Rinderknecht A. Nanoparticles and the brain: cause for concern? Journal of Nanoscience and Nanotechnology 2009;9(8):4996-5007. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) |
Exit |
|
Oberdorster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. Journal of Internal Medicine 2010;267(1):89-105. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) |
Exit Exit Exit |
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Ogulei D, Hopke PK, Chalupa DC, Utell MJ. Modeling source contributions to submicron particle number concentrations measured in Rochester, New York. Aerosol Science and Technology 2007;41(2):179-201. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R831078 (Final) |
Exit Exit Exit |
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Pavlovic J, Hopke PK. Technical note: detection and identification of radical species formed from α-pinene/ozone reaction using DMPO spin trap. Atmospheric Chemistry and Physics Discussions 2009;9(6):23695-23717. |
R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2009) R832415C001 (2010) R832415C001 (2011) |
Exit Exit |
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Pavlovic J, Hopke PK. Detection of radical species formed by the ozonolysis of α-pinene. Journal of Atmospheric Chemistry 2010;66(3):137-155. |
R832415 (2011) R832415 (Final) R832415C001 (2011) |
Exit |
|
Pavlovic J, Hopke PK. Chemical nature and molecular weight distribution of the water-soluble fine and ultrafine PM fractions collected in a rural environment. Atmospheric Environment 2012;59:264-271. |
R832415 (Final) |
Exit Exit Exit |
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Pekkanen J, Peters A, Hoek G, Tiittanen P, Brunekreef B, de Hartog J, Heinrich J, Ibald-Mulli A, Kreyling WG, Lanki T, Timonen KL, Vanninen E. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease:the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 2002;106(8):933-938. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
Exit Exit Exit |
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Peters A, Heinrich J, Wichmann H-E. Gesundheitliche Wirkungen von Feinstaub: Epidemiologie der Kurzzeiteffekte (Health impact of exposure to fine particles: epidemiology of short-term effects). Umweltmedizin in Forschung und Praxis 2002;7(2):101-115. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
Exit Exit |
|
Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H, Cooperative Health Research in the Region of Augsburg Study Group. Exposure to traffic and the onset of myocardial infarction. New England Journal of Medicine 2004;351(17):1721-1730. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Peters A. Particulate matter and heart disease:evidence from epidemiological studies. Toxicology and Applied Pharmacology 2005;207(2-Suppl):477-482. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Peters A, Greven S, Heid IM, Baldari F, Breitner S, Bellander T, Chrysohoou C, Illig T, Jacquemin B, Koenig W, Lanki T, Nyberg F, Pekkanen J, Pistelli R, Ruckerl R, Stefanadis C, Schneider A, Sunyer J, Wichmann HE, AIRGENE Study Group. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. American Journal of Respiratory and Critical Care Medicine 2009;179(6):484-491. |
R832415 (2009) R832415 (2010) R832415 (Final) R832415C002 (2009) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Peters A. Air quality and cardiovascular health:smoke and pollution matter. Circulation 2009;120(11):924-927. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
|
Peters A, Hampel R, Cyrys J, Breitner S, Geruschkat U, Kraus U, Zareba W, Schneider A. Elevated particle number concentrations induce immediate changes in heart rate variability: a panel study in individuals with impaired glucose metabolism or diabetes. Particle and Fibre Toxicology 2015;12:7 (11 pp.). |
R832415 (Final) |
Exit Exit |
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Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdorster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang L-S, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhalation Toxicology 2004;16(Suppl 1):59-72. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (Final) R827354 (Final) R827354C003 (2003) R827354C003 (Final) R827354C004 (Final) |
Exit Exit |
|
Pitz M, Birmili W, Schmid O, Peters A, Wichmann HE, Cyrys J. Quality control and quality assurance for particle size distribution measurements at an urban monitoring station in Augsburg, Germany. Journal of Environmental Monitoring 2008;10(9):1017-1024. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (Final) R832415C002 (2006) R832415C002 (2008) R832415C002 (2010) R832415C002 (2011) |
Exit |
|
Pui DYH, Qi C, Stanley N, Oberdorster G, Maynard A. Recirculating air filtration significantly reduces exposure to airborne nanoparticles. Environmental Health Perspectives 2008;116(7):863-866. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2010) R832415C004 (2011) |
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Reemtsma T, These A, Venkatachari P, Xia X, Hopke PK, Springer A, Linscheid M. Identification of fulvic acids and sulfated and nitrated analogues in atmospheric aerosol by electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry 2006;78(24):8299-8304. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) |
Exit Exit Exit |
|
Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O’Shea K, Wang Y, Utell MJ. Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation? Environmental Health Perspectives 2012;120(8):1162-1169. |
R832415 (Final) |
|
|
Riesenfeld E, Chalupa D, Gibb FR, Oberdo G, Gelein R, Morrow PE, Utell MJ, Frampton MW. Ultrafine particle concentrations in a hospital. Inhalation Toxicology 2000;12(Suppl 2):83-94. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R826781 (2000) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R827354C004 (2000) R827354C004 (Final) |
Exit |
|
Ruckerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. American Journal of Respiratory and Critical Care Medicine 2006;173(4):432-441. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) R827354C002 (2003) R827354C002 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit Exit Exit |
|
Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann HE, Peters A. Ultrafine particles and platelet activation in patients with coronary heart disease – results from a prospective panel study. Particle and Fibre Toxicology 2007;4:1. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
|
Ruckerl R, Hampel R, Breitner S, Cyrys J, Kraus U, Carter J, Dailey L, Devlin RB, Diaz-Sanchez D, Koenig W, Phipps R, Silbajoris R, Soentgen J, Soukup J, Peters A, Schneider A. Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations. Environment International 2014;70:32-49. |
R832415 (Final) |
Exit Exit Exit |
|
Ruckerl R, Schneider A, Hampel R, Breitner S, Cyrys J, Kraus U, Gu J, Soentgen J, Koenig W, Peters A. Association of novel metrics of particulate matter with vascular markers of inflammation and coagulation in susceptible populations--results from a panel study. Environmental Research 2016;150:337-347. |
R832415 (Final) |
Exit Exit Exit |
|
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. Journal of Toxicology and Environmental Health, Part A 2010;73(5-6):445-461. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2010) R832415C004 (2011) R832415C005 (2010) R832415C005 (2011) |
Exit |
|
Schauble CL, Hampel R, Breitner S, Ruckerl R, Phipps R, Diaz-Sanchez D, Devlin RB, Carter JD, Soukup J, Silbajoris R, Dailey L, Koenig W, Cyrys J, Geruschkat U, Belcredi P, Kraus U, Peters A, Schneider AE. Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals. Occupational and Environmental Medicine 2012;69(9):670-678. |
R832415 (Final) |
Exit Exit |
|
Schneider A, Neas L, Herbst MC, Case M, Williams RW, Cascio W, Hinderliter A, Holguin F, Buse JB, Dungan K, Styner M, Peters A, Devlin RB. Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environmental Health Perspectives 2008;116(12):1666-1674. |
R832415 (2008) R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
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Schneider A, Neas LM, Graff DW, Herbst MC, Cascio WE, Schmitt MT, Buse JB, Peters A, Devlin RB. Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals. Particle and Fibre Toxicology 2010;7:14. |
R832415 (2010) R832415 (Final) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Schneider A, Hampel R, Ibald-Mulli A, Zareba W, Schmidt G, Schneider R, Ruckerl R, Couderc JP, Mykins B, Oberdorster G, Wolke G, Pitz M, Wichmann H-E, Peters A. Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease. Particle and Fibre Toxicology 2010;7:29 (12 pp.). |
R832415 (2011) R832415 (Final) R832415C002 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
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Schneider A, Alexis NE, Diaz-Sanchez D, Neas LM, Harder S, Herbst MC, Cascio WE, Buse JB, Peters A, Devlin RB. Ambient PM2.5 exposure up-regulates the expression of costimulatory receptors on circulating monocytes in diabetic individuals. Environmental Health Perspectives 2011;119(6):778-783. |
R832415 (Final) R832415C002 (2011) |
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Semmler-Behnke M, Takenaka S, Fertsch S, Wenk A, Seitz J, Mayer P, Oberdorster G, Kreyling WG. Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium. Environmental Health Perspectives 2007;115(5):728-733. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2006) R832415C004 (2007) R832415C004 (2010) R832415C004 (2011) |
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Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang L-S, Utell MJ, Frampton MW. Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environmental Health Perspectives 2008;116(3):375-380. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2006) R832415C003 (2010) R832415C003 (2011) |
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Silva VM, Corson N, Elder A, Oberdorster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicological Sciences 2005;85(2):983-989. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
Exit Exit Exit |
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Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhalation Toxicology 2005;17(9):415-425. |
R832415 (2010) R832415 (Final) R832415C005 (2011) R827354 (Final) R827354C005 (Final) |
Exit |
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Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Experimental Lung Research 2005;31(6):581-597. |
R832415 (2010) R832415 (Final) R832415C005 (2011) R827354 (Final) R827354C005 (Final) |
Exit |
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Spencer MT, Prather KA. Using ATOFMS to determine OC/EC mass fractions in particles. Aerosol Science and Technology 2006;40(8):585-594. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R831083 (Final) |
Exit Exit Exit |
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Spencer MT, Shields LG, Sodeman DA, Toner SM, Prather KA. Comparison of oil and fuel particle chemical signatures with particle emissions from heavy and light duty vehicles. Atmospheric Environment 2006;40(27):5224-5235. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Spencer MT, Shields LG, Prather KA. Simultaneous measurement of the effective density and chemical composition of ambient aerosol particles. Environmental Science & Technology 2007;41(4):1303-1309. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2006) R832415C001 (2010) R832415C001 (2011) R827354 (Final) R831083 (Final) |
Exit Exit Exit |
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Stewart JC, Villasmil ML, Frampton MW. Changes in fluorescence intensity of selected leukocyte surface markers following fixation. Cytometry Part A 2007;71A(6):379-385. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2006) R832415C003 (2010) R832415C003 (2011) |
Exit Exit Exit |
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Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW. Vascular effects of ultrafine particles in persons with type 2 diabetes. Environmental Health Perspectives 2010;118(12):1692-1698. |
R832415 (2011) R832415 (Final) R832415C003 (2011) |
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Stolzel M, Breitner S, Cyrys J, Pitz M, Wolke G, Kreyling W, Heinrich J, Wichmann H-E, Peters A. Daily mortality and particulate matter in different size classes in Erfurt, Germany. Journal of Exposure Science & Environmental Epidemiology 2007;17(5):458-467. |
R832415 (2010) R832415 (Final) R832415C002 (2011) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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Su Y, Sipin MF, Furutani H, Prather KA. Development and characterization of an aerosol time-of-flight mass spectrometer with increased detection efficiency. Analytical Chemistry 2004;76(3):712-719. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit Exit |
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Su Y, Sipin MF, Prather KA, Gelein RM, Lunts A, Oberdorster G. ATOFMS characterization of individual model aerosol particles used for exposure studies. Aerosol Science and Technology 2005;39(5):400-407. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C004 (Final) |
Exit Exit |
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Su Y, Sipin MF, Spencer MT, Qin X, Moffet RC, Shields LG, Prather KA, Venkatachari P, Jeong C-H, Kim E, Hopke PK, Gelein RM, Utell MJ, Oberdorster G, Berntsen J, Devlin RB, Chen LC. Real-time characterization of the composition of individual particles emitted from ultrafine particle concentrators. Aerosol Science and Technology 2006;40(6):437-455. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit Exit Exit |
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Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Hopke PK. Workgroup report: Workshop on source apportionment of particulate matter health effects—intercomparison of results and implications. Environmental Health Perspectives 2005;113(12):1768-1774. |
R832415 (2010) R832415 (2011) R832415 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C015 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) |
Exit |
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Thurston GD, Bekkedal MY, Roberts EM, Ito K, Pope III CA, Glenn BS, Ozkaynak H, Utell MJ. Use of health information in air pollution health research:past successes and emerging needs. Journal of Exposure Science and Environmental Epidemiology 2009;19(1):45-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2010) R832415C003 (2011) |
Exit Exit |
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Toner SM, Shields LG, Sodeman DA, Prather KA. Using mass spectral source signatures to apportion exhaust particles from gasoline and diesel powered vehicles in a freeway study using UF-ATOFMS. Atmospheric Environment 2008;42(3):568-581. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Utell MJ, Frampton MW. Toxicologic methods: controlled human exposures. Environmental Health Perspectives 2000;108(Suppl 4):605-613. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (Final) R827354 (Final) |
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Utell MJ, Frampton MW. Acute health effects of ambient air pollution: the ultrafine particle hypothesis. Journal of Aerosol Medicine 2000;13(4):355-359. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R827354 (Final) |
Exit |
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Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE. Cardiovascular effects associated with air pollution:potential mechanisms and methods of testing. Inhalation Toxicology 2002;14(12):1231-1247. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R826781 (2001) R826781 (Final) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) |
Exit |
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Venkatachari P, Hopke PK, Grover BD, Eatough DJ. Measurement of particle-bound reactive oxygen species in rubidoux aerosols. Journal of Atmospheric Chemistry 2005;50(1):49-58. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
Exit Exit |
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Venkatachari P, Zhou L, Hopke PK, Felton D, Rattigan OV, Schwab JJ, Demerjian KL. Spatial and temporal variability of black carbon in New York City. Journal of Geophysical Research 2006;111(D10):D10S05 (9 pp.). |
R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Venkatachari P, Zhou L, Hopke PK, Schwab JJ, Demerjian KL, Weimer S, Hogrefe O, Felton D, Rattigan O. An intercomparison of measurement methods for carbonaceous aerosol in the ambient air in New York City. Aerosol Science and Technology 2006;40(10):788-795. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Venkatachari P, Hopke PK, Brune WH, Ren X, Lesher R, Mao J, Mitchell M. Characterization of wintertime reactive oxygen species concentrations in Flushing, New York. Aerosol Science and Technology 2007;41(2):97-111. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit Exit Exit |
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Venkatachari P, Hopke PK. Development and laboratory testing of an automated monitor for the measurement of atmospheric particle-bound reactive oxygen species (ROS). Aerosol Science and Technology 2008;42(8):629-635. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2008) R832415C001 (2010) R832415C001 (2011) |
Exit Exit Exit |
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Venkatachari P, Hopke PK. Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides. Journal of Environmental Monitoring 2008;10(8):966-974. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit |
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Venkatachari P, Hopke PK. Development and evaluation of a particle-bound reactive oxygen species generator. Journal of Aerosol Science 2008;39(2):168-174. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2011) R827354 (Final) |
Exit Exit Exit |
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Veranth JM, Gelein R, Oberdorster G. Vaporization – condensation generation of ultrafine hydrocarbon particulate matter for inhalation toxicology studies. Aerosol Science and Technology 2003;37(7):603-609. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R827354 (Final) |
Exit Exit |
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von Klot S, Peters A, Aalto P, Bellander T, Berglind N, D'Ippoliti D, Elosua R, Hormann A, Kulmala M, Lanki T, Lowel H, Pekkanen J, Picciotto S, Sunyer J, Forastiere F. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 2005;112(20):3073-3079. |
R832415 (2010) R832415 (Final) R827354 (Final) R827354C002 (Final) |
Exit Exit Exit |
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von Klot S, Cyrys J, Hoek G, Kuhnel B, Pitz M, Kuhn U, Kuch B, Meisinger C, Hormann A, Wichmann HE, Peters A. Estimated personal soot exposure is associated with acute myocardial infarction onset in a case-crossover study. Progress in Cardiovascular Diseases 2011;53(5):361-368. |
R832415 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Chalupa DC, Utell MJ. Long-term study of urban ultrafine particles and other pollutants. Atmospheric Environment 2011;45(40):7672-7680. |
R832415 (Final) |
Exit Exit Exit |
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Wang Y, Hopke PK, Sun L, Chalupa DC, Utell MJ. Laboratory and field testing of an automated atmospheric particle-bound reactive oxygen species sampling-analysis system. Journal of Toxicology 2011;2011:419476 (9 pp). |
R832415 (2011) R832415 (Final) R832415C003 (2011) R831078 (Final) |
Exit |
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Wang Y, Hopke PK, Chalupa DC, Utell MJ. Effect of the shutdown of a coal-fired power plant on urban ultrafine particles and other pollutants. Aerosol Science and Techology 2011;45(10):1245-1249. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Wang Y, Hopke PK, Utell MJ. Urban-scale spatial-temporal variability of black carbon and winter residential wood combustion particles. Aerosol and Air Quality Research 2011;11(5):473-481. |
R832415 (2011) R832415 (Final) R832415C003 (2011) R831078 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Rattigan OV, Xia X, Chalupa DC, Utell MJ. Characterization of residential wood combustion particles using the two-wavelength aethalometer. Environmental Science & Technology 2011;45(17):7387-7393. |
R832415 (2011) R832415 (Final) R832415C001 (2011) R832415C003 (2011) |
Exit Exit Exit |
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Wang Y, Hopke PK, Rattigan OV, Chalupa DC, Utell MJ. Multiple-year black carbon measurements and source apportionment using Delta-C in Rochester, New York. Journal of the Air & Waste Management Association 2012;62(8):880-887. |
R832415 (Final) |
Exit Exit |
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Wang Y, Hopke PK, Xia X, Rattigan OV, Chalupa DC, Utell MJ. Source apportionment of airborne particulate matter using inorganic and organic species as tracers. Atmospheric Environment 2012;55:525-532. |
R832415 (Final) |
Exit Exit Exit |
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Wang Y, Hopke PK, Rattigan OV. A new indicator of fireworks emissions in Rochester, New York. Environmental Monitoring and Assessment 2012;184(12):7293-7297. |
R832415 (Final) |
Exit |
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Yue W, Schneider A, Stolzel M, Ruckerl R, Cyrys J, Pan X, Zareba W, Koenig W, Wichmann H-E, Peters A. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2007;621(1-2):50-60. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit Exit Exit |
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Yue W, Schneider A, Ruckerl R, Koenig W, Marder V, Wang S, Wichmann H-E, Peters A, Zareba W. Relationship between electrocardiographic and biochemical variables in coronary artery disease. International Journal of Cardiology 2007;119(2):185-191. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) |
Exit |
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Yue W, Stolzel M, Cyrys J, Pitz M, Heinrich J, Kreyling WG, Wichmann H-E, Peters A, Wang S, Hopke PK. Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany. Science of the Total Environment 2008;398(1-3):133-144. |
R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2008) R832415C001 (2010) R832415C001 (2011) R832415C002 (2006) R832415C002 (2008) R832415C002 (2010) R832415C002 (2011) R827354 (Final) R834797 (2016) |
Exit Exit Exit |
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Zareba W, Nomura A, Couderc JP. Cardiovascular effects of air pollution:what to measure in ECG? Environmental Health Perspectives 2001;109(Suppl 4):533-538. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
Exit |
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Zareba W, Couderc JP, Oberdorster G, Chalupa D, Cox C, Huang L-S, Peters A, Utell MJ, Frampton MW. ECG parameters and exposure to carbon ultrafine particles in young healthy subjects. Inhalation Toxicology 2009;21(3):223-233. |
R832415 (2008) R832415 (2009) R832415 (2010) R832415 (2011) R832415 (Final) R832415C002 (2010) R832415C002 (2011) R832415C003 (2010) R832415C003 (2011) R832415C004 (2009) R832415C004 (2010) R832415C004 (2011) R827354 (Final) |
Exit |
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Zauscher MD, Moore MJK, Lewis GS, Hering SV, Prather KA. Approach for measuring the chemistry of individual particles in the size range critical for cloud formation. Analytical Chemistry 2011;83(6):2271-2278. |
R832415 (Final) |
Exit |
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Zauscher MD, Wang Y, Moore MJK, Gaston CJ, Prather KA. Air quality impact and physicochemical aging of biomass burning aerosols during the 2007 San Diego Wildfires. Environmental Science and Technology 2013;47(14):7633-7643. |
R832415 (Final) |
Exit Exit |
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Zhao J, Hopke PK. Concentration of reactive oxygen species (ROS) in mainstream and sidestream cigarette smoke. Aerosol Science and Technology 2012;46(2):191-197. |
R832415 (Final) |
Exit |
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Zhao W, Hopke PK, Qin X, Prather KA. Predicting bulk ambient aerosol compositions from ATOFMS data with ART-2a and multivariate analysis. Analytica Chimica Acta 2005;549(1-2):179-187. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) R831083 (Final) |
Exit Exit Exit |
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Zhou L, Kim E, Hopke PK, Stanier C, Pandis SN. Mining airborne particulate size distribution data by positive matrix factorization. Journal of Geophysical Research 2005;110(D7):D07S19 (15 pp.). |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
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Zhou L, Hopke PK, Venkatachari P. Cluster analysis of single particle mass spectra at Flushing, NY. Analytica Chimica Acta 2006;555(1):47-56. |
R832415 (2010) R832415 (2011) R832415 (Final) R827354 (Final) R827354C001 (Final) |
Exit Exit Exit |
Supplemental Keywords:
RFA, Scientific Discipline, Health, Air, particulate matter, Health Risk Assessment, Risk Assessments, Biochemistry, airway epithelial cells, atmospheric particles, cardiopulmonary responses, chemical characteristics, fine particles, human health effects, airborne particulate matter, animal model, airway disease, air pollution, pariculate matter, aerosol composition, human exposure, epidemiological studies, atmospheric chemistryProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832415C001 Characterization and Source Apportionment
R832415C002 Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources
R832415C003 Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles
R832415C004 Animal models: Cardiovascular Disease, CNS Injury and Ultrafine Particle Biokinetics
R832415C005 Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading To Altered Gene Expression in Relation to Particle Composition
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2011 Progress Report
- 2009 Progress Report
- 2008 Progress Report
- 2007 Progress Report
- 2006 Progress Report
- Original Abstract
144 journal articles for this center