Grantee Research Project Results
2010 Progress Report: Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
EPA Grant Number: R834513Center: Center for the Health Assessment of Mothers and Children of Salinas - UC Berkeley School of Public Health: CHAMACOS Office, Berkeley, CA
Center Director: Eskenazi, Brenda
Title: Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
Investigators: Eskenazi, Brenda , Rosas, Lisa Goldman , Salvatore, Alicia L. , Holland, Nina T. , Hubbard, Alan , Sjodin, Andreas , Blum, Arlene , Bradman, Asa , Johnson, Caroline , Smith, Donald , Eisen, Ellen , Crinella, Frank , Barlow, Janice , Molitor, John , Harley, Kim , Fenster, Laura , Barcellos, Lisa , Arora, Manish , Harnly, Martha , Minkler, Meredith , Jerrett, Michael , Wallerstein, Nina , Lustig, Robert , McKone, Thomas
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2009 through July 31, 2014 (Extended to July 31, 2017)
Project Period Covered by this Report: August 1, 2010 through May 31,2011
Project Amount: $3,585,582
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Center for Children’s Environmental Health Research at the University of California, Berkeley, is a fully coordinated, interdisciplinary research program that addresses the unique environmental health needs of children living in a primarily Latino, farmworker community. Over the past 12 years, our research has focused on pesticides: children’s routes and levels of exposure, the resulting health consequences, genetic susceptibility and mechanisms of effect, and community-based strategies to reduce exposure. We have developed strong community partnerships with extensive outreach to farmworkers, growers, service providers, and policy makers. We also have leveraged Center resources to obtain additional grants, including resources to examine exposure to polybrominated diphenyl ethers (PBDEs) in this population.
The keystone of our Center has been the CHAMACOS (Center for the Health Assessment of Mothers and Children Of Salinas) study, a longitudinal cohort of primarily low-income, Mexican immigrant farmworker women and their children living in the agricultural Salinas Valley, California. Women were enrolled during pregnancy and their children have been followed through 9 years of age, providing a unique opportunity to examine prospectively the influence of prenatal and early childhood exposures on children’s health. In this, our third phase of the Center, we are following the CHAMACOS boys from age 9 to age 13 years and we are working to double the size of the cohort to 300 boys (girls are being followed under a separate grant). We have expanded our focus to a “California mix” of chemicals: dichlorodiphenyltrichloroethane (DDT), to which the children were exposed in utero due to their mothers’ exposure in Mexico; manganese (Mn), which is a key component of the widely used agricultural fungicides maneb and mancozeb; and PBDE flame retardants, to which exposure is very high in these children due to California’s strict flammability standards. The Center is comprised of several research projects and cores.
Progress Summary:
This report does not cover a full year. It covers the period 8/1/2010-5/31/2011.
(See the individual Annual Progress Reports for R834513C001, R834513C002, R834513C003, and R834513C004 for details on the projects listed below).
Project A: “The CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior & Puberty” (R834513C001)
Project A directly addresses worldwide concerns that changes in onset of sexual maturation may be related to endocrine disruptors in the environment and fills a large data gap on boys. It also addresses concerns that exposure to DDT/E, PBDEs and Mn may compromise neurodevelopment.
Exposure to these chemicals is widespread. PBDEs have been detected in 97% of the U.S. population. Exposure to background levels of DDE also is ubiquitous in the United States and exposure to DDT can be very high in developing countries where DDT is increasingly used for malaria control. In the United States, exposure to manganese (Mn) occurs from industrial sources, but little research has been conducted on agricultural sources, even though approximately 9 million pounds of the manganese-containing fungicides mancozeb and maneb are applied annually in the United States. These exposures may be particularly relevant in agricultural communities in California, which have the potential for high exposure to all three compounds.
Animal studies suggest that PBDEs, DDT/E, and Mn may impact both neurodevelopment and pubertal development, but there have only been a limited number of human studies. This study will fill important data gaps in our knowledge of the health effects of these widespread exposures.
Aims: The specific aims of Project A have not changed this year.
In Project A, we are examining the association of DDT, Mn, and PBDEs with neurodevelopment and onset of puberty in boys in the CHAMACOS cohort.
- To maintain and expand the CHAMACOS cohort as children begin the critical transition to puberty, assessing neurodevelopment and pubertal development in 300 boys from 9 to 13 years of age.
- To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with neurobehavioral functioning at age 9, 10½, and 12 years.
- To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with timing of pubertal development in boys between age 9 and 13 years.
- To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with hormone levels in boys at age 12.
Project B: “Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children” (R834513C002)
In Project B, measurements of Mn in deciduous tooth cross sections will be validated as a new biomarker of Mn exposure in children, substantially contributing to the field of metal exposure and environmental epidemiology. Agricultural use of Mn-containing fungicides is a potential source of Mn in California and nationally. Determining whether these pesticides contribute to human exposures and health effects is an important public health issue. Studies of PBDE exposure will inform researchers about the impact of California flammability laws.
Exposure to these chemicals is widespread. PBDEs have been detected in 97% of the U.S. population. Exposure to background levels of DDE also is ubiquitous in the United States and exposure to DDT can be very high in developing countries where DDT is increasingly used for malaria control. In the United States, exposure to manganese (Mn) occurs from industrial sources, but little research has been conducted on agricultural sources, even though approximately 9 million pounds of the manganese-containing fungicides mancozeb and maneb are applied annually in the United States. These exposures may be particularly relevant in agricultural communities in California which have the potential for high exposure to all three compounds.
Aims: The specific aims of Project B have not changed this year.
In Project B, we will examine novel methods of examining prenatal exposure to Mn, PBDE, and DDT/E compounds using shed deciduous teeth and GIS methods with remote sensing.
- To measure Mn, PBDEs, and DDT/E in shed deciduous teeth. (Population: CHAMACOS children participating since birth.)
- To determine the relationship between Mn, PBDE, and DDT/E levels in teeth with other relevant biological measures.
- To quantify the contribution of agricultural pesticide use to Mn levels in house dust, teeth and child blood.
- To identify population correlates of PBDEs and DDT/E exposure in 9-year-old boys.
Project C: “Epigenetics Project: Epigenetic Effects of DDT/E and PBDEs on Puberty” (R834513C003)
In Project C, we are investigating the effects of exposure on the epigenome and its relationship with pubertal onset. This year, we have continued to assess global methylation in DNA isolated from banked clot specimens of CHAMACOS children using three different assay methods: pyrosequencing (Alu and LINE-1 repeats) and Illumina Infinium. Preliminary analyses suggest that global methylation patterns are likely fluctuating throughout early childhood. If verified through expanded analysis, the opposite directions of the change in global DNA methylation by LINE-1 and Illumina 27k assays may highlight the importance of using site specific methylation data. Furthermore, we have found that global DNA methylation may be modified by prenatal exposure to PBDEs, providing a potential mechanism by which PBDEs and possibly other toxicants affect health.
Aims: The specific aims of Project C have not changed this year.
- To analyze global DNA methylation in newborn children by three different assays.
- To determine ontogenetic changes in global DNA methylation in blood of children between birth and 12 years.
- To investigate the relationship of in utero and 9-year-old blood concentrations of DDT/E and PBDEs with global DNA methylation.
- To determine whether global methylation is associated with onset of puberty and hormonal changes.
- To examine site-specific methylation in relation to age, sex, exposure to DDT/E and PBDEs and puberty onset.
Community Outreach and Translation Core (COTC) (R834513C004)
COTC activities are vital to our Community-University partnership. The COTC permits Center scientists and community partners to communicate study findings in a culturally appropriate manner, to raise awareness of children’s environmental health within and beyond the Salinas Valley, and to mobilize groups toward actions that will improve the health of low-income Latino residents in Monterey County. The specific aims for the COTC remain unchanged.
- To disseminate Center research findings to study participants, the Salinas Valley community, and other stakeholders.
- To increase awareness about children’s environmental health among low-income Latino communities, clinicians, and service providers through widespread dissemination of innovative outreach and educational programs.
- To build the capacity of Salinas Valley youth to promote healthy environmental policies in their community.
- To educate policy makers at the local, state, and national levels about Center research findings and children’s environmental health priorities.
The Biorepository Core: In the past 12 years of Center activity, more than 100,000 environmental and biological specimens have been collected. In the Biorepository Core, our role is to assure that all such samples are collected, managed, and stored so as to maximize their future utility, as well as coordination of sample transfer to analytical laboratories for analysis. We have developed standard operating procedures (SOPs) with quality controls for each specimen type, and we developed comprehensive systems to track, process, and store samples. Each of the Center’s research projects utilizes the Biorepository Core’s stored biological or environmental samples for key exposure or health endpoint data. The Biorepository Core continues to provide critical support to the research projects in sample collection, processing, analysis, storage, tracking, and transport, and in use of banked specimens.
The Administrative Core: This core functions as a centralized facility that coordinates overall Center administration, financial and logistical operations, and allows investigators to concentrate on research. Moreover, this core provides key support necessary to facilitate communications between the Center offices in Berkeley and Salinas and among community partners, project and core directors, collaborators, internal and external advisory boards, NIEHS, EPA, and other participating institutions.
Future Activities:
Project A (R834513C001):
In year 3, we will complete recruitment of new CHAM2 participants, continue data collection at 10½ years, and begin the 12-year visit (in February 2012). Interim visits at 9¾ and 11¼ to assess pubertal development will be ongoing.
Project B (R834513C002):
In the next year, measurements of Mn in teeth, and for a subset, maternal and child blood and urine and breastmilk, will be completed. We will begin analyses examining the interrelationships of Mn in teeth and other biological samples as well as completing the analyses of predictors of Mn in house dust. We also will complete analysis of Mn and PBDEs in blood from CHAMACOS 9-year-old children.
Project C (R834513C003):
Next year, we will expand pyrosequencing and Infinium analyses to additional samples from the same children at other ages (2, 5, 9 years old), and confirm our preliminary finds for Alu, LINE-1 and Illumina for a larger sample size. Additionally, as CHAMACOS puberty data become available at the end of 2011, we will analyze how global and site-specific methylation changes through pubertal development.
COTC (R834513C004):
- Dissemination of Center research findings: We plan to hold our annual community forum, continue targeted outreach to community groups, and respond to invitations for presentations. We also will continue our dissemination to the scientific community.
- Education on children’s environmental health: Over the next year, we plan to set up the Prenatal Environmental Health Kiosk for use in additional health clinics and social service agencies. Environmental education to childcare providers and community groups will continue.
- Youth Community Council (YCC): Over the summer, the YCC will work on a Photovoice Project where they will use cameras to record the positive and negative health impacts of their local environment. After the project is complete, they will present their work to a community audience and their art will be posted in a public space.
- Policy Makers: We will continue to present our research to policy makers as requested. The Tri-County Association of Latino Elected Officials, a regional group, has invited us to describe the CHAMACOS studies and findings.
Journal Articles: 169 Displayed | Download in RIS Format
| Other center views: | All 697 publications | 170 publications in selected types | All 169 journal articles |
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Alexander PG, Clark KL, Tuan RS. Prenatal exposure to environmental factors and congenital limb defects. Birth Defects Research, Part C: Embryo Today: Reviews 2016;108(3):243-273. |
R834513 (Final) R835736 (2015) R835736 (2016) R835736 (2017) R835736C002 (2016) |
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Alkon A, Boyce WT, Davis NV, Eskenazi B. Developmental changes in autonomic nervous system resting and reactivity measures in Latino children from 6 to 60 months of age. Journal of Developmental and Behavioral Pediatrics 2011;32(9):668-677. |
R834513 (2012) R834513 (Final) R834513C001 (2012) R834513C002 (Final) R834513C003 (Final) |
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Alkon A, Boyce WT, Tran L, Harley KG, Neuhaus J, Eskenazi B. Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLoS One 2014;9(1):e86283. |
R834513 (2012) R834513 (2014) R834513 (Final) R834513C001 (2012) R834513C001 (2014) R834513C002 (Final) R834513C003 (Final) R826709 (2002) R831710 (Final) |
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Alkon A, Harley K, Neilands T, Tambellini K, Ltig R, Boyce W, Eskenazi B. Latino Children's Body Mass Index at 2-3.5 Years Predicts Sympathetic Nervo System Activity at 5 Years. CHILDHOOD OBESITY 2014;10(3):214-224. |
R834513 (Final) R831710 (Final) |
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Alkon A, Harley KG, Neilands TB, Tambellini K, Lustig RH, Boyce WT, Eskenazi B. Latino children's body mass index at 2-3.5 years predicts sympathetic nervous system activity at 5 years. Childhood Obesity 2014;10(3):214-224. |
R834513 (2012) R834513 (2014) R834513C001 (2012) R834513C001 (2014) R834513C002 (Final) R834513C003 (Final) R826709 (2002) |
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Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith DR. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environmental Science & Technology 2012;46(9):5118-5125. |
R834513 (2010) R834513 (2012) R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2012) R834513C002 (2012) R834513C002 (2013) R834513C002 (Final) R834513C003 (Final) |
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Audelo J, Kogut K, Harley KG, Rosas LG, Stein L, Eskenazi B. Maternal depression and childhood overweight in the CHAMACOS Study of Mexican-American children. Maternal and Child Health Journal 2016;20(7):1405-1414. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) R834513C002 (Final) R834513C003 (Final) |
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AugsJoost B, Jerman P, Deardorff J, Harley K, Constantine NA. Factors associated with parent support for condom education and availability. Health Education & Behavior 2014;41(2):207-215. |
R834513 (2014) R834513 (Final) R834513C001 (2015) R834513C004 (2014) |
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Austin C, Smith TM, Bradman A, Hinde K, Joannes-Boyau R, Bishop D, Hare DJ, Doble P, Eskenazi B, Arora M. Barium distributions in teeth reveal early-life dietary transitions in primates. Nature 2013;498(7453):216-219. |
R834513 (2013) R834513 (Final) R834513C002 (2013) |
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Beamer PI, Canales RA, Bradman A, Leckie JO. Farmworker children’s residential non-dietary exposure estimates from micro-level activity time series. Environment International 2009;35(8):1202-1209. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
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Beamer PI, Canales RA, Ferguson AC, Leckie JO, Bradman A. Relative pesticide and exposure route contribution to aggregate and cumulative dose in young farmworker children. International Journal of Environmental Research and Public Health 2012;9(1):73-96. |
R834513 (2013) R834513 (Final) R834513C002 (2013) R834513C002 (Final) R834513C003 (Final) |
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Beamer P, Canales RA, Leckie JO. Developing probability distributions for transfer efficiencies for dermal exposure. Journal of Exposure Science and Environmental Epidemiology 2009;19(3):274-283. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (2005) R831710 (Final) |
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Bennett DH, Moran RE, Wu X, Tulve NS, Clifton MS, Colon M, Weathers W, Sjodin A, Jones R, Hertz-Picciotto I. Polybrominated diphenyl ether (PBDE) concentrations and resulting exposure in homes in California:relationships among passive air, surface wipe and dust concentrations, and temporal variability. Indoor Air 2015;25(2):220-229. |
R834513 (Final) R831540 (Final) |
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Berger K, Hyland C, Ames JL, Mora AM, Huen K, Eskenazi B, Holland N, Harley KG. Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort T2 -International Journal of Environmental Research and Public Health. 2021;18(4):1796 |
R834513 (Final) |
not available |
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Binter A, Mora A, Baker J, Brono J, Kogut K, Rauch S, Reiss A, Eskenazi B, Sagiv S. Exposure to DDT and DDE and functional neuroimaging in adolescents from the CHAMACOS cohort. ENVIRONMENTAL RESEARCH 2022;Part C(113461). |
R834513 (Final) |
Exit Exit |
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Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, Trujillo C, Johnson C, Bradman A, Barr DB, Eskenazi B. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental Health Perspectives 2011;119(8):1189-1195. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R831710 (Final) R832734 (Final) |
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Bradman A, Fenster L, Sjodin A, Jones RS, Patterson Jr DG, Eskenazi B. Polybrominated diphenyl ether levels in the blood of pregnant women living in an agricultural community in California. Environmental Health Perspectives 2007;115(1):71-74. |
R834513 (2010) R831710 (2005) R831710 (Final) R831710C001 (2007) R831710C002 (2007) |
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Bradman A, Castorina R, Barr DB, Chevrier J, Harnly ME, Eisen EA, McKone TE, Harley K, Holland N, Eskenazi B. Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community. International Journal of Environmental Research and Public Health 2011;8(4):1061-1083. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C002 (2010) R834513C002 (2011) R834513C002 (2012) R834513C003 (2010) R834513C003 (2011) R834513C003 (Final) R831710 (Final) R832734 (Final) |
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Bradman A, Castorina R, Sjodin A, Fenster L, Jones RS, Harley KG, Chevrier J, Holland NT, Eskenazi B. Factors associated with serum polybrominated diphenyl ether (PBDE) levels among school-age children in the CHAMACOS cohort. Environmental Science & Technology 2012;46(13):7373-7381. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C002 (2012) R834513C002 (2013) R834513C003 (2012) |
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Bradman A, Kogut K, Eisen EA, Jewell NP, Quiros-Alcala L, Castorina R, Chevrier J, Holland NT, Barr DB, Kavanagh-Baird G, Eskenazi B. Variability of organophosphorous pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week. Environmental Health Perspectives 2013;121(1):118-124. |
R834513 (2011) R834513 (2012) R834513 (2013) R834513 (Final) R834513C002 (2011) R834513C002 (2012) R834513C002 (2013) R834513C003 (Final) |
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Bradman A, Castorina R, Gaspar F, Nishioka M, Colon M, Weathers W, Egeghy PP, Maddalena R, Williams J, Jenkins PL, McKone TE. Flame retardant exposures in California early childhood education environments. Chemosphere 2014;116:61-66. |
R834513 (2014) R834513C002 (2014) R834513C003 (Final) |
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Bradman A, Quiros-Alcala L, Castorina R, Schall RA, Camacho J, Holland NT, Barr DB, Eskenazi B. Effect of organic diet intervention on pesticide exposures in young children living in low-income urban and agricultural communities. Environmental Health Perspectives 2015;123(10):1086-1093. |
R834513 (2014) R834513 (2016) R834513C002 (2014) R834513C002 (2015) R834513C002 (2016) R834513C003 (Final) |
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Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti J, Havdahl A, Mulder R. Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular Psychiatry 22;. |
R834513 (Final) R826709 (2002) |
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Castorina R, Bradman A, Fenster L, Barr DB, Bravo R, Vedar MG, Harnly ME, McKone TE, Eisen EA, Eskenazi B. Comparison of current-use pesticide and other toxicant urinary metabolite levels among pregnant women in the CHAMACOS cohort and NHANES. Environmental Health Perspectives 2010;118(6):856-863. |
R834513 (2010) R834513 (2011) R834513 (Final) R834513C002 (2010) R834513C002 (2011) R834513C003 (Final) R831710 (Final) |
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Castorina R, Bradman A, Sjodin A, Fenster L, Jones RS, Harley KG, Eisen EA, Eskenazi B. Determinants of serum polybrominated diphenyl ether (PBDE) levels among pregnant women in the CHAMACOS cohort. Environmental Science & Technology 2011;45(15):6553-6560. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R834513C002 (2010) R834513C002 (2011) R834513C002 (2012) R834513C003 (2012) R834513C003 (Final) R831710 (Final) |
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Castorina R, Bradman A, Stapleton HM, Butt C, Avery D, Harley KG, Gunier RB, Holland N, Eskenazi B. Current-use flame retardants: maternal exposure and neurodevelopment in children of the CHAMACOS cohort. Chemosphere 2017;189:574-580. |
R834513 (2016) R834513 (Final) R834513C001 (2016) R834513C003 (Final) |
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Castorina R, Butt C, Stapleton HM, Avery D, Harley KG, Holland N, Eskenazi B, Bradman A. Flame retardants and their metabolites in the homes and urine of pregnant women residing in California (the CHAMACOS cohort). Chemosphere 2017;179:159-166. |
R834513 (Final) R834513C003 (Final) |
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Chadwick LH, Sawa A, Yang IV, Baccarelli A, Breakefield XO, Deng H-W, Dolinoy DC, Fallin MD, Holland NT, Houseman EA, Lomvardas S, Rao M, Satterlee JS, Tyson FL, Vijayanand P, Greally JM. New insights and updated guidelines for epigenome-wide association studies. Neuroepigenetics 2015;1:14-19. |
R834513 (2014) R834513 (2015) R834513C003 (2014) R834513C003 (2015) |
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Chevrier J, Harley KG, Bradman A, Gharbi M, Sjodin A, Eskenazi B. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environmental Health Perspectives 2010;118(10):1444-1449. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R831710 (Final) |
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Chevrier J, Harley KG, Bradman A, Sjodin A, Eskenazi B. Prenatal exposure to polybrominated diphenyl ether flame retardants and neonatal thyroid-stimulating hormone levels in the CHAMACOS study. American Journal of Epidemiology 2011;174(10):1166-1174. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R831710 (Final) |
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Chevrier J, Harley KG, Kogut K, Holland N, Johnson C, Eskenazi B. Maternal thyroid function during the second half of pregnancy and child neurodevelopment at 6, 12, 24, and 60 months of age. Journal of Thyroid Research 2011;2011:426427 (13 pp.). |
R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) |
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Chevrier J, Gunier RB, Bradman A, Holland NT, Calafat AM, Eskenazi B, Harley KG. Maternal urinary bisphenol A during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environmental Health Perspectives 2013;121(1):138-144. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
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Chevrier J, Warner M, Gunier RB, Brambilla P, Eskenazi B, Mocarelli P. Serum dioxin concentrations and thyroid hormone levels in the Seveso Women’s Health Study. American Journal of Epidemiology 2014;180(5):490-498. |
R834513 (2014) R834513C001 (2014) R834513C001 (2015) |
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Chopra V, Harley K, Lahiff M, Eskenazi B. Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years. Environmental Research 2014;128:64-69. |
R834513 (2014) R834513C001 (2014) |
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Coker E, Gunier R, Bradman A, Harley K, Kogut K, Molitor J, Eskenazi B. Association between Pesticide Profiles Used on Agricultural Fields near Maternal Residences during Pregnancy and IQ at Age 7 Years. International Journal of Environmental Research and Public Health 2017;14(5):506 (20 pp.). |
R834513 (Final) |
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Dannemiller KC, Mendell MJ, Macher JM, Kumagai K, Bradman A, Holland N, Harley K, Eskenazi B, Peccia J. Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development. Indoor Air 2014;24(3):236-247. |
R834513 (2014) R834513 (2015) R834513C001 (2015) R834513C002 (2014) |
Exit Exit |
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Daredia S, Huen K, van der Laan L, Collender P, Nwanaji-Enwerem J, Harley K, Deardorff J, Eskenazi B, Holland N, Cardenas A. Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort. EPIGENETICS 2022;842. |
R834513 (Final) R826709 (2002) R831710 (Final) |
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Dave V, Yousefi P, Huen K, Volberg V, Holland N. Relationship between expression and methylation of obesity-related genes in children. Mutagenesis 2015;30(3):411-420. |
R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) |
Exit Exit Exit |
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Dave V, Street K, Francis S, Bradman A, Riley L, Eskenazi B, Holland N. Bacterial microbiome of breast milk and child saliva from low-income Mexican-American women and children. Pediatric Research 2016;79(6):846-854. |
R834513 (Final) R834513C002 (2016) R834513C003 (2015) |
Exit Exit Exit |
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Deardorff J, Borgen N, Rauch S, Kogut K, Eskenazi B. Maternal Adverse Childhood Experiences and Young Adult Latino Children's Mental Health. AMERICAN JOURNAL OF PREVENTATIVE MEDICINE 2024;66(1):119-127 |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit |
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Deardorff J, Reeves J, Hayland C, Tilles S, Rauch S, Kogut K, Greenspan L, Shirtcliff E, Lustig R, Eskenazi B. Childhood Overweight and Obesity and Pubertal Onset Among Mexican-American Boys and Girls in the CHAMACOS Longitudinal Study. American Journal of Epidemiology 23;191(1):7-16. |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit |
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Duramad P, Holland NT. Biomarkers of immunotoxicity for environmental and public health research. International Journal of Environmental Research and Public Health 2011;8(5):1388-1401. |
R834513 (2010) R834513 (2011) R834513 (2013) R834513 (Final) R834513C003 (2010) R834513C003 (2011) |
Exit Exit Exit |
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Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR. Hair as a biomarker of environmental manganese exposure. Environmental Science & Technology 2013;47(3):1629-1637. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C002 (2013) |
Exit |
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Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glucose levels in women without diabetes or gestational diabetes and childhood cardiometabolic risk at 7 years of age. Journal of Pediatrics 2012;161(6):1016-1021. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
Exit |
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Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glycemia in Mexican-American women without diabetes or gestational diabetes and programming for childhood obesity. American Journal of Epidemiology 2013;177(8):768-775. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
Exit Exit Exit |
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Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Barr LHDB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland N, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. Prenatal organophosphate pesticide exposure and child neurodevelopment at 24 months:an analysis of four birth cohorts. Environmental Health Perspectives 2016;124(6):822-30. |
R834513 (2016) R834513C001 (2016) |
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Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Hoepner LA, Barr DB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland NT, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. Prenatal organophosphorus pesticide exposure and child neurodevelopment at 24 months: an analysis of four birth cohorts. Environmental Health Perspectives 2016;124(6):822-830. |
R834513 (2014) R834513 (2015) R834513C001 (2014) R834513C001 (2015) R834513C002 (2014) |
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Erkin-Cakmak A, Harley KG, Chevrier J, Bradman A, Kogut K, Huen K, Eskenazi B. In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS Study. Environmental Health Perspectives 2015;123(6):636-642. |
R834513 (2015) R834513 (Final) R834513C001 (2014) R834513C001 (2015) |
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Eskenazi B, Huen K, Marks A, Harley KG, Bradman A, Barr DB, Holland N. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environmental Health Perspectives 2010;118(12):1775-1781. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C003 (2010) R834513C003 (2011) R831710 (Final) R832734 (Final) |
Exit |
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Eskenazi B, Fenster L, Castorina R, Marks AR, Sjodin A, Rosas LG, Holland N, Guerra AG, Lopez-Carrillo L, Bradman A. A comparison of PBDE serum concentrations in Mexican and Mexican-American children living in California. Environmental Health Perspectives 2011;119(10):1442-1448. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R834513C002 (2010) R834513C002 (2011) R834513C002 (2012) R834513C003 (2010) R834513C003 (2011) R831710 (Final) |
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Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, Trujillo C, Sjodin A, Bradman A. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environmental Health Perspectives 2013;121(2):257-262. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513C001 (2012) R834513C001 (2013) R834513C003 (2013) |
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Eskenazi B, Bradman A, Finkton D, Purwar M, Noble JA, Pang R, Burnham O, Cheikh Ismail L, Farhi F, Barros FC, Lambert A, Papageorghiou AT, Carvalho M, Jaffer YA, Bertino E, Gravett MG, Altman DG, Ohuma EO, Kennedy SH, Bhutta ZA, Villar J, International Fetal and Newborn Growth Consortium for the 21st Century. A rapid questionnaire assessment of environmental exposures to pregnant women in the INTERGROWTH-21st Project. BJOG: An International Journal of Obstetrics & Gynaecology 2013;120(Suppl 2):129-138. |
R834513 (2014) R834513C002 (2014) |
Exit Exit Exit |
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Eskenazi B, Warner M, Sirtori M, Fuerst T, Rauch SA, Brambilla P, Mocarelli P, Rubinacci A. Serum dioxin concentrations and bone density and strucure in the Seveso Women’s Health Study. Environmental Health Perspectives 2014;122(1):51-57. |
R834513 (2014) R834513C001 (2014) |
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Eskenazi B, Quiros-Alcala L, Lipsitt JM, Wu LD, Kruger P, Ntimbane T, Nawn JB, Bornman R, Seto E. mSpray: a mobile phone technology to improve malaria control efforts and monitor human exposure to malaria control pesticides in Limpopo, South Africa. Environment International 2014;68:219-226. |
R834513 (2014) R834513C002 (2014) |
Exit Exit Exit |
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Eskenazi B, Kogut K, Huen K, Harley KG, Bouchard M, Bradman A, Boyd-Barr D, Johnson C, Holland N. Organophosphate pesticide exposure, PON1, and neurodevelopment in school-age children from the CHAMACOS study. Environmental Research 2014;134:149-157. |
R834513 (2014) R834513 (2015) R834513C001 (2014) R834513C001 (2015) R826709 (2002) R832734 (Final) |
Exit Exit Exit |
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Eskenazi B, Rauch SA, Tenerelli R, Huen K, Holland NT, Lustig RH, Kogut K, Bradman A, Sjödin A, Harley KG. In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: the CHAMACOS study. International Journal of Hygiene and Environmental Health 2017;220(2 Pt B):364-372. |
R834513 (2016) R834513 (Final) R834513C001 (2016) |
Exit Exit Exit |
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Ferguson KK, Meeker JD, Cantonwine DE, Chen Y-H, Mukherjee B, McElrath TF. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016;94:531-537. |
R834513 (Final) R835436 (2016) R835436 (2017) R836155 (2017) R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
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Gao Y, Li R, Ma Q, Baker J, Rauch S, Gunier R, Mora A, Kogut K, Bradman A, Eskenazi B, Reiss A, Sagiv S. Childhood exposure to organophosphate pesticides: Functional connectivity and working memory in adolescents. NEUROTOXICOLOGY 2024;103:206-214 |
R834513 (Final) R831710 (Final) |
Exit |
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Gaspar FW, Castorina R, Maddalena RL, Nishioka MG, McKone TE, Bradman A. Phthalate exposure and risk assessment in California child care facilities. Environmental Science & Technology 2014;48(13):7593-7601. |
R834513 (2014) R834513C002 (2014) R834513C002 (2015) |
Exit Exit Exit |
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Gaspar FW, Harley KG, Kogut K, Chevrier J, Mora AM, Sjodin A, Eskenazi B. Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort. Environment International 2015;85:206-212. |
R834513 (2014) R834513 (2015) R834513C001 (2014) R834513C001 (2015) |
Exit Exit Exit |
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Gemmill A, Gunier RB, Bradman A, Eskenazi B, Harley KG. Residential proximity to methyl bromide use and birth outcomes in an agricultural population in California. Environmental Health Perspectives 2013;121(6):737-743. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) |
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Gomez N, Guendelman S, Harley KG, Gomez SL. Nativity and neighborhood characteristics and cervical cancer stage at diagnosis and survival outcomes among Hispanic women in California. American Journal of Public Health 2015;105(3):538-545. |
R834513C001 (2015) |
Exit |
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Guerrero J, Madrigal DS, Minkler M. What is…?: a research ethics Jeopardy™ game to help community partners understand human subjects protections and their importance. Progress in Community Health Partnerships: Research, Education, and Action 2014;8(3):405-411. |
R834513 (2014) R834513 (2015) R834513 (Final) R834513C004 (2013) R834513C004 (2014) R834513C004 (2015) |
Exit Exit |
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Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environmental Science & Technology 2013;47(19):11249-11257. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C002 (2013) R834513C002 (2014) R826709 (2002) |
Exit Exit |
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Gunier RB, Mora AM, Smith D, Arora M, Austin C, Eskenazi B, Bradman A. Biomarkers of manganese exposure in pregnant women and children living in an agricultural community in California. Environmental Science & Technology 2014;48(24):14695-14702. |
R834513 (2011) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C002 (2014) R834513C002 (2015) R834513C004 (2011) R826709 (2002) |
Exit Exit Exit |
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Gunier RB, Jerrett M, Smith DR, Jursa T, Yousefi P, Camacho J, Hubbard A, Eskenazi B, Bradman A. Determinants of manganese levels in house dust samples from the CHAMACOS cohort. Science of the Total Environment 2014;497-498:360-368. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C002 (2010) R834513C002 (2012) R834513C002 (2014) R834513C002 (2015) |
Exit Exit Exit |
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Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B. Manganese in teeth and neurodevelopment in young Mexican-American children. Environmental Research 2015;142:688-695. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) R834513C002 (2014) |
Exit Exit Exit |
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Gunier RB, Bradman A, Harley KG, Eskenazi B. Will buffer zones around schools in agricultural areas be adequate to protect children from the potential adverse effects of pesticide exposure? PLoS Biology 2017;15(12):e2004741 (7 pp.). |
R834513 (Final) |
Exit Exit Exit |
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Gunier RB, Bradman A, Harley KG, Kogut K, Eskenazi B. Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children. Environmental Health Perspectives 2017;125(5):057002 (8 pp.). |
R834513 (Final) R834513C001 (2015) R834513C001 (2016) |
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Gunier RB, Bradman A, Castorina R, Holland NT, Avery D, Harley KG, Eskenazi B. Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children. Environmental Research 2017;158:358-365. |
R834513 (Final) |
Exit Exit Exit |
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Gunier R, Deardorff J, Rauch S, Bradshaw P, Kogut K, Sagiv S, Hyland C, Mora A, Eskenazi B. Residential proximity to agricultural pesticide use and risk-taking behaviors in young adults from the CHAMACOS study. ENVIRONMENTAL MANAGEMENT 2022;215(2) |
R834513 (Final) R826709 (2002) |
Exit |
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Harley KG, Marks AR, Chevrier J, Bradman A, Sjodin A, Eskenazi B. PBDE concentrations in women’s serum and fecundability. Environmental Health Perspectives 2010;118(5):699-704. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
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Harley KG, Huen K, Aguilar Schall R, Holland NT, Bradman A, Barr DB, Eskenazi B. Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PLoS ONE 2011;6(8):e23923 (10 pp.). |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R832734 (Final) |
Exit Exit Exit |
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Harley KG, Chevrier J, Schall RA, Sjodin A, Bradman A, Eskenazi B. Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight. American Journal of Epidemiology 2011;174(8):885-892. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R831710 (Final) |
Exit Exit Exit |
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Harley KG, Aguilar Schall R, Chevrier J, Tyler K, Aguirre H, Bradman A, Holland NT, Lustig RH, Calafat AM, Eskenazi B. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(4):514-520. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C001 (2013) |
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Harley KG, Gunier RB, Kogut K, Johnson C, Bradman A, Calafat AM, Eskenazi B. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environmental Research 2013;126:43-50. |
R834513 (2014) R834513C001 (2014) |
Exit Exit Exit |
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Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. |
R834513C001 (2015) R826709 (2002) R826886 (2000) R827027 (2002) R827039 (2002) R828609 (Final) R831710 (Final) R832141 (Final) |
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Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphate pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2014) R834513C002 (2014) R834513C002 (Final) R834513C003 (Final) |
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Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environmental Health Perspectives 2016;124(10):1600-1607. |
R834513C001 (2016) R834513C002 (2015) R834513C004 (2015) |
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Harley KG, Rauch SA, Chevrier J, Kogut K, Parra KL, Trujillo C, Lustig RH, Greenspan LC, Sjodin A, Bradman A, Eskenazi B. Association of prenatal and childhood PBDE exposure with timing of puberty in boys and girls. Environment International 2017;100:132-138. |
R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2014) R834513C001 (2015) |
Exit Exit Exit |
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Harley KG, Berger K, Rauch S, Kogut K, Henn BC, Calafat AM, Huen K, Eskenazi B, Holland N. Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity. Pediatric Research 2017;82(3):405-415. |
R834513 (Final) |
Exit Exit Exit |
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Harnly ME, Bradman A, Nishioka M, McKone TE, Smith D, McLaughlin R, Kavanagh-Baird G, Castorina R, Eskenazi B. Pesticides in dust from homes in an agricultural area. Environmental Science & Technology 2009;43(23):8767-8774. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
Exit Exit Exit |
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Heggeseth B, Harley K, Warner M, Jewell N, Eskenazi B. Detecting associations between early-life DDT exposures and childhood growth patterns: a novel statistical approach. PLoS ONE 2015;10(6):e0131443 (13 pp.). |
R834513 (2015) R834513C001 (2015) |
Exit Exit Exit |
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Heggeseth B, Holland N, Eskenazi B, Harley K. Heterogeneity in childhood body mass trajectories in relation to prenatal phthalate exposure. Environmental Research 2019;175:22-23. |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit Exit |
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Holland N, Lizarraga D, Huen K. Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health. Current Opinion in Pediatrics 2015;27(2):240-247. |
R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) R834513C004 (2013) |
Exit Exit Exit |
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|
Holland N. 2016. Future of environmental research in the age of epigenomics and exposomics. Review of Environmental Health. 32(1-2), 45-54. |
R834513 (2016) |
not available |
|
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Holm S, Balmes J, Gunier R, kogut K, Harley K, Eskenazi B. Cognitive Development and Prenatal Air Pollution Exposure in the CHAMACOS Cohort. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(3):037007 |
R834513 (Final) R831710 (Final) |
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Huen K, Richter R, Furlong C, Eskenazi B, Holland N. Validation of PON1 enzyme activity assays for longitudinal studies. Clinica Chimica Acta 2009;402(1-2):67-74. |
R834513 (2010) R834513 (2011) R834513 (Final) R831709 (2007) R831709 (Final) R831710 (Final) R832734 (2009) R832734 (Final) |
Exit |
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Huen K, Harley K, Brooks J, Hubbard A, Bradman A, Eskenazi B, Holland N. Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms. Environmental Health Perspectives 2009;117(10):1632-1638. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) R832734 (2009) R832734 (Final) |
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Huen K, Harley K, Bradman A, Eskenazi B, Holland N. Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes. Toxicology and Applied Pharmacology 2010;244(2):181-189. |
R834513 (2010) R834513 (2011) R834513 (Final) R832734 (2009) R832734 (Final) |
Exit Exit Exit |
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Huen K, Barcellos L, Beckman K, Rose S, Eskenazi B, Holland N. Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children. Environmental and Molecular Mutagenesis 2011;52(2):105-116. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R831710 (Final) R832734 (Final) |
Exit Exit |
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Huen K, Bradman A, Harley K, Yousefi P, Boyd Barr D, Eskenazi B, Holland N. Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community. Environmental Research 2012;117:8-16. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C002 (2010) R834513C002 (2012) R834513C002 (2013) R834513C003 (2010) R834513C003 (2011) R834513C003 (2012) R831710 (Final) R832734 (Final) |
Exit Exit Exit |
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|
Huen K, Harley K, Beckman K, Eskenazi B, Holland N. Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One 2013;8(5):e62565. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit Exit |
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|
Huen K, Yousefi P, Bradman A, Yan L, Harley KG, Kogut K, Eskenazi B, Holland N. Effects of age, sex, and persistent organic pollutants on DNA methylation in children. Environmental and Molecular Mutagenesis 2014;55(3):209-222. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2015) R834513C003 (2010) R834513C003 (2012) R834513C003 (2014) |
Exit Exit |
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Huen K, Yousefi P, Street K, Eskenazi B, Holland N. PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genes. Environmental Epigenetics 2015;1(1):dvv003. |
R834513 (2015) R834513C003 (2015) |
Exit Exit Exit |
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|
Huen K, Harley K, Kogut K, Rauch S, Eskenazi B, Holland N. DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children. Pediatric Research 2016;79(6):855-862. |
R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2015) R834513C003 (2016) |
Exit Exit Exit |
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Huland C, Bradshaw P, Deardorff J, Sagiv S, Bradman A, Eskenzai B. Interactions of agricultural pesticide use near home during pregnancy and adverse childhood experiences on adolescent neurobehavioral development in the CHAMACOS study. Environmental Research 2022;204(2). |
R834513 (Final) R826709 (2002) R832141 (Final) |
Exit Exit |
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Hyland C, Mora A, Kogut K, Calafat A, Harley K, Deardorff J, Holland N, Eskenazi B, Sagiv S. Prenatal Exposure to Phthalates and Neurodevelopment in the CHAMACOS Cohort. Environmental Health Perspectives 2019;127(10):107010-107010. |
R834513 (Final) |
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Johnson M, Deardorff J, Davis EL, Martinez W, Eskenazi B, Alkon A. The relationship between maternal responsivity, socioeconomic status, and resting autonomic nervous system functioning in Mexican American children. International Journal of Psychophysiology 2017;116:45-52. |
R834513 (Final) |
Exit |
|
|
Kalantzi O, Castorina R, Gunier R, Kogut K, Holland N, Eskenazi B, Bradman A. Determinants of organophosphorus pesticide urinary metabolite levels in pregnant women from the CHAMACOS cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2022;854(158551). |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit Exit |
|
|
Kalantzi O, Castorina R, Gunier R, Kogut K, Holland N, Eskenazi B, Bradman A. Determinants of organophosphorus pesticide urinary metabolite levels in pregnant women from the CHAMACOS cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2022;854(158551). |
R834513 (Final) |
Exit Exit |
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|
Khodasevich D, Holland N, Harley K, Eskenazi B, Barcellow L, Cardenas A. Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood. ENVIRONMENTAL INTERNATIONAL 2024;190 |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit |
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Lizarraga D, Huen K, Combs M, Escudero-Fung M, Eskenazi B, Holland N. miRNAs differentially expressed by next-generation sequencing in cord blood buffy coat samples of boys and girls. Epigenomics 2016;8(12):1619-1635. |
R834513 (Final) |
Exit |
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Lopez-Espinosa M-J, Mondal D, Armstrong BG, Eskenazi B, Fletcher T. Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6-9 years of age: a cross-sectional analysis within the C8 Health Project. Environmental Health Perspectives 2016;124(8):1269-1275. |
R834513 (2014) R834513C001 (2014) R834513C001 (2015) |
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Macher JM, Mendell MJ, Kumagai K, Holland NT, Camacho JM, Harley KG, Eskenazi B, Bradman A. Higher measured moisture in California homes with qualitative evidence of dampness. Indoor Air 2016;26(6):892-902. |
R834513C002 (2015) |
Exit Exit |
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Madrigal DS, Salvatore A, Casillas G, Casillas C, Vera I, Eskenazi B, Minkler M. Health in my community: conducting and evaluating PhotoVoice as a tool to promote environmental health and leadership among Latino/a youth. Progress in Community Health Partnerships: Research, Education, and Action 2014;8(3):317-329. |
R834513 (2014) R834513 (2015) R834513 (Final) R834513C004 (2013) R834513C004 (2014) R834513C004 (2015) |
Exit |
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Marks AR, Harley K, Bradman A, Kogut K, Barr DB, Johnson C, Calderon N, Eskenazi B. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS Study. Environmental Health Perspectives 2010;118(12):1768-1774. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R831710 (Final) R832734 (Final) |
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Mora AM, van Wendel de Joode B, Mergler D, Cordoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Lundh T, Lindh CH, Bradman A, Eskenazi B. Blood and hair manganese concentrations in pregnant women from the Infants’ Environmental Health Study (ISA) in Costa Rica. Environmental Science & Technology 2014;48(6):3467-3476. |
R834513 (2014) R834513C001 (2014) R834513C002 (2014) R834513C002 (2015) |
Exit Exit Exit |
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Mora AM, van Wendel de Joode B, Mergler D, Cordoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Eskenazi B. Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica. Environmental Research 2015;136:47-56. |
R834513 (2014) R834513C001 (2015) |
Exit Exit Exit |
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Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernandez-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Environment International 2015;84:39-54. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) R826709 (2002) |
Exit Exit Exit |
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Payne-Sturges D, Cohen J, Castorina R, Axelrad DA, Woodruff TJ. Evaluating cumulative organophosphorus pesticide body burden of children: a national case study. Environmental Science & Technology 2009;43(20):7924-7930. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
Exit Exit Exit |
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Percy Z, La Guardia M, Xu Y, Hale R, Dietrich K, Lanphear B, Yolton K, Vuong A, Cecil K, Braun J, Xie C, Chen A. Concentrations and loadings of organophosphate and replacement brominated flame retardants in house dust from the home study during the PBDE phase-out. CHEMOSPHERE 2020;239. |
R834513 (Final) R829389 (Final) |
Exit Exit Exit |
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Quiros-Alcala L, Bradman A, Nishioka M, Harnly ME, Hubbard A, McKone TE, Eskenazi B. Concentrations and loadings of polybrominated diphenyl ethers in dust from low-income households in California. Environment International 2011;37(3):592-596. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513C001 (2010) R834513C001 (2011) R834513C002 (2010) R834513C002 (2011) R834513C002 (2012) R831710 (Final) |
Exit Exit Exit |
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Quiros-Alcala L, Bradman A, Nishioka M, Harnly ME, Hubbard A, McKone TE, Ferber J, Eskenazi B. Pesticides in house dust from urban and farmworker households in California: an observational measurement study. Environmental Health 2011;10:19 (15 pp.). |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C002 (2010) R834513C002 (2011) R834513C002 (2012) R831710 (Final) |
Exit Exit Exit |
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Quiros-Alcala L, Alkon AD, Boyce WT, Lippert S, Davis NV, Bradman A, Barr DB, Eskenazi B. Maternal prenatal and child organophosphate pesticide exposures and children's autonomic function. NeuroToxicology 2011;32(5):646-655. |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C001 (2012) R832734 (Final) |
Exit Exit Exit |
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Quiros-Alcala L, Bradman A, Smith K, Weerasekera G, Odetokun M, Barr DB, Nishioka M, Castorina R, Hubbard AE, Nicas M, Hammond SK, McKone TE, Eskenazi B. Organophosphorous pesticide breakdown products in house dust and children's urine. Journal of Exposure Science & Environmental Epidemiology 2012;22(6):559-568. |
R834513 (2012) R834513 (2013) R834513 (Final) R834513C002 (2012) R834513C002 (2013) |
Exit Exit Exit |
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Quiros-Alcala L, Eskenazi B, Bradman A, Ye X, Calafat AM, Harley K. Determinants of urinary bisphenol A concentrations in Mexican/Mexican-American pregnant women. Environment International 2013;59:152-160. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C002 (2013) R834513C002 (2014) |
Exit Exit Exit |
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Quiros-Alcala L, Mehta S, Eskenazi B. Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. children: NHANES 1999-2002. Environmental Health Perspectives 2014;122(12):1336-1342. |
R834513 (2014) R834513C001 (2014) R834513C001 (2015) |
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Raanan R, Harley KG, Balmes JR, Bradman A, Lipsett M, Eskenazi B. Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort. Environmental Health Perspectives 2015;123(2):179-185. |
R834513 (2010) R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2014) R834513C001 (2015) R826709 (2002) R831710 (Final) |
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Raanan R, Balmes JR, Harley KG, Gunier RB, Magzamen S, Bradman A, Eskenazi B. Decreased lung function in 7-year-old children with early-life organophosphate exposure. Thorax 2016;71(2):148-153. |
R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) R826709 (2002) R831710 (Final) |
Exit Exit |
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Raanan R, Gunier RB, Balmes JR, Beltran AJ, Harley KG, Bradman A, Eskenazi B. Elemental sulfur use and associations with pediatric lung function and respiratory symptoms in an agricultural community (California, USA). Environmental Health Perspectives 2017;125(8):087007 (8 pp.). |
R834513 (Final) R826709 (2002) R831710 (Final) R834514 (Final) |
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Rahmani E, Ghenhav L, Schweiger R, Yoefi P, Huen K, Eskenazi B, Eng C, Huntsman S, Hu D, Glanter J, Oh S, Waldenberger M, Strauch K, Grallert H, Meitinger T, Geiger C, Holland N, Burchard E, aetlen N, Halperin E. Genome-wide methylation data mirror ancestry information. EPIGENETICS & CHROMATIN 2017;10(1). |
R834513 (Final) R826709 (2002) |
Exit Exit |
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Rosas LG, Harley K, Fernald LC, Guendelman S, Mejia F, Neufeld LM, Eskenazi B. Dietary associations of household food insecurity among children of Mexican descent: results of a binational study. Journal of the American Dietetic Association 2009;109(12):2001-2009. |
R834513 (2010) R834513 (2011) R834513 (Final) |
Exit |
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Rosas LG, Harley KG, Guendelman S, Fernald LC, Mejia F, Eskenazi B. Maternal perception of child weight among Mexicans in California and Mexico. Maternal and Child Health Journal 2010;14(6):886-894. |
R834513 (2010) R834513 (2011) R834513 (Final) |
Exit Exit Exit |
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Rosas LG, Guendelman S, Harley K, Fernald LC, Neufeld L, Mejia F, Eskenazi B. Factors associated with overweight and obesity among children of Mexican descent:results of a binational study. Journal of Immigrant and Minority Health 2011;13(1):169-180. |
R834513 (2010) R834513 (Final) R831710 (Final) |
Exit Exit Exit |
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Rosas LG, Trujillo C, Camacho J, Madrigal D, Bradman A, Eskenazi B. Acceptability of health information technology aimed at environmental health education in a prenatal clinic. Patient Education and Counseling 2014;97(2):244-247. |
R834513 (2014) R834513 (2015) R834513 (Final) R834513C004 (2014) R834513C004 (2015) |
Exit Exit |
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Rowe C, Gunier R, Bradman A, Harley KG, Kogut K, Parra K, Eskenazi B. Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children. Environmental Research 2016;150:128-137. |
R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2015) R834513C001 (2016) |
Exit Exit Exit |
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Sagiv SK, Kogut K, Gaspar FW, Gunier RB, Harley KG, Parra K, Villasenor D, Bradman A, Holland N, Eskenazi B. Prenatal and childhood polybrominated diphenyl ether (PBDE) exposure and attention and executive function at 9-12 years of age. Neurotoxicology and Teratology 2015:52(Pt B):151-161. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) |
Exit Exit Exit |
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Sagiv SK, Bruno JL, Baker JM, Palzes V, Kogut K, Rauch S, Gunier R, Mora AM, Reiss AL, Eskenazi B. Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application. Proceedings of the National Academy of Sciences. 2019;116(37):18347-56 |
R834513 (Final) R834513C001 (2016) R831710 (Final) |
Exit Exit |
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Sagiv S, Kogut K, Harley K, Bradman A, Morga N, Eskenazi B. Gestational Exposure to Organophosphate Pesticides and Longitudinally Assessed Behaviors Related to Attention-Deficit/Hyperactivity Disorder and Executive Function. American Journal of Epidemiology 01;190(11):2420-2431. |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit Exit |
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Sagiv S, Rauch S, Kogut K, Huland C, Gunier R, Mora A, Bradman A, Deardorff J, Eskenazi B. Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood. Environmental Health 10;21(1). |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit Exit |
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Sagiv S, Mora A, Rauch S, Kogut K, Hyland C, Gunier R, Bradman A, Deardorff J, Eskenazi B. Prenatal and Childhood Exposure to Organophosphate Pesticides and Behavior Problems in Adolescents and Young Adults in the CHAMACOS Study. EMVIRONMENTAL HEALTH PERSPECTIVES 2023;131(6):067008 |
R834513 (Final) R826709 (2002) R831710 (Final) |
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Salvatore AL, Chevrier J, Bradman A, Camacho J, Lopez J, Kavanagh-Baird G, Minkler M, Eskenazi B. A community-based participatory worksite intervention to reduce pesticide exposures to farmworkers and their families. American Journal of Public Health 2009;99(Suppl 3):S578-S581. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
Exit Exit |
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Salvatore AL, Castorina R, Camacho J, Morga N, Lopez J, Nishioka M, Barr DB, Eskenazi B, Bradman A. Home-based community health worker intervention to reduce pesticide exposures to farmworkers’ children: a randomized-controlled trial. Journal of Exposure Science & Environmental Epidemiology 2015;25(6):608-615. |
R834513 (2014) R834513 (2015) R834513 (2016) R834513C002 (2014) R834513C002 (2015) R834513C002 (2016) R834513C004 (2015) |
Exit |
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Scholtz, RI, McLaughlin KR, Cirillo PM, Petreas M, Park J-S, Wolff MS, Factor-Litvak P, Eskenazi B, Krigbaum N, Cohn BA. Assaying organochlorines in archived serum for a large, long-term cohort:implications of combining assay results from multiple laboratories over time. Environment International 2011;37(4):709-714. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
Exit Exit Exit |
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Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges Jr. E, Lotti F, Steegers-Theunissen RPM, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Levy R, Czernichow S. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update 2013;19(3):221-231. |
R834513 (2014) R834513C001 (2014) |
Exit Exit Exit |
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Sjodin A, Jones RS, Gunier RB, Wong LY, Holland N, Eskenazi B, Bradman, A. Polybrominated diphenyl ethers, polychlorinated biphenyls, and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene in 7-and 9-year-old children and their mothers in the Center for the Health Assessment of Mothers and Children of Salinas Cohort. Environmental Science & Technology 2018;52(4):2287-2294. |
R834513 (Final) R834513C002 (2015) |
Exit Exit Exit |
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Sly PD Eskenazi B, Pronczuk J, Sram R, Diaz-Barriga F, Machin DG, Carpenter DO, Surdu S, Meslin EM. Ethical issues in measuring biomarkers in children's environmental health. Environmental Health Perspectives 2009;117(8):1185-1190. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) R832734 (2009) R832734 (Final) |
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Solomon O, Yousefi P, Huen K, Gunier RB, Escudero-Fung M, Barcellos LF, Eskenazi B, Holland N. Prenatal phthalate exposure and altered patterns of DNA methylation in cord blood. Environmental and Molecular Mutagenesis 2017;58(6):398-410. |
R834513 (Final) |
Exit Exit Exit |
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Stein LJ, Gunier RB, Harley K, Kogut K, Bradman A, Eskenazi B. Early childhood adversity potentiates the adverse association between prenatal organophosphate pesticide exposure and child IQ: the CHAMACOS cohort. Neurotoxicology 2016;56:180-187. |
R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2015) R834513C001 (2016) |
Exit Exit Exit |
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Torres JM, Deardorff J, Gunier RB, Harley KG, Alkon A, Kogut K, Eskenazi B. Worry about deportation and cardiovascular disease risk factors among adult women: the Center for the Health Assessment of Mothers and Children of Salinas Study. Annals of Behavioral Medicine 2018;52(2):186-193. |
R834513 (Final) R834513C001 (2016) |
Exit Exit |
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van Wendel de Joode B, Mora AM, Cordoba L, Cano JC, Quesada R, Faniband M, Wesseling C, Ruepert C, Oberg M, Eskenazi B, Mergler D, Lindh CH. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants’ Environmental Health Study (ISA). Environmental Health Perspectives 2014;122(12):1321-1328. |
R834513 (2014) R834513C002 (2014) R834513C002 (2015) |
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Vargas A, Constaneda J, Lilgedahl E, Mora A, Menezes J, Smith D, Mergler D, Reich B, Giffin A, Hoppin J, Lindh C, de Joode B. Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants' Environmental Health (ISA) study, Costa Rica. SCIENCE OF THE TOTAL ENVIRONMENT 2022;810:151288. |
R834513 (Final) |
Exit Exit |
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Verner M-A, Gaspar FW, Chevrier J, Gunier RB, Sjodin A, Bradman A, Eskenazi B. Increasing sample size in prospective birth cohorts:back-extrapolating prenatal levels of persistent organic pollutants in newly enrolled children. Environmental Science & Technology 2015;49(6):3940-3948. |
R834513 (2014) R834513 (2015) R834513C001 (2015) R834513C002 (2014) R834513C002 (2015) |
Exit Exit Exit |
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Vernet C, Johnson M, Kogut K, Hyland C, Deardorff J, Bradman A, Eskenazi B. Organophosphate pesticide exposure during pregnancy and childhood and onset of juvenile delinquency by age 16 years:The CHAMACOS cohort. Environmental Research 2021;197. |
R834513 (Final) R826709 (2002) R831710 (Final) |
Exit Exit |
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Volberg V, Harley KG, Aguilar RS, Rosas LG, Huen K, Yousefi P, Dave V, Phan N, Lustig RH, Eskenazi B, Holland N. Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children. Pediatric Obesity 2013;8(6):454-463. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C003 (2014) |
Exit Exit |
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Volberg V, Heggeseth B, Harley K, Huen K, Yousefi P, Dave V, Tyler K, Vedar M, Eskenazi B, Holland N. Adiponectin and leptin trajectories in Mexican-American children from birth to 9 years of age. PLoS One 2013;8(10):e77964 (8 pp.). |
R834513 (2014) R834513C003 (2014) |
Exit Exit |
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Volberg V, Harley K, Calafat AM, Dave V, McFadden J, Eskenazi B, Holland N. Maternal bisphenol A exposure during pregnancy and its association with adipokines in Mexican-American children. Environmental and Molecular Mutagenesis 2013;54(8):621-628. |
R834513 (2014) R834513C001 (2014) |
Exit Exit Exit |
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Warner M, Mocarelli P, Brambilla P, Wesselink A, Samuels S, Signorini S, Eskenazi B. Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso Women's Health Study. Environmental Health Perspectives 2013;121(8):906-911. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) |
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Warner M, Schall RA, Harley KG, Bradman A, Barr D, Eskenazi B. In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(5):631-636. |
R834513 (2013) R834513 (2014) R834513 (Final) R834513C001 (2013) R834513C001 (2014) R834513C003 (2013) |
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Warner M, Wesselink A, Harley KG, Bradman A, Kogut K, Eskenazi B. Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS Study cohort. American Journal of Epidemiology 2014;179(11):1312-1322. |
R834513 (2014) R834513C001 (2014) |
Exit Exit Exit |
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Warner M, Mocarelli P, Brambilla P, Wesselink A, Patterson Jr. DG, Turner WE, Eskenazi B. Serum TCDD and TEQ concentrations among Seveso women, 20 years after the explosion. Journal of Exposure Science & Environmental Epidemiology 2014;24(6):588-594. |
R834513 (2014) R834513C002 (2014) |
Exit Exit |
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Warner M, Ye M, Harley K, Kogut K, Bradman A, Eskenazi B. Prenatal DDT exposure and child adiposity at 12 years of age in the CHAMACOS cohort. Environmental Research 2017;159:606-612. |
R834513 (2016) R834513 (Final) R834513C001 (2016) |
Exit Exit Exit |
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Waters SF, Boyce WT, Eskenazi B, Alkon A. The impact of maternal depression and overcrowded housing on associations between autonomic nervous system reactivity and externalizing behavior problems in vulnerable Latino children. Psychophysiology 2016;53(1):97-104. |
R834513 (Final) R834513C001 (2016) |
Exit |
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Watkins DJ, Milewski S, Domino SE, Meeker JD, Padmanabhan V. Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: a preliminary analysis. Reproductive Toxicology 2016;65:59-66. |
R834513 (Final) R835436 (2016) R835436 (2017) |
Exit Exit Exit |
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Weerasekera G, Smith KD, Quiros-Alcala L, Fernandez C, Bradman A, Eskenazi B, Needham LL, Barr DB. A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice. Journal of Environmental Monitoring 2009;11(7):1345-1351. |
R834513 (2010) R834513 (2011) R834513 (Final) R831710 (Final) |
Exit Exit |
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Weldon RH, Webster M, Harley KG, Bradman A, Fenster L, Davis MD, Hubbard A, Barr DB, Holland N, Eskenazi B. Serum persistent organic pollutants and duration of lactation among Mexican-American women. Journal of Environmental and Public Health 2010;2010:861757 (11 pp.). |
R834513 (2010) R834513 (2011) R834513 (2012) R834513 (2013) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2010) R834513C001 (2011) R834513C002 (2010) R834513C002 (2011) R834513C003 (2010) R834513C003 (2011) R831710 (Final) |
Exit Exit Exit |
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Weldon RH, Barr DB, Trujillo C, Bradman A, Holland N, Eskenazi B. A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of California. Journal of Environmental Monitoring 2011;13(11):3136-3144. |
R834513 (2011) R834513 (2012) R834513 (2013) R834513 (Final) R834513C001 (2012) R834513C002 (2012) |
Exit Exit |
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Wesselink A, Warner M, Samuels S, Parigi A, Brambilla P, Mocarelli P, Eskenazi B. Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environment International 2014;63:143-148. |
R834513 (2014) R834513C001 (2014) |
Exit Exit Exit |
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Yousefi P, Huen K, Schall RA, Decker A, Elboudwarej E, Quach H, Barcellos L, Holland N. Considerations for normalization of DNA methylation data by Illumina 450K BeadChip assay in population studies. Epigenetics 2013;8(11):1141-1152. |
R834513 (2012) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C003 (2012) R834513C003 (2013) R834513C003 (2014) R834513C003 (2015) |
Exit Exit Exit |
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Yousefi P, Huen K, Quach H, Motwani G, Hubbard A, Eskenazi B, Holland N. Estimation of blood cellular heterogeneity in newborns and children for epigenome-wide association studies. Environmental and Molecular Mutagenesis 2015;56(9):751-758. |
R834513 (2015) R834513C003 (2015) |
Exit Exit |
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Yousefi P, Huen K, Dave V, Barcellos L, Eskenazi B, Holland N. Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. BMC Genomics 2015;16:911. |
R834513C003 (2015) R834513C003 (2016) |
Exit Exit Exit |
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Yousefi, P., Huen, K., Dave, V., Barcellos, L., Eskenazi, B., Holland, N., 2015. Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. BMC Genomics 16, 911. |
R834513 (2016) |
not available |
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Huen, K., Harley, K., Kogut, K., Rauch, S., Eskenazi, B., Holland, N., 2016. DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children. Pediatr Res 79(6), 855-862. |
R834513 (2016) |
not available |
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Zhang, B., R. C. Owen, J. A. Perlinger, A. Kumar, S. Wu, M. Val Martin, L. Kramer, D. Helmig, and R. E. Honrath, A Lagrangian view of ozone production tendency in North American outflow in summers 2009 and 2010, Atmos. Chem. Phys., 14, 2267-2287, doi:10.5194/acp-14-2267-2014, 2014. |
R834513C003 (2016) |
not available |
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Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1,-2 and-3:What are their functions? Chem Biol Interact. doi:10.1016/j.cbi.2016.05.036. PMID:27238723. |
R834513C003 (2016) R834514C004 (Final) |
not available |
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Salvatore AL, Castorina R, Camacho J, Morga N, López J, Niskioka M, Boyd-Barr D, Eskenazi B, Bradman A. Home-based intervention to reduce pesticide exposures to farmworkers’ children:a randomized controlled trial. Journal of Exposure Science and Environmental Epidemiology. 2015 June 3. [Epub]. |
R834513 (2016) |
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Gaspar F, Harley KG, Kogut K, Chevrier J*, Bradman A, Eskenazi B. Prenatal DDT/E exposure and child IQ in the CHAMACOS cohort. Environ Int, 85:206-12, 2015. |
R834513 (2016) R834513C001 (2016) |
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Joubert, B.R., Felix, J.F., Yousefi, P., et al., 2016. DNA Methylation in Newborns and Maternal Smoking in Pregnancy:Genome-wide Consortium Meta-analysis. American Journal of Human Genetics 98(4), 680-696. |
R834513 (2016) |
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Relevant Websites:
Center for Environmental Research and Children's Health Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834513C001 CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
R834513C002 Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children
R834513C003 Epigenetics Project
R834513C004 Community Outreach and Translation Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
169 journal articles for this center