Grantee Research Project Results
2017 Progress Report: Center for Research on Early Childhood Exposure and Development in Puerto Rico
EPA Grant Number: R836155Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Investigators: Alshawabkeh, Akram
Current Investigators: Alshawabkeh, Akram , Suh, Helen H. , Cordero, Jose , Manjourides, Justin , Zimmerman, Emily , Gu, April , Meeker, John D.
Institution: Northeastern University
EPA Project Officer: Hahn, Intaek
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2022)
Project Period Covered by this Report: July 1, 2016 through June 30,2017
Project Amount: $2,099,537
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) investigates the impact of a mixture of environmental exposures and modifying factors on fetal and early childhood health and development in this under-served, highly-exposed population. Since 2010, our interdisciplinary research team has been conducting a highly productive NIEHS-funded pregnancy study of a cohort of 1800 pregnant women in Puerto Rico to investigate links between exposure to groundwater contamination and the unusually high preterm birth rate on the island. The CRECE Center leverages this rich dataset and the infrastructure established to study a cohort of 600 mothers and follow up on 510 children whose prenatal exposures were documented in the PROTECT study, tracking them through age four.
CRECE research projects couple air-pollution epidemiology (Project 1), high throughput toxicity screening of multi-media pollutant mixtures (Project 2), and biomarker epidemiology (Project 3) to analyze the impacts of early life exposure (both specific stressors and mixture effects) on fetal/child health and development, taking into account environmental, clinical, social, demographic, behavioral, dietary, and other factors. Through CRECE’s centralized Human Subjects Core (facility/service core), observed, self-reported, and biological measures are collected, providing new information characterizing the early life exposures to air and water pollution, including contaminants of emerging concern (CECs).
Progress Summary:
Aim 1: Investigate the impact of prenatal and early childhood exposure to air pollution and prenatal exposure to chemicals, including CECs, on fetal/child health and development.
During Year 2, the CRECE team continued its efforts to characterize concentrations of fine particles with aerodynamic diameters under 2.5 microns (PM2.5) and its components in the Northern Shore of Puerto Rico (Project 1). Air monitoring stations were set up at three locations on the island and are fully operational; samples are collected on a weekly basis and shipped to Northeastern University for analysis each month. Analysis of these filters is ongoing, with analysis of PM2.5 and black carbon (BC), a tracer of motor vehicle pollution, conducted each month. In addition, to characterize historical PM2.5 and component concentrations, the CRECE team has obtained PM2.5 and PM10 filters collected by the Puerto Rico Department of Environmental Protection in 2010 and 2011. These filters are being catalogued and will be analyzed further for BC and the elements. The team also is working on updating the protocol for analysis of the metals by X-ray fluorescence (XRF) to optimize XRF performance for the expected mass of PM2.5 collected on sampled filters.
Recruitment and follow-up of CRECE participants is ongoing. In 2016, our ability to recruit and follow CRECE participants was substantially improved through the openings of additional clinic spaces. Our main clinic was officially opened (Figure 2) at Calle Hernandez Carrion E-13 in Manatí, Puerto Rico. This space is close to the Manatí Medical Center, which allows our researchers to meet with our mothers and infants in a centralized, familiar location where the patients will feel comfortable being interviewed for our study. Additionally, we opened two new clinics, in Lares and Camuy, to increase recruitment.
Through March 1, 2017, our recruitment of CRECE participants meets our proposed goals, with a total of 113 participants agreeing to participate in the study. These participants are being regularly evaluated at the main Manatí clinic and at the Morovis Community Health Center. Evaluations are comprehensive, including a complete physical examination, anthropometric (growth and development) measurement, anogenital distance (AGD), Ages and Stages Questionnaire (ASQ), and Battelle Developmental Inventory, Version 2 (BDI-2) assessment. These measures currently are being evaluated, with additional metrics being considered. To facilitate this evaluation and consideration, team members from the Human Subjects Core, Project 1, Project 3, and the CRECE Scientific Advisory Board traveled to the University of Illinois in April 2017, to observe and review the developmental testing. The team in Puerto Rico will begin taking the Non-Nutritive Suck measure at the clinic in May 2017.
CRECE Project 3 team analyzed phenols and parabens from more than 500 mothers across all three trimesters of pregnancy with the CDC National Laboratory in Atlanta. The team conducted an exploratory analysis of urinary phenols/parabens and birth weight. We observed inverse associations with birth weight for dichlorophenols at Visit 1, but increased birth weight in relation to parabens at Visit 3. We plan to re-do these analyses in the next couple of months after adding in the new exposure data as well as data for important covariates.
Aim 2: Provide evidence for biological mechanisms (Projects 2 and 3) that may mediate the impact of early life exposure to air pollution (Project 1) and chemicals, including CECs (Project 3), and fetal/child health and development.
As described previously, the air monitoring stations are in place and are regularly producing air quality samples for analysis. Sampling also has begun for well water and tap water. As of March 2017, our recruitment reached 113 CRECE participants agreeing to participate in the study. This allowed us to start the tap water and urine sample collections from these participants. Quantitative measures of pathway-specific and chemical-specific biomarkers of exposure to water contaminants, including CECs and metals, and associated toxicity fingerprints have been performed for the initial batch of water sample using HTS assays for oxidative stress, DNA damage, and inflammation. Biological samples from the mothers continue to be collected and analyzed. In addition to the analysis of samples collected during pregnancy for phenols and parabens, Project 3 is measuring thyroid and reproductive hormone levels. Additional samples have been sent for analysis of oxidative stress and inflammation, and are expected to be returned in the next few months. In the next year, further analysis under this goal will be conducted.
Aim 3: Evaluate effect modification for individual risk factors including socioeconomic status and maternal stress on the relationship between environmental exposure and fetal/child health and development (Projects 1 and 3).
The CRECE center continues to conduct questionnaires and assessments related to individual risk factors such as socioeconomic status and maternal stress for all participants. Protocols are being developed for compiling location-based data for each participant while maintaining participant anonymity, and information on neighborhood characteristics (including socioeconomic status, proximity to roads, and racial composition) is being compiled. Analysis on these measures will begin in the next year.
Aim 4: Explore effects (Projects 1 and 3) and relevant mechanistic pathways (Project 2) of early life exposure to mixtures of multiple pollutants in relation to fetal/child health and development.
Sampling of tap water and well water began in Year 2, and pathway-specific toxicity analysis has been conducted on 15 samples so far. Project 2 also conducted non-targeted organic chemical analysis, metals analysis, and targeted analysis of volatile DBPs (disinfection by-products), and DEHP. The protocols have been refined for the special study of urine samples and analysis, and the first samples have been taken and shipped to Northeastern University. In addition, Project 2 has established preliminary protocols for air sample (PM2.5) extraction. The toxicity impacts of PM2.5 components will be assessed using HTS assays for oxidative stress and DNA damage for the air samples collected in Project 1.
As mentioned previously, the CRECE team is working with experts in the field of child development to refine the neurodevelopmental measures being taken. Currently, the evaluation process for participants includes a physical examination, the ASQ, and the BDI-2. Analysis of the effects of pollutant mixtures on early development is expected to begin in the next year.
Aim 5: Engage stakeholders (COTC) to support environmental health practice, innovation and policy, professional development, and awareness around our theme.
CRECE has conducted a number of outreach events to the community and other researchers. The COTC team has begun meeting with mothers who participate in CRECE to discuss the method and structure of report back of results to participants and the wider community. The team also held an educational event at the CRECE clinic that presented information on child development and educational resources to parents of CRECE participants. Both the COTC and the HSC have continued to work closely with the community health centers, particularly Manatí Medical Center and Morovis Community Health Center. In 2016, the Morovis center administration provided a second clinic space to the CRECE team for evaluating participants who may have difficulty traveling to Manatí.
Future Activities:
During the next reporting period, we will continue to focus on recruitment of participants, including in the special urine study for Project 2. We will ensure that routine collection of air filters continues, and work to acquire additional historical air filters when available. Collection of the NNS data will begin in May 2017, and will be a regular part of the first visit going forward. The team will finalize the adjustments to the neurodevelopmental measurements during the next couple of months, and will implement the changes accordingly.
Now that the data collection systems and recruitment procedures are completely or nearly in place, we can begin to focus more on the analysis of the data in the coming year. The projects and cores will work together to implement a data sharing plan and to begin conducting cross-project analyses.
We will continue to present our findings to other research institutions as well as the general public, and will continue to provide training opportunities to students, postdoctoral associates, and faculty whenever possible.
Journal Articles: 47 Displayed | Download in RIS Format
| Other center views: | All 68 publications | 47 publications in selected types | All 47 journal articles |
|---|
| Type | Citation | ||
|---|---|---|---|
|
|
Aker AM, Watkins DJ, Johns LE, Ferguson KK, Soldin OP, Anzalota Del Toro LV, Alshawabkeh AN, Cordero JF, Meeker JD. Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environmental Research 2016;151:30-37. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
|
|
Aker AM, Johns L, McElrath TF, Cantonwine DE, Mukherjee B, Meeker JD. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: a repeated measures study. Environment International 2018;113:341-349. |
R836155 (2018) R836155 (2019) R836155 (2020) |
Exit Exit Exit |
|
|
Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Cordero JF, Meeker JD. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2019;169:41-51. |
R836155 (2019) R836155 (2020) |
|
|
|
Aung MT, Johns LE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: a repeated measures study. Environment International 2017;104:33-40. |
R836155 (2018) R836155 (2019) R836155 (2020) |
Exit Exit Exit |
|
|
Aung MT, Ferguson KK, Cantonwine DE, McElrath TF, Meeker JD. Preterm birth in relation to the bisphenol A replacement, bisphenol S, and other phenols and parabens. Environmental Research 2019;169:131-138. |
R836155 (2019) R836155 (2020) |
|
|
|
Bedrosian LD, Ferguson KK, Cantonwine DE, McElrath TF, Meeker JD. Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women. Science of the Total Environment 2018;613-614:1349-1352. |
R836155 (2018) R836155 (2019) R836155 (2020) |
Exit Exit Exit |
|
|
Cantonwine DE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Urinary bisphenol A levels during pregnancy and risk of preterm birth. Environmental Health Perspectives 2015;123(9):895-901. |
R836155 (2020) R836155C003 (2017) |
|
|
|
Cathey A, Ferguson KK, McElrath TF, Cantonwine DE, Pace G, Alshawabkeh A, Cordero JF, Meeker JD. Distribution and predictors of urinary polycyclic aromatic hydrocarbon metabolites in two pregnancy cohort studies. Environmental Pollution 2018;232:556-562. |
R836155 (2018) R836155 (2019) R836155 (2020) |
Exit Exit Exit |
|
|
Ferguson KK, Cantonwine DE, McElrath TF, Mukherjee B, Meeker JD. Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reproductive Toxicology 2016;66:93-98. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
|
|
Ferguson KK, Meeker JD, Cantonwine DE, Chen Y-H, Mukherjee B, McElrath TF. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016;94:531-537. |
R836155 (2017) R836155 (2020) R836155C003 (2017) R834513 (Final) R835436 (2016) R835436 (2017) |
Exit Exit Exit |
|
|
Ferguson KK, McElrath TF, Pace GG, Weller D, Zeng L, Pennathur S, Cantonwine DE, Meeker JD. Urinary polycyclic aromatic hydrocarbon metabolite associations with biomarkers of inflammation, angiogenesis, and oxidative stress in pregnant women. Environmental Science & Technology 2017;51(8):4652-4660. |
R836155 (2018) R836155 (2019) R836155 (2020) |
Exit Exit Exit |
|
|
Honda T, Henry E, Corlin L, Kirwa K, Alshawabkeh A, Varshavsky J, Kennedy W, Cordero J, Vega C, Pabon Z, Meeker J, Suh H. Associations Between Ambient PM2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico. TOXICS 2025;13(1) |
R836155 (Final) |
Exit |
|
|
Johns LE, Ferguson KK, Meeker JD. Relationships between urinary phthalate metabolite and bisphenol A concentrations and vitamin D levels in U.S. adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010. Journal of Clinical Endocrinology and Metabolism 2016;101(11):4062-4069. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
|
|
Lan J, Gou N, Rahman SM, Gao C, He M, Gu AZ. A quantitative toxicogenomics assay for high-throughput and mechanistic genotoxicity assessment and screening of environmental pollutants. Environmental Science & Technology 2016;50(6):3202-3214. |
R836155 (2020) R836155C002 (2016) |
Exit Exit Exit |
|
|
Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012. International Journal of Environmental Research and Public Health 2015;12(6):6098-6114. |
R836155 (2020) R836155C003 (2017) R835436 (2014) R835436 (2015) R835436 (2017) |
Exit Exit Exit |
|
|
Watkins DJ, Fortenberry GZ, Sanchez BN, Barr DB, Panuwet P, Schnaas L, Osorio-Valencia E, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM, Meeker JD. Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: distribution and relationships with child neurodevelopment. Environmental Research 2016;147:307-313. |
R836155 (2017) R836155 (2020) R836155C003 (2017) R835436 (2015) R835436 (2016) R835436 (2017) |
Exit Exit Exit |
|
|
Yuan Y, Meeker JD, Ferguson KK. Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: the National Health and Nutrition Examination Survey 2003-2004. Science of the Total Environment 2017;575:400-405. |
R836155 (2017) R836155 (2018) R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
|
|
Watkins DJ, Ferguson KK, Anzalota Del Toro LV, Alshawabkeh AN, Cordero JF, Meeker JD. Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. International Journal of Hygiene and Environmental Health 2015;218(2):212-219. |
R836155 (2020) R836155C003 (2017) |
Exit Exit Exit |
|
|
Ashrap P, Watkins DJ, Calafat AM, Ye X, Rosario Z, Brown P, Velez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD. Elevated concentrations of urinary triclocarban, phenol and paraben among pregnant women in northern Puerto Rico:predictors and trends. Environment International 2018;121:990-1002. |
R836155 (2019) R836155 (2020) |
|
|
|
Ferguson KK, Meeker JD, Cantonwine DE, Mukherjee B, Pace GG, Weller D, McElrath TF. Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environment International 2018;112:243-250. |
R836155 (2019) R836155 (2020) |
|
|
|
Lan J, Rahman SM, Gou N, Jiang T, Plewa MJ, Alshawabkeh A, Gu AZ. Genotoxicity assessment of drinking water disinfection byproducts by DNA damage and repair pathway profiling analysis. Environmental Science & Technology 2018;52(11):6565-6675. |
R836155 (2019) R836155 (2020) |
|
|
|
Zhang Y, Gu AZ, Xie S, Li X, Cen T, Li D, Chen J. Nano-metal oxides induce antimicrobial resistance via radical-mediated mutagenesis. Environment International 2018;121:1162-1171. |
R836155 (2019) R836155 (2020) |
Exit |
|
|
Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Calafat AM, Cordero JF, Meeker JD. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019;18(1):28. |
R836155 (2019) R836155 (2020) |
|
|
|
Li D, Gu AZ. Antimicrobial resistance:a new threat from disinfection byproducts and disinfection of drinking water?. Current Opinion in Environmental Science & Health 2019;7:83-91. |
R836155 (2019) R836155 (2020) |
Exit Exit |
|
|
Aung MT, Ferguson KK, Cantonwine DE, Bakulski KM, Mukherjee B, Loch-Caruso R, McElrath TF, Meeker JD. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy:a repeated measures study. Science of The Total Environment 2019;650:1131-1140. |
R836155 (2019) R836155 (2020) |
|
|
|
Eick SM, Meeker JD, Brown P, Swartzendruber A, Rios-McConnell R, Shen Y, Milne GL, Vega CV, Rosario Z, Alshawabkeh A, Cordero JF. Associations between socioeconomic status, psychosocial stress, and urinary levels of 8-iso-prostaglandin-F2α during pregnancy in Puerto Rico. Free Radical Biology and Medicine 2019;143:95-100. |
R836155 (2020) |
Exit |
|
|
Cathey AL, Watkins D, Rosario ZY, Vélez C, Alshawabkeh AN, Cordero JF, Meeker JD. Associations of phthalates and phthalate replacements with CRH and other hormones among pregnant women in puerto rico. Journal of the Endocrine Society 2019;3(6):1127-49. |
R836155 (2020) |
Exit |
|
|
Ferguson KK, Rosario Z, McElrath TF, Vélez Vega C, Cordero JF, Alshawabkeh A, Meeker JD. Demographic risk factors for adverse birth outcomes in Puerto Rico in the PROTECT cohort. PloS one 2019;14(6):e0217770.. |
R836155 (2020) |
Exit |
|
|
Ferguson KK, Rosen EM, Rosario Z, Feric Z, Calafat AM, McElrath TF, Vega CV, Cordero JF, Alshawabkeh A, Meeker JD. Environmental phthalate exposure and preterm birth in the PROTECT birth cohort. Environment international 2019;132:105099. |
R836155 (2020) |
Exit |
|
|
Boss J, Mukherjee B, Ferguson KK, Aker A, Alshawabkeh AN, Cordero JF, Meeker JD, Kim S. Estimating outcome-exposure associations when exposure biomarker detection limits vary across batches. Epidemiology 2019;30(5):746-55. |
R836155 (2020) |
Exit |
|
|
Kirwa K, McConnell-Rios R, Manjourides J, Cordero J, Alshawabekeh A, Suh HH. Low birth weight and PM2. 5 in Puerto Rico. Environmental epidemiology 2019;3(4). |
R836155 (2020) |
|
|
|
Aung MT, Yu Y, Ferguson KK, Cantonwine DE, Zeng L, McElrath TF, Pennathur S, Mukherjee B, Meeker JD. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific reports 2019;9(1):1-7. |
R836155 (2020) |
Exit |
|
|
Xie S, Gu AZ, Cen T, Li D, Chen J. The effect and mechanism of urban fine particulate matter (PM2. 5) on horizontal transfer of plasmid-mediated antimicrobial resistance genes. Science of the Total Environment 2019;683:116-23. |
R836155 (2020) |
Exit |
|
|
Ingle ME, Watkins D, Rosario Z, VélezVega CM, Calafat AM, Ospina M, Ferguson KK, Cordero JF, Alshawabkeh A, Meeker JD. An exploratory analysis of urinary organophosphate ester metabolites and oxidative stress among pregnant women in Puerto Rico. Science of the Total Environment 2020;703:134798. |
R836155 (2020) |
Exit |
|
|
Manjourides J, Zimmerman E, Watkins DJ, Carpenito T, Vélez-Vega CM, Huerta-Montañez G, Rosario Z, Ayala I, Vergara C, Feric Z, Ondras M. Cohort profile:Center for Research on Early Childhood Exposure and Development in Puerto Rico. BMJ open 2020;10(7):e036389. |
R836155 (2020) |
|
|
|
Lin Y, Sevillano-Rivera M, Jiang T, Li G, Cotto I, Vosloo S, Carpenter CM, Larese-Casanova P, Giese RW, Helbling DE, Padilla IY. Impact of Hurricane Maria on Drinking Water Quality in Puerto Rico. Environmental Science & Technology 2020;54(15):9495-509. |
R836155 (2020) |
Exit |
|
|
Welton M, Vega CM, Murphy CB, Rosario Z, Torres H, Russell E, Brown P, Huerta-Montanez G, Watkins D, Meeker JD, Alshawabkeh A. Impact of Hurricanes Irma and Maria on Puerto Rico Maternal and Child Health Research Programs. Maternal and child health journal 2020;24(1):22-9. |
R836155 (2020) |
Exit |
|
|
Aker A, McConnell RE, Loch-Caruso R, Park SK, Mukherjee B, Rosario ZY, Vélez-Vega CM, Huerta-Montanez G, Alshawabkeh AN, Cordero JF, Meeker JD. Interactions between chemicals and non-chemical stressors:the modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. Science of The Total Environment 2020;708:134719. |
R836155 (2019) R836155 (2020) |
Exit |
|
|
Eick SM, Ferguson KK, Milne GL, Rios-McConnell R, Vélez-Vega C, Rosario Z, Alshawabkeh A, Cordero JF, Meeker JD. Repeated measures of urinary oxidative stress biomarkers and preterm birth in Puerto Rico. Free Radical Biology and Medicine 2020;146:299-305. |
R836155 (2020) |
Exit |
|
|
Zimmerman E, Watkins DJ, Huerta-Montanez G, Pabon ZR, Feric Z, Manjourides J, Velez-Vega CM, Figueroa A, Hines M, Martens A, Cordero J. Associations of gestational phthalate exposure and non-nutritive suck among infants from the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) birth cohort study. Environment international 2021;152:106480. |
R836155 (2021) |
Exit |
|
|
Jiang T, Lin Y, Amadei CA, Gou N, Rahman SM, Lan J, Vecitis CD, Gu AZ. Comparative and mechanistic toxicity assessment of structure-dependent toxicity of carbon-based nanomaterials. Journal of Hazardous Materials 2021;418:126282. |
R836155 (2021) |
Exit |
|
|
Aung MT, Ashrap P, Watkins DJ, Mukherjee B, Rosario Z, Vélez-Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific reports 2021;11(1):1-1. |
R836155 (2021) |
Exit |
|
|
Morton S, Honda T, Zimmerman E, Kirwa K, Huerta-Montanez G, Martens A, Hines M, Ondras M, Eum KD, Cordero JF, Alshawabekeh A. Non-nutritive suck and airborne metal exposures among Puerto Rican infants. Science of The Total Environment 2021;789:148008. |
R836155 (2021) |
Exit |
|
|
Silver MK, Fernandez J, Tang J, McDade A, Sabino J, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero JF, Meeker JD. Prenatal exposure to glyphosate and its environmental degradate, aminomethylphosphonic acid (AMPA), and preterm birth:a nested case–control study in the PROTECT cohort (Puerto Rico). Environmental health perspectives 2021;129(5):057011. |
R836155 (2021) |
|
|
|
Kirwa K, Feric Z, Manjourides J, Alshawabekeh A, Vega CM, Cordero JF, Meeker JD, Suh HH. Preterm birth and PM2. 5 in Puerto Rico:evidence from the PROTECT birth cohort. Environmental Health 2021;20(1):1-1.. |
R836155 (2021) |
Exit |
|
|
Ashrap P, Aker A, Watkins DJ, Mukherjee B, Rosario-Pabón Z, Vélez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021;149:106418. |
R836155 (2021) |
Exit |
|
|
Muenter MM, Aiken A, Akanji JO, Baig S, Bellou S, Carlson A, Conway C, Cowell CM, DeLateur NA, Hester A, Joshi C. The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2019;840:1-10. |
R836155 (2019) R836155 (2020) |
Exit |
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836155C001 Air Pollution Impacts on Neonatal and Early Childhood Development
R836155C002 Toxicogenomics-based Mechanistic Multimedia Exposure Assessment and Child Development
R836155C003 Biomarker Epidemiology of In Utero Environmental Exposures and Child Development
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2021 Progress Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- 2016 Progress Report
- Original Abstract
47 journal articles for this center