Grantee Research Project Results
2016 Progress Report: Center for Research on Early Childhood Exposure and Development in Puerto Rico
EPA Grant Number: R836155Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Investigators: Alshawabkeh, Akram
Current Investigators: Alshawabkeh, Akram , Suh, Helen H. , Cordero, Jose , Manjourides, Justin , Zimmerman, Emily , Gu, April , Meeker, John D.
Institution: Northeastern University
EPA Project Officer: Hahn, Intaek
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2022)
Project Period Covered by this Report: September 1, 2015 through August 31,2016
Project Amount: $2,099,537
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
Children in the northern coast of Puerto Rico are exposed to a complex mix of environmental contaminants. The region has over 200 hazardous waste sites, including 16 active Superfund sites, resulting in contaminated water resources. Air pollution from refineries, power plants, motor vehicles, and large ships at ports is also very high, and made worse by Saharan dust storms crossing the Atlantic which have increased in frequency in recent decades. In addition, the population is, on average, significantly poorer than the general U.S. population.
At the same time, Puerto Rico has the highest rate of childhood asthma in the United States, more than twice that of Hispanic children on the mainland (16.5% versus 7.9%). Puerto Rico’s preterm birth rate has risen dramatically in recent years, from being on par with the US average in the 1990s (12%) to among the highest (16.9%) within the U.S. and the world. Infants born preterm suffer significant increases in the risk of a range of serious short- and long-term complications, including blindness, deafness, cerebral palsy and development disorders. Similar trends can be seen in Puerto Rico’s now-higher rates of autism and childhood obesity. In spite of the known pollutant contamination, the connection between exposure to a complex mix of environmental factors and the high rates of adverse health outcomes for children in Puerto Rico has not been comprehensively investigated. More broadly, the relationships between total human exposures to multiple environmental contaminants, psychosocial factors, and adverse fetal and childhood development are not well understood.
To address this gap, the Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) studies the impact of a mixture of environmental exposures and modifying factors on fetal and early childhood health and development in this under-served, highly-exposed population.- Specific Aim 1: Investigate the impact of prenatal and early childhood exposure to air pollution and prenatal exposure to chemicals, including CECs, on fetal/child health and development.
- Specific Aim 2. Provide evidence for biological mechanisms that may mediate the impact of early life exposure to air pollution and chemicals, including CECs, and fetal/child health and development.
- Specific Aim 3. Evaluate effect modification for individual risk factors including socioeconomic status and maternal stress on the relationship between environmental exposure and fetal/child health and development.
- Specific Aim 4. Explore effects and relevant mechanistic pathways of early life exposure to mixtures of multiple pollutants in relation to fetal/child health and development.
- Specific Aim 5: Engage stakeholders to support environmental health practice, innovation and policy, professional development; and awareness around our theme.
Progress Summary:
Specific Aim 1
In Year 1, the majority of efforts have been in building the infrastructure required for implementing the CRECE project, including setting up a new clinic space for participants, optimizing the non-nutritive suck (NNS) sampler (Project 1), identifying air monitoring locations, training study personnel, and obtaining IRB approval from all necessary institutions. In order to prepare to investigate the impact of prenatal and early childhood exposure to air pollution (Project 1) and prenatal exposure to chemicals, including CECs (Project 3), on fetal/child health and development, we have also conducted a small pilot with a small number of infants to ensure that study visits and examinations run smoothly. To prepare to collect air pollution data (Project 1), PM2.5 samplers have been built and the locations for the air monitoring systems have been selected. Upon approval the devices will be installed by Northeastern University researchers who will provide training to Puerto Rico field technicians who will collect the weekly air samples. Work with local agencies is ongoing to retrieve historical air pollution data from preexisting monitoring locations.
Specific Aim 2
In order to collect evidence for biological mechanisms (Projects 2 and 3) that may mediate the impact of early life exposure to air pollution (Project 1) and chemicals, including CECs (Project 3), and fetal/child health and development, in Year 1, 928 urine samples, collected from mothers across all three trimesters of pregnancy, were shipped from Puerto Rico to the CDC National Laboratory for analysis of phenols and parabens (Project 3). These samples have been sent to the UM CLASS lab for analysis of thyroid and reproductive hormones, and we expect to receive these data by July 2016. We have completed the first round of well-water sampling in Puerto Rico (25 samples collected, 13 analyzed) and performed the toxicity analysis (Project 2). Initial testing with tap water samples has been conducted to refine assays and protocols, and quantify the robustness, reproducibility and sensitivity for tap water samples analysis. The results showed that the assay is sensitive enough to reveal the potential toxicity of tap water at up to 100-100x enrichment factor. We have conducted initial testing with urine samples to refine assay protocols and quantify the robustness, reproducibility, and sensitivity for tap water samples analysis (Project 2). The results showed that the assay is sensitive enough to reveal the potential toxicity of a urine sample at original concentration 1X. With these steps taken and the infrastructure in place, we were able to begin infant follow-up upon receiving IRB approval.
Specific Aim 3
In order to evaluate effect modification for individual risk factors including socioeconomic status and maternal stress on the relationship between environmental exposure and fetal/child health and development (Projects 1 and 3), the CRECE center has begun recruiting eligible infants upon receiving IRB approval on April 12, 2016, and conducting follow up assessments including examination, AGD, BDI-2, patient history, and questionnaires. As more infants are examined and data from air pollution monitors and mother biological data from PROTECT is correlated, we will begin to make our evaluation.
Specific Aim 4
As detailed in Aim 1, 2 and 3, actions have been taken to prepare the study to conduct air pollution sampling as Project 3 awaits lab analysis of biological samples collected from PROTECT, and Project 2 has prepared protocols and equipment for water and urine toxicity analysis. These measures are essential in preparation to explore effects (Projects 1 and 3) and relevant mechanistic pathways (Project 2) of early life exposure to mixtures of multiple pollutants in relation to fetal/child health and development as we begin recruitment of eligible infants.
Specific Aim 5
All efforts have been directed toward preparing the physical areas for evaluation of the CRECE participants and informing community partners of the new project. Our Community Outreach and Translation Core has been meeting with collaborators from the Community Health Clinics and other providers that have supported PROTECT for the past 5 years, to explain the procedures of the CRECE research. Specifically, we have had meetings with the Manatí Medical Center to talk about the non-nutritive suck (NNS) measurement and have provided training on the use of this device with Dr. Emily Zimmerman (Project 1 researcher).
We have presented health education activities to the community, including PROTECT participants who give birth to potential CRECE participants, to address the present and urgent situation of Zika in Puerto Rico. As we work with pregnant women and babies, we have developed an education and orientation process for Zika and are providing complimentary mosquito nets for the at-risk mothers and their babies. We are also providing information to the healthcare providers in the network where our participants receive services. We have received requests for orientation on Zika from local institutions of education and healthcare services. Dr. Gredia Huertas, Dr. Carmen M. Velez, Ms. Abigail Figueroa and Dr. José Cordero have been active in several activities in the Manatí Medical Center, Puerto Rico OBGYN Association, a local Community College, and an EPA conference in Puerto Rico. As part of the Core’s work, we are providing orientation and information on the research projects in order to support the communities in the areas of expressed need and also provide information that may help recruitment. The CRECE team has provided information on the radio, printed press, and TV locally and in the US. Dr. José F. Cordero, CRECE Health Specialist, has been asked to provide direct consultation on Zika for the State Epidemiologist at the PR Department of Health. He and Dr. Carmen M. Velez Vega are also members of the Puerto Rico Prematurity Task Force, who are working on important issues of maternal and child heath in Puerto Rico.
Future Activities:
In the next funding cycle, the projects and cores will continue their work to achieve their specific aims. The Center will integrate and direct the work done in the projects and cores to address the Center specific aims. This will include:
- Continuing recruitment, tracking and integrating results from Projects 1 and 3 to evaluate the relationship between prenatal and early childhood exposure to air pollution and prenatal exposure to chemicals on fetal/child health and development;
- Following up with Projects 2 and 3 to better understand the potential role of biological mechanisms that may mediate the impact of early life exposure to air pollution and chemicals, including CECs, and fetal/child health and development;
- Continuing to evaluate the effect modification for individual risk factors including socioeconomic status and maternal stress on the relationship between environmental exposure and fetal/child health and development;
- Integrating information on the effects and relevant mechanistic pathways of early life exposure to mixtures of multiple pollutants in relation to fetal/child health and development utilizing data from Projects 1, 2, and 3, and
- Working closely with the cores to continue to engage the CRECE team and stakeholders (community, industry, and government) to support environmental health practice, innovation and policy, professional development; and awareness around the issues of prenatal and early childhood environmental exposures and fetal/child health and development.
Journal Articles: 47 Displayed | Download in RIS Format
| Other center views: | All 68 publications | 47 publications in selected types | All 47 journal articles |
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Aker AM, Watkins DJ, Johns LE, Ferguson KK, Soldin OP, Anzalota Del Toro LV, Alshawabkeh AN, Cordero JF, Meeker JD. Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environmental Research 2016;151:30-37. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
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Aker AM, Johns L, McElrath TF, Cantonwine DE, Mukherjee B, Meeker JD. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: a repeated measures study. Environment International 2018;113:341-349. |
R836155 (2018) R836155 (2019) R836155 (2020) |
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Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Cordero JF, Meeker JD. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2019;169:41-51. |
R836155 (2019) R836155 (2020) |
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Aung MT, Johns LE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: a repeated measures study. Environment International 2017;104:33-40. |
R836155 (2018) R836155 (2019) R836155 (2020) |
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Aung MT, Ferguson KK, Cantonwine DE, McElrath TF, Meeker JD. Preterm birth in relation to the bisphenol A replacement, bisphenol S, and other phenols and parabens. Environmental Research 2019;169:131-138. |
R836155 (2019) R836155 (2020) |
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Bedrosian LD, Ferguson KK, Cantonwine DE, McElrath TF, Meeker JD. Urinary phthalate metabolite concentrations in relation to levels of circulating matrix metalloproteinases in pregnant women. Science of the Total Environment 2018;613-614:1349-1352. |
R836155 (2018) R836155 (2019) R836155 (2020) |
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Cantonwine DE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Urinary bisphenol A levels during pregnancy and risk of preterm birth. Environmental Health Perspectives 2015;123(9):895-901. |
R836155 (2020) R836155C003 (2017) |
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Cathey A, Ferguson KK, McElrath TF, Cantonwine DE, Pace G, Alshawabkeh A, Cordero JF, Meeker JD. Distribution and predictors of urinary polycyclic aromatic hydrocarbon metabolites in two pregnancy cohort studies. Environmental Pollution 2018;232:556-562. |
R836155 (2018) R836155 (2019) R836155 (2020) |
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Ferguson KK, Cantonwine DE, McElrath TF, Mukherjee B, Meeker JD. Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reproductive Toxicology 2016;66:93-98. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
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Ferguson KK, Meeker JD, Cantonwine DE, Chen Y-H, Mukherjee B, McElrath TF. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016;94:531-537. |
R836155 (2017) R836155 (2020) R836155C003 (2017) R834513 (Final) R835436 (2016) R835436 (2017) |
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Ferguson KK, McElrath TF, Pace GG, Weller D, Zeng L, Pennathur S, Cantonwine DE, Meeker JD. Urinary polycyclic aromatic hydrocarbon metabolite associations with biomarkers of inflammation, angiogenesis, and oxidative stress in pregnant women. Environmental Science & Technology 2017;51(8):4652-4660. |
R836155 (2018) R836155 (2019) R836155 (2020) |
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Honda T, Henry E, Corlin L, Kirwa K, Alshawabkeh A, Varshavsky J, Kennedy W, Cordero J, Vega C, Pabon Z, Meeker J, Suh H. Associations Between Ambient PM2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico. TOXICS 2025;13(1) |
R836155 (Final) |
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Johns LE, Ferguson KK, Meeker JD. Relationships between urinary phthalate metabolite and bisphenol A concentrations and vitamin D levels in U.S. adults: National Health and Nutrition Examination Survey (NHANES), 2005-2010. Journal of Clinical Endocrinology and Metabolism 2016;101(11):4062-4069. |
R836155 (2017) R836155 (2020) R836155C003 (2017) |
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Lan J, Gou N, Rahman SM, Gao C, He M, Gu AZ. A quantitative toxicogenomics assay for high-throughput and mechanistic genotoxicity assessment and screening of environmental pollutants. Environmental Science & Technology 2016;50(6):3202-3214. |
R836155 (2020) R836155C002 (2016) |
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Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012. International Journal of Environmental Research and Public Health 2015;12(6):6098-6114. |
R836155 (2020) R836155C003 (2017) R835436 (2014) R835436 (2015) R835436 (2017) |
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Watkins DJ, Fortenberry GZ, Sanchez BN, Barr DB, Panuwet P, Schnaas L, Osorio-Valencia E, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM, Meeker JD. Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: distribution and relationships with child neurodevelopment. Environmental Research 2016;147:307-313. |
R836155 (2017) R836155 (2020) R836155C003 (2017) R835436 (2015) R835436 (2016) R835436 (2017) |
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Yuan Y, Meeker JD, Ferguson KK. Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: the National Health and Nutrition Examination Survey 2003-2004. Science of the Total Environment 2017;575:400-405. |
R836155 (2017) R836155 (2018) R836155 (2020) R836155C003 (2017) |
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Watkins DJ, Ferguson KK, Anzalota Del Toro LV, Alshawabkeh AN, Cordero JF, Meeker JD. Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. International Journal of Hygiene and Environmental Health 2015;218(2):212-219. |
R836155 (2020) R836155C003 (2017) |
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Ashrap P, Watkins DJ, Calafat AM, Ye X, Rosario Z, Brown P, Velez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD. Elevated concentrations of urinary triclocarban, phenol and paraben among pregnant women in northern Puerto Rico:predictors and trends. Environment International 2018;121:990-1002. |
R836155 (2019) R836155 (2020) |
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Ferguson KK, Meeker JD, Cantonwine DE, Mukherjee B, Pace GG, Weller D, McElrath TF. Environmental phenol associations with ultrasound and delivery measures of fetal growth. Environment International 2018;112:243-250. |
R836155 (2019) R836155 (2020) |
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Lan J, Rahman SM, Gou N, Jiang T, Plewa MJ, Alshawabkeh A, Gu AZ. Genotoxicity assessment of drinking water disinfection byproducts by DNA damage and repair pathway profiling analysis. Environmental Science & Technology 2018;52(11):6565-6675. |
R836155 (2019) R836155 (2020) |
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Zhang Y, Gu AZ, Xie S, Li X, Cen T, Li D, Chen J. Nano-metal oxides induce antimicrobial resistance via radical-mediated mutagenesis. Environment International 2018;121:1162-1171. |
R836155 (2019) R836155 (2020) |
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Aker AM, Ferguson KK, Rosario ZY, Mukherjee B, Alshawabkeh AN, Calafat AM, Cordero JF, Meeker JD. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019;18(1):28. |
R836155 (2019) R836155 (2020) |
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Li D, Gu AZ. Antimicrobial resistance:a new threat from disinfection byproducts and disinfection of drinking water?. Current Opinion in Environmental Science & Health 2019;7:83-91. |
R836155 (2019) R836155 (2020) |
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Aung MT, Ferguson KK, Cantonwine DE, Bakulski KM, Mukherjee B, Loch-Caruso R, McElrath TF, Meeker JD. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy:a repeated measures study. Science of The Total Environment 2019;650:1131-1140. |
R836155 (2019) R836155 (2020) |
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Eick SM, Meeker JD, Brown P, Swartzendruber A, Rios-McConnell R, Shen Y, Milne GL, Vega CV, Rosario Z, Alshawabkeh A, Cordero JF. Associations between socioeconomic status, psychosocial stress, and urinary levels of 8-iso-prostaglandin-F2α during pregnancy in Puerto Rico. Free Radical Biology and Medicine 2019;143:95-100. |
R836155 (2020) |
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Cathey AL, Watkins D, Rosario ZY, Vélez C, Alshawabkeh AN, Cordero JF, Meeker JD. Associations of phthalates and phthalate replacements with CRH and other hormones among pregnant women in puerto rico. Journal of the Endocrine Society 2019;3(6):1127-49. |
R836155 (2020) |
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Ferguson KK, Rosario Z, McElrath TF, Vélez Vega C, Cordero JF, Alshawabkeh A, Meeker JD. Demographic risk factors for adverse birth outcomes in Puerto Rico in the PROTECT cohort. PloS one 2019;14(6):e0217770.. |
R836155 (2020) |
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Ferguson KK, Rosen EM, Rosario Z, Feric Z, Calafat AM, McElrath TF, Vega CV, Cordero JF, Alshawabkeh A, Meeker JD. Environmental phthalate exposure and preterm birth in the PROTECT birth cohort. Environment international 2019;132:105099. |
R836155 (2020) |
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Boss J, Mukherjee B, Ferguson KK, Aker A, Alshawabkeh AN, Cordero JF, Meeker JD, Kim S. Estimating outcome-exposure associations when exposure biomarker detection limits vary across batches. Epidemiology 2019;30(5):746-55. |
R836155 (2020) |
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Kirwa K, McConnell-Rios R, Manjourides J, Cordero J, Alshawabekeh A, Suh HH. Low birth weight and PM2. 5 in Puerto Rico. Environmental epidemiology 2019;3(4). |
R836155 (2020) |
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Aung MT, Yu Y, Ferguson KK, Cantonwine DE, Zeng L, McElrath TF, Pennathur S, Mukherjee B, Meeker JD. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific reports 2019;9(1):1-7. |
R836155 (2020) |
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Xie S, Gu AZ, Cen T, Li D, Chen J. The effect and mechanism of urban fine particulate matter (PM2. 5) on horizontal transfer of plasmid-mediated antimicrobial resistance genes. Science of the Total Environment 2019;683:116-23. |
R836155 (2020) |
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Ingle ME, Watkins D, Rosario Z, VélezVega CM, Calafat AM, Ospina M, Ferguson KK, Cordero JF, Alshawabkeh A, Meeker JD. An exploratory analysis of urinary organophosphate ester metabolites and oxidative stress among pregnant women in Puerto Rico. Science of the Total Environment 2020;703:134798. |
R836155 (2020) |
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Manjourides J, Zimmerman E, Watkins DJ, Carpenito T, Vélez-Vega CM, Huerta-Montañez G, Rosario Z, Ayala I, Vergara C, Feric Z, Ondras M. Cohort profile:Center for Research on Early Childhood Exposure and Development in Puerto Rico. BMJ open 2020;10(7):e036389. |
R836155 (2020) |
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Lin Y, Sevillano-Rivera M, Jiang T, Li G, Cotto I, Vosloo S, Carpenter CM, Larese-Casanova P, Giese RW, Helbling DE, Padilla IY. Impact of Hurricane Maria on Drinking Water Quality in Puerto Rico. Environmental Science & Technology 2020;54(15):9495-509. |
R836155 (2020) |
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Welton M, Vega CM, Murphy CB, Rosario Z, Torres H, Russell E, Brown P, Huerta-Montanez G, Watkins D, Meeker JD, Alshawabkeh A. Impact of Hurricanes Irma and Maria on Puerto Rico Maternal and Child Health Research Programs. Maternal and child health journal 2020;24(1):22-9. |
R836155 (2020) |
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Aker A, McConnell RE, Loch-Caruso R, Park SK, Mukherjee B, Rosario ZY, Vélez-Vega CM, Huerta-Montanez G, Alshawabkeh AN, Cordero JF, Meeker JD. Interactions between chemicals and non-chemical stressors:the modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. Science of The Total Environment 2020;708:134719. |
R836155 (2019) R836155 (2020) |
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Eick SM, Ferguson KK, Milne GL, Rios-McConnell R, Vélez-Vega C, Rosario Z, Alshawabkeh A, Cordero JF, Meeker JD. Repeated measures of urinary oxidative stress biomarkers and preterm birth in Puerto Rico. Free Radical Biology and Medicine 2020;146:299-305. |
R836155 (2020) |
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Zimmerman E, Watkins DJ, Huerta-Montanez G, Pabon ZR, Feric Z, Manjourides J, Velez-Vega CM, Figueroa A, Hines M, Martens A, Cordero J. Associations of gestational phthalate exposure and non-nutritive suck among infants from the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) birth cohort study. Environment international 2021;152:106480. |
R836155 (2021) |
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Jiang T, Lin Y, Amadei CA, Gou N, Rahman SM, Lan J, Vecitis CD, Gu AZ. Comparative and mechanistic toxicity assessment of structure-dependent toxicity of carbon-based nanomaterials. Journal of Hazardous Materials 2021;418:126282. |
R836155 (2021) |
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Aung MT, Ashrap P, Watkins DJ, Mukherjee B, Rosario Z, Vélez-Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific reports 2021;11(1):1-1. |
R836155 (2021) |
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Morton S, Honda T, Zimmerman E, Kirwa K, Huerta-Montanez G, Martens A, Hines M, Ondras M, Eum KD, Cordero JF, Alshawabekeh A. Non-nutritive suck and airborne metal exposures among Puerto Rican infants. Science of The Total Environment 2021;789:148008. |
R836155 (2021) |
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Silver MK, Fernandez J, Tang J, McDade A, Sabino J, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero JF, Meeker JD. Prenatal exposure to glyphosate and its environmental degradate, aminomethylphosphonic acid (AMPA), and preterm birth:a nested case–control study in the PROTECT cohort (Puerto Rico). Environmental health perspectives 2021;129(5):057011. |
R836155 (2021) |
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Kirwa K, Feric Z, Manjourides J, Alshawabekeh A, Vega CM, Cordero JF, Meeker JD, Suh HH. Preterm birth and PM2. 5 in Puerto Rico:evidence from the PROTECT birth cohort. Environmental Health 2021;20(1):1-1.. |
R836155 (2021) |
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Ashrap P, Aker A, Watkins DJ, Mukherjee B, Rosario-Pabón Z, Vélez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021;149:106418. |
R836155 (2021) |
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Muenter MM, Aiken A, Akanji JO, Baig S, Bellou S, Carlson A, Conway C, Cowell CM, DeLateur NA, Hester A, Joshi C. The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2019;840:1-10. |
R836155 (2019) R836155 (2020) |
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Supplemental Keywords:
biomarkers, environmental exposure, phenols, parabens, endocrine disrupters, EDCs, air pollution, metals, neurodevelopment, adverse birth outcomesProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836155C001 Air Pollution Impacts on Neonatal and Early Childhood Development
R836155C002 Toxicogenomics-based Mechanistic Multimedia Exposure Assessment and Child Development
R836155C003 Biomarker Epidemiology of In Utero Environmental Exposures and Child Development
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2021 Progress Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- 2017 Progress Report
- Original Abstract
47 journal articles for this center