Grantee Research Project Results
2007 Progress Report: Johns Hopkins Particulate Matter Research Center
EPA Grant Number: R832417Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Johns Hopkins Particulate Matter Research Center
Investigators: Samet, Jonathan M. , Ondov, John M. , Breysse, Patrick N. , Dominici, Francesca , Garcia, Joe , Chillrud, Steven
Institution: The Johns Hopkins University , University of Maryland - College Park , Lamont Doherty Earth Observatory of Columbia University , University of Chicago , Yale University
Current Institution: The Johns Hopkins University , Lamont Doherty Earth Observatory of Columbia University , University of Chicago , University of Maryland - College Park , Yale University
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010
Project Period Covered by this Report: August 1, 2006 through July 31,2007
Project Amount: $7,993,275
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
This Center integrates epidemiological, toxicological, and exposure assessment research with a goal of identifying characteristics of particulate matter (PM) associated with risk to health. The overall strategy uses epidemiological analyses of Medicare hospitalization data to identify locations where risks are at the lower and higher ends of the distribution of estimates nationwide. At these locations, particles will be characterized as to their size and chemical properties and collected for use in detailed chemical analyses and in bioassays. The work is being accomplished in three phases, with the first involving methods development and site selection and the second, the monitoring and particle collaboration and characterization, and the bioassays. In the third phase, research will be carried out to test hypotheses arising from findings of the second phase.
Progress Summary:
During the last year, work related to Phase I was brought to a close. Specific accomplishments included the completion of time-series analyses of the Medicare hospitalization data as the basis for site selection; development of a cyclone system for PM collection and of a suite of instruments for PM characterization in the field; and pilot testing and methods development for PM bioassays involving murine models of congestive heart failure and asthma.
The second phase of the center’s activities will begin in August 2007. Project #1 involves analysis of national data bases of mortality and of hospitalization among Medicare enrollees. Over the year, analyses have been completed with the Medicare hospitalization data for 1999 – 2002 for 203 counties. We have divided the country into five regions and then selected one city in each region from the high and low ends of the distribution of the estimated effect of PM 2.5 (PM <2.5 μm in aerodynamic diameter) on hospitalization risk. Additional analyses carried out under Project #1 have addressed methodological issues and, also changes in risk of PM over time and long-term effects of PM on mortality in Medicare enrollees.
Project #2 involves PM collection and characterization at the selected sites. For bioassays in Project #3, as well as for PM characterization, substantial mass is needed. To collect the needed mass, the Project #2 investigators have designed and tested a cyclone device with a high rate of flow that collects PM in the size range of PM10-2.5 and PM2.5; the cut-off at the lower size range is at approximately 0.5 μm. A prototype device that provides the desired cut points has been tested and six devices are in production. The Project #2 Team has also assembled the instruments for field monitoring of PM and developed a plan for field implementation.
Project #3 has used bulk PM collected in Baltimore to develop and evaluate bioassay systems: an in vitro approach with cultured epithelial cells and two in vivo murine models—the transgenic CREB mutant mouse model of congestive heart failure (CHF) and the ovalbumin-induced asthma model in the asthma-susceptible AJ mouse strain. The initial studies with the in vitro system showed limited utility for Phase II assays and, partially at the recommendation of the SAC, these assays will not be used for the bioassay panel. The CHF and asthma models include physiological indicators (e.g., heart rate and rhythm) as well as use of tissue microarrays for gene expression. Effects were readily demonstrated at an aspiration dose of 20 mg/kg; a smaller dose will be used in further pilot testing. The Center investigators faced both scientific and logistical challenges during the past year.
Project #2 grappled with finding the most cost-effective and feasible strategy for PM collection and monitoring at the field sites, leading to the decision to not use the mobile trailer. Project #2 also needed several rounds of testing to complete the development of the cyclone collector, while Project #3 implemented new animal models for PM research. An overall challenge remains the integration of the Projects to meet the multidisciplinary goals of the Center.
Future Activities:
The next year's activity will rest largely with PM collection and monitoring in Project #2, and further refinements of the methods of Projects #1 and #3.
Journal Articles: 64 Displayed | Download in RIS Format
| Other center views: | All 89 publications | 66 publications in selected types | All 64 journal articles |
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Anderson BG, Bell ML. Weather-related mortality: how heat, cold, and heat waves affect mortality in the United States. Epidemiology 2009;20(2):205-213. |
R832417 (Final) |
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Anderson GB, Bell ML. Heat waves in the United States: mortality risk during heat waves and effect modification by heat wave characteristics in 43 U.S. communities.Environmental Health Perspectives 2011;119(2):210-218. |
R832417 (Final) |
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Anderson GB, Bell ML. Lights out: impact of the August 2003 power outage on mortality in New York, NY. Epidemiology 2012;23(2):189-193. |
R832417 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (Final) |
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Barr CD, Dominici F. Comment on article by Craigmile et al. Bayesian Analysis 2009;4(1):37-40. |
R832417C001 (2009) |
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Barr CD, Dominici F. Cap and trade legislation for greenhouse gas emissions: public health benefits from air pollution mitigation. JAMA-Journal of the American Medical Association 2010;303(1):69-70. |
R832417 (Final) R832417C001 (Final) R833622 (Final) |
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Barr CD, Diez DM, Wang Y, Dominici F, Samet JM. Comprehensive smoking bans and acute myocardial infarction among Medicare enrollees in 387 US counties:1999–2008. American Journal of Epidemiology 2012;176(7):642-648. |
R832417 (Final) R833622 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834894 (2012) R834894 (2013) |
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Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environmental Health Perspectives 2006;114(4):532-536. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Bell ML, Dominici F. Effect modification by community characteristics on the short-term effects of ozone exposure and mortality in 98 US communities. American Journal of Epidemiology 2008;167(8):986-997. |
R832417 (Final) R832417C001 (2009) R832417C001 (Final) |
Exit Exit Exit |
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Bell ML, Ebisu K, Peng RD, Walker J, Samet JM, Zeger SL, Dominici F. Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US counties, 1999-2005. American Journal of Epidemiology 2008;168(11):1301-1310. |
R832417 (2008) R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833622 (Final) |
Exit Exit |
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Bell ML, Ebisu K, Peng RD, Samet JM, Dominici F. Hospital admissions and chemical composition of fine particle air pollution. American Journal of Respiratory and Critical Care Medicine 2009;179(12):1115-1120. |
R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833863 (2009) R833863 (Final) |
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Bell ML, Ebisu K, Peng RD, Dominici F. Adverse health effects of particulate air pollution: modification by air conditioning. Epidemiology 2009;20(5):682-686. |
R832417 (Final) R832417C001 (Final) R833863 (2009) R833863 (Final) |
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Bell ML, Peng RD, Dominici F, Samet JM. Emergency hospital admissions for cardiovascular diseases and ambient levels of carbon monoxide: results for 126 United States urban counties, 1999-2005. Circulation 2009;120(11):949-955. |
R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833863 (2009) R833863 (Final) |
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Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP. Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources. Epidemiology 2010;21(6):884-891. |
R832417 (Final) |
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Bell ML, Ebisu K, Peng RD. Community-level spatial heterogeneity of chemical constituent levels of fine particulates and implications for epidemiological research. Journal of Exposure Science & Environmental Epidemiology 2011;21(4):372-384. |
R832417 (Final) R832417C001 (Final) |
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Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012;117:83-89. |
R832417 (Final) R834798 (2013) R834798 (2014) R834798 (Final) |
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Bobb JF, Dominici F, Peng RD. A Bayesian model averaging approach for estimating the relative risk of mortality associated with heat waves in 105 U.S. cities. Biometrics 2011;67(4):1605-1616. |
R832417 (Final) R832416 (Final) R833622 (Final) |
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Chang HH, Peng RD, Dominici F. Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics 2011;12(4):637-652. |
R832417 (Final) R832417C001 (Final) R832416 (Final) R833622 (Final) |
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Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. |
R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
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Datta S, Rule AM, Mihalic JN, Chillrud SN, Bostick BC, Ramos-Bonilla JP, Han I, Polyak LM, Geyh AS, Breysse PN. Use of X-ray absorption spectroscopy to speciate manganese in airborne particulate matter from five counties across the United States. Environmental Science & Technology 2012;46(6):3101-3109. |
R832417 (Final) |
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Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA-Journal of the American Medical Association 2006;295(10):1127-1134. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (2005) |
Exit Exit |
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Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. |
R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to "Heterogeneity of particulate matter health risks." American Journal of Epidemiology 2007;166(8):892-893. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
Exit Exit |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R833622 (2008) R833622 (2009) |
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Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
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Dominici F, Peng RD, Barr CD, Bell ML. Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach. Epidemiology 2010;21(2):187-194. |
R832417 (Final) R832417C001 (Final) |
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Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) |
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Greven S, Dominici F, Zeger S. An approach to the estimation of chronic air pollution effects using spatio-temporal information. Journal of the American Statistical Association 2011;106(494):396-406. |
R832417 (Final) R832416 (Final) R833622 (2009) R833622 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834894 (2012) R834894 (2013) |
Exit Exit |
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Han I, Ramos-Bonilla JP, Rule AM, Mihalic JN, Polyak LM, Breysse PN, Geyh AS. Comparison of spatial and temporal variations in p-PAH, BC, and p-PAH/BC ratio in six US counties. Atmospheric Environment 2011;45(40):7644-7652. |
R832417 (Final) R832417C002 (Final) |
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Han I, Mihalic JN, Ramos-Bonilla JP, Rule AM, Polyak LM, Peng RD, Geyh AS, Breysse PN. Assessment of heterogeneity of metal composition of fine particulate matter collected from eight U.S. counties using principal component analysis. Journal of the Air & Waste Management Association 2012;62(7):773-782. |
R832417 (Final) |
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Heaton MJ, Peng RD. Flexible distributed lag models using random functions with application to estimating mortality displacement from heat-related deaths. Journal of Agricultural Biological and Environmental Statistics 2012;17(3):313-331. |
R832417 (Final) |
Exit |
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Janes H, Dominici F, Zeger S. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) R833622 (Final) |
Exit Exit Exit |
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Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality: an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R833622 (Final) |
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Janes H, Dominici F, Zeger S. On quantifying the magnitude of confounding. Biostatistics 2010;11(3):572-582. |
R832417 (Final) R832417C001 (Final) R833622 (Final) |
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Krall JR, Anderson GB, Dominici F, Bell ML, Peng RD. Short-term exposure to particulate matter constituents and mortality in a national study of U.S. urban communities. Environmental Health Perspectives 2013;121(10):1148-1153. |
R832417 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (Final) R834894 (Final) |
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Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. |
R832417 (Final) R832416C001 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2014) R834798C005 (2012) R834798C005 (Final) R834894 (2012) R834894 (2013) |
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Mauderly JL, Samet JM. Is there evidence for synergy among air pollutants in causing health effects? Environmental Health Perspectives 2009;117(1):1-6. |
R832417 (Final) CR831455 (Final) |
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Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society Series A-Statistics in Society 2006;169(2):179-203. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R830548 (Final) |
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Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
Exit Exit Exit |
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Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. JAMA-Journal of the American Medical Association 2008;299(18):2172-2179. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) R833622 (Final) |
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Peng RD. A Method for Visualizing Multivariate Time Series Data. Journal of Statistical Software 2008;25(Code Snippet 1):1-17 |
R832417 (2008) |
not available |
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Peng RD, Dominici F, Welty LJ. A Bayesian hierarchical distributed lag model for estimating the time course of risk of hospitalization associated with particulate matter air pollution. Journal of the Royal Statistical Society Series C--Applied Statistics 2009;58(1):3-24. |
R832417 (2008) R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833622 (Final) |
Exit Exit |
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Peng RD, Bell ML, Geyh AS, McDermott A, Zeger SL, Samet JM, Dominici F. Emergency admissions for cardiovascular and respiratory diseases and the chemical composition of fine particle air pollution. Environmental Health Perspectives 2009;117(6):957-963. |
R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833622 (Final) R833863 (2009) R833863 (Final) |
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Peng RD, Bell ML. Spatial misalignment in time series studies of air pollution and health data. Biostatistics 2010;11(4):720-740. |
R832417 (Final) R832417C001 (Final) |
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Peng RD, Bobb JF, Tebaldi C, McDaniel L, Bell ML, Dominici F. Toward a quantitative estimate of future heat wave mortality under global climate change. Environmental Health Perspectives 2011;119(5):701-706. |
R832417 (Final) R833622 (Final) |
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Ramos-Bonilla JP, Breysse PN, Dominici F, Geyh A, Tankersley CG. Ambient air pollution alters heart rate regulation in aged mice. Inhalation Toxicology 2010;22(4):330-339. |
R832417 (Final) R832417C002 (Final) |
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Rava M, White RH, Dominici F. Does attainment status for the PM10 National Air Ambient Quality Standard change the trend in ambient levels of particulate matter? Air Quality, Atmosphere & Health 2011;4(2):133-143. |
R832417 (Final) R832417C001 (Final) R833622 (2009) R833622 (Final) |
Exit Exit |
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Rule AM, Geyh AS, Ramos-Bonilla JP, Mihalic JN, Margulies JD, Polyak LM, Kesavan J, Breysse PN. Design and characterization of a sequential cyclone system for the collection of bulk particulate matter. Journal of Environmental Monitoring 2010;12(10):1807-1814. |
R832417 (Final) R832139 (Final) |
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Samet JM. Air pollution risk estimates: Determinants of heterogeneity. Journal of Toxicology and Environmental Health-Part A-Current Issues 2008;71(9-10):578-582 |
R832417 (2008) |
not available |
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Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
Exit Exit Exit |
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Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health-Part A 2007;70(3-4):311-315. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R831861 (2005) |
Exit |
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Venturini S, Dominici F, Parmigiani G. Gamma shape mixtures for heavy-tailed distributions. The Annals of Applied Statistics 2008;2(2):756-776. |
R832417 (2007) |
Exit Exit |
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Wang C, Parmigiani G, Dominici F. Bayesian effect estimation accounting for adjustment uncertainty. Biometrics 2012;68(3):661-671. |
R832417 (Final) R832416 (Final) R833622 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798 (Final) R834798C005 (2012) R834798C005 (2013) R834798C005 (Final) R834894 (2012) R834894 (2013) |
Exit Exit Exit |
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Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JGN. Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environmental Health Perspectives 2008;116(11):1500-1508. |
R832417 (2008) R832417 (Final) R832417C003 (2008) R832417C003 (2009) |
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Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JGN. Particulate matter disrupts human lung endothelial barrier integrity via ROS-and p38 MAPK-dependent pathways. American Journal of Respiratory Cell and Molecular Biology 2010;42(4):442-449. |
R832417 (Final) R832417C003 (2009) |
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Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakarz NR, Garcia JGN. Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. American Journal of Respiratory Cell and Molecular Biology 2012;46(4):524-531. |
R832417 (Final) |
Exit Exit |
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Wang T, Wang L, Moreno-Vinasco L, Lang GD, Siegler JH, Mathew B, Usatyuk PV, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN. Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Particle and Fibre Toxicology 2012;9:35 (12 pp.). |
R832417 (Final) |
Exit Exit |
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Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG. Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. American Journal of Respiratory Cell and Molecular Biology 2012;47(4):491-496. |
R832417 (Final) R832417C003 (Final) |
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Welty LJ, Peng RD, Zeger SL, Dominici F. Bayesian distributed lag models: estimating effects of particulate matter air pollution on daily mortality. Biometrics 2009;65(1):282-291. |
R832417 (2008) R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833622 (Final) |
Exit Exit |
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Zeger SL, Dominici F, McDermott A, Samet JM. Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000–2005). Environmental Health Perspectives 2008;116(12):1614-1619. |
R832417 (2008) R832417 (2009) R832417 (Final) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) R833622 (Final) |
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Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JGN, Natarajan V. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2009;40(1):19-30. |
R832417 (2008) R832417 (Final) R832417C003 (2008) R832417C003 (2009) |
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Zhou Y, Dominici F, Louis TA. Racial disparities in risks of mortality in a sample of the US Medicare population. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2010;59(2):319-339. |
R832417 (2007) |
Exit Exit |
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Zigler CM, Dominici F, Wang Y. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 2012;13(2):289-302. |
R832417 (Final) R833622 (Final) R834798 (2012) R834798 (2013) R834798 (2014) R834798C005 (2012) R834798C005 (2013) R834894 (2012) R834894 (2013) |
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Supplemental Keywords:
RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, atmospheric particulate matter, lung epithelial cells, toxicology, epidemiology, cardiopulmonary responses, chemical characteristics, human health effects, airborne particulate matter, cardiovascular vulnerability, exposure, endothelial function, pariculate matter, particle exposure, pulmonary toxicity, biological mechanisms, ambient particle health effects, ultrafine particulate matter, cardiopulmonary mechanisms, human exposure, particulate exposure, respiratory impact, PM, cardiotoxicity, particulate matter components, cardiovascular disease, human health riskProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832417C001 Estimation of the Risks to Human Health of PM and PM Components
R832417C002 PM Characterization and Exposure Assessment (Project 2)
R832417C003 Biological Assessment of the Toxicity of PM and PM Components
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.