Grantee Research Project Results
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
EPA Grant Number: R834797Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Great Lakes Air Center for Integrative Environmental Research (GLACIER)
Investigators:
Current Investigators: Brooks, Robert P. , Kaplan, Marianna J. , Oral, Elif , Araujo, Jesus
Institution: Michigan State University , University of California - Los Angeles , University of Michigan , The Ohio State University
Current Institution: Michigan State University , The Ohio State University , University of California - Los Angeles , University of Michigan
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2015 (Extended to December 31, 2016)
Project Amount: $7,999,875
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
GLACIER is a multidisciplinary center with the objective to explore one of the most prevalent and important global health-environment interfaces: the interrelationships between facets of the cardiometabolic syndrome (CMS) and air pollution. CMS is among the leading causes of death and threats to worldwide health. In tandem, exposure to air pollution, most notably fine particle matter (PM2.5), remains highly prevalent and ranks among the leading causes of global mortality. Inter-relationships and health impacts of this burgeoning confluence between these two epidemics are of tremendous importance to elucidate. Our previous research has elucidated that PM2.5 exposure plays a critical, yet under-appreciated, role in eliciting or exacerbating several key facets of the CMS-including elevating blood pressure, impairing vascular function, and even worsening metabolic insulin sensitivity and adiposity over a chronic duration. We have also found that the location of exposure, multipollutant context, and constituents within PM2.5 affect the responses. The full extent and importance of inter-relationships between CMS and air pollution, individual susceptibility, specific pollution components, multipollutant atmospheres, PM2.5 - ozone (O3) coexposures, and underlying mechanisms of toxicity are all key issues remaining to be clarified. Our center’s overall hypothesis is that PM2.5 and O3 are 1) capable of eliciting multiple important adverse cardiometabolic health effects that are dependent on 2) the local multipollutant milieu, 3) an individual’s pre-existing cardiovascular (CV) and metabolic condition (susceptibility), and 4) the interactive toxicity of PM2.5 and O3 coexposure.
Approach:
In conjunction with core facilities, GLACIER consists of 3 controlled exposure projects that each addresses specific aspects of the CMS-air pollution interface. The projects are scientifically integrated and interactive which will foster synergistic insights and cohesive synthesis of conclusions. The Exposure Characterization Core (ECC) is an integral part of all three Projects of the Great Lakes Air Center for Integrative Environmental Research (GLACIER). In coordination with and support of the GLACIER Research Projects, the ECC will provide measurements of multi-pollutant exposures for both human subject (Project 1) and animal toxicology (Projects 2 and 3) studies. The overall objectives of the ECC are to 1) determine the mass, size, and chemical composition of pollutants for each exposure period, 2) determine the atmospheric emission sources responsible for the observed exposure concentrations, and 3) provide a detailed assessment of the differences in air pollution composition, sources, and chemistry between each of the exposure sites across each of the Projects. The objectives of the GLACIER BDMC are to provide guidance for the statistical design and analysis of studies and data management services that allow for the integration of the data into a single platform that facilitates timely analysis for GLACIER investigators and projects. Specific aims for this Core are (1) to assist GLACIER investigators with statistical and data aspects of their research by providing expertise in the design, conduct and analysis of studies in Projects 1-3; (2) to establish a database for each project on a secure computerized system; and (3) to implement a website to allow data import and export in a secured, controlled environment with a user-friendly interface.
Project 1 aims to elucidate in humans the mechanisms of adverse CMS responses and the concentration-response relationships of acute exposures to differing PM2.5 mixtures.
Project 2 aims to determine the short-term CV, autonomic and airway toxicity in rats exposed to differing PM2.5 mixtures.
Project 3 expands upon the main theme by determining the CMS toxicity of differing longer-term exposures in mice. Each project will also investigate the role of pre-existing susceptibility and the comparative effects of PM2.5 mixtures derived from 2-3 dissimilar multipollutant milieus of regional importance (near-roadway, industrial, transported). Toxic effects of PM2.5, O3, each alone and in combination, will be evaluated at each location.
Expected Results:
We will address 1) temporal-response relationships to pollutant exposure and the development of CMS, 2) CMS effects of ozone and fine particle mixtures from 3 differing locations and their interactive toxicity, 3) the role of obesity and pre-existing cardiometabolic abnormalities in individual susceptibility, 4) concentration-response relationships for particles and O3; and 5) mechanisms whereby air pollutants elicit CV and metabolic health effects. Our results will provide critical insights into the health effects of PM2.5, O3, and their coexposures in a multipollutant context.
Journal Articles: 72 Displayed | Download in RIS Format
| Other center views: | All 148 publications | 72 publications in selected types | All 72 journal articles |
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Balasubramanian P, Sirivelu MP, Weiss KA, Wagner JG, Harkema JR, Morishita M, Mohankumar PS, Mohankumar SM. Differential effects of inhalation exposure to PM 2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. NeuroToxicology 2013;36:106-111. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2012) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (Final) |
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Blazek A, Rutsky J, Osei K, Maiseyeu A, Rajagopalan S. Exercise-mediated changes in high-density lipoprotein: impact on form and function. American Heart Journal 2013;166(3):392-400. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2013) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR. Enhanced allergic airway disease in old mice is associated with a Th17 response. Clinical & Experimental Allergy 2014;44(10):1282-1292. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) |
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Brook RD, Rajagopalan S, Pope III CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 2010;121(21):2331-2378. |
R834797 (2016) R834797C001 (Final) EM833367 (Final) |
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Brook RD, Rajagopalan S. Can what you breathe trigger a stroke within hours? Comment on "ambient air pollution and the risk of acute ischemic stroke". Archives of Internal Medicine 2012;172(3):235-236. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2012) R834797C003 (Final) |
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Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L, Yang H-Y, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013;25(10):587-592. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2013) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2013) R834797C003 (Final) R833740 (2012) R833740 (Final) |
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Brook RD, Xu X, Bard RL, Dvonch JT, Morishita M, Kaciroti N, Sun Q, Harkema J, Rajagopalan S. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. The Science of the Total Environment 2013;448:66-71. |
R834797 (2012) R834797 (2013) R834797 (2014) R834797 (2015) R834797 (Final) R834797C001 (2012) R834797C001 (2013) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2012) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (Final) |
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Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S. Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environmental Health Perspectives 2014;122(6):624-630. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2013) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R833740 (2012) R833740 (Final) |
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Byrd JB, Morishita M, Bard RL, Das R, Wang L, Sun Z, Spino C, Harkema J, Dvonch JT, Rajagopalan S, Brook RD. Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location. Journal of the American Society of Hypertension 2016;10(2):133-139. |
R834797 (2016) R834797 (Final) R834797C001 (2016) R834797C002 (2016) R834797C002 (Final) |
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Carey SA, Ballinger CA, Plopper CG, McDonald RJ, Bartolucci AA, Postlethwait EM, Harkema JR. Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. American Journal of Physiology:Lung Cellular and Molecular Physiology 2011;300(2):L242-L254. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Deiuliis JA, Kampfrath T, Zhong J, Oghumu S, Maiseyeu A, Chen LC, Sun Q, Satoskar AR, Rajagopalan S. Pulmonary T cell activation in response to chronic particulate air pollution. American Journal of Physiology:Lung Cellular and Molecular Physiology 2012;302(4):L399-L409. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (Final) |
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Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, Nelson RJ. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Molecular Psychiatry 2011;16(10):987-995. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Higher fine particulate matter and temperature levels impair exercise capacity in cardiac patients. Heart 2015;101(16):1293-1301. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) |
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Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Particulate matter air pollution and ambient temperature: opposing effects on blood pressure in high-risk cardiac patients. Journal of Hypertension 2015;33(10):2032-2038. |
R834797 (2014) R834797 (2015) R834797 (Final) R834797C001 (2015) R834797C001 (2016) |
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Gong Jr. H, Linn WS, Terrell SL, Clark KW, Geller MD, Anderson KR, Cascio WE, Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhalation Toxicology 2004;16(6-7):335-343. |
R834797 (2016) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Harkema J, Wagner J. Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone:A New Paradigm in Pathogenesis. TOXICOLOGY PATHOLOGY 2019;47(8):993-1003. |
R834797 (Final) |
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Huang W, Wang L, Li J, Liu M, Xu H, Liu S, Chen J, Zhang Y, Morishita M, Bard RL, Harkema JR, Rajagopalan S, Brook RD. Short-term blood pressure responses to ambient fine particulate matter exposures at the extremes of global air pollution concentrations. American Journal of Hypertension 2018;31(5):590-599. |
R834797 (Final) |
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Hubbs AF, Mercer RR, Benkovic SA, Harkema J, Sriram K, Schwegler-Berry D, Goravanahally MP, Nurkiewicz TR, Castranova V, Sargent LM. Nanotoxicology--a pathologist's perspective. Toxicologic Pathology 2011;39(2):301-324. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Kamal AS, Rohr AC, Mukherjee B, Morishita M, Keeler GJ, Harkema JR, Wagner JG. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011;23(7):417-430. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Kumagai K, Lewandowski R, Jackson-Humbles D, Buglak N, Li N, White K, Van Dyken S, Wagner J, Harkema J. Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Muco Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone. TOXICOLOGIC PATHOLOGY 2017;45(6):692-704. |
R834797 (Final) |
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Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicologic Pathology 2013;41(2):361-373. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2012) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2013) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. Air pollution-mediated susceptibility to inflammation and insulin resistance:influence of CCR2 pathways in mice. Environmental Health Perspectives 2014;122(1):17-26. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, Maurya SK, Periasamy M, Morishita M, Harkema J, Ying Z, Sun Q, Rajagopalan S. Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Particle and Fibre Toxicology 2014;11:27. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Liu C, Fonken LK, Wang A, Maiseyeu A, Bai Y, Wang T-Y, Maurya S, Ko Y-A, Periasamy M, Dvonch T, Morishita M, Brook RD, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson RJ, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle and Fibre Toxicology 2014;11:53. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Maiseyeu A, Yang H-Y, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014;26(1):23-29. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R833740 (Final) |
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Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. American Journal of Physiology:Lung Cellular and Molecular Physiology 2011;300(3):L462-L471. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Mathew AV, Yu J, Guo Y, Byun J, Chen YE, Wang L, Liu M, Bard RL, Morishita M, Huang W, Li J, Harkema JR, Rajagopalan S, Pennathur S, Brook RD. Effect of ambient fine particulate matter air pollution and colder outdoor temperatures on high-density lipoprotein function. The American Journal of Cardiology 2018;122(4):565-570. |
R834797 (Final) |
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Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American Journal of Translational Research 2013;5(2):224-234. |
R834797 (2016) R834797 (Final) R834797C003 (2014) R834797C003 (Final) |
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Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Source identification of ambient PM2.5 for inhalation exposure studies in Steubenville, Ohio using highly time-resolved measurements. Atmospheric Environment 2011;45(40):7688-7697. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Identification of ambient PM2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements. Atmospheric Environment 2011;45(8):1627-1637. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) |
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Morishita M, Bard RL, Kaciroti N, Fitzner CA, Dvonch T, Harkema JR, Rajagopalan S, Brook RD. Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):145-152. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2015) R834797C003 (Final) |
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Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):153-159. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2015) R834797C003 (Final) R833740 (Final) |
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Munzel T, Sorensen M, Gori T, Schmidt FP, Rao X, Brook FR, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part II–mechanistic insights. European Heart Journal 2017;38(8):557-564. |
R834797 (Final) |
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Munzel T, Sorensen M, Gori T, Schmidt FP, Rao X, Brook J, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part I–epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies. European Heart Journal 2017;38(8):550-556. |
R834797 (Final) |
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Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, Forastiere F, Franchini M, Franco OH, Graham I, Hoek G, Hoffmann B, Hoylaerts MF, Kunzli N, Mills N, Pekkanen J, Peters A, Piepoli MF, Rajagopalan S, Storey RF, ESC Working Group on Thrombosis, European Association for Cardiovascular Prevention and Rehabilitation, ESC Heart Failure Association. Expert position paper on air pollution and cardiovascular disease. European Heart Journal 2015;36(2):83-93b. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2015) R834797C003 (Final) |
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Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-HumblesDN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. (2016) Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. American Journal of Respiratory Cell and Molecular Biology 2016;54(3):331-340. |
R834797 (Final) R834797C002 (2016) R834797C002 (Final) |
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Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-induced type 2 immunity in nasal airways. Development and lymphoid cell dependence in mice. American Journal of Respiratory Cell and Molecular Biology 2016;54(3):331-340. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) |
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Pancras JP, Landis MS, Norris GA, Vedantham R, Dvonch JT. Source apportionment of ambient fine particulate matter in Dearborn, Michigan, using hourly resolved PM chemical composition data. The Science of the Total Environment 2013;448:2-13. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (Final) R834797C002 (2016) |
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Rajagopalan S, Brook RD. Personalizing your airspace and your health. Journal of the American College of Cardiology 2015;65(21):2288-2290. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2015) R834797C003 (Final) |
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Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR, Sun Q, Rajagopalan S. CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circulation Research 2014;115(9):770-780. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2015) R834797C002 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Rao X, Patel P, Puett R, Rajagopalan S. Air pollution as a risk factor for type 2 diabetes. Toxicological Sciences 2015;143(2):231-241. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Rao X, Montresor-Lopez J, Puett R, Rajagopalan S, Brook RD. Ambient air pollution:an emerging risk factor for diabetes mellitus. Current Diabetes Reports 2015;15(6):603. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2015) R834797C003 (Final) |
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Rohr AC, Kamal A, Morishita M, Mukherjee B, Keeler GJ, Harkema JR, Wagner JG. Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan. Environmental Health Perspectives 2011;119(4):474-480. |
R834797 (2014) R834797 (2015) R834797 (Final) |
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Sarnat SE, Suh HH, Coull BA, Schwartz J, Stone PH, Gold DR. Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio. Occupational and Environmental Medicine 2006;63(10):700-706. |
R834797 (2016) R826780 (Final) R827353 (Final) R827353C003 (Final) R832416 (2008) |
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Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR, Sun Q, Fan Z. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Particle and Fibre Toxicology 2013;10:43. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (Final) R834797C001 (2013) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (Final) R834797C003 (2013) R834797C003 (2014) R834797C003 (Final) |
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Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C. Alterations of the murine gut microbiome with age and allergic airway disease. Journal of Immunology Research 2015;2015:892568 (8 pp.). |
R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) |
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Wagner JG, Morishita M, Keeler GJ, Harkema JR. Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma:a comparison of field exposure studies. Environmental Health 2012;11:45 (13 pp.). |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (Final) |
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Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR. Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome. Environmental Health Perspectives 2014;122(1):27-33. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2013) R834797C001 (Final) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2013) R834797C003 (Final) |
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Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC. PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions. Particle and Fibre Toxicology 2014;11:25 (10 pp.). |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) |
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Wang Y, Eliot MN, Kuchel GA, Schwartz J, Coull BA, Mittleman MA, Lipsitz LA, Wellenius GA. Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston Study. Journal of Occupational and Environmental Medicine 2014;56(9):e73-e77. |
R834797 (2016) R834798 (Final) R834798C002 (2014) R834798C002 (Final) R834798C003 (Final) |
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Wellenius GA, Boyle LD, Wilker EH, Sorond FA, Coull BA, Koutrakis P, Mittleman MA, Lipsitz LA. Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke 2013;44(6):1532-1536. |
R834797 (2016) R834797 (Final) R834797C001 (Final) R834797C002 (2016) R834797C003 (Final) R834798 (2013) R834798 (2014) R834798 (Final) R834798C002 (Final) R834798C003 (2013) R834798C003 (2014) R834798C003 (Final) |
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Wold LE, Ying Z, Hutchinson KR, Velten M, Gorr MW, Velten C, Youtz DJ, Wang A, Lucchesi PA, Sun Q, Rajagopalan S. Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution. Circulation:Heart Failure 2012;5(4):452-461. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2012) R834797C003 (Final) |
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Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S, Sun Q. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicological Sciences 2011;124(1):88-98. |
R834797 (2014) R834797 (2015) R834797 (Final) R834797C002 (2016) R831697 (Final) |
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Xu X, Liu C, Xu Z, Tzan K, Wang A, Rajagopalan S, Sun Q. Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice. Life Sciences 2012;90(25-26):1001-1009. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2012) R834797C003 (Final) |
Exit Exit Exit |
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Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen L-C, Sun Q. Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues. Particle and Fibre Toxicology 2011;8:20 (14 pp.). |
R834797 (2014) R834797 (2015) R834797 (Final) |
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Ying Z, Xu X, Chen M, Liu D, Zhong M, Chen L-C, Sun Q, Rajagopalan S. A synergistic vascular effect of airborne particulate matter and nickel in a mouse model. Toxicological Sciences 2013;135(1):72-80. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
Exit Exit Exit |
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Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S. Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of sympathetic nervous system:a role for hypothalamic inflammation. Environmental Health Perspectives 2014;122(1):79-86. |
R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2013) R834797C003 (2014) R834797C003 (2015) R834797C003 (Final) |
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Ying Z, Xie X, Bai Y, Chen M, Wang X, Zhang X, Morishita M, Sun Q, Rajagopalan S. Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats. Particle and Fibre Toxicology 2015;12:15 (10 pp.). |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (2015) R834797C003 (Final) |
Exit Exit |
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Yue W, Stolzel M, Cyrys J, Pitz M, Heinrich J, Kreyling WG, Wichmann H-E, Peters A, Wang S, Hopke PK. Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany. Science of the Total Environment 2008;398(1-3):133-144. |
R834797 (2016) R827354 (Final) R832415 (2007) R832415 (2008) R832415 (2010) R832415 (2011) R832415 (Final) R832415C001 (2008) R832415C001 (2010) R832415C001 (2011) R832415C002 (2006) R832415C002 (2008) R832415C002 (2010) R832415C002 (2011) |
Exit Exit Exit |
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Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Huttemann M, Grossman LI, Chen LC, Rajagopalan S, Sun Q, Zhang K. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. Journal of Hepatology 2013;58(1):148-154. |
R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C003 (Final) |
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Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R, Sun Q, Harkema JR, Rajagopalan S. (2016) Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. Inhalation Toxicology 2016;28(9):383-392. |
R834797 (Final) R834797C003 (Final) |
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Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG, Harkema JR (2016). Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells. American Journal of Respiratory Cell and Molecular Biology 2016;54(6):782-791. |
R834797 (Final) R834797C002 (2016) R834797C002 (Final) |
Exit Exit Exit |
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Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR. Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model. Inhalation Toxicology 2016;28(4):155-163. |
R834797 (Final) R834797C002 (2016) R834797C002 (Final) |
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Harkema JR, Hotchkiss LA, Vetter NA, Jackson-Humbles DN, Lewandowski RP, Wagner JG. Strain Differences in a Murine Model of Air Pollutant-induced Nonatopic Asthma and Rhinitis. Toxicologic Pathology 2017;45(1):161-171. |
R834797 (Final) R834797C002 (Final) |
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Rajagopalan S, Brook RD. (2012) Air Pollution and Type II Diabetes:Mechanistic Insights Diabetes. 2012 Dec;61(12):3037-45. PMCID:PMC3501850. |
R834797C003 (Final) |
not available |
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Xu X, Rao X, Wang TY, Jiang SY, Ying Z, Liu C, Wang A, Zhong M, Deiuliis JA, Maiseyeu A, Rajagopalan S, Lippmann M, Chen LC, Sun Q. (2012) Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model. Part Fibre Toxicol. 2012 Nov 5;9:40. PMCID:PMC3545913. |
R834797C003 (Final) |
not available |
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Münzel T, Sørensen M, Gori T, Schmidt FP, Rao X, Brook FR, Chen LC, Brook RD, Rajagopalan S. (2016) Environmental stressors and cardio-metabolic disease:part II-mechanistic insights.Eur Heart J. 2016 Jul 26. pii:ehw294. [Epub ahead of print] PMID:27460891. |
R834797C003 (Final) |
not available |
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Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR. (2016) Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model. Inhal Toxicol. 2016;28(4):155-63. PMCID:PMC4836866. |
R834797C003 (Final) |
not available |
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Carll, A.P., Crespo, S.M., Filho, M.S., Zati, D.H., Coull, B.A., Diaz, E.A., Raimundo, R.D., Jaeger, T.N.G., Ricci-Vitor, A.L., Papapostolou, V., Lawrence, J.E., Garner, D.M., Perry, B.S., Harkema, J.R., and Godleski, J.J. (2017). Inhaled Ambient-level Traffic-derived Particulates Decrease Cardiac Vagal Influence and Baroreflexes and Increase Arrhythmia in a Rat Model of Metabolic Syndrome. Particle and Fibre Toxicology 14, 16. |
R834797C002 (Final) |
not available |
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Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R, Sun Q, Harkema JR, Rajagopalan S (2016). Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. Inhal Toxicol. 28(9):383-92. PubMed PMID:27240593. |
R834797C002 (2016) R834797C002 (Final) |
not available |
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Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model. Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR. Inhal Toxicol. 2016;28(4):155-63. |
R834797C003 (2016) R834797C003 (Final) |
not available |
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Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R, Sun Q, Harkema JR, Rajagopalan S. Inhal Toxicol. 2016 Aug;28(9):383-92. |
R834797C003 (2016) R834797C003 (Final) |
not available |
Supplemental Keywords:
Multipollutant, PM2.5, O3, cardiometabolic syndrome, Great Lakes,, Scientific Discipline, Air, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, air toxics, Exposure, Health Risk Assessment, Biochemistry, Biology, Risk Assessment, ambient air quality, particulate matter, aerosol particles, susceptible populations, acute cardiovascualr effects, human exposure, physiology, cardiopulmonary, cardiotoxicity, acute exposureProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834797C001 Cardiometabolic Effects of Exposure to Differing Mixtures and Concentrations of PM2.5 in Obese and Lean Adults
R834797C002 Cardiometabolic, Autonomic, and Airway Toxicity of Acute Exposures to PM2.5 from Multipollutant Atmospheres in the Great Lakes Region
R834797C003 Long Term Metabolic Consequences of Exposures to Multipollutant Atmospheres in the Great Lakes Region
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2015 Progress Report
- 2014 Progress Report
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
72 journal articles for this center