Grantee Research Project Results

Final Report: Cardiovascular Effects of Urban and Rural Coarse Particulate Matter in Obese and Lean Adults

EPA Grant Number: R833740
Title: Cardiovascular Effects of Urban and Rural Coarse Particulate Matter in Obese and Lean Adults
Investigators: Brook, Robert D. , Keeler, Gerald J. , Gold, Diane R. , Brook, Jeffrey R. , Dvonch, Joseph T. , Urch, Bruce , Silverman, Frances , Kaciroti, Niko
Institution: University of Michigan , Harvard University , University of Toronto
EPA Project Officer: Chung, Serena
Project Period: March 1, 2008 through February 28, 2011 (Extended to February 28, 2014)
Project Amount: $1,199,500
RFA: Sources, Composition, and Health Effects of Coarse Particulate Matter (2006) RFA Text | Recipients Lists
Research Category: Air , Air Quality and Air Toxics , Particulate Matter

Objective:

Coarse particulate matter (PM_10-2.5) is a heterogeneous mixture of crustal materials, trace metals/elements, and bio-aerosols. The components vary considerably due to location differences in primary sources. In order to support the biological plausibility that coarse PM exposure is causally linked to CV disease, it is essential to demonstrate that it can rapidly trigger adverse biological responses in humans capable of acutely promoting CV events. The overall hypothesis is that short-term exposure to both urban and rural coarse PM is capable of promoting pro-vasoconstrictive vascular dysfunctions and CV autonomic imbalance.

Summary/Accomplishments (Outputs/Outcomes):

We have completed all exposures and measurement of all health outcomes. Our results have shown that coarse CAP exposure leads to increases in circulating endothelial progenitor cell and does not alter HDL function. Coarse CAP causes elevations in heart rate and blood pressure via autonomic imbalance (reduced heart rate variability). There were no changes in vascular function parameters due to coarse CAP, or other outcomes (insulin sensitivity, inflammatory markers).

Journal Articles on this Report : 5 Displayed | Download in RIS Format

Publications Views
Other project views:	All 7 publications	5 publications in selected types	All 5 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L, Yang H-Y, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013;25(10):587-592.	R833740 (2012) R833740 (Final) R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2013) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2013) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2013) R834797C003 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Abstract: Taylor&Francis-Abstract Exit
Journal Article	Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S. Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environmental Health Perspectives 2014;122(6):624-630.	R833740 (2012) R833740 (Final) R834797 (2013) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2013) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Full-text: EHP-Full Text PDF Abstract: EHP-Abstract & Full Text HTML
Journal Article	Ejike C, Wang L, Liu M, Wang W, Morishita M, Bard RL, Huang W, Harkema J, Rajagopalan S, Brook RD. Personal-level exposure to environmental temperature is a superior predictor of endothelial-dependent vasodilatation than outdoor-ambient level. Journal of the American Society of Hypertension 2017;11(11):746-753.e1.	R833740 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Abstract: ASH-Abstract Exit
Journal Article	Maiseyeu A, Yang H-Y, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014;26(1):23-29.	R833740 (Final) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2014) R834797C002 (2015) R834797C002 (2016)	Full-text from PubMed Abstract from PubMed Associated PubMed link Abstract: Taylor&Francis-Abstract Exit Other: ResearchGate-Abstract Exit
Journal Article	Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):153-159.	R833740 (Final) R834797 (2014) R834797 (2015) R834797 (2016) R834797 (Final) R834797C001 (2014) R834797C001 (2015) R834797C001 (2016) R834797C001 (Final) R834797C002 (2015) R834797C002 (2016) R834797C002 (Final) R834797C003 (2015) R834797C003 (Final)	Full-text from PubMed Abstract from PubMed Associated PubMed link Abstract: Nature.com-Abstract Exit Other: ResearchGate-Abstract Exit

Supplemental Keywords:

Health effects, sensitive populations, ethnic groups, exposure, epidemiology, RFA, Scientific Discipline, Air, particulate matter, Health Risk Assessment, Environmental Chemistry, Biology, atmospheric particulate matter, sensitive populations, atmospheric particles, cardiopulmonary responses, human health effects, bioavailability, cardiovascular vulnerability, sensitive subgroups, cardiotoxicity

Relevant Websites:

Great Lakes Clean Air Center for Integrated Environmental Research (GLACIER) Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.