Grantee Research Project Results
2015 Progress Report: Center for Child Environmental Health Risks Research
EPA Grant Number: R834514Center: Predictive Toxicology Center for Organotypic Cultures and Assessment of AOPs for Engineered Nanomaterials
Center Director: Faustman, Elaine
Title: Center for Child Environmental Health Risks Research
Investigators: Faustman, Elaine , Fenske, Richard , Griffith, William C. , Costa, Lucio G , Karr, Catharine J. , Vigoren, Eric M. , Furlong, Clement , Thompson, Engelberta , Yost, Michael
Current Investigators: Faustman, Elaine , Fenske, Richard , Griffith, William C. , Yost, Michael , Costa, Lucio G , Furlong, Clement , Thompson, Engelberta , Vigoren, Eric M. , Karr, Catharine J.
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: September 25, 2009 through September 24, 2016
Project Period Covered by this Report: September 25, 2014 through September 24,2015
Project Amount: $5,417,075
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Since 1998, researchers of the University of Washington Center for Child Environmental Health Risks Research (the Center) have been using a multi-disciplinary research approach working in the lab, in the field, and in the community to understand the mechanisms that define children’s susceptibility to pesticides, identify the implications of this susceptibility for development and learning, and partner with our communities to translate our findings into risk communication, risk management, and prevention strategies.
The Center has received a third cycle of funding from the National Institute of Environmental Health Sciences (NIEHS) and the Environmental Protection Agency (EPA).
The Center is administratively housed within the Institute for Risk Analysis and Risk Communication, also directed by Center Director Dr. Elaine M. Faustman, which is in the University of Washington’s School of Public Health. The Center includes partnerships with the Fred Hutchinson Cancer Research Center and the Yakima Valley community, located in the agricultural center of Washington State, to jointly sponsor a Community Based Participatory Research (CBPR) Project aimed at reducing childhood pesticide exposure.
All Center efforts are highly integrated and comprise two field-based research projects, two laboratory-based research projects, three facility cores, an Administrative Core, and Faculty Development Investigator.
The specific objectives of the two field-based projects—the CBPR project and the pesticide exposure pathways research project—are:
- To improve our understanding of critical pathways of potential pesticide exposure for children; and
- To apply culturally appropriate interventions to reduce children’s exposure to pesticides.
The specific objectives of the laboratory-based research projects—a molecular mechanisms research project and a genetic susceptibility research project—are:
- To identify cellular, biochemical and molecular mechanisms that cause adverse developmental neurotoxicity of pesticides; and
- To identify susceptibility factors for developmental neurotoxicity of pesticides.
The three facility cores are: Biomarkers and Exposure Assessment (BEA), Biostatistics, Modeling and Risk Characterization (BMRC), and Community Outreach and Translation (COTC). The cores are designed to support the research objectives and to put the research into a child-specific risk assessment context. Thus, the specific objectives of the facility cores are:
- To provide core support for the development and application of risk assessment methods, enabling basic research on pesticide toxicity and exposure to inform risk decisions to protect children’s health from pesticides; and
- To foster partnerships between academic researchers and the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the needs of both.
Work in the Center is organized around the Public Health paradigm “V-diagram,” which connects occurrence of disease in humans to the original source of the problem (see Figure 1). Along the pathway from source/stressor to disease, the diagram identifies intermediate processes (which may be subject to public health intervention) and conditions (which may be observable for public health monitoring and hypothesis testing). This paradigm is central to the overall organization and integration of the various components of the Center. Using Global Positioning System (GPS) tools to relate human activities and land use helps identify how organophosphate (OP) pesticide (stressor) application is transferred/transported to create OP environmental conditions. The CBPR Project focuses on the multiple potential pathways of OP transfer potentially leading to exposure and resulting dose in children. The biological sampling efforts help identify susceptibility factors and genetic mechanisms relating dose to early biological effect. Biostatistical analyses and outreach link all these components together.
Community Based Participatory Research Project
Specifically, the aims are to:
- Characterize the seasonal variability of OP exposure across our cohort by sampling at times of peak OP usage and by evaluating OP metabolite profiles across time during these seasons;
- Assess the influence of gene environment interactions on OP exposure and response profiles; and
- Calculate the contributions from gene, environment and season to within-person and between-person variability of the urinary OP metabolites in farmworkers to identify quantitatively difference between persons and across seasons.
Secondarily, we will coordinate our cohort and household sampling with agricultural practices and field air monitoring done by our colleagues in the Pesticide Exposure Pathways Research Project. This will measure parent and oxon concentration for 3 OPs.
Pesticide Exposure Pathways Research Project
Specific aims addressed between 09/25/2009 and 07/31/2014:
- Determine the dominant transport mechanism for the proximity pathway in a community setting
- Establish the spatial extent of the proximity pathway
- Estimate pesticide residues in the community by combining land-use regression with models of spray drift, volatilization and pest-pressure
- Assess the importance of proximity through land-use regression estimates of exposure
- Monitor indoor/outdoor pesticide levels to assess infiltration into indoor environments
- Assess the relative importance of the take-home vs. proximity pathway
- Evaluate the effect of personal activities on exposures in families living far from applied fields
Specific aims addressed between 08/01/2014 and 07/31/2015:
- Assess the importance of proximity through land-use regression estimates of exposure
Molecular Mechanisms Research Project
The project has four initial Aims:
- To investigate the direct effects of organophosphates (OPs) on neurite outgrowth, neuronal proliferation and viability in neurodevelopmental-stage specific in vitro models.
- To elucidate the impact of OP-induced oxidative stress and its effects on neuritogenesis and neurogenesis in neurodevelopmental-stage specific in vitro models.
- To examine developmental stage dependent impacts of chlorpyrifos (CP) on proliferation and differentiation gene expression pathways.
- To investigate whether OP exposure results in impairment of glial-neuronal interactions affecting the ability of astrocytes to promote neuritogenesis.
There were no changes to the specific aims for any of the following:
Biomarkers and Exposure Assessment Facility Core
Biostatistics, Modeling, and Risk Characterization Facility Core
Community Outreach and Translation Facility Core
Progress Summary:
Community Based Participatory Research Project:
In February 2011 our community health promoters began re-contacting farmworkers and nonfarm workers in our cohort (from Years 05 through 09 studies) to participate in this new study. A total of 132 farmworkers and 90 non-farm workers were re-contacted before we were able to reach our recruitment goal of 60 farmworker and 40 non-farmworker households. Data collection began on March 17, 2011.
Data collection for Season 1 (Pre-Thinning season) was completed in late May, 2011, Season 2 (Thinning season) data collection took place June - August, 2011, and the final season of data collection (Non-spray season) occurred in November and December of 2011. During Season 2, we asked female participants, between 18 and 49 years of age, who were participating in the parent study, if they would be interested in participating in an additional Stress and Cortisol Project. We successfully recruited 27 women. We also coordinated with the Pesticides Exposure Pathways Research group to complete indoor and outdoor air sampling.
In the spring of 2012, a random selection of 41 participants from the larger CBPR Project were re-contacted to participate in one-on-one interviews to learn more about why they chose to provide biological samples for research and their experience in doing so. We learned that the selected participants have a strong understanding of and desire to contribute to biomedical research. Most participants were eager to participate because of self-described duty to help others and used words like “proud”, “satisfied” and “pleasure” when describing their ability to contribute to a cause like this.
In February 2013, we held two Community Forums (one in English with the Community Advisory Board members and one in Spanish open to the community). During the forums we provided examples of information from this project that would be available for dissemination at a later date. We then queried the audience on the presentation and understandability of the information. The information gathered during these meetings informed the dissemination tools that were used to return individual results to participants in June - July 2015. During this time all 100 families (60 farm worker and 40 non-farm worker families) were re-contacted and offered a one-on-one meeting with one of our community health promoters to learn about the DMTP levels detected in their urine during the study; as well more information on pesticides and reducing pesticide exposure at home and in the work place. We were successful in locating and returning results to 92 of the 100 participating adults; eight were lost to follow-up (moved out of the area). The 92 participants who received their results also completed a short survey which will assist us in better understanding the nature of their work environment and potential points of pesticide exposure. The majority of participants who met with a community health worker to discuss their results voiced great appreciation for the results and information provided to them.
Pesticide Exposure Pathways Research Project:
Previously, we have demonstrated elevated concentrations of outdoor chlorpyrifos (CPF) and its more potent transformation product CPF-oxon in outdoor air samples in the Yakima Valley during dormant spray applications periods (Armstrong 2014). These exposures are strongly associated with proximity to crops (pome fruit and stone fruit) using ground-applications of CPF. In addition, we have shown that the importance of proximity persists beyond short distances and that living within 2 km of a field is strongly (R2 = 0.55) predictive of outdoor concentrations of CPF and CPF-oxon.
A land-use regression (LUR) exposure model was built to describe the relationship between agricultural land-use characteristics and chlorpyrifos air sampling results from households in the CHC Yakima Valley cohort that were instrumented with PUF-PAS (polyurethane foam passive air sampling) disks (described in previous annual progress reports). Using the instrumented households model, monthly outdoor chlorpyrifos concentrations are now being estimated for non-instrumented households using the same measures of agricultural activity. The exposure model building process and predictions are being prepared for submission to a peer-reviewed journal.
Molecular Mechanisms Research Project:
Aims of this research project are carried out in a collaborative manner by two laboratories, the Faustman Lab and the Costa Lab. Studies and Results are reported herein for these joint efforts.
In the years preceding this latest funding cycle, Dr. Costa’s laboratory had been exploring novel mechanisms by which OP insecticides may adversely influence brain development. Two important findings were that OPs were able to inhibit proliferation of astrocytes, particularly in the presence of mitogens such as carbachol (an analog of acetylcholine) (Guizzetti, et al., 2005) and that the cytotoxicity of OPs on neurons was due to their ability to induce oxidative stress (Giordano, et al., 2007). For this latter study we utilized an in vitro system consisting of cerebellar granule neurons (CGNs) isolated from wild-type mice (Gclm +/+) or from mice lacking the modifier subunit of glutamate cysteine ligase (Gclm -/-), the first and limiting step in the synthesis of glutathione. These neurons display very low levels of glutathione and are more susceptible to the toxicity of agents that increase oxidative stress.
During the same period, the Costa lab studied the interactions of astrocytes and neurons in mediating chemical toxicity. Various in vitro systems were implemented to study such interactions and a preliminary characterization of a number of parameters was carried out. Rat cortical or hippocampal astrocytes, when co-cultured with hippocampal neurons, increase their differentiation, and stimulation of astrocytes with carbachol greatly enhances their ability to induce neuritogenesis. This effect is mediated by an effect of carbachol on the expression and release of at least three neuritogenic factors: fibronectin, laminin and PAI-1 (Guizzetti, et al., 2008). Ethanol can interfere with muscarinic receptor signaling in astrocytes and inhibit their ability to foster neuritogenesis in hippocampal neurons (Guizzetti, et al., 2010). More germane to this project is the finding that manganese, by accumulating and causing oxidative stress in astrocytes, inhibits their ability to induce neuritogenesis in hippocampal neurons (Giordano, et al., 2009).
Genetic Susceptibility Research Project:
The overall goal of the Genetic Susceptibility Research Project was to develop specific biomarkers of exposure to organophosphate (OP) compounds, and to use these biomarkers to explore gene-environment interactions related to genetic variability in the paraoxonase (PON1) gene, particularly with respect to OP exposures that occur during early development.
Specific Aim 1 was to develop and validate immunomagnetic bead (IMB) isolation protocols for the biomarker proteins of interest: butyrylcholinesterase (BChE), acyl peptide hydrolase (APH), and acetylcholinesterase (AChE), and to use a proteomic approach to validate the use of these proteins as biomarkers of OP exposure.
We had demonstrated that a single step IMB protocol will purify BChE from plasma and APH from red cell extracts. The OP adducts to these proteins have been identified. The serine adduct from the active metabolite of tri-cresyl phosphates was found to undergo a unique aging reaction. In vitro inhibition of BChE with the active metabolite of TCP, cyclic saligenin cresyl phosphate (CBDP) generated both a cresyl phosphoserine and an aged phosphoserine. However, in samples from exposed individuals, only the fully aged phosphoserine modification was observed. More recent experiments have shown that AChE does not age in the same way and retains a cresyl group. We had anti-AChE antibodies generated in chicken (Aves Labs, Tigard, OR) based on the sequence differences between human and chicken upstream from the active site serine. We have used these antibodies to develop a protocol for isolation of the human active site tryptic peptide using the chicken antibodies similar to the protocols that we have developed for the rapid isolation of BChE and APH. We are currently using this protocol to examine AChE adduction by OP insecticides as well as the neurotoxins to which children are exposed during flights in commercial aircraft, the triaryl phosphates.
A second biomarker protein, acylpeptide hydrolase – APH, has proven in our mouse in vivo experiments to be very sensitive to CPO exposure and is useful because it has a half-life three times as long as BChE (33d vs. 11d). We have prepared and sent to CDC OP modified and unmodified APH as well as a small quantity of 15N-labeled APH produced in our E. coli expression system to serve as an internal standard when quantifying OP exposures.
The immunomagnetic bead/mass spec protocols are sufficiently sensitive to determine exposures from dried blood spots which are much easier to collect, ship and archive.
We also added a fourth potentially useful biomarker to our targeted proteins that are modified by OP exposures. While it has been known for many years, there is no carboxylesterase 1 (CES1) in human serum/plasma, non-the-less, we can pull sufficient CES1 out of white cells to analyze for OP adduction, in fact, CES1 is also known as monocyte carboxylesterase. It has the unique property of being modified by non-bioactivated triaryl phosphates.
Specific Aims 2 and 3 made use of knockout and humanized mouse models to evaluate interactions among biomarkers of OP sensitivity, exposure and response during critical stages of development. The experiments in Aim 2 involved chronic exposure of pregnant mice to CP and CPO. The experiments in Aim 3 involve neonatal exposures.
For the experiments characterizing PON1 status as a biomarker of sensitivity to chlorpyrifos (CP) and CPO during gestation, the initial chronic dose-response studies in pregnant and nonpregnant mice demonstrated steep dose-response curves for inhibition of BChE and AChE, with higher doses leading to weight loss and fetal abnormalities. PON1-/- mice were more sensitive than PON1+/+ mice to the effects of chronic CPO exposure. Fetuses were more resistant than dams to CPO inhibition of BChE, and tgHuPON1R192 females were more resistant than females expressing tgHuPON1Q192. In our earlier experiments, dose-response experiments were completed for CPO that involved gestational exposure of mice of all four genotypes (n = 10 pregnant dams per treatment group). After timed matings were performed (n = 20 females per treatment group), mice with copulatory plugs were exposed transdermally to CPO daily from GD6 to GD17. PON1+/+, tgHuPON1Q192, and tgHuPON1R192 mice were exposed to vehicle (acetone) or to CPO at 0.75 mg/kg/d or 0.85 mg/kg/d. PON1-/- mice were exposed to vehicle alone, or to CPO at 0.50 mg/kg/d or 0.75 mg/kg/d. Dams were sacrificed at GD18, and fetal and maternal tissues were dissected for measurement of enzyme inhibition in different tissues. Additionally, fetal brains were placed in RNAlater and analyzed for gene expression using microarrays. At GD18 there was greater inhibition of BChE in the plasma of fetuses from PON1- /- and tgHuPON1Q192 dams, as compared to the plasma of fetuses from PON1+/+ and tgHuPON1R192 dams. Thus, the PON1 status of the dam clearly influenced CPO toxicity to the fetus. The gene expression analysis showed that gene expression in brains of the fetuses of the PON1-/- mice was more significantly affected than in brains of fetuses of wild type mice. Also, gene expression in the brains fetuses of the PON1R192 mice was less affected than expression in the brains of fetuses of PON1Q192 mice, consistent with the higher efficiency of hydrolysis of CPO by the PON1R192 alloform (Cole, et al., 2014). Thus, PON1 status was important in modulating CPO exposure both pre- and postnatally.
Also interesting was the observation that RBC APH showed a better correlation with brain AChE inhibition than the classic biomarker protein BChE, validating our use of APH as an important and useful biomarker protein for OP exposures. Similar results in fetuses were observed when the four mouse strains were exposed to DZO during gestation (Wan-Fen Li, manuscript in preparation).
Biomarkers and Exposure Assessment Facility Core:
The Biomarkers and Exposure Assessment Core has provided support to the Pesticide Exposure Pathways Research Project and the Community Based Participatory Research (CBPR) project for analysis of field samples collected from our study cohort in Yakima Valley. This study expands upon previous studies of the cohort. Samples were collected during the previous project years between March and December 2011 and inventoried into the Center biorepository. We collected samples earlier in the year than in the previous funding cycles. We collected samples during the early Spring (to capture the time of chlorpyrifos (CP) pesticide use), late Spring-early Summer (to coincide with the timing of previous sample collections), and again in the off season during Winter. Because children in our CHC cohort were older, in this study (CHC3), it was possible to collect whole blood from the children and examine a wider variety of biomarkers. Based on our previous studies we have expanded the list of biomarkers that are being studied.
Biostatistics, Modeling, and Risk Characterization Core:
The Core provides innovative statistical, modeling, and risk assessment capabilities in order to interpret results of the Center research. A unique feature of our Center is its close integration and place with the Institute of Risk Analysis and Risk Communication. This Core has used high dimension statistical models that are innovative for exposure analysis and allow for successful interpretation and analysis of complex cohort studies. Collaboration with investigators on statistical designs and analysis is the start of an integrated process whereby this core has improved the initial design and construct of studies to increase their power to detect statistically significant results. Some of the challenges the Core has taken into account when performing analyses include field samples with frequent values below quantification limits, missing data, multiple data collection protocols, combinations of random and fixed effects, repeated measures, and multiple spatial and temporal scales.
The Core has been deeply involved in the design of the field sampling to collect information on the cohort identified in previous Center studies. The Center has extended the time period for characterizing exposures by going into the field earlier than previous studies to include the early spring when different organophosphate (OP) pesticides are used, in particular chlorpyrifos (CP). In the previous studies the first season we collected was the thinning season in spring when dimethyl OP pesticides such as azinphos-methyl (AZ) are primarily used. By including the early spring we will gain a more complete understanding of OP exposures of orchard workers and their children in the Yakima Valley.
Analysis of exposure data from the Community Based Participatory Research Project (CBPR) and the Pesticide Exposure Pathways Research Project from Years 6-10 (also known as CHC2) of and the current funding cycle Years 11-15 (also known as CHC3) has focused on using Bayesian Markov chain Monte Carlo methods using multivariate distributions in hierarchical models to understand the relationship between child and adult exposures from the take home pathway for orchard workers, trends in exposures across agricultural seasons, differences between exposures of farmworker and non-farmworker household exposures, and sources of variability.
In each of the seasons from the CHC3 study, we collected dust from two different days in each season, the first and last days (day 1, day 7) on which we collect urine, in contrast to previous studies where we collected dust on a single day each season. In order to characterize potential risks associated with these exposures, the BMRC has built exposome and Gene X Environment X Time models. These models help to characterize the temporal and spatial variability of the exposure as well as the potential impacts of multiple chemical and nonchemical stressor exposure.
Community Outreach and Translation Core:
The COTC members were involved in a variety of exciting outreach and translational activities on both the local and national level. The COTC shares membership with the Administrative Core and includes the Center’s Faculty Development Investigator/Pediatric Health Specialist, Dr. Catherine Karr. The COTC, Dr. Karr, and the Administrative Core work in close collaboration. Examples include hosting three annual regional conferences and developing outreach materials, and in the coming year develop pesticide education materials for delivery to health professionals. Because a major aim of the COTC is to engage the Pediatric Health Specialist in clinical translation and needs assessment, Dr. Karr’s efforts related to this aim are reported here. Meanwhile, Dr. Karr’s other pediatric educational activities and pursuits related to her position as Faculty Development Investigator are reported in the Faculty Development Investigator report.
Future Activities:
Community Based Participatory Research Project:
Data analyses of survey data continues and we continue to meet with our colleagues at the University of Washington to review outcomes and discuss dissemination and manuscript ideas and drafts. Data analyses of dust and biological samples continue at the University of Washington. We will work closely with the Biomarkers and Exposure Assessment Facility Core and the Biostatistics, Modeling and Risk Characterization Facility Core as more information is available.
Pesticide Exposure Pathways Research Project:
Future efforts will continue to focus on validating the final PLS LUR exposure model for chlorpyrifos and explore the impact of joint effect exposures on children’s health. Other future work aims to investigate the short-term and long-term joint effect of exposures to (1) chlorpyrifos (and its oxon), (2) PM2.5 a criteria air pollutant with important sources in the Yakima Valley, including biomass burning and animal feed lot operations, and (3) nitrogen oxides, with important motor vehicle sources. Exposure to these pollutants has been associated with oxidative stress, increased inflammatory responses, asthma symptoms, including wheeze, and neurological outcomes such as delayed psychomotor development, decreased cognitive abilities, and risk of developing ADD/ADHD. Yakima Valley provides a unique location within which to study the single and joint effect of these pollutants on children’s health and development because (1) these pollutants are heterogeneously distributed over time and space within the geographic study area due to their highly localized sources and (2) the short-term concentrations of CP and criteria pollutants NO2 and PM2.5 are not correlated in time or space due to their distinct sources and temporal trends. This independence in concentrations makes it possible to include both in epidemiological models and still retain the ability to make valid inference on the models created.
Molecular Mechanisms Research Project:
During the anticipated No-Cost Extension, the Faustman and Costa labs will continue with their investigations to support the aims of the Molecular Mechanisms project and publish drafted manuscripts.
Biomarkers and Exposure Assessment Facility Core:
This Core will continue to coordinate the analysis and storage of field samples from the CHC3 CBPR. The BEA Core also provides the archiving and storage of results and datasets for all of the Center research projects. We anticipate that during the next year the results from CHC3 samples will become available for analysis and reporting to better understand the exposure of children to pesticides and how this exposure varies across agricultural seasons.
Biostatistics, Modeling, and Risk Characterization Core:
We continue to work on an Integrative Tools that links exposure to OP pesticides to early indicators of potential disease and which uses a sequence of linked models. Data for constructing the integrated tools use the multiple measures of exposure and the multiple biomarkers of effect that we are measuring in farmworkers, non-farmworkers and their children following them across multiple seasons and multiple years.
We are evaluating the importance of additional information on minor allele frequencies in our population with additional data on over 300 single nucleotide polymorphisms for CYP450s and other metabolizing enzymes. These values are being linked with our biomarkers of early response, cholinesterase inhibition. We have analyzed 80 households in our population for the single nucleotide polymorphisms and found significant differences between the polymorphisms in the slope between cholinesterase inhibition and OP metabolite levels in the urine. We have expanded our coverage beyond the 80 households to greatly increase the number of households under evaluation. The additional genomic data analyzed in 2014 and 2015 have moved us closer to this goal.
It is possible to build these models because we have longitudinally collected many types of samples (i.e., blood, urine, saliva, buccal cells) for endpoints across seasons and years in the same individuals with a child and adult paired in the same household. This makes it possible to associate the actual exposures with the observed biomarkers in the same individuals. The Integrative Tools link exposure to OP pesticides to biomarkers of effect and early indicators of potential disease using a sequence of linked models. The Integrative Tools also provide a framework for accountability by evaluating the impact of policies and new scientific studies in reducing harmful effects from changes in exposures to OP pesticides in the community.
Community Outreach and Translation Core:
We intend for our work to remain consistent with the original proposal. Committee activities, seminars, co-sponsored continuing education courses, and other outreach efforts will continue. Translation of research findings and attendance at conferences and symposiums will go on uninterrupted. We feel strongly that communicating with the public health community and other stakeholders is the best way to ensure the relevance and impact of our work. Namely, Drs. Faustman and Karr will continue to foster interdisciplinary, inter-institution activity and communication from within the Center.
Specific planned activities include:
- Finalize, market and evaluate pesticide educational materials (toolkit) for clinicians in the community where the Center’s research is focused and nationally.
- Continue to provide guest lectures and trainee opportunities within the UW Schools of Public Health and Medicine as described above.
- Continue advisory roles to WA State Department of Health and other government agencies.
- Continue to provide research and practicum opportunities for trainees interested in the topics and activities related to the center work.
- Continue to partner with the NW PEHSU program and host a workshop on “practical application of evidence to practice” for core regional CEH topics including pesticides for key invited participants. The goal is to develop wider additional partnerships with medical and public health leaders in all of the NW region states.
- Publish an instructive case report as an invited publication in a special issue "Children’s Exposure to Environmental Contaminants" in the International Journal of Environmental Research and Public Health.
References:
- Armstrong JL, Dills RL, Yu J, Yost MG, and Fenske RA. 2014. A sensitive LC-MS/MS method for measurement of organophosphorus pesticides and their oxygen analogs in air sampling matrices. Journal of Environmental Science and Health, Part B. 49(2): 102-108.
- Cole TB, Li WF, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicological Sciences. Oct 1;141(2):409-22.
- Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh T, Costa L. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology. Vol. 219:181-189.
- Giordano G, Pizzuro D, VanDeMark K, Guizzetto M, Costa LG. 2009. Manganeze Inhibits the ability of astrocytes to promote neuronal differentiation. Toxicology and Applied Pharmacology. Vol. 240:226-235.
- Guizzetti M, Pathak S, Giordano D, Costa L. 2005. Effect of organophosporus insecticides and their metabolites on astroglial cell proliferation. Toxicology. Vol. 215 182-190.
- Guizzetti M, Moore NH, Giordano G, Costa LG. 2008. Modulation of neuritogenesis by astrocyte muscarinic receptors. J. Biol Chem. Vol. 283:1884-97.
- Guizzetti M, Moore NH, Giordano G, VanDeMark KL, Costa LG 2010. Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia. Vol. 58:1395-1406.
Journal Articles: 178 Displayed | Download in RIS Format
| Other center views: | All 510 publications | 227 publications in selected types | All 178 journal articles |
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Armstrong JL, Fenske RA, Yost MG, Galvin K, Tchong-French M, Yu J. Presence of organophosphorus pesticide oxygen analogs in air samples. Atmospheric Environment 2013;66:145-150. |
R834514 (2012) R834514 (2013) R834514 (Final) R834514C002 (Final) |
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Armstrong JL, Fenske RA, Yost MG, Tchong-French M, Yu J. Comparison of polyurethane foam and XAD-2 sampling matrices to measure airborne organophosphorus pesticides and their oxygen analogs in an agricultural community. Chemosphere 2013:92(4):451-457. |
R834514 (2013) R834514 (Final) R834514C002 (Final) |
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Armstrong JL, Fitzpatrick CF, Loftus CT, Yost MG, Tchong-French M, Karr CJ. Development of a unique multi-contaminant air sampling device for a childhood asthma cohort in an agricultural environment. Environmental Science: Processes & Impacts 2013;15(9):1760-1767. |
R834514 (2013) R834514 (Final) R834514C002 (Final) |
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Armstrong JL, Dills RL, Yu J, Yost MG, and Fenske RA. A sensitive LC-MS/MS method for measurement of organophosphorus pesticides and their oxygen analogs in air sampling matrices. Journal of Environmental Science and Health, Part B 2014;49(2):102-108. |
R834514 (Final) R834514C002 (Final) |
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Armstrong JL, Yost MG, Fenske RA. Development of a passive air sampler to measure airborne organophosphorus pesticides and oxygen analogs in an agricultural community. Chemosphere 2014;111:135-143. |
R834514 (Final) R834514C002 (Final) |
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Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics 2012;91(5):823-838. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. |
R834514C004 (Final) R834798C005 (Final) |
not available |
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Baker PE, Cole TB, Cartwright M, Suzuki SM, Thummel KE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chemico-Biological Interactions 2013;203(1):257-264. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit Exit |
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Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. ALTEX 2012;29(2):202-215. |
R834514 (2013) |
Exit Exit |
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Balk SJ, Council on Environmental Health, Section on Dermatology. Technical report—ultraviolet radiation: a hazard to children and adolescents. Pediatrics 2011;127(3):e791-e817. |
R834514 (2011) R834514 (2012) R834514 (Final) |
Exit Exit |
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Below JE, Earl DL, Shively KM, McMillin MJ, Smith JD, Turner EH, Stephan MJ, Al-Gazali LI, Hertecant JL, Chitayat D, Unger S, Cohn DH, Krakow D, Swanson JM, Faustman EM, Shendure J, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics. Whole-genome analysis reveals that mutations in inositol polyphosphate phosphatase-like 1 cause opsismodysplasia. American Journal of Human Genetics 2013;92(1):137-143. |
R834514 (2013) |
Exit Exit |
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Besler C, Heinrich K, Rohrer L, Doerries C, Riwanto M, Shih DM, Chroni A, Yonekawa K, Stein S, Schaefer N, Mueller M, Akhmedov A, Daniil G, Manes C, Templin C, Wyss C, Maier W, Tanner FC, Matter CM, Corti R, Furlong C, Lusis AJ, von Eckardstein A, Fogelman AM, Luscher TF, Landmesser U. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. The Journal of Clinical Investigation 2011;121(7):2693-2708. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Buka I, Osornio-Vargas A, Karr C. Melamine food contamination: relevance to Canadian children. Paediatrics and Child Health 2009;14(4):222-224. |
R834514 (2012) R834514 (2013) R834514 (Final) |
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Chen J, Zhang XL, Kusumo H, Costa LG, Guizzetti M. 2013. Cholesterol efflux is differentially regulated in neurons and astrocytes:Implications for brain cholesterol homeostasis. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 1831(2):263-275.PMC3534809. |
R834514 (2013) |
Exit |
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Clark NA, Demers PA, Karr CJ, Koehoorn M, Lencar C, Tamburic L, Brauer M. Effect of early life exposure to air pollution on development of childhood asthma. Environmental Health Perspectives 2010;118(2):284-290. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
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Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 2010;660:47-60. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514C004 (Final) R831709 (2007) |
Exit Exit |
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Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicological Sciences 2011;123(1):155-169. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Cole TB, Giordano G, Co AL, Mohar I, Kavanagh TJ, Costa LG. Behavioral characterization of GCLM-knockout mice, a model for enhanced susceptibility to oxidative stress. Journal of Toxicology 2011;2011:157687 (7 pp.). |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicology and Teratology. 2012;34(3):311-22. |
R834514 (Final) R834514C004 (Final) R834693 (2015) |
Exit Exit Exit |
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Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicology and Teratology 2012;34(3):311-322. |
R834514 (2011) R834514 (2012) R834514 (2013) R834693 (Final) |
Exit Exit Exit |
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Committee on Environmental Health, Committee on Infectious Diseases, Rogan WJ, Brady MT. Drinking water from private wells and risks to children. Pediatrics 2009;123(6):1599-1605. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Committee on Environmental Health, Tester JM. The built environment: designing communities to promote physical activity in children. Pediatrics 2009;123(6):1591-1598. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Committee on Environmental Health, Committee on Substance Abuse, Committee on Adolescence, Committee on Native American Child Health. Tobacco use: a pediatric disease. Pediatrics 2009;124(5):1474-1484. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Coronado GD, Vigoren EM, Griffith WC, Faustman EM, Thompson B. Organophosphate pesticide exposure among pome and non-pome farmworkers:a subgroup analysis of a community randomized trial. Journal of Occupational and Environmental Medicine 2009;51(4):500-509. |
R834514 (2011) R834514 (Final) R834514C001 (Final) R831709 (2007) R832734 (Final) |
Exit |
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Coronado GD, Griffith WC, Vigoren EM, Faustman EM, Thompson B. Where's the dust? Characterizing locations of azinphos-methyl residues in house and vehicle dust among farmworkers with young children. Journal of Occupational and Environmental Hygiene 2010;7(12):663-671. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C001 (Final) |
Exit |
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Coronado GD, Holte S, Vigoren E, Griffith WC, Faustman E, Thompson B. Organophosphate pesticide exposure and residential proximity to nearby fields:evidence for the drift pathway. Journal of Occupational and Environmental Medicine 2011;53(8):884-891. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C001 (Final) |
Exit |
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Coronado GD, Holte SE, Vigoren EM, Griffith WC, Barr DB, Faustman EM, Thompson B. Do workplace and home protective practices protect farm workers? Findings from the "For Healthy Kids" study. Journal of Occupational and Environmental Medicine 2012;54(9):1163-1169. |
R834514 (2013) R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Costa LG, Giordano G, Guizzetti M. In vitro models to study cell-cell interactions that influence developmental neurotoxicity. ALTEX 2010;27(Special Issue 1):303-308. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Costa LG, Giordano G, Furlong CE. Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression: the hunt goes on. Biochemical Pharmacology 2011;81(3):337-344. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Costa LG, Giordano G, Cole TB, Marsillach J, Furlong CE. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology 2013;307:115-122. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Costa LG. The birth and early years of INA, the International Neurotoxicology Association. Neurotoxicology 2013;36:89-103. |
R834514 (2013) |
Exit Exit |
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Costa LG, Giordano G, Guizzetti M. Inhibition of cholinergic muscarinic signaling by ethanol: potential mechanism of developmental neurotoxicity and biological plausibility for the beneficial effects of choline supplementation. The International Journal of Alcohol and Drug Research 2013;2(3):17-25. |
R834514 (2013) |
Exit Exit |
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Costa LG, Pellacani C, Dao K, Kavanagh TJ, Roque PJ. The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. NeuroToxicology 2015;48:68-76. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) |
Exit Exit Exit |
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Council on Environmental Health, Section on Dermatology. Ultraviolet radiation: a hazard to children and adolescents. Pediatrics 2011;127(3):588-597. |
R834514 (2013) |
Exit Exit Exit |
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Council on Environmental Health. Chemical-management policy: prioritizing children’s health. Pediatrics 2011;127(5):983-990. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Council on Environmental Health. Policy statement: pesticide exposure in children. Pediatrics 2012;130(6):e1757-e1763. |
R834514 (2012) |
Exit Exit |
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Daniell WE, Van Tung L, Wallace RM, Havens DJ, Karr CJ, Bich Diep N, Croteau GA, Beaudet NJ, Duy Bao N. Childhood lead exposure from battery recyling in Vietnam. Biomed Research International 2015;2015:193715. |
R834514 (Final) |
Exit |
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Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. Human PON1, a biomarker of risk of disease and exposure. Chemico-Biological Interactions 2010;187(1-3):355-361. |
R834514 (2011) R834514 (2012) R834514 (2013) R831709 (2007) |
Exit Exit Exit |
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Furlong CE. Exposure to triaryl phosphates: metabolism and biomarkers of exposure. Journal of Biological Physics and Chemistry 2011;11(4):165-171. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Furlong CE, Marsillach J, Jarvik GP, Costa LG. Paraoxonases-1,-2 and-3: what are their functions? Chemico-Biological Interactions 2016;259(Pt B):51-62. |
R834514 (Final) |
Exit Exit Exit |
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Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. Developmental expression of paraoxonase 2. Chemico-Biological Interactions 2016;259(Pt B):168-174. |
R834514 (Final) |
Exit Exit Exit |
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Gibbs JL, Yost MG, Negrete M, Fenske RA. Passive sampling for indoor and outdoor exposures to chlorpyrifos, azinphos-methyl, and oxygen analogs in a rural agricultural community. Environmental Health Perspectives 2017;125(3):333-341. |
R834514 (Final) R834514C002 (Final) |
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Giordano G, Guizzetti M, Dao K, Mattison HA, Costa LG. Ethanol impairs muscarinic receptor-induced neuritogenesis in rat hippocampal slices: role of astrocytes and extracellular matrix proteins. Biochemical Pharmacology 2011;82(11):1792-1799. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Giordano G, Cole TB, Furlong CE, Costa LG. Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role? Toxicology and Applied Pharmacology 2011;256(3):369-378. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Giordano G, Costa LG. Developmental neurotoxicity: some old and new issues. ISRN Toxicology 2012;2012:814795. |
R834514 (2013) |
Exit Exit |
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Giordano G, Kavanagh TJ, Faustman EM, White CC, Costa LG. Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione. Toxicological Sciences 2013;132(2):399-408. |
R834514 (2013) |
Exit Exit Exit |
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Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radical Biology and Medicine 2013;58:98-108. |
R834514 (2013) R834514C004 (Final) |
Exit Exit |
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Griffith W, Curl CL, Fenske RA, Lu CA, Vigoren EM, Faustman EM. Organophosphate pesticide metabolite levels in pre-school children in an agricultural community:within-and between-child variability in a longitudinal study. Environmental Research 2011;111(6):751-756. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C002 (Final) |
Exit Exit Exit |
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Guizzetti M, Moore NH, Giordano G, VanDeMark KL, Costa LG. Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia 2010;58(12):1395-1406. |
R834514 (2011) R834514 (2012) R834514 (2013) R831709 (2007) |
Exit |
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Guizzetti M, Moore NH, VanDeMark KL, Giordano G, Costa LG. Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons. European Journal of Pharmacology 2011;659(2-3):102-107. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Guo Y, Lanktree MB, Taylor KC, Hakonsarson H, Lange LA, Keating BJ, IBC 50K SNP Array BMI Consortium. Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics 2013;22(1):184-201. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Harris S, Hermsen SA, Yu X, Hong SW, Faustman EM. Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. Reproductive Toxicology 2015;58:149-159. |
R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
Exit Exit Exit |
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Harris S, Wegner S, Hong SW, Faustman EM. Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicology in Vitro 2016;32:123-131. |
R834514 (Final) R834514C003 (Final) R833772 (2009) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2016) R835738C004 (2017) |
Exit Exit Exit |
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Harris S, Shubin SP, Wegner S, Van Ness K, Green F, Hong SW, Faustman EM. The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicology In Vitro 2016;36:210-215. |
R834514 (Final) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2016) R835738C004 (2017) |
Exit Exit |
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Hofmann JN, Keifer MC, Furlong CE, De Roos AJ, Farin FM, Fenske RA, van Belle G, Checkoway H. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environmental Health Perspectives 2009;117(9):1402-1408. |
R834514 (2012) R834514 (2013) |
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Hofmann JN, Keifer MC, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occupational and Environmental Medicine 2010;67(6):375-386. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Hohl SD, Gonzalez C, Carosso E, Ibarra G, Thompson B. "I did it for us and I would do it again": perspectives of rural Latinos on providing biospecimens for research. American Journal of Public Health 2014;104(5):911-916. |
R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Holme F, Thompson B, Holte S, Vigoren EM, Espinoza N, Ulrich A, Griffith W, Faustman EM. The role of diet in children's exposure to organophosphate pesticides. Environmental Research 2016;147:133-140. |
R834514 (Final) R834514C001 (2015) R834514C001 (Final) |
Exit Exit Exit |
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Inoue S, Becker AL, Kim J-H, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H-B, Furlong CE, Oh K, Lee K-H, Gao D, Chung J-H, Cangelosi GA. Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum. PLoS One 2014;9(1):e86018. |
R834514 (Final) R834514C004 (2015) |
Exit Exit |
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Jackson JE, Yost MG, Karr CJ, Fitzpatrick C, Lamb BK, Chung S, Chen J, Avise J, Rosenblatt RA, Fenske RA. Public health impacts of climate change in Washington State: projected mortality risks due to heat events and air pollution. Climatic Change 2010;102(1-2):159-186. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C002 (Final) |
Exit |
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Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG. Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. Toxicology and Applied Pharmacology 2009;236(2):142-153. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Karr CJ, Rudra CB, Miller KA, Gould TR, Larson T, Sathyanarayana S, Koenig JQ. Infant exposure to fine particulate matter and traffic and risk of hospitalization for RSV bronchiolitis in a region with lower ambient air pollution. Environmental Research 2009;109(3):321-327. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Karr CJ, Demers PA, Koehoorn MW, Lencar CC, Tamburic L, Brauer M. Influence of ambient air pollutant sources on clinical encounters for infant bronchiolitis. American Journal of Respiratory and Critical Care Medicine 2009;180(10):995-1001. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Karr CJ. Adding fuel to the fire: increasing evidence for developmental toxicity of indoor solid fuel combustion. Archives of Pediatric & Adolescent Medicine 2011;165(6):565-566. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Karr CJ. Children's environmental health in agricultural settings. Journal of Agromedicine 2012;17(2):127-139. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Karr C. Addressing environmental contaminants in pediatric practice. Pediatrics in Review 2011;32(5):190-200. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Kim DS, Burt AA, Ranchalis JE, Richter RJ, Marshall JK, Eintracht JF, Rosenthal EA, Furlong CE, Jarvik GP. Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. Journal of Lipids 2012;2012:476316 (11 pp.). |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Kim DS, Burt AA, Ranchalis JE, Richter RJ, Marshall JK, Nakayama KS, Jarvik ER, Eintracht JF, Rosenthal EA, Furlong CE, Jarvik JP. Dietary cholesterol increases paraoxonase 1 enzyme activity. Journal of Lipid Research 2012;53(11):2450-2458. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Kim DS, Burt AA, Crosslin DR, Robertson PD, Ranchalis JE, Boyko EJ, Nickerson DA, Furlong CE, Jarvik GP. Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL. Journal of Lipid Research 2013;54(2):552-560. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Kim DS, Burt AA, Ranchalis JE, Jarvik ER, Rosenthal EA, Hatsukami TS, Furlong CE, Jarvik GP. Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol. Journal of Lipid Research 2013;54(5):1512-1520. |
R834514 (2013) |
Exit Exit Exit |
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Kim DS, Marsillach J, Furlong CE, Jarvik GP. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease. Pharmacogenomics 2013;14(12):1495-1515. |
R834514 (2013) R834514C004 (Final) |
Exit |
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Kim DS, Burt AA, Rosenthal EA, Ranchalis JE, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. Journal of the American Heart Association 2014;3(3):e000902. |
R834514 (Final) R834514C004 (2015) |
Exit Exit |
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Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth Jr. WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. Journal of Lipid Research 2014;55(6):1173-1178. |
R834514 (Final) R834514C004 (2015) |
Exit Exit Exit |
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Kim DS, Burt AA, Ranchalis JE, Jarvik LE, Eintracht JF, Furlong CE, Jarvik GP. Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants. Nutrition & Metabolism 2014;11(1):44 (9 pp.). |
R834514C004 (2015) |
Exit Exit |
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Kim DS, Burt AA, Ranchalis JE, Vuletic S, Vaisar T, Li WF, Rosenthal EA, Dong W, Eintracht JF, Motulsky AG, Brunzell JD, Albers JJ, Furlong CE, Jarvik GP. PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity. Journal of Lipid Research 2015;56(7):1351-1362. |
R834514 (Final) R834514C004 (2015) |
Exit Exit Exit |
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Kim DS, Li YK, Bell GA, Burt AA, Vaisar T, Hutchins PM, Furlong CE, Otvos JD, Polak JF, Arnan MK, Kaufman JD, McClelland RL, Longstreth Jr WT, Jarvik GP. Concentration of smaller high-density lipoprotein particle (HDL-P) is inversely correlated with carotid intima media thickening after confounder adjustment: the Multi Ethnic Study of Atherosclerosis (MESA). Journal of the American Heart Association 2016;5(5):e002977. |
R834514 (Final) |
Exit Exit Exit |
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Kim HY, Wegner SH, Van Ness KP, Park JJ, Pacheco SE, Workman T, Hong S, Griffith W, Faustman EM. Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells. Reproductive Toxicology 2016;65:212-223. |
R834514 (Final) R834514C003 (2015) R834514C003 (Final) |
Exit Exit Exit |
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Kim JH, Stevens RC, MacCoss MJ, Goodlett DR, Scherl A, Richter RJ, Suzuki SM, Furlong CE. Identification and characterization of biomarkers of organophosphorus exposures in humans. Advances in Experimental Medicine and Biology 2010;660:61-71. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Kim JH, Yeo WH, Shu Z, Soelberg SD, Inoue S, Kalyanasundaram D, Ludwig J, Furlong CE, Riley JJ, Weigel KM, Cangelosi GA, Oh K, Lee KH, Gao D, Chung JH. Immunosensor towards low-cost, rapid diagnosis of tuberculosis. Lab on a Chip 2012;12(8):1437-1440. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Kim NJ, Vasquez VB, Torres E, Nicola RM, Karr C. Breaking the silence: sexual harassment of Mexican women farmworkers. Journal of Agromedicine 2016;21(2):154-162. |
R834514 (Final) |
Exit |
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Kullman SW, Hamm JT, Hinton DE. Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes). Archives of Biochemistry and Biophysics 2000;380(1):29-38. |
R834514 (2011) R834514 (Final) R825298 (Final) |
Exit Exit |
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Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, et al. Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height. American Journal of Human Genetics 2011;88(1):6-18. |
R834514 (2011) R834514 (Final) |
Exit Exit |
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Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O. Exposure to tri-o-cresyl phosphate detected in jet airplane passengers. Toxicology and Applied Pharmacology 2011;256(3):337-347. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Loftus C, Yost M, Sampson P, Arias G, Torres E, Vasquez VB, Bhatti P, Karr C. Regional PM2.5 and asthma morbidity in an agricultural community: a panel study. Environmental Research 2015;136:505-512. |
R834514 (2015) R834514 (Final) R834514C002 (2015) R834514C002 (Final) |
Exit Exit Exit |
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Loftus C, Yost M, Sampson P, Torres E, Arias G, Breckwich Vasquez V, Hartin K, Armstrong J, Tchong French M, Vedal S, Bhatti P, Karr C. Ambient ammonia exposures in an agricultural community and pediatric asthma morbidity. Epidemiology 2015;26(6):794-801. |
R834514 (2015) |
Exit |
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MacIntyre EA, Karr CJ, Koehoorn M, Demers P, Tamburic L, Lencar C, Brauer M. Otitis media incidence and risk factors in a population-based birth cohort. Paediatrics and Child Health 2010;15(7):437-442. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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MacIntyre EA, Karr CJ, Koehoorn M, Demers PA, Tamburic L, Lencar C, Brauer M. Residential air pollution and otitis media during the first two years of life. Epidemiology 2011;22(1):81-89. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Mackenzie Ross SJ, Brewin CR, Curran HV, Furlong CE, Abraham-Smith KM, Harrison V. Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. Neurotoxicology and Teratology 2010;32(4):452-459. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Malen R, Knerr S, Delgado F, Fullerton SM, Thompson B. Rural Mexican-Americans’ perceptions of family health history, genetics, and disease risk: implications for disparities-focused research dissemination. Journal of Community Genetics 2016;7(1):91-96. |
R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Marsillach J, Richter RJ, Kim JH, Stevens RC, MacCoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE. Biomarkers of organophosphorus (OP) exposures in humans. NeuroToxicology 2011;32(5):656-660. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Furlong CE. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chemico-Biological Interactions 2013;203(1):85-90. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Marsillach J, Costa LG, Furlong CE. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 2013;307:46-54. |
R834514 (2013) R834514C004 (Final) |
Exit Exit |
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Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 2014;9(10):e110054. |
R834514 (Final) R834514C004 (2015) |
Exit Exit |
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Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, deBoer IH, McMahon MA, Hoofnagle AN, DCCT/EDIC Research Group. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. Journal of Proteome Research 2015;14(5):2046-2054. |
R834514 (Final) R834514C004 (2015) |
Exit Exit Exit |
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Marsillach J, Costa LG, Furlong CE. Paraoxonase-1 and early-life environmental exposures. Annals of Global Health 2016;82(1):100-110. |
R834514 (Final) |
Exit Exit Exit |
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McMillin MJ, Below JE, Shively KM, Beck AE, Gildersleeve HI, Pinner J, Gogola GR, Hecht JT, Grange DK, Harris DJ, Earl DL, Jagadeesh S, Mehta SG, Robertson SP, Swanson JM, Faustman EM, Mefford HC, Shendure J, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics. Mutations in ECEL1 cause distal arthrogryposis type 5D. American Journal of Human Genetics 2013;92(1):150-156. |
R834514 (2013) |
Exit Exit |
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Mehta AJ, Zanobetti A, Bind MA, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. Long-term exposure to ambient fine particulate matter and renal function in older men: the Veterans Administration Normative Aging Study. Environmental Health Perspectives 2016;124(9):1353-1360. |
R834514C004 (Final) R834798 (Final) R834798C002 (Final) |
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Moreira EG, Yu X., Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM. Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicology and Applied Pharmacology 2010;245(3):310-325. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) R831709 (2007) |
Exit Exit Exit |
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Nonnenmann MW, Coronado G, Thompson B, Griffith WC, Hanson JD, Vesper S, Faustman EM. Utilizing pyrosequencing and quantitative PCR to characterize fungal populations among house dust samples. Journal of Environmental Monitoring 2012;14(8):2038-2043. |
R834514 (2013) R834514 (Final) |
Exit |
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O’Toole TE, Conklin DJ, Bhatnagar A. Environmental risk factors for heart disease. Reviews on Environmental Health 2008;23(3):167-202. |
R834514 (2011) R834514 (Final) EM833367 (2009) EM833367 (Final) |
Exit |
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Paulson JA, Karr CJ, Seltzer JM, Cherry DC, Sheffield PE, Cifuentes E, Buka I, Amler RW. Development of the pediatric environmental health specialty unit network in North America. American Journal of Public Health 2009;99(Suppl 3):S511-S516. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Perkins A, Walters F, Sievert J, Rhodes B, Morrissey B, Karr CJ. Home use of a pyrethroid-containing pesticide and facial paresthesia in a toddler:a case report. International Journal of Environmental Research and Public Health 2016;13(8):829 (7 pp.). |
R834514 (Final) |
Exit Exit Exit |
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Perla ME, Rue T, Cheadle A, Krieger J, Karr CJ. Population-based comparison of biomarker concentrations for chemicals of concern among Latino-American and non-Hispanic white children. Journal of Immigrant and Minority Health 2015;17(3):802-819. |
R834514 (2015) |
Exit |
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Perla ME, Iman E, Campos L, Perkins A, Liebman AK, Miller ME, Beaudet NJ, Karr CJ. Agricultural occupational health and safety perspectives among Latino-American youth. Journal of Agromedicine 2015;20(2):167-177. |
R834514 (2015) |
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Perla ME, Rue T, Cheadle A, Krieger J, Karr CJ. Biomarkers of insecticide exposure and asthma in children: a National Health and Nutrition Examination Survey (NHANES) 1999-2008 analysis. Archives of Environmental & Occupational Health 2015;70(6):309-322. |
R834514 (2015) |
Exit |
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Pizzurro DM, Dao K, Costa LG. Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione. Toxicology 2014;318:59-68. |
R834514C003 (Final) |
Exit Exit Exit |
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Pizzurro DM, Dao K, Costa LG. Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons. Toxicology and Applied Pharmacology 2014;274(3):372-382. |
R834514C003 (Final) |
Exit Exit Exit |
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Plascak JJ, Molina Y, Wu-Georges S, Idris A, Thompson B. Latino residential segregation and self-rated health among Latinos: Washington State Behavioral Risk Factor Surveillance System, 2012-2014. Social Science & Medicine 2016;159:38-47. |
R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Postma J, Karr C, Kieckhefer G. Community health workers and environmental interventions for children with asthma: a systematic review. Journal of Asthma 2009;46(6):564-576. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Postma J, Younglove LR, Odom-Maryon T, Brooks K, Burbacher TM, Butterfield PW, Butterfield PG, Cederblom N, Grant K, Beresford SAA, Faustman EM. Hispanic representation in a longitudinal birth cohort study. Journal of Health Disparities Research and Practice 2016;9(2):66-77. |
R834514 (Final) |
Exit Exit |
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Raanan R, Gunier RB, Balmes JR, Beltran AJ, Harley KG, Bradman A, Eskenazi B. Elemental sulfur use and associations with pediatric lung function and respiratory symptoms in an agricultural community (California, USA). Environmental Health Perspectives 2017;125(8):087007 (8 pp.). |
R834514 (Final) R826709 (2002) R831710 (Final) R834513 (Final) |
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Ramaprasad J, Tsai MG, Fenske RA, Faustman EM, Griffith WC, Felsot AS, Elgethun K, Weppner S, Yost MG. Children's inhalation exposure to methamidophos from sprayed potato fields in Washington State:exploring the use of probabilistic modeling of meteorological data in exposure assessment. Journal of Exposure Science and Environmental Epidemiology 2009;19(6):613-623. |
R834514 (Final) R834514C002 (Final) R831709 (2007) |
Exit Exit |
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Richter RJ, Jarvik GP, Furlong CE. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicology and Applied Pharmacology 2009;235(1):1-9. |
R834514 (2012) R834514 (2013) R834514 (Final) R831709 (2007) |
Exit Exit Exit |
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Richter RJ, Jarvik GP, Furlong CE. Paraoxonase 1 status as a risk factor for disease or exposure. Advances in Experimental Medicine and Biology 2010;660:29-35. |
R834514 (2011) R834514 (2013) |
Exit |
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Roberts JR, Karr CJ, Council on Environmental Health. Pesticide exposure in children. Pediatrics 2012;130(6):e1765-e1788. |
R834514 (2013) R834514 (Final) |
Exit Exit |
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Roberts JR, Karr CJ, de Ybarrondo L, McCurdy LE, Freeland KD, Husley TC, Forman J. Improving pediatrician knowledge about environmental triggers of asthma. Clinical Pediatrics 2013;52(6):527-533. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Roberts JR, Newman N, McCurdy LE, Chang JS, Salas MA, Eskridge B, De Ybarrondo L, Sandel M, Mazur L, Karr CJ. Integrating environmental management of asthma into pediatric health care: what worked and what still needs improvement? Clinical Pediatrics 2016;55(14):1271-1278. |
R834514 (Final) |
Exit Exit |
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Robinson JF, Guerrette Z, Yu X, Hong S, Faustman EM. A systems-based approach to investigate dose-and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Research. Part B: Developmental and Reproductive Toxicology 2010;89(3):188-200. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit |
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Robinson JF, Yu X, Hong S, Zhou C, Kim N, DeMasi D, Faustman EM. Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reproductive Toxicology 2010;29(3):279-285. |
R834514 (2011) R834514 (2012) R834514 (2013) R831709 (2007) |
Exit Exit Exit |
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Robinson JF, Port JA, Yu X, Faustman EM. Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders. Birth Defects Research. Part A--Clinical and Molecular Teratology 2010;88(10):920-930. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM. Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reproductive Toxicology 2010;30(2):284-291. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
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Robinson JF, Yu X, Moreira EG, Hong S, Faustman EM. Arsenic-and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicology and Applied Pharmacology 2011;250(2):117-129. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
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Robinson JF, Theunissen PT, van Dartel DA, Pennings JL, Faustman EM, Piersma AH. Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology. Reproductive Toxicology 2011;32(2):180-188. |
R834514 (Final) R834514C003 (Final) |
Exit Exit Exit |
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Sathyanarayana S, Basso O, Karr CJ, Lozano P, Alavanja M, Sandler DP, Hoppin JA. Maternal pesticide use and birth weight in the Agricultural Health Study. Journal of Agromedicine 2010;15(2):127-136. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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Sathyanarayana S, Zhou C, Rudra CB, Gould T, Larson T, Koenig J, Karr CJ. Prenatal ambient air pollution exposure and small for gestational age birth in the Puget Sound Air Basin. Air Quality, Atmosphere & Health 2013;6(2):455-463. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Bohm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM; Look AHEAD Research Group; DIAGRAM consortium, Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW 2nd, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics 2012;90(3):410-425. |
R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Schopfer LM, Furlong CE, Lockridge O. Development of diagnostics in the search of an explanation of aerotoxic syndrome. Analytical Biochemistry 2010;404(1):64-74. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit Exit |
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Serrano SE, Karr CJ, Seixas NS, Nguyen RH, Barrett ES, Janssen S, Redmon B, Swan SH, Sathyanarayana S. Dietary phthalate exposure in pregnant women and the impact of consumer practices. International Journal of Environmental Research and Public Health 2014;11(6):6193-6215. PMID:24927036. |
R834514 (2015) |
Exit Exit |
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Shepherd-Banigan M, Ulrich A, Thompson B. Macro-activity patterns of farmworker and non-farmworker children living in an agricultural community. Environmental Research 2014;132:176-181. |
R834514 (Final) R834514C001 (Final) |
Exit Exit Exit |
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Shepherd-Banigan M, Hohl SD, Vaughan C, Ibarra G, Carosso E, Thompson B. "The promotora explained everything": participant experiences during a household-level diabetes education program. The Diabetes Educator 2014;40(4):507-515. |
R834514C001 (2015) |
Exit |
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Smith MN, Griffith WC, Beresford SA, Vredevoogd M, Vigoren EM, Faustman EM. Using a biokinetic model to quantify and optimize cortisol measurements for acute and chronic environmental stress exposure during pregnancy. Journal of Exposure Science and Environmental Epidemiology 2014;24(5):510-516. |
R834514 (2013) R834514 (Final) |
Exit |
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Smith MN, Wilder CS, Griffith WC, Workman T, Thompson B, Dills R, Onstad G, Vredevoogd M, Vigoren EM, Faustman EM. Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region. Biomarkers 2015;20(5):299-305. |
R834514 (2015) R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Smith MN, Grice J, Cullen A, Faustman EM. A toxicological framework for the prioritization of Children’s Safe Product Act data. International Journal of Environmental Research and Public Health 2016;13(4):431 (24 pp.). |
R834514 (Final) R835738 (2016) R835738 (2017) R835738C005 (2015) R835738C005 (2016) R835738C005 (2017) |
Exit Exit Exit |
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|
Smith MN, Workman T, McDonald KM, Vredevoogd MA, Vigoren EM, Griffith WC, Thompson B, Coronado GD, Barr D, Faustman EM. Seasonal and occupational trends of five organophosphate pesticides in house dust. Journal of Exposure Science and Environmental Epidemiology 2017;27(4):372-378. |
R834514 (Final) |
Exit |
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|
Smith M, Hubal E, Faustman E. A Case study on the utility of predictive toxicology tools in alternatives assessments for hazardous chemicals in children's consumer products. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 2020;30(1):160-170. |
R834514 (Final) |
Exit |
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Souza-Nogueira A, Camargo AE, Remondi FA, Paoliello MM, Richter RJ, Furlong CE, Barbosa DS, Maes M, Moreira EG. Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score. Archives of Endocrinology and Metabolism 2016;60(5):426-435. |
R834514 (Final) |
Exit Exit |
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Sridharan G, Wamalwa D, John-Stewart G, Tapia K, Langat A, Moraa Okinyi H, Adhiambo J, Chebet D, Maleche-Obimbo E, Karr CJ, Benki-Nugent S. High viremia and wasting before antiretroviral therapy are associated with pneumonia in early-treated HIV-infected Kenyan infants. Journal of the Pediatric Infectious Diseases Society 2017;6(3):245-252. |
R834514 (Final) |
Exit Exit |
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Stanaway IB, Wallace JC, Shojaie A, Griffith WC, Hong S, Wilder CS, Green FH, Tsai J, Knight M, Workman T, Vigoren EM, McLean JS, Thompson B, Faustman EM. Human oral buccal microbiomes are associated with farmworker status and azinphos-methyl agricultural pesticide exposure. Applied and Environmental Microbiology 2017;83(2):e02149-16. |
R834514 (Final) |
Exit Exit Exit |
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|
Stanaway I, Wallace J, Hong S, WIlder C, Green F, Tsai J, Knight M, Workman T, Vigoren E, Smith M, Griffith W, Thompson B, Shojaie A, Faustman E. Alteration of oral microbiome composition in children living with pesticide-exposed farm workers. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 2023;248(114090). |
R834514 (Final) R832733 (Final) |
Exit |
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|
Strong LL, Thompson B, Koepsell TD, Meischke H, Coronado GD. Reducing the take-home pathway of pesticide exposure:behavioral outcomes from the Para Niños Saludables study. Journal of Occupational and Environmental Medicine 2009;51(8):922-933. |
R834514 (Final) R834514C001 (Final) R831709 (2007) |
Exit |
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|
Strong LL, Starks HE, Meischke H, Thompson B. Perspectives of mothers in farmworker households on reducing the take-home pathway of pesticide exposure. Health Education & Behavior 2009;36(5):915-929. |
R834514 (Final) R834514C001 (Final) |
Exit Exit Exit |
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|
Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. Engineering human PON1 in an E. coli expression system. Advances in Experimental Medicine and Biology 2010;660:37-45. |
R834514 (2011) R834514 (2012) R834514 (2013) R831709 (2007) |
Exit |
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|
Thompson B, Griffith WC, Barr DB, Coronado GD, Vigoren EM, Faustman EM. Variability in the take-home pathway: farmworkers and non-farmworkers and their children. Journal of Exposure Science & Environmental Epidemiology 2014;24(5):522-531. |
R834514 (Final) R834514C001 (Final) |
Exit Exit |
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Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Levva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silani V, Furlong CE, Brown Jr. RH, Landers JE. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of Neurology 2010;68(1):102-107. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
Exit |
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|
Wegner SH, Yu X, Pacheco Shubin S, Griffith WC, Faustman EM. Stage-specific signaling pathways during murine testis development and spermatogenesis: a pathway-based analysis to quantify developmental dynamics. Reproductive Toxicology 2015;51:31-39. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) R835738 (2016) R835738 (2017) R835738C004 (2015) R835738C004 (2017) |
Exit Exit Exit |
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|
Wegner S, Hong S, Yu X, Faustman EM. Preparation of rodent testis co-cultures. Current Protocols in Toxicology 2013;Chapter 16:Unit 16.10. |
R834514 (2013) |
Exit |
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|
Wegner S, Yu X, Kim HY, Harris S, Griffith WC, Hong S, Faustman EM. Effect of dipentyl phthalate in 3-dimensional in vitro testis co-culture is attenuated by cyclooxygenase-2 inhibition. Journal of Toxicology and Environmental Health Sciences 2014;6(8):161-169. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) |
Exit Exit |
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Wegner S, Park J, Workman T, Workman T, Hermsan S, Wallace J, Stanaway I, Kim H, Griffith W, Hong S, Faustman E. Anchoring a dynamic in vitro model of human neuronal differentiation to key processes of early brain development in vivo. Reproductive Toxicology 2020;91:116-130. |
R834514 (Final) R835738 (2018) |
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Wegner S, Workman T, Park J, Harris S, Wallace J, Stanaway I, Hong S, Hansen B, Griffith W, Faustman E. A dynamic in vitro developing testis model reflects structures and functions of testicular development in vivo. REPRODUCTIVE TOXICOLOGY 2023;118(108362) |
R834514 (Final) R835738 (Final) |
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Weiner MW, Meyerhoff DJ, Neylan TC, Hlavin J, Ramage ER, McCoy D, Studholme C, Cardenas V, Marmar C, Truran D, Chu PW, Kornak J, Furlong CE, McCarthy C. The relationship between Gulf War war illness, brain N-acetylaspartate, and post-traumatic stress disorder. Military Medicine 2011;176(8):896-902. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
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Weldon BA, Shubin SP, Smith MN, Workman T, Artemenko A, Griffith WC, Thompson B, Faustman EM. Urinary microRNAs as potential biomarkers of pesticide exposure. Toxicology and Applied Pharmacology 2016;312:19-25. |
R834514 (Final) R834514C001 (Final) |
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Whitely Binder LC, Barcelos JK, Booth DB, Darzen M, Elsner MM, Fenske R, Graham TF, Hamlet AF, Hodges-Howell J, Jackson JE, Karr C, Keys PW, Littell JS, Mantua N, Marlow J, McKenzie D, Robinson-Dorn M, Rosenberg EA, Stockle CO, Vano JA. Preparing for climate change in Washington State. Climatic Change 2010;102(1-2):351-376. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C002 (Final) |
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Woodruff TJ, Parker JD, Darrow LA, Slama R, Bell ML, Choi H, Glinianaia S, Hoggatt KJ, Karr CJ, Lobdell DT, Wilhelm M. Methodological issues in studies of air pollution and reproductive health. Environmental Research 2009;109(3):311-320. |
R834514 (2012) R834514 (2013) R834514 (Final) R833863 (2009) |
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Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and ethylmercury in mouse embryonic fibroblast. Toxicological Sciences 2010;114(2):356-377. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) R834514C003 (Final) R831709 (2007) |
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Yu X, Sidhu JS, Hong S, Robinson JF, Ponce RA, Faustman EM. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological Sciences 2011;120(2):403-412. |
R834514 (2011) R834514 (2012) R834514 (2013) R834514 (Final) |
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Zachek CM, Karr CJ, Daniell W, Sweeney C, Miller MD. A network of Pediatric Environmental Health Specialty Units (PEHSUs): filling a critical gap in the health care system. Medycyna Środowiskowa--Environmental Medicine 2012;15(3):9-20. |
R834514 (2012) R834514 (2013) R834514 (Final) |
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Zhou C, Chen J, Zhang X, Costa LG, Guizzetti M. Prenatal ethanol exposure up-regulates the cholesterol transporters ATP-binding cassette A1 and G1 and reduces cholesterol levels in the developing rat brain. Alcohol and Alcoholism 2014;49(6):626-634. |
R834514 (2015) R834514 (Final) R834514C003 (2015) R834514C003 (Final) |
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Marsillach, J., E.J. Hsieh, R.J. Richter, M.J. Maccoss, and C.E. Furlong, Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact, 2012. |
R834514C004 (Final) |
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Kim, DS, Crosslin, DR, Auer, PL, Suzuki, SM, Marsillach, J, Burt, AA, Gordon, AS, Meschia, JF, Nalls, MA, Worrall, BB, Longstreth, WT, Jr., Gottesman, RF, Furlong, CE, Peters, U, Rich, SS, Nickerson, DA and Jarvik, GP. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 55(6):1173-1178. 4031948. |
R834514C004 (Final) |
not available |
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Guizzetti, M., N.H. Moore, G. Giordano, K.L. VanDeMark, and L.G. Costa, Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia, 2010. 58(12):p. 1395-406. PMCID2925144. |
R834514C004 (Final) |
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Richter RJ, Jarvik GP, Furlong CE. 2010. Paraoxonase 1 (PON1) Status as a Risk Factor for Disease or Exposure. Adv Exp Med Biol 660:29-35. PMID 20221868. DOI 10.1007/978-1-60761-350-3_. NIHMSID #193805. |
R834514C004 (Final) |
not available |
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Kim, DS, Burt, AA, Ranchalis, JE, Richter, RJ, Marshall, JK, Nakayama, KS, Jarvik, ER, Eintracht, JF, Rosenthal, EA, Furlong, CE and Jarvik, GP. 2012. Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res. 53(11):2450-8. PMCID:PMC3466014. |
R834514C004 (Final) |
not available |
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Kim, DS, Burt, A, Ranchalis, J, Richter, RJ, Marshall, E, Rosenthal, E, Furlong, C and Jarvik, GP. 2012. Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids 2012:476316. PMCID:PMC3364586. |
R834514C004 (Final) |
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Costa, LG, Giordano, G, Cole, TB, Marsillach, J and Furlong, CE. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology. 307(10):115-122. PMCID:PMC3516631. |
R834514C004 (Final) |
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Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Furlong, CE. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact 203(1):85-90. |
R834514C004 (Final) |
not available |
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Kim, DS, Burt, AA, Crosslin, DR, Robertson, PD, Ranchalis, JE, Boyko, EJ, Nickerson, DA, Furlong, CE and Jarvik, GP. 2013. Novel common and rare genetic determinants of paraoxonase activity:FTO, SERPINA12, and ITGAL. J Lipid Res. 54(2):552-60. PMCID:PMC3588879. |
R834514C004 (Final) |
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Costa, LG, de Laat, R, Dao, K, Pellacani, C, Cole, TB and Furlong, CE. 2013. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology. 3942372. |
R834514C004 (Final) |
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Costa, LG, Tait, L, de Laat, R, Dao, K, Giordano, G, Pellacani, C, Cole, TB and Furlong, CE. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin:a mechanism of neuroprotection? Neurochem Res. 38(9):1809-18. 3735620. |
R834514C004 (Final) |
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Cole, TB, Li, WF, Co, AL, Hay, AM, MacDonald, JW, Bammler, TK, Farin, FM, Costa, LG and Furlong, CE. 2014. Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon is Associated with Paraoxonase 1 (PON1)-Modulated Effects in Maternal and Fetal Tissues. Toxicol Sci. |
R834514C004 (Final) |
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Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. 2016. Developmental expression of paraoxonase 2. Chem Biol Interact. pii:S0009-2797(16)30116-8. doi:10.1016/j.cbi.2016.04.001. PMID:27062895. |
R834514C004 (Final) |
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Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1,-2 and-3:What are their functions? Chem Biol Interact. doi:10.1016/j.cbi.2016.05.036. PMID:27238723. |
R834514C004 (Final) R834513C003 (2016) |
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Marsillach J, Costa LG, Furlong CE. 2016. Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health. 82(1):100-10. PMID:27325068; PMCID:PMC4916371. |
R834514C004 (Final) |
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Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. |
R834514C004 (Final) R834798C003 (Final) |
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Burton C, Marsillach J, Zhang YS, Zhao W, Zheng X. Bioanalysis. 2015;7(13):1667-73. doi:10.4155/bio.15.90. Epub 2015 Jul 7** Judit Marsillach selected as a finalist for the Young Investigator Award to identify and reward promising early career researchers in the community. |
R834514C004 (Final) |
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Furlong, C.E., R.J. Richter, L.G. Costa, and G.P. Jarvik, Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics, in Chapter 9:Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. 2012, American Chemical Society:Available at:http://pubs.acs.org/doi/abs/10.1021/bk-2012-1099.ch009. p. 133-147. |
R834514C004 (Final) |
not available |
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Costa, L.G., G. Giordano, and C.E. Furlong, Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression:the hunt goes on. Biochem Pharmacol, 2011. 81(3):p. 337-344. PMCID3077125. |
R834514C004 (Final) |
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Kim, D.S., A.A. Burt, J.E. Ranchalis, R.J. Richter, J.K. Marshall, K.S. Nakayama, E.R. Jarvik, J.F. Eintracht, E.A. Rosenthal, C.E. Furlong, and G.P. Jarvik, Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res, 2012. 53(11):p. 2450-8. |
R834514C004 (Final) |
not available |
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Kim, D.S., A. Burt, J. Ranchalis, R.J. Richter, E. Marshall, E. Rosenthal, C. Furlong, and G.P. Jarvik, Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids, 2012. 2012(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364586/pdf/JL2012-476316.pdf). |
R834514C004 (Final) |
not available |
Supplemental Keywords:
Children’s health, environmental health, pesticide, environmental exposure, risk assessment, risk management, risk communication, community based participatory research, CBPR, intervention, Washington State, outreach and translation, mechanisms, susceptibility, genetics, gene-environment interactions, modeling, biostatistics, exposure assessment, exposure pathway, pesticide exposure, age-related differences, children's vulnerablity, biological markers, agricultural community, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Biochemistry, Children's Health, Environmental Policy, Biology, Risk Assessment, pesticide exposure, age-related differences, pesticides, children's vulnerablity, biological markers, agricultural communityProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834514C001 Community-Based Participatory Research
R834514C002 Pesticide Exposure Pathways
R834514C003 Molecular Mechanisms
R834514C004 Genetic Susceptibility
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.