Grantee Research Project Results
2002 Progress Report: CECEHDPR - University of Michigan
EPA Grant Number: R826710Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: CECEHDPR - University of Michigan
Investigators: Israel, Barbara A. , Keeler, Gerald J. , Remick, Daniel , Parker, Edith , Philbert, Martin , Brown, Randall , Robins, Thomas , Lin, Xihong
Current Investigators: Israel, Barbara A.
Institution: University of Michigan
EPA Project Officer: Hahn, Intaek
Project Period: September 1, 1998 through August 31, 2003 (Extended to August 31, 2005)
Project Period Covered by this Report: September 1, 2001 through August 31, 2002
Project Amount: $2,830,746
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Center for Children’s Environmental Health and Disease Prevention – University of Michigan consists of three core projects as follows:
Core 1: Community-Based Intervention to Reduce Environmental Triggers for
Asthma Among Children, and
Core 2: Indoor and Outdoor Air Contaminant Exposures
Please note: The Intervention and Exposure Cores of MCECH continue to have the same specific aims as stated in the proposal, but because the two are so integrated and have the same participants and current goals, their research teams and activities have been combined into one "meta"-project called: Community Action Against Asthma, or CAAA.
Specific Aims and Significance: There have been no changes in the specific aims. The asthma intervention core will test the ability of individually tailored interventions to reduce exposure to environmental contaminants and to improve asthma related health status. At the same time, the intervention will provide direct benefit to the children and families enrolled in the study. The central hypothesis being addressed in the asthma exposure core is that exposure to ambient air contaminants will aggravate the health status of asthmatic children largely through the potentiation of the adverse effects of common indoor air contaminants. Proving or refuting this hypothesis will lead to substantial advances in scientific knowledge and have a direct impact on public health recommendations.
Core 3: Chemokines in the Pathogenesis of Asthma
This research project will test the hypothesis that asthma-like pulmonary injury
is mediated by the local production of specific mediators, which are called
chemokines. Chemokines are small molecular weight proteins which induce the
movement and recruitment of inflammatory cells. The chemokines are powerful
mediators with long lasting and potent biological activities. The first specific
aim is to determine the acute and chronic pulmonary inflammation that develops
after direct injection of the chemokines into the lung. The assessment of
the injury will include a microscopic analysis of the lung as well as an
assessment of the nerves within the airways. The second specific aim is to
develop a mouse model of asthma-like pulmonary inflammation in response to
cockroach allergens. For this specific aim, a model in mice which is similar
to humans will be set up to attempt to decipher the specific mediators that
cause the lung injury. This model will be established by locating households
with high levels of cockroach allergens and using this material to immunize
the mice. The mice will be challenged by exposure to aerosols containing
the dust with the cockroach allergens and the pulmonary injury carefully
quantitated including an analysis of innervation of the airways. The third
specific aim is to investigate the signals responsible for inducing the cells
to make the chemokines. This will be done in cells sensitized and then challenged
with cockroach allergens. This will focus on reactive oxygen and reactive
nitrogen intermediates since they have been demonstrated to increase the
synthesis of chemokines. The last specific aim is to rigorously test the
central hypothesis that chemokines are important in causing asthma. This
will be tested by blocking the biological activity of the chemokines with
specific therapies to inhibit the chemokines and then determining if there
is a reduction in the pulmonary inflammation induced by repeated exposures
to the cockroach allergens. Successful completion of this project will both
delineate the underlying mechanisms of disease and identify potential novel
targets for intervention.
Progress Summary:
See individual Progress Reports for details – (R826710C001 – R826710C003 – 2002 Progress Reports)
Journal Articles: 22 Displayed | Download in RIS Format
| Other center views: | All 45 publications | 24 publications in selected types | All 22 journal articles |
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Clark NM, Brown RW, Parker E, Robins TG, Remick Jr. DG, Philbert MA, Keeler GJ, Israel BA. Childhood asthma. Environmental Health Perspectives 1999;107(Suppl 3):421-429. |
R826710 (Final) R826710C001 (1999) R826710C002 (1999) R826710C003 (1999) |
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Dvonch JT, Marsik FJ, Keeler GJ, Robins TG, Yip F, Morishita M. Field comparison of PM2.5 teom and PM2.5 manual filter-based measurement methods in urban atmospheres. Journal of Aerosol Science 2000;31(Suppl 1):190-191. |
R826710 (Final) |
Exit Exit |
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Edgren KK, Parker EA, Israel BA, Lewis TC, Salinas MA, Robins TG, Hill YR. Community involvement in the conduct of a health education intervention and research project: Community Action Against Asthma. Health Promotion Practice 2005;6(3):263-269. |
R826710 (Final) |
Exit Exit |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R831710 (2004) R831710 (2005) R831710 (Final) R831861 (2005) R831861 (2006) R831861C001 (2006) R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) R832141 (2006) R832141 (2007) R832141 (Final) |
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Farquhar SA, Parker EA, Schulz AJ, Israel BA. In their words: how Detroit residents perceive the effects of their physical environment. Local Environment:The International Journal of Justice and Sustainability 2005;10(3):259-274. |
R826710 (Final) |
Exit |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R826710 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R832139 (2006) R832141 (2006) R832141 (2007) R832141 (Final) |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391 (Final) R829391C005 (2006) R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831710C004 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832139 (2006) |
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Keeler GJ, Dvonch T, Yip FY, Parker EA, Isreal BA, Marsik FJ, Morishita M, Barres JA, Robins TG, Brakefield-Caldwell W, Sam M. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of Community Action Against Asthma (CAAA). Environmental Health Perspectives 2002;110(Suppl 2):173-181. |
R826710 (2002) R826710 (Final) |
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Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG. Eotaxin represents the principal eosinophil chemoattractant in a novel murine asthma model induced by house dust containing cockroach allergens. Journal of Immunology 2001;167(5):2808-2815. |
R826710 (2002) R826710 (Final) |
Exit Exit |
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Kim J, McKinley L, Siddiqui J, Bolgos GL, Remick DG. Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust. American Journal of Physiology-Lung Cellular and Molecular Physiology 2004;287(3):L503-L509. |
R826710 (2002) R826710 (Final) |
Exit Exit Exit |
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Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, Remick DG. Anti-tumor necrosis factor-α antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clinical and Experimental Allergy 2006;36(1):122-132. |
R826710 (Final) |
Exit Exit |
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Lewis TC, Robins TG, Joseph CLM, Parker EA, Israel BA, Rowe Z, Edgren KK, Salinas MA, Martinez ME, Brown RW. Identification of gaps in the diagnosis and treatment of childhood asthma using a community-based participatory research approach. Journal of Urban Health 2004;81(3):472-488. |
R826710 (Final) |
Exit |
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Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, Lin X, Parker EA, Israel BA, Gonzalez L, Hill Y. Air pollution-associated changes in lung function among asthmatic children in Detroit. Environmental Health Perspectives 2005;113(8):1068-1075. |
R826710 (Final) |
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Lopez ED, Parker EA, Edgren KK, Brakefield-Caldwell W. Disseminating research findings back to partnering communities: lessons learned from a community-based participatory research approach. Metropolitan Universities Journal 2005;16(1):57-76. |
R826710 (Final) |
Exit Exit |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Reproducibility of a novel model of murine asthma-like pulmonary inflammation. Clinical & Experimental Immunology 2004;136(2):224-231. |
R826710 (Final) |
Exit Exit |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma. Cytokine 2005;32(3-4):178-185. |
R826710 (2002) R826710 (Final) |
Exit |
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McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Respiratory Research 2006;7(1):129. |
R826710 (Final) |
Exit Exit |
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Parker EA, Israel BA, Williams M, Brakefield-Caldwell W, Lewis TC, Robins T, Ramirez E, Rowe Z, Keeler G. Community action against asthma: examining the partnership process of a community-based participatory research project. Journal of General Internal Medicine 2003;18(7):558-567. |
R826710 (Final) |
Exit |
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Parker EA, Baldwin GT, Israel B, Salinas MA. Application of health promotion theories and models for environmental health. Health Education & Behavior 2004;31(4):491-509. |
R826710 (Final) |
Exit Exit |
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Parker EA, Israel BA, Robins TG, Mentz G, Lin X, Brakefield-Caldwell W, Ramirez E, Edgren KK, Salinas M, Lewis TC. Evaluation of community action against asthma: a community health worker intervention to improve children's asthma-related health by reducing household environmental triggers for asthma. Health Education & Behavior 2008;35(3):376-395. |
R826710 (Final) |
Exit |
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Trout D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Applied Occupational and Environmental Hygiene 2003;18(11):953-960. |
R826710 (Final) |
Exit |
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Yip FY, Keeler GJ, Dvonch JT, Robins TG, Parker EA, Israel BA, Brakefield-Caldwell W. Personal exposures to particulate matter among children with asthma in Detroit, Michigan. Atmospheric Environment 2004;38(31):5227-5236. |
R826710 (Final) |
Exit Exit Exit |
Supplemental Keywords:
Children's Health, asthma, community-based intervention, indoor air quality, human health risk, human exposure, particulate matter, environmental monitoring, Michigan, exposure assessment., RFA, Health, Scientific Discipline, Air, Geographic Area, HUMAN HEALTH, Health Risk Assessment, Environmental Chemistry, Indoor Air Pollution, State, Risk Assessments, Health Effects, Allergens/Asthma, indoor air, Children's Health, Molecular Biology/Genetics, asthma, asthma triggers, acute lung injury, respiratory disease, second hand smoke, airway disease, respiratory problems, exposure, asthma indices, children, indoor air chemistry, air pollution, Human Health Risk Assessment, airway inflammation, assessment of exposure, childhood respiratory disease, children's vulnerablity, susceptibility, asthmatic children, human exposure, airborne pollutants, inhalation, cigarette smoke, children's environmental health, allergic response, environmental tobacco smoke, air quality, cockroaches, airborne urban contaminants, allergen, exposure assessment, human health riskRelevant Websites:
"Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation
Among Children (Asthma Exposure)"
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1069/report/2002
"Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)"
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1076/report/2002
"A Community-Based Intervention to Reduce Environmental Triggers for
Asthma Among Children (Asthma Intervention)"
https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1077/report/2002
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826710C001 Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
R826710C002 Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)
R826710C003 A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.