Grantee Research Project Results
Final Report: CECEHDPR - University of Southern California
EPA Grant Number: R826708Center: Great Lakes Air Center for Integrative Environmental Research
Center Director: Harkema, Jack
Title: CECEHDPR - University of Southern California
Investigators: Gong, Henry , Hinds, William C. , Gilliland, Frank D. , Avol, Edward L. , Peters, John M. , McConnell, Rob Scot , Jones, Craig , Diaz-Sanchez, David , Gauderman, William
Institution: University of California - Los Angeles
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 1998 through July 31, 2003
Project Amount: $2,895,926
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The broad objectives of the Center’s research activities during its first 5 years were:
(1) To identify childhood determinants of respiratory susceptibility to environmental factors with a focus on ambient air pollution and secondhand smoke;
(2) To identify the modulating effects of secondhand smoke on allergic inflammation in children; and
(3) To determine the feasibility and efficacy of a community-based intervention to reduce adverse health outcomes from co-exposures to indoor allergens and secondhand smoke in a high-risk group of children.
Summary/Accomplishments (Outputs/Outcomes):
The Children’s Environmental Health Center (CEHC) was established in 1998 as a specialized center for investigating the effects of the environment on children’s respiratory health with a focus on asthma and allergic airway disease. The theme of the Center and its research focus were chosen based on the clinical and public health importance of childhood respiratory diseases and the potential importance of common environmental exposures on the etiology of these conditions, especially among susceptible subgroups of children. In 1998, the Center also established a community outreach and education program to translate research findings into education and public health policy. During the first 5 years of the CEHC, we made substantial progress in understanding the effects of ambient air pollutants and tobacco smoke on children’s respiratory health and identified important susceptible groups of children. The specific accomplishments are summarized in the Final Reports for R826708C001–R826708C003.
Conclusions:
The key findings for the first 5 years of Center research are:
- In utero exposure to maternal smoking increased the risk of asthma, especially among children with two phase II enzymes variant genotypes: GSTM1 null and GSTP1 A105G (Gilliland, et al., 2003a; Gilliland, et al., 2002a).
- High levels of exposure to locally emitted fresh vehicle exhaust were associated with increased risk of early life asthma (Gilliland, et al., 2002a).
- The incidence of newly diagnosed asthma is increased in children playing team sports in high, but not low, O3 communities (McConnell, et al., 2002).
- The TNF–308 genotype is associated with early life asthma prevalence, but the effect of the genetic variant is limited to low O3 communities (Gilliland, et al., 2003b).
- Early life experiences including exposures to farming, pesticides and herbicides, cockroaches, and early day care were associated with increased risk of asthma onset before age 5 years (Gilliland, et al., 2003c).
- In utero exposure was associated with deficits in lung function that were larger in children who were diagnosed with asthma early in life (Gilliland, et al., 2000).
- Chronic lung function deficits occur in children with asthma, especially those with early diagnosis of asthma (Berhane, et al., 2000).
- Overweight and obese children are at increased risk for new onset asthma (Gilliland, et al., in press a; Gilliland, et al., 2001a).
- Increased prevalence of bronchitic symptoms occur among children with asthma with higher exposures to ambient NO2 and particulate matter, especially the elemental and organic carbon fractions (McConnell, et al., 1999; McConnell, et al., submitted a).
- Deficits in lung function growth with nitrogen dioxide (NO2) levels (and a cluster of highly correlated pollutants, including nitric acid vapor and particulates) (Gauderman, et al., 2000). This result has also been replicated in our second cohort of fourth graders enrolled 3 years later (Gauderman, et al., 2002).
- Improvement in the rate of lung function growth in subjects who moved to areas of lower PM10 compared with those who moved to areas of higher PM10 (Avol, et al., 2001a).
- Diets low in antioxidant vitamins or magnesium are associated with chronic deficits in lung function (Gilliland, et al., 2001b).
- There is a large increase in respiratory-related school absences with daily fluctuations in O3 levels, particularly in low PM10/NO2 communities (Gilliland, et al., 2001c; Berhane and Thomas, 2002).
- There is increased risk of respiratory-related school absences among children with and without asthma exposed to secondhand smoke (Gilliland, et al., in press b).
- Risk of respiratory-related school absences varied by GSTM1 and GSTP1 genotype (Gilliland, et al., 2002b).
- Secondhand smoke exposure has adjuvant effects on allergen induced nasal allergic responses that is 10-fold larger in children than adults (Diaz-Sanchez, et al., 2002).
- Risk of asthma is increased among children with a dog, but not a cat, in the home.
- The adjuvant effects of diesel exhaust particles (DEP) on nasal allergic responses strongly depends on GSTM1 and GSTP1 genotype (McConnell, et al., 2003a).
- Nasal allergic responses to DEP are reproducible and identify a subpopulation of children with enhanced allergic responses from DEP (Bastain, et al., 2003; Bastain, et al., accepted).
- Methods and materials for community-based interventions to reduce indoor allergens in the homes of children with asthma can be developed and implemented with community involvement (McConnell, et al., 2005; McConnell, et al., 2003b).
- Cockroach counts can be reduced by a community-based intervention using Integrated Pest Management (IPM) (McConnell, et al., 2005; McConnell, et al., 2003b).
- Parents of children with asthma who have been tested for allergies using skin prick test are well informed by clinicians about the test results (Richardson, et al., 2004).
- Indoor allergen and endotoxin can be measured using dust wipes that could be self-collected by participants in research studies (Avol, et al., 2001b; Thorne, et al., 2005).
- Communities are concerned about the effects of ambient air pollution and local traffic on asthma and want to be involved in understanding and reducing any risks to their children.
Taken together, these findings support the conclusions that in utero and childhood exposures to tobacco smoke and childhood exposure to ambient air pollution at current levels have adverse effects on children’s airways.
References:
Avol E, Cozen W, Diaz-Sanchez D. A novel antigen/dust collection method performed by residents for use in field investigations. Presented at the International Society for Exposure Analysis Annual Meeting, Charleston, SC, November 4-8, 2001b.
Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. American Journal of Respiratory and Critical Care Medicine 2001;164(11):2067-2072.
Bastain TM, Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Intra-individual reproducibility of nasal allergic responses to diesel exhaust particles indicates a susceptible phenotype. American Journal of Respiratory and Critical Care Medicine 2003;167:A218.
Bastain TM, Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Intraindividual reproducibility of nasal allergic responses to diesel exhaust particles indicates a susceptible phenotype. Clinical Immunology 2003;109(2):130-136.
Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. Sex-specific effects of asthma on pulmonary function in children. American Journal of Respiratory and Critical Care Medicine 2000;162(5):1723-1730.
Berhane K, Thomas D. A two-stage model for time series data of counts from many sites. Biostatistics 2002;3:21-32.
Diaz-Sanchez D, Rumold R, Gong H. Controlled second-hand smoke exposure enhances ragweed-induced IgE, Th2 cytokines and histamine production in allergic subjects. Journal of Allergy and Clinical Immunology 2002;109(S1):S90.
Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. Association between air pollution and lung function growth in southern California children: results from a second cohort. American Journal of Respiratory and Critical Care Medicine 2002;166(1):76-84.
Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. Association between air pollution and lung function growth in southern California children. American Journal of Respiratory and Critical Care Medicine 2000;162(4):1383-1390.
Gilliland F, Li Y, Peters J. Effects of vitamin A, C, and E intake on children’s lung function. American Journal of Respiratory and Critical Care Medicine 2001b;163:A37.
Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology 2001c;12(1):43-54.
Gilliland FD, Li Y-F, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2002a;166(4):457-463.
Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. American Journal of Respiratory and Critical Care Medicine 2002;166(3):346-351.
Gilliland FD, Berhane K, Islam T, Wenten M, Rappaport E, Avol E, Gauderman WJ, McConnell R, Peters JM. Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren. American Journal of Epidemiology 2003;157(10):861-869.
Gilliland FD, Li Y-F, Tsai W, Dubeau L. GSTP1 and GSTM1 contribute to susceptibility for asthma and wheezing following in utero exposure to tobacco smoke. American Journal of Respiratory and Critical Care Medicine 2003a;167:A942.
Gilliland FD, Salam MT, Li Y-F, Langholz B. Early life risk factors for asthma: findings from the Children’s Health Study. American Journal of Respiratory and Critical Care Medicine 2003c;167:A831.
McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. Air pollution and bronchitic symptoms in Southern California children with asthma. Environmental Health Perspectives 1999; 107(9):757-760.
McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003a;168(7):790-797.
McConnell R, Jones C, Milam J, Gonzalez P, Berhane K, Clement L, Richardson J, Hanley-Lopez J, Kwong K, Maalouf N, Galvan J, Platts-Mills T. Cockroach counts and house dust allergen concentrations after professional cockroach control and cleaning. Annals of Allergy, Asthma and Immunology 2003;91(6):546-552.
Journal Articles: 72 Displayed | Download in RIS Format
| Other center views: | All 104 publications | 74 publications in selected types | All 72 journal articles |
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American Lung Association. Urban air pollution and health inequities: a workshop report. Environmental Health Perspectives 2001;109(Suppl 3):357-374. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. American Journal of Respiratory and Critical Care Medicine 2001;164(11):2067-2072. |
R826708 (Final) |
Exit Exit |
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Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. Sex-specific effects of asthma on pulmonary function in children. American Journal of Respiratory and Critical Care Medicine 2000;162(5):1723-1730. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) |
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Berhane K, Thomas DC. Combining evidence on air pollution and daily mortality from the 20 largest US cities: a hierarchical modeling strategy-Discussion. Journal of the Royal Statistical Society, Series A, Statistics in Society 2000;163(3):292. |
R826708 (Final) |
not available |
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Blanc N, Liao W, Gilliland F, Zhang J, Berhane K, Huang G, Yan W, Chen Z. A systematic review of evidence for maternal preconception exposure to outdoor air pollution on Children's health. ENVIRONMENTAL POLLUTION 2023;318(120850) |
R826708 (Final) R831861 (Final) |
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Chang MC, Sioutas C, Kim S, Gong Jr. H, Linn WS. Reduction of nitrate losses from filter and impactor samplers by means of concentration enrichment. Atmospheric Environment 2000;34(1):85-98. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Corren J, Diaz-Sanchez D, Saxon A, Deniz Y, Reimann J, Sinclair D, Davancaze T, Adelman D. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis. Annals of Allergy, Asthma and Immunology 2004;93(3):243-248. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Current Allergy and Asthma Reports 2003;3(2):146-152. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Diaz-Sanchez D, Riedl M. Diesel effects on human health: a question of stress? American Journal of Physiology—Lung Cellular and Molecular Physiology 2005;289(5):L722-L723. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (Final) R831861C003 (Final) |
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Enright PL, Linn WS, Avol EL, Margolis HG, Gong Jr. H, Peters JM. Quality of spirometry test performance in children and adolescents: experience in a large field study. Chest 2000;118(3):665-671. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC. Diesel exhaust particles suppress in vivo IFN-γ production by inhibiting cytokine effects on NK and NKT cells. Journal of Immunology 2004;172(6):3808-3813. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
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Garcia E, Urman R, Berhane K, McConnell R, Gilland F. Effects of policy-driven hypothetical air pollutant interventions on childhood asthma incidence in southern California. PNAS 2019;116(32):15883-15888. |
R826708 (Final) R831861 (Final) |
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Garcia E, Berhane KT, Islam T, McConnell R, Urman R, Chen ZH, Gilliand FD. association of changes in air quality with incident asthma in children in California, 1993-2014. JAMA-Journal of the American Medical Association 2019;321(19):1906-1915. |
R826708 (Final) R831861 (Final) |
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Garcia E, Zhang Y, Rapport E, Berhane K, Muchmore P, Silkoff P, Molshatzki N, Gilliland F, Eckel S. Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period. European Respiratory Journal 2020;56(1). |
R826708 (Final) |
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Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. Association between air pollution and lung function growth in southern California children. American Journal of Respiratory and Critical Care Medicine 2000;162(4 Pt 1):1383-1390. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C001 (2001) R826708C003 (2001) |
Exit Exit Exit |
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Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. Association between air pollution and lung function growth in southern California children: results from a second cohort. American Journal of Respiratory and Critical Care Medicine 2002;166(1):76-84. |
R826708 (Final) |
Exit Exit Exit |
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Gilliland FD, McConnell R, Peters J, Gong Jr. H. A theoretical basis for investigating ambient air pollution and children's respiratory health. Environmental Health Perspectives 1999;107(Suppl 3):403-407. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) |
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Gilliland FD, Linn W, Rappaport E, Avol E, Gong H, Peters J. Effect of spirometer temperature on FEV1 in a longitudinal epidemiological study. Occupational and Environmental Medicine 1999;56(10):718-720. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000;55(4):271-276. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) |
Exit Exit |
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Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2001;163(2):429-436. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) |
Exit Exit Exit |
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Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology 2001;12(1):43-54. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) |
Exit Exit Exit |
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Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. American Journal of Respiratory and Critical Care Medicine 2002;166(3):346-351. |
R826708 (Final) |
Exit Exit Exit |
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Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2002;166(4):457-463. |
R826708 (Final) |
Exit Exit Exit |
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Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. Dietary magnesium, potassium, sodium, and children's lung function. American Journal of Epidemiology 2002;155(2):125-131. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2000) |
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Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. American Journal of Respiratory and Critical Care Medicine 2002;166(5):710-716. |
R826708 (Final) R826708C002 (Final) |
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Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, Avol E, Peters JM. Obesity and the risk of newly diagnosed asthma in school-age children. American Journal of Epidemiology 2003;158(5):406-415. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
Exit Exit |
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Gilliland FD, Berhane KT, Li Y-F, Gauderman WJ, McConnell R, Peters J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. American Journal of Epidemiology 2003;158(6):576-584. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
Exit Exit |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363(9403):119-125. |
R826708 (2000) R826708 (2001) R826708 (Final) |
Exit Exit |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363(9403):119-125. |
R826708 (2002) R831861 (2004) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Glutathione-S-Transferase M1 and P1 genotypes protect against xenobiotic enhancement of allergic responses. Lancet 2004;363:119-125. |
R826708C002 (Final) |
Exit Exit |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R832139 (2006) R832141 (2006) R832141 (2007) R832141 (Final) |
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Gong Jr. H, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles:methodology and preliminary health-effect findings. Inhalation Toxicology 2000;12(Suppl 1):107-119. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Gong Jr. H, Linn WS, Terrell SL, Anderson KR, Clark KW. Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulfur dioxide. Chest 2001;119(2):402-408. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Gong Jr. H, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhalation Toxicology 2005;17(3):123-132. |
R826708 (Final) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) R831861 (2005) |
Exit Exit |
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Harrington-Brock K, Cabrera M, Collard DD, Doerr CL, McConnell R, Moore MM, Sandoval H, Fuscoe JC. Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile:a pilot study. Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis 1999;431(2):247-257. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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Kim S, Sioutas C, Chang M-C, Gong Jr. H. Factors affecting the stability of the performance of ambient fine-particle concentrators. Inhalation Toxicology 2000;12(Suppl 4):281-298. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R825513C024 (Final) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R828598 (Final) R828598C700 (Final) |
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Kuenzli N, McConnell R, Bates D, Bastain TM, Hricko A, Lurmann F, Avol E, Gilliland FD, Peters JM. Breathless in Los Angeles: the exhausting search for clean air. American Journal of Public Health 2003;93(9):1494-1499. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
Exit Exit Exit |
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Levin A, Mathias R, Huang L, Roth L, Daley D, Myers R, Himes B, Romieu I, Yang M, Eng C, Park J, Zoratti K, Gignoux C, Torgerson D, Galanter J, Huntsman S, Nguyen E, Becker A, Chan-Yeung M, Kozyrskyj A, Dwok P, Gilliland F, Gauderman W, Bleecker E, Raby B, Meyers D, London S, Martinez F, Weiss S, Burchard E, Nicolae D, Ober C, Barnes K, WIlliams L. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2013;131(4):1176-1184. |
R826708 (Final) R831861 (Final) R832139 (Final) |
Exit Exit |
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Li Y-F, Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. American Journal of Respiratory and Critical Care Medicine 2000;162(6):2097-2104. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) |
Exit Exit Exit |
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Li Y-F, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127(4):1232-1241. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit Exit Exit |
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Li Y-F, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Human Genetics 2005;117(5):476-484. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit |
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Li Y-F, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. American Journal of Respiratory and Critical Care Medicine 2006;173(9):970-976. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit Exit Exit |
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Liao J, Gheissari R, Thomas D, Gilliland F, Lurmann R, Islam K, Checn Z. Transcriptomic and metabolomic associations with exposures to air pollutants among young adults with childhood asthma history. Enviromental Pollution 15;299(118903). |
R826708 (Final) |
Exit Exit |
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Linn WS, Gong Jr. H, Clark KW, Anderson KR. Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. Journal of the Air & Waste Management Association 1999;49(9 Spec No):108-115. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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Linn WS, Adkins RH, Gong Jr. H, Waters RL. Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 Southern California adult outpatients. Archives of Physical Medicine and Rehabilitation 2000;81(6):757-763. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
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Linn WS, Szlachcic Y, Gong Jr. H, Kinney PL, Berhane KT. Air pollution and daily hospital admissions in metropolitan Los Angeles. Environmental Health Perspectives 2000;108(5):427-434. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R827352 (2004) R827352 (Final) R827352C012 (Final) |
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McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. Air pollution and bronchitic symptoms in Southern California children with asthma. Environmental Health Perspectives 1999;107(9):757-760. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: a cohort study. Lancet 2002;359(9304):386-391. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit |
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McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R827352 (2004) R827352 (Final) R827352C007 (Final) R827352C009 (Final) R831861 (2004) R831861 (2005) |
Exit Exit Exit |
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McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K. Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study. Clinical & Experimental Allergy 2005;35(4):426-433. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861C001 (2005) R831861C001 (2006) |
Exit |
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McConnell R, Berhane K, Molitor J, Gilliland F, Kunzli N, Thorne PS, Thomas D, Gauderman WJ, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. |
R826708 (Final) R827352 (Final) R827352C007 (Final) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) |
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McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. |
R826708 (Final) R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (2007) R831861C003 (Final) |
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Myers R, Himes B, Gignoux C, Yang J, Gauderman W, REbordosa C, Xie J, Torgerson D, Levin A, Baurley J, Graves P, Mathias R, Romieu I, Roth L, Conti D, Avila L, Eng C, Bora H, LeNoir M, Soto-Quirs M, Liu J, Celedon J, Farber J, Kumar R, Avila P, Meade K, Srebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana J, Borrell L, Lemanske R, Bleeker E, meyers D, London S, Barnes K, Raby B, Martinez F, Gilliland F, Williams L, Burchard E, Weiss S, Nocolae D, Ober C. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012;130(6):1294-1301. |
R826708 (Final) R831861 (Final) |
Exit Exit |
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Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong Jr. H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. American Journal of Respiratory and Critical Care Medicine 1999;159(3):760-767. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
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Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong Jr. H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. American Journal of Respiratory and Critical Care Medicine 1999;159(3):768-775. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
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Richardson JL, Milam JE, Galvan J, Jones C, McConnell R. Knowledge of skin test results among parents of asthmatic children. Journal of Asthma 2004;41(2):199-204. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
Exit |
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Riedl MA, Landaw EM, Saxon A, Diaz-Sanchez D. Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen. Journal of Immunology 2005;174(11):7440-7445. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. Journal of Allergy and Clinical Immunology 2005;115(2):221-228. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Rumold R, Jyrala M, Diaz-Sanchez D. Secondhand smoke induces allergic sensitization in mice. Journal of Immunology 2001;167(8):4765-4770. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C002 (2001) |
Exit Exit |
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Salam MT, Li Y-F, Langholz B, Gilliland FD. Early-life environmental risk factors for asthma:findings from the Children's Health Study. Environmental Health Perspectives 2004;112(6):760-765. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (2005) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Salam MT, Li Y-F, Langholz B, Gilliland FD. Maternal fish consumption during pregnancy and risk of childhood asthma. Journal of Asthma 2005;42(6):513-518. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit |
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Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nature Immunology 2005;6(3):223-226. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Sioutas C, Kim S, Chang M, Terrell LL, Gong Jr. H. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmospheric Environment 2000;34(28):4829-4838. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Solomon O, MacIssac J, Tindula G, Kobor M, Eskenazi B, Holland N. 5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns. Mutagenisis 2019;34(4):315-322. |
R826708 (Final) R831710 (Final) |
Exit |
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Thorne PS, Metwali N, Avol E, McConnell RS. Surface sampling for endotoxin assessment using electrostatic wiping cloths. Annals of Occupational Hygiene 2005;49(5):401-406. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Urman R, Garcia E, Berhane K, McConnell R, Gauderman W, Gilliland F. The Potential Effects of Policy-driven Air Pollution Interventions on Childhood Lung Development. American Journal of Respiratory and Critical Care Medicine 2020;201(4):438-444. |
R826708 (Final) R831861 (Final) |
Exit |
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Wan J, Diaz-Sanchez D. Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. Journal of Immunology 2006;177(5):3477-3483. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (2006) R831861C002 (2007) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American Journal of Respiratory and Critical Care Medicine 2005;172(12):1563-1568. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit Exit |
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Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. Journal of Immunology 2002;168(5):2560-2567. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) R827352 (Final) R827352C002 (Final) |
Exit Exit |
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Xie B, Gilliland FD, Li Y-F, Rockett HRH. Effects of ethnicity, family income, and education on dietary intake among adolescents. Preventive Medicine 2003;36(1):30-40. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R831861 (2004) R831861 (2005) |
Exit |
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Zhang Y, Berhane K, Eckel S, Muchmore P, Molshatzki N, Rappaport E, Linn W, Habre R, Gilliland F. Adverse Effects of Annual Fluctuations in Air Pollution on FeNO in Children: A Longitudinal Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018;197 |
R826708 (Final) |
Exit |
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Zhang Y, Chen Z, Berhane K, Urman R, Chatzi V, Breton C, Gilliland F. The Dynamic Relationship Between Asthma and Obesity in Schoolchildren. American Journal of Epidemiology 2020;189(6):583-591. |
R826708 (Final) R836158 (Final) |
Exit Exit |
Supplemental Keywords:
children’s health, respiratory health, allergic airway disease, secondhand smoke, air pollution, diesel exhaust particles, integrated pest management, community-based participatory research, susceptibility, genetics, gene expression, inflammation,, RFA, Scientific Discipline, Health, Geographic Area, Health Risk Assessment, Epidemiology, State, Risk Assessments, Allergens/Asthma, Children's Health, asthma, asthma triggers, acute lung injury, airway disease, respiratory problems, asthma indices, second hand smoke, exposure, respiratory disease, air pollution, children, airway inflammation, childhood respiratory disease, children's vulnerablity, susceptibility, airborne pollutants, asthmatic children, human exposure, children's environmental health, cigarette smoke, tobacco smoke, California (CA), allergic response, allergenRelevant Websites:
The Department of Preventive Medicine at the Keck School of Medicine of USC Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826708C001 Asthma in Children: A Community-based Intervention Project
R826708C002 Children's Exposure to Environmental Tobacco Smoke: Changes in Allergic Response
R826708C003 Respiratory Disease and Prevention Center
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.