Grantee Research Project Results
2004 Progress Report: Center for the Study of Prevalent Neurotoxicants in Children
EPA Grant Number: R829389Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Center for the Study of Prevalent Neurotoxicants in Children
Investigators: Lanphear, Bruce , Bearer, Cynthia , Ris, Douglas , Khoury, Jane , Dietrich, Kim , Cecil, Kim , Yolton, Kimberly , Hornung, Richard , Roda, Sandy
Current Investigators: Lanphear, Bruce , Barr, Dana Boyd , Bearer, Cynthia , Ris, Douglas , Dietrich, Kim , Cecil, Kim , Yolton, Kimberly , Hornung, Richard , Roda, Sandy
Institution: Children Hospital of Cincinnati , Case Western Reserve University , University of Cincinnati
Current Institution: Children Hospital of Cincinnati
EPA Project Officer: Aja, Hayley
Project Period: November 1, 2001 through October 31, 2006
Project Period Covered by this Report: November 1, 2003 through October 31, 2004
Project Amount: $3,714,505
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The objectives of the Children’s Environmental Health Center are to: (1) test the efficacy of an intervention for the primary prevention of lead toxicity, as measured by lead concentration and neurobehavioral functioning at 36 months of age; (2) serve as a model to evaluate the adverse effects of exposures to multiple prevalent toxicants among fetuses and children; (3) test meconium levels as a biomarker of fetal exposure to numerous toxicants; and (4) provide exposure and risk assessment data for residential pesticides.
Exposure to numerous environmental agents, including lead, mercury, polychlorinated biphenyls(PCBs) , and environmental tobacco smoke (ETS), has been linked with adverse neurobehavioral effects. Still, the ideal biomarker for measuring in utero exposure to specific toxicants has not been established and the adverse effects of many potential neurotoxicants have not been tested rigorously. Fetal exposure typically is measured with self-reported surveys, maternal blood and urine, or cord blood. In contrast, meconium as a biomarker is a noninvasive method to test simultaneously for cumulative exposures to numerous toxicants. It is unclear, however, whether conventional biomarkers or meconium levels are more predictive of the adverse effects linked with specific toxicants. For lead exposure, emerging data indicate that our efforts should emphasize primary prevention; however, the efficacy of lead hazard controls is uncertain, especially for children with low blood lead concentrations.
We propose to conduct a cohort study of 400 children, followed from less than 16 weeks’ gestation to 36 months of age, to examine the effect of low-level exposures to prevalent neurotoxicants. Endpoints include behavioral problems, such as conduct disorder and features consistent with Attention Deficit Hyperactivity Disorder, cognitive deficits, and hearing loss. We also will conduct a nested, randomized controlled trial to test the efficacy of lead hazard controls on the development of adverse neurobehavioral effects. We will test the following hypotheses: (1) children in the Lead Reduction Group will have lower blood lead levels, significantly higher cognitive scores, less hearing loss, and fewer behavioral problems than the Control Group at 36 months of age; (2) fetal and postnatal exposures to pesticides, ETS, and lead are associated with adverse neurobehavioral effects, growth delay, and hearing loss in early childhood; and (3) fetal exposures are less predictive of the adverse effects of toxicants on cognition, behavioral problems, and hearing, compared with the same toxicants in meconium.
Progress Summary:
Cincinnati Children’s Environmental Health Center (CEHC) has had a productive year. The administrative activities of the Center are described in this progress report. The progress for each research project is described in the individual 2004 Annual Reports for R829389C001 through R829389C005. The Intervention Component Supplement project update is included in the 2004 Annual Report for R829389C001..
In our last progress report, we described a meeting, held in Cincinnati in May 2003, of principal investigators representing longitudinal lead-exposed cohorts from the United States, Australia, and Mexico. This meeting was arranged to study the results of the analyses of pooled data from more than 1,300 children and the findings of intellectual impairments at blood lead levels below 10 μg/dL, compared with higher blood lead levels. Our analyses have been completed, and a manuscript was submitted recently to the Journal of the American Medical Association. The title of the paper is “Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis.”
As mentioned in our previous progress report, National Public Radio’s weekly environmental science show, “Living on Earth,” received a grant from the National Science Foundation to study nine emerging areas of research. The CEHC was the first selected to highlight emerging neuroscience research. The Center was featured on several national broadcasts and was received very well by the “Living on Earth” radio audience. This series was completed largely during this past year.
The CEHC has continued to play an important role in training researchers and clinicians in children’s environmental health. Center Director Dr. Bruce Lanphear and two of our pediatricians, Dr. Stephen Wilson and Dr. Adam Spanier, who currently are in the Ambulatory Pediatric Association’s (APA) Pediatric Environmental Health Fellowship Training Program, attended the APA’s Second Annual Environmental Health Scholars retreat in March 2004. Both Drs. Wilson and Spanier presented their research and benefited from an open discussion of their work from peers and invited faculty. Dr. Gwen Collman was an invited speaker.
A Scientific Advisory Review of the CEHC was conducted on June 2, 2003. Dr. Brenda Eskenazi, Professor of Maternal and Child Health and Epidemiology, and Director of the Center for Children’s Environmental Health Research at the University of California School of Public Health in Berkeley, California, reviewed our program. The Center was given an extremely positive review, which is available upon request.
Both the CEHC Internal Advisory Board and External Scientific Advisory Board met during this reporting period. The agenda for both meetings consisted of an overview of the Center, which included an update on projects that are part of the overall effort of Center faculty. Each project funded by the Center grant was presented and updated by each respective principal investigator or project director. Lastly, new children’s environmental health research projects were presented. Time for questions and feedback from the Board members, as well as a group discussion, completed each meeting. In addition to hearing the progress of each grant project, the focus of both Board meetings was an open discussion and exchange of ideas to assist in planning for future Center research studies and to reiterate our responsibility to the community to be informative and responsive regarding issues of children’s environmental health. Both the CEHC Internal and External Boards convene at approximately 18 month intervals.
As suggested in the Centers for Children’s Environmental Health and Disease Prevention Request for Applications, the CEHC’s original application requested funding to support two new investigators. One of those individuals, Dr. Kim Cecil, in addition to being a new scientist, is principal investigator of project R829389C005, “MR [magnetic resonance] Assessment of Brain Function Altered by Lead Exposure.”
Our other new scientist is Dr. Kim Yolton. During her first year with the Cincinnati CEHC, she spent 30 percent of her research effort on activities related to Project R829389C001, the Health Outcomes and Measures of the Environment (HOME) Study. She has been involved in questionnaire development, staff training and preparation for study visits, and discussions of future directions of the project. In addition, she has led data collection procedures related to her particular interest in how newborns may exhibit signs of prenatal exposure to environmental neurotoxicants. She has administered newborn neurobehavioral examinations on 89 of 99 (90%) HOME Study newborns shortly after birth and 73 of 82 (89%) HOME Study infants at 4 weeks of age. These efforts have resulted in preliminary data to support a proposal that was submitted on June 1, 2004, to obtain federal funding to further this study.
In the past year, she has collaborated on four manuscripts that were submitted for publication in peer-reviewed journals, one as first author. Two of these publications are in press, and two are currently in review. Other activities have included four local and one out-of-state presentation on topics related to children’s environmental health.
Dr. Yolton recently received federal funding to explore the effects of ETS exposure on the behaviors and sleep patterns of children (1 R21 ES012952-01), and she has submitted an additional grant proposal to study the impact of prenatal exposure to neurotoxicants on newborn neurobehavior as mentioned above.
Dr. Yolton’s goals for the coming year include continued collection of newborn neurobehavioral data, training and development efforts with staff related to psychometric testing, contributions to future grant proposals related to the HOME Study, execution of the grant related to ETS effects on child behavior and sleep, and exploration of additional funding opportunities in which to study further the impact of prenatal environmental neurotoxicant exposure on newborns.
Future Activities:
See the individual 2004 Annual Reports for projects R829389C001 through R829389C005 for a description of future activities.
Journal Articles: 114 Displayed | Download in RIS Format
| Other center views: | All 154 publications | 118 publications in selected types | All 114 journal articles |
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Adler CM, Holland SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disorders 2004;6(6):540-549. |
R829389 (2005) R829389 (Final) |
Exit |
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Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM. Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disorders 2004;6(3):197-203. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Auinger P, Lanphear BP, Kalkwarf HJ, Mansour ME. Trends in otitis media among children in the United States. Pediatrics 2003;112(3):514-520. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Barr DB, Bravo R, Weerasekera G, Caltabiano LM, Whitehead RD Jr, Olsson AO, Caudill SP, Schober SE, Pirkle JL, Sampson EJ, Jackson RJ, Needham LL. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environmental Health Perspectives 2004;112(2):186-200. |
R829389 (2005) R829389 (Final) |
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Barr JR, Maggio VL, Barr DB, Turner WE, Sjodin A, Sandau CD, Pirkle JL, Needham LL, Patterson DG Jr. New high-resolution mass spectrometric approach for the measurement of polychlorinated biphenyls and organochlorine pesticides in human serum. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 2003;794(1):137-148. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Bearer CF. Meconium as a biological marker of prenatal exposure. Ambulatory Pediatrics 2003;3(1):40-43. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Bearer CF, Linsalata N, Yomtovian R, Walsh MR, Singer LT. Blood transfusions: a hidden source of lead exposure. Lancet 2003;362(9380):332. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Molteno CD, Viljoen DL, Marais A-S, Chiodo LM, Cwik AS. Validation of a new biomarker of fetal exposure to alcohol. Journal of Pediatrics 2003;143(4):463-469. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Bearer CF, Santiago LM, O'Riordan MA, Buck K, Lee SC, Singer LT. Fatty acid ethyl esters: quantitative biomarkers for maternal alcohol consumption. Journal of Pediatrics 2005;146(6):824-830. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Beckwith T, Dietrich K, Wright J, Altaye M, Cecil K. Criminal arrests associated with reduced regional brain volumes in an adult population with documented childhood lead exposure. Environmental Research 2021;201. |
R829389 (Final) |
Exit Exit |
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Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspectives 2006;114(12):1904-1909. |
R829389 (2005) R829389 (Final) |
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Brent R, Weitzman M, Balk S, Lanphear B, Landrigan P, Reigart R. The vulnerability, sensitivity, and resiliency of the developing embryo, infant, child, and adolescent to the effects of environmental chemicals, drugs, and physical agents as compared to the adult. Pediatrics 2004:113(Suppl 3):932-1172. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Breysse P, Farr N, Galke W, Lanphear B, Morley R, Bergofsky L. The relationship between housing and health: children at risk. Environmental Health Perspectives 2004;112(15):1583-1588. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Canfield RL, Henderson Jr CR, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter. New England Journal of Medicine 2003;348(16):1517-1526. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Cecil I, Xu Y, Chen A, Khoury J, Altaye M, Braun J, Sjodin A, Lanphear B, Newman N, Strawn J, Vuong A, Yolton K. Gestational PBDE concentrations, persistent externalizing, and emerging internalizing behaviors in adolescents:The HOME study. ENVIRONMENTAL RESEARCH 2024;252(3):118981. |
R829389 (Final) |
Exit |
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Cecil KM, DeGrauw TJ, Salomons GS, Jakobs C, Egelhoff JC, Clark JF. Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency. Journal of Computer Assisted Tomography 2003;27(1):44-47. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Cecil KM, DelBello MP, Sellars MC, Strakowski SM. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. Journal of Child and Adolescent Psychopharmacology 2003;13(4):545-555. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Cecil KM, Kos RS. Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders. Topics in Magnetic Resonance Imaging 2006;17(4):275-293. |
R829389 (2005) R829389 (Final) |
Exit |
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Cecil KM. MR spectroscopy of metabolic disorders. Neuroimaging Clinics of North America 2006;16(1):87-116. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Cecil KM, Patel NC, DelBello MP. Inositol metabolism in pediatric bipolar disorder. Clinical Neuropsychiatry: Journal of Treatment Evaluation 2006;3(3):177-183. |
R829389 (2005) R829389 (Final) |
Exit |
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Chen A, Dietrich KN, Ware JH, Radcliffe J, Rogan WJ. IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds? Environmental Health Perspectives 2005;113(5):597-601. |
R829389 (2005) R829389 (Final) |
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Chen A, Cai B, Dietrich KN, Radcliffe J, Rogan WJ. Lead exposure, IQ, and behavior in urban 5-to 7-year-olds: does lead affect behavior only by lowering IQ? Pediatrics 2007;119(3):650-658. |
R829389 (2005) R829389 (Final) |
Exit |
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Coscia JM, Ris MD, Succop PA, Dietrich KN. Cognitive development of lead exposed children from ages 6 to 15 years: an application of growth curve analysis. Child Neuropsychology 2003;9(1):10-21. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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deGrauw TJ, Cecil KM, Byars AW, Salomons GS, Ball WS, Jakobs C. The clinical syndrome of creatine transporter deficiency. Molecular and Cellular Biochemistry 2003;244(1-2):45-48. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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DelBello MP, Cecil KM, Adler CM, Daniels JP, Strakowski SM. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology 2006;31(6):1264-1273. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads GG, Fay ME, Davoli CT, Denckla MB, Bornschein RL, Schwarz D, Dockery DW, Adubato S, Jones RL. Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 2004;114(1):19-26. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. |
R829389 (2005) R829389 (Final) R827027 (2002) R829388 (2006) R829388 (Final) R829388C006 (2005) R829390 (2005) R829390 (Final) R829390C002 (2005) R831710 (2005) R831710 (Final) R831711 (2005) R832141 (2006) R832141 (2007) R832141 (Final) |
Exit |
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Dinopoulos A, Cecil KM, Schapiro MB, Papadimitriou A, Hadjigeorgiou GM, Wong B, deGrauw T, Egelhoff JC. Brain MRI and proton MRS findings in infants and children with respiratory chain defects. Neuropediatrics 2005;36(5):290-301. |
R829389 (2005) R829389 (Final) |
Exit |
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Dinopoulos A, Gorospe JR, Egelhoff JC, Cecil KM, Nicolaidou P, Morehart P DeGrauw T. Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease. American Journal of Neuroradiology 2006;27(10):2088-2092. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Donnelly LF, O'Brien KJ, Dardzinski BJ, Poe SA, Bean JA, Holland SK, Daniels SR. Using a phantom to compare MR techniques for determining the ratio of intraabdominal to subcutaneous adipose tissue. American Journal of Roentgenology 2003;180(4):993-998. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit Exit |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R826710 (Final) R827027 (2002) R831710 (2004) R831710 (2005) R831710 (Final) R831861 (2005) R831861 (2006) R831861C001 (2006) R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) R832141 (2006) R832141 (2007) R832141 (Final) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R827027 (2002) R829390 (2005) R829390 (Final) R829390C002 (2005) R831709 (2005) R831709C001 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) R832141 (2007) R832141 (Final) |
Exit |
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Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY-J, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor α by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 2005;314(1):260-270. |
R829389 (Final) R829388 (2006) R829388 (Final) R833292 (Final) |
Exit Exit Exit |
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Farkas T, Thornton SA, Wilton N, Zhong W, Altaye M, Jiang X. Homologous versus heterologous immune responses to Norwalk-like viruses among crew members after acute gastroenteritis outbreaks on 2 US Navy vessels. The Journal of Infectious Diseases 2003;187(2):187-193. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Fossa A, Manz K, Papandonatos G, Chen A, La Guardia M, Lenphear B, Hale R, Pagano A, Pennell K, Yolton K, Braun J. A randomized controlled trial of a housing intervention to reduce endocrine disrupting chemical exposures in children. ENVIRONMENTAL INTERNATIONAL 2024;191 |
R829389 (Final) |
Exit |
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Froehlich TE, Lanphear BP, Dietrich KN, Cory-Slechta DA, Wang N, Kahn RS. Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Biological Psychiatry 2007;62(3):243-249. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Haynes EN, Kalkwarf HJ, Hornung R, Wenstrup R, Dietrich K, Lanphear BP. Vitamin D receptor Fok1 polymorphism and blood lead concentration in children. Environmental Health Perspectives 2003;111(13):1665-1669. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Haynes E, Lanphear BP, Tohn E, Farr N, Rhoads GG. The effect of interior lead hazard controls on children's blood lead concentrations:a systematic evaluation. Environmental Health Perspectives 2002;110(1):103-107. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Hornung R, Lanphear B, Dietrich K. Response to: "What is the meaning of non-linear dose-response relationships between blood lead concentration and IQ?" Neurotoxicology 2006;27(4):635. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Huang P, Farkas T, Marionneau S, Zhong W, Ruvoen-Clouet N, Morrow AL, Altaye M, Pickering LK, Newburg DS, LePendu J, Jiang X. Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens:identification of 4 distinct strain-specific patterns. Journal of Infectious Diseases 2003;188(1):19-31. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Jusko TA, Canfield RL, Henderson CR, Lanphear BP. Comments on "Recent developments in low-level lead exposure and intellectual impairment in children." Environmental Health Perspectives 2005;113(1):A16. |
R829389 (2005) R829389 (Final) |
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Kahn RS, Khoury J, Nichols WC, Lanphear BP. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Journal of Pediatrics 2003;143(1):104-110. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Kalkwarf HJ, Khoury JC, Lanphear BP. Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. American Journal of Clinical Nutrition 2003;77(1):257-265. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Kuiper J, Braun J, Calafat A, Lanphear B, Cecil K, Chen A, Xu Y, Yolton K, Kalwarf H, Buckley J. Associations of pregnancy phthalate concentrations and their mixture with early adolescent bone mineral content and density:The Health Outcomes and Measures of the Environment (HOME) study. BONE 2022;154(2). |
R829389 (Final) |
Exit Exit |
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Lamba M, Holland SK, Schmithorst V, Dardzinski B, d'Errico F, Nath R. Fast high-resolution 3D segmented echo planar imaging for dose mapping using a superheated emulsion chamber. Magnetic Resonance in Medicine 2003;49(4):675-681. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Lanphear BP, Hornung R, Ho M, Howard CR, Eberly S, Knauf K. Environmental lead exposure during early childhood. Journal of Pediatrics 2002;140(1):40-47. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Lanphear BP, Dietrich KN, Berger O. Prevention of lead toxicity in US children. Ambulatory Pediatrics 2003;3(1):27-36. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP, Gergen PJ. Invited commentary: asthma surveillance in US children. American Journal of Epidemiology 2003;158(2):105-107. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP, Succop P, Roda S, Henningsen G. The effect of soil abatement on blood lead levels in children living near a former smelting and milling operation. Public Health Reports 2003;118(2):83-91. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL, Dietrich KN, Bornschein R, Greene T, Rothenberg SJ, Needleman HL, Schnaas L, Wasserman G, Graziano J, Roberts R. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environmental Health Perspectives 2005;113(7):894-899. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Lanphear BP, Bearer CF. Biomarkers in paediatric research and practice. Archives of Disease in Childhood 2005;90(6):594-600. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Lanphear BP, Wright RO, Dietrich KN. Environmental neurotoxins. Pediatrics in Review 2005;26(6):191-198. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R831725 (2009) R831725C001 (2005) |
Exit |
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Lanphear BP, Vorhees CV, Bellinger DC. Protecting children from environmental toxins. PLoS Medicine 2005;2(3):e61. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Lanphear BP. Childhood lead poisoning prevention: too little, too late. Journal of the American Medical Assocation 2005;293(18):2274-2276. |
R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP, Hornung R, Ho M. Screening housing to prevent lead toxicity in children. Public Health Reports 2005;120(3):305-310. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP. Origins and evolution of children's environmental health. Environmental Health Perspectives 2005;Special Issue:24-32 (Special Issue: Essays on the Future of Environmental Health Research). |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Lanphear BP, Hornung R, Khoury J, Yolton K, Dietrich KN. Lead and IQ in children: Lanphear et al. respond. Environmental Health Perspectives 2006;114(2):A86-A87. |
R829389 (Final) |
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Lanphear BP, Paulson J, Beirne S. Trials and tribulations of protecting children from environmental hazards. Environmental Health Perspectives 2006;114(10):1609-1612. |
R829389 (2005) R829389 (Final) |
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Lanphear B, Hornung R, Khoury J, Yolton K. Effects of lead on IQ in children. Environmental Health Perspectives 2006;114(2):A85-A86. |
R829389 (2005) |
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Liu X, Dietrich KN, Radcliffe J, Ragan NB, Rhoads GG, Rogan WJ. Do children with falling blood lead levels have improved cognition? Pediatrics 2002;110(4):787-791. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Moya J, Bearer CF, Etzel RA. Children's behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 2004;113(Suppl 4):996-1006. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Newburg DS, Ruiz-Palacios GM, Altaye M, Chaturvedi P, Meinzen-Derr J, de Lourdes Guerrero M, Morrow AL. Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants. Glycobiology 2004;14(3):253-263. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Newmeyer A, Cecil KM, Schapiro M, Clark JF, Degrauw TJ. Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imaging. Journal of Developmental and Behavioral Pediatrics 2005;26(4):276-282. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Noland JS, Singer LT, Arendt RE, Minnes S, Short EJ, Bearer CF. Executive functioning in preschool-age children prenatally exposed to alcohol, cocaine, and marijuana. Alcoholism: Clinical and Experimental Research 2003;27(4):647-656. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Noland JS, Singer LT, Short EJ, Minnes S, Arendt RE, Kirchner HL, Bearer C. Prenatal drug exposure and selective attention in preschoolers. Neurotoxicology and Teratology 2005;27(3):429-438. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Oh J, Bennett D, Calafat A, Tancredi D, Roa D, Schmidt R, Hertz-Picciotto I, Shin H. Prenatal exposure to per-and polyfluoroalkyl substances in association with autism spectrum disorder in the MARBLES study. Enviornmenal International 2020;(106328). |
R829389 (Final) R829388 (Final) R833292 (Final) R835432 (Final) |
Exit Exit |
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Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM. Lithium treatment effects on Myo-inositol in adolescents with bipolar depression. Biological Psychiatry 2006;60(9):998-1004. |
R829389 (2005) R829389 (Final) |
Exit |
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Patel NC, DelBello MP, Cecil KM, Stanford KE, Adler CM, Strakowski SM. Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium. Journal of Child and Adolescent Psychopharmacology 2008;18(2):132-139. |
R829389 (2005) R829389 (Final) |
Exit |
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Percey Z, Chen A, Yang W, Braun J, Lanphear B, Ospina M, Calafat A, Xie C, Cecil K, Vuong A, Xu Y, Yolton K. Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study. ENVIRONMENTAL RESEARCH 2022;12(1):6746 |
R829389 (Final) |
Exit |
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Percy Z, La Guardia M, Xu Y, Hale R, Dietrich K, Lanphear B, Yolton K, Vuong A, Cecil K, Braun J, Xie C, Chen A. Concentrations and loadings of organophosphate and replacement brominated flame retardants in house dust from the home study during the PBDE phase-out. CHEMOSPHERE 2020;239. |
R829389 (Final) R834513 (Final) |
Exit Exit Exit |
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Percy Z, Vuong A, Ospina M, Calafat A, La Guardia M, Xu Y, Hale R, Dietrich K, Xie C, Lanphear B. Organophosphate esters in a cohort of pregnant women:Variability and predictors of exposure. ENVIRONMENTAL RESEARCH 2020;184. |
R829389 (Final) |
Exit Exit |
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Percy Z, Vuong A, Xu Y, Xie C, Ospina M, Calafat A, Hoofnagle A, Lanphear B, Braun J, Cecil K. Maternal Urinary Organophosphate Esters and Alterations in Maternal and Neonatal Thyroid Hormones. American Journal of Epidemiology 2021;19(9):1793-1802. |
R829389 (Final) |
Exit Exit |
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Phelan KJ, Khoury J, Kalkwarf H, Lanphear B. Residential injuries in U.S. children and adolescents. Public Health Reports 2005;120(1):63-70. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Pyne-Geithman GJ, deGrauw TJ, Cecil KM, Chuck G, Lyons MA, Ishida Y, Clark JF. Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study. Molecular and Cellular Biochemistry 2004;262(1-2):35-39. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Ris MD. Casual inference in lead research: introduction to the special section on the neurobehavioral effects of environmental lead. Child Neuropsychology 2003;9(1):1-9. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Ris MD, Dietrich KN, Succop PA, Berger OG, Bornschein RL. Early exposure to lead and neuropsychological outcome in adolescence. Journal of the International Neuropsychological Society 2004;10(2):261-270. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Ris MD, Ryan PM, Lamba M, Brenemen J, Cecil K, Succop P, Ball W. An improved methodology for modeling neurobehavioral late-effects of radiotherapy in pediatric brain tumors. Pediatric Blood & Cancer 2005;44(5):487-493. |
R829389 (2005) R829389 (Final) |
Exit |
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Rosner D, Markowitz G, Lanphear B. J. Lockhart Gibson and the discovery of the impact of lead pigments on children's health: a review of a century of knowledge. Public Health Reports 2005;120(3):296-300. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Salomons GS, Van Dooren SJM, Verhoeven NM, Marsden D, Schwartz C, Cecil KM, DeGrauw TJ, Jakobs C. X-linked creatine transporter defect: an overview. Journal of Inherited Metabolic Disease 2003;26(2-3):309-318. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Sandau CD, Sjodin A, Davis MD, Barr JR, Maggio VL, Waterman AL, Preston KE, Preau JL Jr., Barr DB, Needham LL, Patterson DG Jr. Comprehensive solid-phase extraction method for persistent organic pollutants. Validation and application to the analysis of persistent chlorinated pesticides. Analytical Chemistry 2003;75(1):71-77. |
R829389 (2005) R829389 (Final) |
Exit |
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Sandel M, Phelan K, Wright R, Hynes HP, Lanphear BP. The effects of housing interventions on child health. Pediatric Annals 2004;33(7):474-481. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Schapiro M, Cecil KM, Doescher J, Kiefer AM, Jones BV. MR imaging and spectroscopy in juvenile Huntington disease. Pediatric Radiology 2004;34(8):640-643. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Schmithorst VJ, Holland SK. The effect of musical training on music processing: a functional magnetic resonance imaging study in humans. Neuroscience Letters 2003;348(2):65-68. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Schmithorst VJ, Holland SK. Event-related fMRI technique for auditory processing with hemodynamics unrelated to acoustic gradient noise. Magnetic Resonance in Medicine 2004;51(2):399-402. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Schmithorst VJ, Holland SK. The effect of musical training on the neural correlates of math processing: a functional magnetic resonance imaging study in humans. Neuroscience Letters 2004;354(3):193-196. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Schmithorst VJ, Holland SK. Comparison of three methods for generating group statistical inferences from independent component analysis of functional magnetic resonance imaging data. Journal of Magnetic Resonance Imaging 2004;19(3):365-368. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Spanier A, Lanphear BP. Follow-up testing among children with elevated screening blood lead levels.Journal of Pediatrics 2005;147(5):708-709. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Stroop DM, Dietrich KN, Hunt AN, Suddendorf LR, Giangiacomo M. Lead-based paint health risk assessment in dependent children living in military housing. Public Health Reports 2002;117(5):446-452. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N, Taylor E, Casey BJ, Castellanos FX, Wadhwa PD. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology Review 2007;17(1):39-59. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Szaflarski JP, Holland SK, Schmithorst VJ, Dunn RS, Privitera MD. High-resolution functional MRI at 3 T in healthy and epilepsy subjects: hippocampal activation with picture encoding task. Epilepsy & Behavior 2004;5(2):244-252. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Vuong AM, Youlton K, Xie CC, Deitrich KN, Braun JM, Joseph M, Webster GM, Calafat AM, Lanphear BP, Chen AM. Prenatal and childhood exposure to poly- and perfluoroalkyl substances (PFAS) and cognitive development in children at age 8 years. Environmental Research 2019;172:242-248. |
R829389 (Final) |
Exit |
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Vuong AM, Yolton K, Cecil KM, Braun JM, Lanphear BP, Chen AM. Flame Retardants and Neurodevelopment:an Updated Review of Epidemiological Literature. Current Epidemiology Reports 2020;7:220-236. |
R829389 (Final) |
Exit |
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Vuong A, Yolton A, Braun J, Lanphear B, Chen A. Chemical mixtures and neurobehavior:a review of epidemiologic findings and future directions. Reviews on Environmental Health 2020;35(3):245-256. |
R829389 (Final) |
Exit |
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Vuong A, Yolton K, Braun J, Shodin A, Calafat A, Antonia M, XU Y, Dietrich K, Lanphear B, Chen A. Polybrominated diphenyl ether (PBDE) and poly-and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression. Environmental International 2020;139(UNSP 105694). |
R829389 (Final) |
Exit Exit |
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Vuong A, Xie C, Jandarov R, Dietrich K, Zhang H, Sjodin A, Calafat A, Lanphear B, McCaldless L, Braun J. Prenatal exposure to a mixture of persistent organic pollutants (POPs) and child reading skills at school age. International Journal of Hygiene and Environmental Health 2020;228(113527). |
R829389 (Final) |
Exit Exit |
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Vuong A, Braun J, Sjodin S, Calafat A, Yolton K, Lanphear B, Chen A. Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy:The HOME Study. Environment International 2021;156. |
R829389 (Final) |
Exit Exit |
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Vuong A, Percy Z, Yang W, Godbole A, Ospina M, Calafat A, Cecil K, Lanphear B, Braun J, Yolton K, Chen A. Gestational organophosphate esters (OPEs) and executive function in adolescence: The HOME Study. ENVIRONMENTAL RESEARCH 2024;263(3) |
R829389 (Final) |
Exit |
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Vuong A, Webster G, Yolton K, Calafat A, Muckle G, Lanphear B, Chen A. Prenatal exposure to per-and polyfluoroalkyl substances (PFAS) and neurobehavior in US children through 8 years of age:The HOME study. Environmental Research 01;195(110825). |
R829389 (Final) |
Exit Exit |
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Walz NC, Cecil KM, Wade SL, Michaud LJ. Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. Journal of Neurotrauma 2008;25(2):94-103. |
R829389 (2005) R829389 (Final) |
Exit |
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Wigle DT, Lanphear BP. Human health risks from low-level environmental exposures: no apparent safety thresholds. PLoS Medicine 2005;2(12):e350. |
R829389 (2005) R829389 (Final) |
Exit Exit |
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Wilke M, Holland SK, Ball Jr WS. Language processing during natural sleep in a 6-year-old boy, as assessed with functional MR imaging. American Journal of Neuroradiology 2003;24(1):42-44. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit Exit |
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Wilke M, Holland SK, Myseros JS, Schmithorst VJ, Ball Jr WS. Functional magnetic resonance imaging in pediatrics. Neuropediatrics 2003;34(5):225-233. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Wilke M, Holland SK. Variability of gray and white matter during normal development: a voxel-based MRI analysis. NeuroReport 2003;14(15):1887-1890. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Wilke M, Schmithorst VJ, Holland SK. Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data. Magnetic Resonance in Medicine 2003;50(4):749-757. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Wilke M, Sohn J-H, Byars AW, Holland SK. Bright spots: correlations of gray matter volume with IQ in a normal pediatric population. NeuroImage 2003;20(1):202-215. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
Exit |
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Wilson SE, Kahn RS, Khoury J, Lanphear BP. Racial differences in exposure to environmental tobacco smoke among children. Environmental Health Perspectives 2005;113(3):362-367. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Wright J, Lanphear B, Dietrich K, Bolger M, Tully L, Cecil K, Sacarellos C. Developmental lead exposure and adult criminal behavior:A 30-year prospective birth cohort study. Neurotoxicology and Teratology 2021;85. |
R829389 (Final) |
Exit Exit |
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Yang W, Braun J, Vuong A, Percy Z, Xu Y, Xie C, Deka R, Calafat A, Ospina M, Yolton K, Lanphear B, Chen A. Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy:The HOME Study. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 2022;245(114026). |
R829389 (Final) |
Exit |
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Yang W, Braun J, Vuong A, Percy Z, Xu Y, Xie C, Deka R, Calafat A, Ospina M, Yolton K, Lanphear B, Chen A. Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study. ENVIRONMENTAL POLLUTION 2023;316(1) |
R829389 (Final) |
Exit |
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Yang W, Braun J, Vuong A, Percy Z, Xu Y, Xie C, Deka R, Calafat A, Ospina M, Burris H, Yolton K, Cecil K, Lanphear B, Chen A. Gestational exposure to organophosphate esters and infant anthropometric measures in the first 4 weeks after birth. SCIENCE OF THE TOTAL ENVIRONMENT 2023;857(1):159322 |
R829389 (Final) |
Exit |
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Yang W, Braun J, Vuong A, Percy Z, Xu Y, Xie C, Deka R, Calafat A, Werner E. Maternal urinary OPE metabolite concentrations and blood pressure during pregnancy:The HOME study. Environmental Research 23;207(112220). |
R829389 (Final) |
Exit Exit |
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Yolton K, Dietrich K, Auinger P, Lanphear BP, Hornung R. Exposure to environmental tobacco smoke and cognitive abilities among U.S. children and adolescents. Environmental Health Perspectives 2005;113(1):98-103. |
R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) |
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Yuan W, Holland SK, Cecil KM, Dietrich KN, Wessel SD, Altaye M, Hornung RW, Ris MD, Egelhoff JC, Lanphear BP. The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function. Pediatrics 2006;118(3):971-977. |
R829389 (2005) R829389 (Final) |
Exit |
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Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. American Journal of Neuroradiology 2007;28(10):1919-1925. |
R829389 (2005) R829389 (Final) |
Exit Exit |
Supplemental Keywords:
toxicology, ADHD behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants,, RFA, Scientific Discipline, Health, Toxics, Toxicology, Health Risk Assessment, pesticides, Chemistry, Risk Assessments, Children's Health, genetic susceptability, Biology, pesticide exposure, risk assessment, biomarkers, hearing loss, behavioral assessment, lead, exposure, neurotoxicity, children, toxicity, behavioral deficits, biological markers, toxicants, exposure assessmentRelevant Websites:
http://www.healthyhomestoday.com Exit
http://www.cincinnatichildrens.org/research/project/enviro Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.