Grantee Research Project Results
2005 Progress Report: FRIENDS Children's Environmental Health Center
EPA Grant Number: R829390Center: Water Innovation Network for Sustainable Small Systems
Center Director: Reckhow, David A.
Title: FRIENDS Children's Environmental Health Center
Investigators: Schantz, Susan L.
Institution: University of Illinois Urbana-Champaign
EPA Project Officer: Hahn, Intaek
Project Period: November 1, 2001 through October 31, 2006 (Extended to October 31, 2008)
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
Project Amount: $5,568,992
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Fox River Environment and Diet Study (FRIENDS) Children’s Environmental Health Center was established to investigate the health effects of combined exposure to PCBs and MeHg in Hmong and Lao refugees consuming contaminated fish from the Fox River in northeastern Wisconsin. The objectives of the FRIENDS Center are to: (1) study the impact of PCB and MeHg exposure on women’s reproductive health and child development; (2) develop effective educational strategies to reduce exposure; and (3) conduct laboratory studies aimed at understanding the mechanisms through which these contaminants induce neurological deficits in children.
Progress Summary:
The accomplishments of the Center are described in the individual 2005 Annual Reports for the FRIENDS Center projects:
R829390C001: Neurobehavioral Effects of PCBs and Methylmercury in Rats.
R829390C002: Perinatal PCB Exposure and Neurophysical/Auditing Function.
R829390C003: FRIENDS Analytical Toxicology Core Facility.
R829390C004: Development Effects of PCB and Methylmercury.
Future Activities:
See the individual 2005 Annual Reports for R829390C001 through R829390C004 for future activities.
Journal Articles: 23 Displayed | Download in RIS Format
| Other center views: | All 40 publications | 24 publications in selected types | All 23 journal articles |
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Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environmental Health Perspectives 1999;107(11):879-885. |
R829390 (2005) R829390 (Final) R825812 (1999) |
Exit |
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Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. NeuroToxicology 2000;21(6):1123-1134. |
R829390 (2005) R829390 (Final) R825812 (1999) |
Exit |
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Bemis JC, Seegal RF. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicological Sciences 2004;80(2):288-295. |
R829390 (2005) R829390 (Final) R829390C004 (2004) R825812 (1999) |
Exit Exit Exit |
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Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. |
R829390 (2005) R829390 (Final) R829390C002 (2005) R827027 (2002) R829388 (2006) R829388 (Final) R829388C006 (2005) R829389 (2005) R829389 (Final) R831710 (2005) R831710 (Final) R831711 (2005) R832141 (2006) R832141 (2007) R832141 (Final) |
Exit |
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Dreiem A, Gertz CC, Seegal RF. The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent. Toxicological Sciences 2005;87(1):156-162. |
R829390 (2005) R829390 (Final) R829390C004 (2005) |
Exit Exit Exit |
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Dreiem A, Seegal RF. Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent. NeuroToxicology 2007;28(4):720-726. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R829390 (2005) R829390 (Final) R829390C002 (2005) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R831709 (2005) R831709C001 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) R832141 (2007) R832141 (Final) |
Exit |
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Kornosky JL, Peck JD, Sweeney AM, Adelson PL, Schantz SL. Reproductive characteristics of Southeast Asian immigrants before and after migration. Journal of Immigrant and Minority Health 2008;10(2):135-143. |
R829390 (2005) R829390 (Final) |
Exit |
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Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicological Sciences 2005;88(2):400-411. |
R829390 (2005) R829390 (Final) R829388 (2006) R829388 (Final) R829388C006 (2005) |
Exit Exit Exit |
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Lyng GD, Synder-Keller A, Seegal RF. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain Research 2007;1133(1):1-9. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Lyng GD, Synder-Keller A, Seegal RF. Polychlorinated biphenyl-induced neurotoxicity in organotypic co-cultures of developing rat ventral mesencephalon and striatum. Toxicological Sciences 2007;97(1):128-139. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Lyng GD, Seegal RF. Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA. NeuroToxicology 2008;29(2):301-308. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Powers BE, Widholm JJ, Lasky RE, Schantz SL. Auditory deficits in rats exposed to an environmental PCB mixture during development. Toxicological Sciences 2006;89(2):415-422. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Powers B, Poon E, Sable H, Schantz S. Developmental Exposure to PCBs, MeHg, or Both:Long-Term Effects on Auditory Function. ENVIRONMENTAL HEALTH PERSPECTIVES 2009;117(7):1101-1107. |
R829390 (Final) |
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Roegge CS, Wang VC, Powers BE, Klintsova AY, Villareal S, Greenough WT, Schantz SL. Motor impairment in rats exposed to PCBs and methylmercury during early development. Toxicological Sciences 2004;77(2):315-324. |
R829390 (2005) R829390 (Final) R829390C001 (2004) |
Exit Exit |
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Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. |
R829390 (2005) R829390 (Final) R829390C001 (2005) R829388 (2006) R829388 (Final) R829388C006 (2005) |
Exit Exit Exit |
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Roegge CS, Schantz SL. Motor function following developmental exposure to PCBS and/or MEHG. Neurotoxicology and Teratology 2006;28(2):260-277. |
R829390 (2005) R829390 (Final) R829390C001 (2005) |
Exit Exit Exit |
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Roegge CS, Wang VC, Powers BE, Klintsova A, Villareal S, Greenough WT, Schantz SL. Motor functions in rats exposed to PCBs and methylmercury during early development. Neurotoxicology and Teratology 2002;24(3):424-425. |
R829390C001 (2002) R829390C001 (2003) |
not available |
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Sable HJK, Powers BE, Wang VC, Widholm JJ, Schantz SL. Alterations in DRH and DRL performance in rats developmentally exposed to an environmental PCB mixture. Neurotoxicology and Teratology 2006;28(5):548-556. |
R829390 (2005) R829390 (Final) |
Exit Exit Exit |
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Sable H, Eubig P, Powers B, Wang V, Schantz S. Developmental exposure to PCBs and/or MeHg:Effects on a differential reinforcement of low rates DRL operant task before and after amphetamine drug challenge. NEUROTOXICOLOGY AND TERATOLOGY 2009;31(3):149-158. |
R829390 (Final) |
Exit Exit |
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Seegal RF, Brosch KO, Okoniewski RJ. Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. Toxicological Sciences 2005;86(1):125-131. |
R829390 (2005) R829390 (Final) R829390C004 (2005) |
Exit Exit Exit |
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Sweeney AM, Peck JD, Gasior DM, Gardiner J, Schantz SL. Perinatal PCBs and mercury exposure and neurodevelopmental effects. Epidemiology 2004;15(4):S147-S148. |
R829390 (Final) R829390C002 (2004) |
Exit |
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Widholm JJ, Villareal S, Seegal RF, Schantz SL. Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicological Sciences 2004;82(2):577-589. |
R829390 (2002) R829390 (2005) R829390 (Final) R829390C001 (2004) |
Exit Exit Exit |
Supplemental Keywords:
children’s health, disease and cumulative effects, ecological risk assessment, susceptibility, sensitive population, toxicology, Fox River, PCBs, exposure assessment, heavy metals, methylmercury, pesticides, fish consumption,, RFA, Health, Scientific Discipline, Geographic Area, Midwest, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Children's Health, genetic susceptability, Ecological Risk Assessment, Molecular Biology/Genetics, neurotoxic, human data, Fox River, PCBs, pesticides, behavioral assessment, children, neurotoxicity, motor development, methylmercury, PCB, behavioral deficits, cognitive development, Wisconsin (WI), reproductive health, animal studies, biomedical research, exposure assessmentProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
R829390C003 FRIENDS Analytical Toxicology Core Facility
R829390C004 Developmental Effects of PCBs and Methylmercury
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2007
- 2006
- 2004 Progress Report
- 2003 Progress Report
- 2002 Progress Report
- Original Abstract
23 journal articles for this center