Grantee Research Project Results

Developmental Effects of PCBs and Methylmercury

EPA Grant Number: R829390C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R829390
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center
Center Director: Schantz, Susan L.
Title: Developmental Effects of PCBs and Methylmercury
Investigators: Seegal, Richard F. , Lawrence, David A. , Snyder-Keller, Abigail M.
Current Investigators: Seegal, Richard F.
Institution: New York State Department of Health
EPA Project Officer: Hahn, Intaek
Project Period: October 17, 2001 through October 16, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

Determine the neurochemical and neuropathological consequences of developmental exposure of the laboratory rat to polychlorinated biphenyls (PCBs), methylmercury (MeHg) or the two neurotoxicants in combination. These data may aid in explaining the associations that have been observed between maternal consumption of fish contaminated with these and other toxicants and neurobehavioral deficits in their infants and children.

Publications and Presentations:

Publications have been submitted on this subproject: View all 7 publications for this subproject | View all 40 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 3 journal articles for this subproject | View all 23 journal articles for this center

Supplemental Keywords:

mixtures, interactions., RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Physical Processes, Children's Health, genetic susceptability, Molecular Biology/Genetics, Risk Assessment, sensitive populations, neurotoxic, developmental neurotoxicology, biomarkers, childhood cancer, exposure, PCBs, animal model, developmental effects, children, Human Health Risk Assessment, methylmercury, residential populations, PCB, children's vulnerablity, assessment of exposure, neurodevelopmental toxicity, neurobehavioral effects, biological markers, toxics

Progress and Final Reports:

Final

Main Center Abstract and Reports:

R829390 CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
R829390C003 FRIENDS Analytical Toxicology Core Facility
R829390C004 Developmental Effects of PCBs and Methylmercury

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.