Grantee Research Project Results
FRIENDS Analytical Toxicology Core Facility
EPA Grant Number: R829390C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R829390
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Water Innovation Network for Sustainable Small Systems
Center Director: Reckhow, David A.
Title: FRIENDS Analytical Toxicology Core Facility
Investigators: Kostyniak, Paul J. , Olson, James , Fitzpatrick, Richard
Current Investigators: Kostyniak, Paul J.
Institution: The State University of New York at Buffalo
EPA Project Officer: Aja, Hayley
Project Period: October 17, 2001 through October 16, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The objective of the Analytical Toxicology Core Facility (ATCF) is to provide analytical support to both the epidemiological and animal research projects of the FRIENDS Children's Environmental Health Center. The ATCF support involves the development of new analytical techniques, analyses of samples and analyses of data. All procedures are controlled by a strict QC/QA program. The techniques available Include GC with EC, FID, PID and Hall detection, HPLC with diode array, fluorescence and electrochemical detection, GC-MS, AAS, mercury determinations, high temperatures GPC for absolute molecular weight and molecular weight distribution determinations. This laboratory has extensive experience determining specific congeners of PCBs and pesticides and heavy metals at ppb levels in biological samples, and has participated in nationwide proficiency programs for PCBs, pesticides and mercury. The ATCF also performs a reporter gene bioassay for the quantification of total dioxin (TCDD) toxic equivalents (TEQs) in Hepa 1c1c7, mouse hepatoma cells, which are stably transfected with the reporter plasmid p2Dluc containing 2 copies of the DRED consensus sequence.
Supplemental Keywords:
PCBs, Methymercury, dioxin-like, TEQ, PBDE., RFA, Scientific Discipline, Health, ENVIRONMENTAL MANAGEMENT, Geographic Area, POLLUTANTS/TOXICS, Midwest, Toxicology, Health Risk Assessment, Epidemiology, Chemistry, Chemicals, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Ecological Risk Assessment, Molecular Biology/Genetics, Children's Health, genetic susceptability, Biology, Risk Assessment, human data, neurotoxic, behavioral assessment, PCBs, pesticides, animal model, electrochemical detection, children, neurotoxicity, motor development, behavioral deficits, methylmercury, PCB, cognitive development, human exposure, Wisconsin (WI), animal studies, reproductive health, exposure assessment, biomedical research, heavy metalsProgress and Final Reports:
Main Center Abstract and Reports:
R829390 Water Innovation Network for Sustainable Small Systems Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
R829390C003 FRIENDS Analytical Toxicology Core Facility
R829390C004 Developmental Effects of PCBs and Methylmercury
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.