Grantee Research Project Results

2005 Progress Report: Community-Based Participatory Research Project

EPA Grant Number: R831709C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R831709
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Air, Climate, and Energy Solutions
Center Director: Robinson, Allen
Title: Community-Based Participatory Research Project
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The objectives of the research project are to: (1) intervene to reduce children’s exposure to pesticides, including the development of a culturally appropriate intervention to break the take-home pathway; and (2) foster partnerships between academic researchers and the community in which information requested by the community and basic research deficiencies/gaps are translated into studies that address the health needs of both.

As a result of receipt of donor funds, we were able to increase the scope of work for this research project to include collection of additional biological specimens that will enhance the project further. The additional tasks include: (1) comparing the levels of organophosphorus pesticide (OP) parent compounds in the blood of adult farmworkers and nonfarmworkers, adjusting for the multiple pathways; (2) compare levels of pesticide residues in saliva to those in urine and blood to determine reliability and validity of data and to assess more accurately the presence of Ops; (3) conduct blood analysis through finger sticks to ascertain cholinesterase levels; and (4) conduct analysis of buccal cell samples in adults and children of farmworkers and nonfarmworkers to gain a better understanding of the mechanisms of toxicity of OPs.

Progress Summary:

Final preparation for data collection was completed. Local interviewers were hired and trained in study procedures. Study participants have been recruited and we have completed the data collection for the spray season phase of the research project. The data collection included an initial and follow-up survey and collection of urine, venous blood, finger-stick blood, buccal cells, saliva, and house and vehicle dust samples from farmworker and nonfarmworker families, as indicated by the study protocol.

We have increased the sample size for each cohort to 100 to account for potential losses in participation; 101 farmworker and 99 nonfarmworker families have been enrolled in this portion of the study. We will follow these families through the harvest and nonspray seasons.

Data from the surveys from this data collection are being entered. Biological specimens have been shipped to the Centers for Disease Control and Prevention and the University of Washington for analysis.

Significance

The most significant achievements are two-fold. First, we provided empirical support for the take-home pathway of pesticides to the children of farmworkers; second, we demonstrated that the urinary metabolites of pesticides among children were associated directly with urinary metabolites of the farmworker in the household.

Once the data for this study are analyzed, we will be able to identify the parent compound of OPs in blood. We also will be able to examine cholinesterase levels in farmworkers (as opposed to in pesticide handlers) and in their children.

Another innovative achievement is the ability and practice of providing accurate scientific data to farmworkers and growers in the Valley. This led to numerous opportunities to address media throughout the state and country.

This is one of the largest studies conducted with farmworkers and pesticide exposure that provides data from biomarkers, as well as from survey information.

Future Activities:

We will continue with data collection during the harvest and nonspray seasons. We will analyze the data that we have collected recently. We will work with the Centers for Disease Control and Prevention and the University of Washington to have the biological samples analyzed.

We will plan for and conduct the exploratory study of pesticide exposure among warehouse workers and their children.

Journal Articles on this Report : 3 Displayed | Download in RIS Format

Publications Views
Other subproject views:	All 14 publications	10 publications in selected types	All 10 journal articles
Other center views:	All 175 publications	127 publications in selected types	All 107 journal articles

Publications
Type	Citation	Sub Project	Document Sources
Journal Article	Coronado GD, Thompson B, Griffith WC. Children's exposure to OP pesticides:response to Fenske et al. Environmental Health Perspectives 2004;112(15):A866 (correspondence).	R831709 (2005) R831709C003 (2005)	Full-text from PubMed Abstract from PubMed Associated PubMed link
Journal Article	Coronado GD, Thompson B, Strong L, Griffith WC, Islas I. Activities and organophosphate exposures: response. Environmental Health Perspectives 2004;112(13):A725-A726 (correspondence).	R831709 (2005) R831709 (2007) R831709C003 (2005)	Full-text from PubMed Abstract from PubMed Associated PubMed link
Journal Article	Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471.	R831709 (2005) R831709 (2007) R831709C003 (2005) R831709C003 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831710C004 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) R832139 (2006)	Full-text from PubMed Abstract from PubMed Associated PubMed link

Supplemental Keywords:

children’s health, epidemiology, genetics, health risk assessment, risk assessment, assessment of exposure, asthma, children’s environmental health, diesel exhaust, environmental risks, exposure assessment, genetic mechanisms, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Environmental Chemistry, Health Risk Assessment, Biochemistry, Children's Health, Risk Assessment, environmental health, health effects, pesticide exposure, community-based intervention, developmental neurotoxicity, biological response, environmental risks, Human Health Risk Assessment, assessment of exposure, children's vulnerablity

Relevant Websites:

http://depts.washington.edu/chc Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R831709 Center for Air, Climate, and Energy Solutions

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831709C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R831709C002 Genetic Susceptibility to Pesticides
R831709C003 Community-Based Participatory Research Project
R831709C004 Pesticide Exposure Pathways Research Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.