Grantee Research Project Results
2018 Progress Report: Center for Native American Environmental Health Equity Research
EPA Grant Number: R836157Center: Center for Native American Environmental Health Equity Research
Center Director: Lewis, Johnnye Lynn
Title: Center for Native American Environmental Health Equity Research
Investigators: Lewis, Johnnye Lynn , MacKenzie, Debra Ann , Cerrato Corrales, Jose Manuel , Hudson, Laurie , Gonzales, Melissa
Current Investigators: Lewis, Johnnye Lynn , Gonzales, Melissa , Hudson, Laurie , Cerrato Corrales, Jose Manuel , MacKenzie, Debra Ann
Institution: University of New Mexico
EPA Project Officer: Callan, Richard
Project Period: July 1, 2015 through June 30, 2020 (Extended to June 30, 2021)
Project Period Covered by this Report: July 1, 2017 through June 30,2018
Project Amount: $1,500,000
RFA: NIH/EPA Centers of Excellence on Environmental Health Disparities Research (2015) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Aim 1: Integrate long-standing community partnerships in three Native American tribal nations to develop integrated approaches to data collection, management, and analysis in order to identify interactions in key environmental, cultural, traditional and social determinants of health and their contribution to disparities in key health outcomes of concern.
Aim 2: Develop research capacity and an infrastructure to assist tribes and researchers with identification of key environmental exposure sources, biogeochemical factors controlling their mobility and transfer through the environment, and social and cultural practices driving exposures and risks, and to use this information to better understand risk and develop risk reduction recommendations.
Aim 3: Build capacity for tribal-academic research partnerships through an intensive series of workshops encouraging multi-directional communication among community members, students and faculty at tribal colleges, tribal elders and leaders, senior and junior academic researchers with the goal of sharing approaches to research, knowledge transfer, and perspectives on health and the environment
Aim 4: Based on knowledge gained in the process, identify and recommend cost-effective, readily implemented, and sustainable strategies to mitigate risk, reduce environmental health disparities, and inform regulatory decision-making.
Progress Summary:
(1) Research performed during the reporting period and results (outputs/outcomes) that have been generated.
Aim 1: Integrate long-standing community partnerships in three Native American tribal nations to develop integrated approaches to data collection, management, and analysis in order to identify interactions in key environmental, cultural, traditional and social determinants of health and their contribution to disparities in key health outcomes of concern.
The format of the Annual Center Progress Report is highly integrative, such as our Center, results in substantial redundancy. In this Overall section, we highlight key concepts and reference the component(s) in which they are discussed in more detail to minimize this redundancy.
Integration of our partner communities and building of integrated data sets has been a great challenge for which significant strides in addressing have been made this year. Each of our performance sites and partners have had their own research programs focused on their issues for several years and shifting that focus to truly understand benefits of combining resources has benefited from synchrony and a catalyst event. Our environmental core and pilot projects in the past year have provided that catalyst in several converging activities. Our CEC and EC, building on strengths of our CDIs, developed a student intern training at Cheyenne River, teaching undergraduate interns basic concepts of environmental health and risk assessment, as well as methods for collecting environmental samples for analysis. The results from that work generated data showing potential exposure pathways through traditional uses of plant material that had accumulated arsenic as a result of contact with contaminated sediments. Simultaneously, CDI Rodriguez-Freire made significant progress in her pilot project to understand how this uptake could occur, and the role of microbial communities in the process. Mr. Three Irons in his diversity supplement had already been examining microbial contamination of well waters at Crow with concerns for contact of wells with surface water that could introduce microbes, and subsequently alter both direct gastroenteric risk and metal mobility. At Cheyenne River, a community member began to raise concerns on social media that swimming beaches on the Cheyenne River used extensively by tribal members could be unsafe due to elevated arsenic, and EAC member Runsafter suggested this would be an opportunity for the Center to provide data to assess this concern.
Pulling together these varied interests in microbial mobilization of metals and ultimate risks from these exposure pathways in the environment, the Center has been able to incorporate in this summer’s workshop on Cheyenne River consideration of these exposure pathways within their focus of resource restoration, with student interns then collecting water samples in key recreational areas to analyze for microbial content over the summer. We are talking with Crow colleagues to have the students drive to Crow for analysis of their samples with Mr. Three Irons, are diversity supplement student, and then doing specific NexGen sequencing of the samples from both Crow and Cheyenne River, to compare results with those already generated in Dr. Rodriguez-Freire in her pilot project using samples from other reaches of the Cheyenne River. This cross-site initiative is described in the Admin Core in discussion of CDIs, as well as in the CEC and EC reports. The EC and CDIs will be directly involved in all aspects.
Currently, we have been able to generate DNA damage/repair and immunologic data on the available blood samples from both Navajo Nation and Cheyenne River, with the third set from Crow starting to be collected this year. This again will provide a catalyst for collaboration as we begin to generate common data. The results so far are reported in detail in the Research Project 1 and 2 reports. However, the interpretation of these results to date has been hampered by delays in development of our biospecimen trace-metal analysis protocols. Substantial institutional support has been provided to help us overcome this barrier (discussed under Aim 2), and we anticipate analysis of all banked biospecimens to date will occur in the coming 6 months, generating the common research results for which we have been waiting.
While waiting for the data for Crow and Cheyenne River biomonitoring analyses, however, we have been able to generate results from our Navajo samples, and to investigate the roles of metals and combinations of metals in those samples. We have demonstrated that the zinc-reversible increase in retained DNA damage is most likely the result of inhibition of DNA repair proteins as we hypothesized. A potential competing pathway, direct metal-induced oxidative stress, has not been shown to be related to either uranium exposures or responsive to concentrations of zinc in the serum. This manuscript has been submitted and final responses to comments are in progress. The work has also led to our data team comparing approaches for expanding the analyses of complex mixtures in a methodological manuscript currently in review by CDC prior to submission to a journal. (CDC requests review of any manuscripts using samples generated through their funding.) These analyses have looked not only at the responses to metals, but also examined key sociodemographic and culture-related variables interacting with the exposures. This process has allowed us to develop the platforms that will be used for analysis of the combined results from the three populations, determining similarities and differences in responses in these molecular mechanisms in toxicity across the three tribes and exposure mixtures. We have also been able to begin characterizing the complexity in cytokine and lymphocyte responses to metal mixtures using the Navajo samples, again developing the platform for completion of the Crow and Cheyenne River samples.
While we have not been able to link findings on Cheyenne River to biomonitoring yet, we have been able to generate the analyses of immunologic profiles. Similar autoantibody profiles have been observed to those seen in Navajo samples in relation to metal exposures, with both exceeding the US norms. Comparison with Crow samples will begin this year, as will the analyses of the relationship to exposure.
Animal exposures to mimic our population exposures are in progress with no data yet to report.
As a result of needs of our Center, leveraged on related projects, both UNM Health Sciences Center and the Earth and Planetary Sciences Department in Arts and Sciences have contributed to development of a Trace Metals Analysis Laboratory. Earth and Planetary Sciences has renovated a laboratory to create a clean room in which a state-of-the-art ICP-MS purchased by Health Sciences Center will be housed. The Center and our NIH ECHO project will jointly support a dedicated analytical chemist to staff this laboratory. Once analytical protocols have all been validated on the new equipment, a technician will be hired to support analyses. This resource will serve not only UNM and this Center, but will become a resource for community biomonitoring research analyses through a fee-for-service structure and partnered specimen stewardship agreements.
Aim 2: Develop research capacity and an infrastructure to assist tribes and researchers with identification of key environmental exposure sources, biogeochemical factors controlling their mobility and transfer through the environment, and social and cultural practices driving exposures and risks, and to use this information to better understand risk and develop risk reduction recommendations.
As mentioned above, the EC, working with the CEC, CDIs, and related Pilot Projects, has made substantial progress in understanding the mobility of arsenic in plants with roots in contact with contaminated water and sediments. These analyses of environmental samples have been able to proceed as the concentrations in these media exceed those in human biospecimen monitoring and do not require the same sensitivity of instrumentation. Surveys with tribal members and focus groups indicating potential exposure pathways have identified uses of various parts of the plants, and will allow us to work on assessing the risk provided by the specified use of the various components of the plant. The analyses have also indicated the potential for variation in the results across the growing season, suggesting the possibility of developing guidelines for use to ensure collection of specimens from clean areas at times of greatest risk, but allowing the use in contaminated zones to resume as concentrations in parts used drop. These results are pilot at this point, but if replicated across years, could be very beneficial in allowing the community to resume activities that previously ceased because of exposure concerns.
Dr. Gonzales, working with CDI Hoover and an undergraduate intern built on data from all tribes relative to cultural uses associated with ceremonial smoke inhalation exposures. The model contains graphic representations of exposure assumptions, as well as the formulas used to develop exposures. It can readily be adapted to characterize risk based on the concentrations in the combustion sources, the distance from the fire, and the frequency and duration in the exposure setting. This model then can allow the tribes to look at relative risks and share with regulators without detailing cultural practices.
Center members Lewis, Shuey, Erdei, MacKenzie, and Dashner are participating in a series of conferences, the K’e Conferences, being held across Navajo Nation every other Saturday in March and April. The intent of the conferences is to increase awareness of environmental health research and to work with communities in developing strategies to mitigate risks.
Dr. Lewis was also invited to organize and present at a session on environmental disparities in cancer at the American Association of Cancer Research annual disparities conference in 2017. The work of the Center was highlighted, and Edith Hood from our Red Water Pond Road community partner on Navajo Nation was also an invited speaker in the session.
Center work was also presented by Dr. Lewis in an invited session for a Canadian conference. The University of Manitoba is interested in the tribal partnerships model used by the Center and has invited Dr. Lewis to serve as an advisor to their initiatives to develop partnerships with First Nations communities in Northern Manitoba in order to partner in research initiatives to improve child health outcomes.
A final initiative in developing infrastructure stems from our work to develop a trace metals analysis laboratory to conduct biomonitoring studies. Currently, only a limited number of laboratories can analyze uranium in biological samples at limits of detection sufficiently low to assess concentration associated with toxicity in our research studies. CDC is the major laboratory with this capability. As CDC is not a fee-for-service contract laboratory, but rather a research facility, negotiating contracts for analysis can be a lengthy process, as can the time necessary to get submitted samples analyzed and returned. Also, some communities have a reluctance to allowing samples to be transferred to a federal agency with which they do not have established trust relationships. As we develop the trace analysis laboratory, we are hoping to make this a facility that can be used by other communities on a fee for service basis with a chain of custody designed in partnership to facilitate trust in the analysis, transfer and return of samples.
Aim 3: Build capacity for tribal-academic research partnerships through an intensive series of workshops encouraging multi-directional communication among community members, students and faculty at tribal colleges, tribal elders and leaders, senior and junior academic researchers with the goal of sharing approaches to research, knowledge transfer, and perspectives on health and the environment.
Following last year’s model workshop held on Navajo during our annual meeting, we convened a conference in South Dakota this year. Held in Rapid City, the conference drew from tribal elders and leadership, tribal students, and tribal scientists. The council vice-chairman, Robert Chasing Hawk, attended the full conference and synthesizing what he had heard, brought forward an idea for looking at approaches to work with one of the communities to design a model to restore resources lost with the contamination. Dr. Josie Chase, a Native Researcher who has worked with Dr. Maria Braveheart to study historical trauma and ways of healing, participated in the conference by invitation as well. The proposed project to restore the community use area was also seen as something appropriate in addressing historical trauma. This year’s summer intern training sessions will explore how to involve the suggested community, as well as a colleague of Dr. Lefthand-Begay’s at Sitting Bull College who has been preserving Native seed stocks. This effort remains in progress.
In August/September of 2017, the Center sponsored a workshop on Tribal Data Sharing and Genetic Analyses. The conference was held at the University of New Mexico Comprehensive Cancer Center, with financial support from the NIH-OD Tribal Research Office and the National Congress of American Indians.
Invited speakers included primarily members of the Navajo Nation, including the President, members of Tribal Council, Navajo research scientists in genetics and bioethics, Community members, and representatives of three traditional medicine men associations, as well as the Navajo Nation Human Research Review Board. Navajo Nation has had a moratorium on genetic analyses for more than 20 years, with its removing reliant on development of an informed policy. Members of other tribes attended the conference, and representatives of NIH as well as a limited number of non-Native researchers also provided context in areas such as epigenetics. Attendees included members of other tribes including Sioux, Turtle Mountain, and the Pueblos. Albuquerque Area Southwest Tribal Epidemiology Center (AASTEC) leadership also attended. With very minimal dissent, all presenters were positive about the opportunities that could result from lifting the moratorium, but also clear that a policy to protect against the fears of misuse needed to be carefully developed to replace the moratorium. At the end of the meeting two working groups were struck – one the focus on development of a genetic research policy; the second to focus on data sharing. The workgroups have continued to meet in the intervening months. At present, a data sharing policy that was drafted at two subsequent work sessions among the NIH-OD as well as UNM researchers Lewis, MacKenzie, and Begay; Navajo Nation Human Research Review Board; and representatives of tribal council; and Navajo Department of Health has gone through review by NIH legal advisors and in the past week been returned to Navajo Nation for their legal review and sign-off. The policy will be limited in scope, will not cover sharing of biospecimens or genetic data, and will be tested and reevaluated after 6 months of signing, and regularly thereafter. It will be specific to data collected for the ECHO research program, involve NIH storing shared tribal data on a separate server, incorporation of tribal members on the publication proposal committee, and a tiered system of interaction with the Navajo Nation Human Research Review Board based on whether or not the research encompasses agreed to final outcomes of concern, or has a separate focus. The NIH Legal team also added opportunities for Navajo Nation to provide educational initiatives to program scientists to clearly educate them as to tribal concerns and policies. The Nation retains veto authority on use of their data in any specific publication. The genetics working group, with participation from Dr. Begay, is currently drafting subsections of the final policy, continuing to meet regularly, and recently was officially designated by tribal council with the task of developing this policy. Dr. Lewis remains in regular communication with the group through both Dr. Begay and chair Dr. Nanibaa Garrison (UW) who worked with Dr. Lewis in developing the initial conference. The success of the workshop has led Pueblo participants to request a second workshop specific to the Pueblos which we are currently working to develop in collaboration with our AASTEC colleagues and CDI Dr. Yazzie. The NIH-OD Tribal Research Office recently released a summary report on the conference. NCAI this week invited Drs. Lewis and Garrison to provide a summary of the conference and an update on outcomes at their summer tribal research meeting.
Aim 4: Based on knowledge gained in the process, identify and recommend cost-effective, readily implemented, and sustainable strategies to mitigate risk, reduce environmental health disparities, and inform regulatory decision-making.
While the major work in this area is a bit premature, we have developed initial steps in this approach. Dr. Gonzales’s model discussed above developed with CDI Hoover and her UPN student provides an example of an approach that we will try to parameterize in other pathways. The work on arsenic uptake through the EC, if reproducible, provides an opportunity for developing community information strategies if uptake patterns can be validated and confirmed – potentially restoring use of a community/cultural/traditional resource. In addition, the EC results will be shared with USEPA Region 8 to inform the discussion of uncertainties in a model based on cultural usage of resources that was negotiated with the tribe in consultation with Dr. Lewis and is being used to evaluate the long-term implications for the tribe from the Homestake mine contamination. We are also working with University of Arizona colleagues to combust some of the Cheyenne River wood samples we have analyzed to determine arsenic content in ash and smoke to refine parameters for exposure through the inhalation pathway.
A key part of this aim will require effective communication of our results and any information strategies we develop. Our initial work to support an artist-in-residence to work with our team has been highly successful. We are now expanding on this to investigate other avenues of communication that may further enhance this approach. Pueblo cartoonist has become very concerned with restoration of agriculture within his tribe and has developed tools for eliciting community feedback on fears and stressors limiting their use of resources. Ms. Quetawki, our artist-in-residence, in working on an overarching environmental health model for use by the Center, has also been working with this artist to integrate concepts that have been raised using his approach. After a pilot run at Laguna Pueblo feast day in March, we plan to work with the two of them to integrate their work and develop a stronger focus on environmental health for exchange of information. Involving them has also increased input from youth. This effort will be developed in more detail in the coming year. We have already learned that communities report very specific environmental concerns that can affect health, while the perspective on health concerns is much broader and more holistic. In other words – a very specific concern about livestock uptake of contaminants and transfer to humans is associated with an overall general reduction in health. Health is seen as much more holistic rather than disease specific. We are encouraged that this relationship is very consistent with our approach of examining specific molecular mechanisms underlying toxicity that could manifest in a wide range of adverse health outcomes from suppression of immune response to cancer.
(2) Difficulties the Center has (or might) encountered in carrying out its mission, and remedial actions (to be) taken. If the goals/hypotheses of any project funded under this Center have been modified from the original application, provide the revised goals and discuss the reason for the change. A discussion of any problems, delays, or adverse conditions which may materially impair the ability to meet the results (outputs/outcomes) specified in the application.
Center has faced challenges working with multiple institutions, NGOs, and tribal partners in establishing a common set of operating procedures within varying institutional policies. In addition, changing the ethos from community specific needs to center-wide thinking has also been challenging. We feel this year significant steps have been made to truly make the whole greater than the sum of its parts, that we have a clearer understanding of the needs in accomplishing that shift, and that projects outline in the plans for the coming year will further push that process forward.
We also experienced challenges in getting our first round of pilot projects funded due to unanticipated delays associated with NIH approvals, and applicants from partner institutions not clearing IDCs with their sponsored projects office which later wanted these costs added to the projects. These challenges are discussed in the pilot program report and have been addressed to smooth the process in this year's pilots. In addition, the call was issued in February, allowing for funding decisions to be complete by the start of the next FY cycle, which should also speed the funding of the projects.
The biggest challenge in the Center remains the distances between sites. However, as we continue our dialogue, and develop more joint initiatives, our various monthly interactions continue to help us overcome those challenges. We think the proposed joint work discussed in overall that will involve new investigations of biological processes modifying metal availability in water sources is an initiative that demonstrates increasing collaborations among our disparate sites. This initiative will involve all three communities, plus NJIT CDI and UW CDI as well as engaging our Environmental Core. We are very excited about the potential in this initiative.
We also are excited by the opportunity to conduct the livestock study mentioned throughout in collaboration with NAU but frustrated that delays in USEPA approval of that process have resulted in substantial delays to this collaborative effort moving forward. This work will be funded by EPA Region 9 as trustees of an award from a settlement with Tronox to fund remedial actions on Navajo Nation, and not associated with EPA funding of this Center. This work will also be in collaboration with the Navajo Tribal College (Dine College), and will be applicable to tribal risk assessments, answering significant gaps in current knowledge of transfer factors by incorporating a well characterized exposure assessment. We continue to participate in regular discussions and understand the work should be funded "soon" but had hoped to be in the field last fall and for now continue with watchful waiting and hopefulness.... We hope to be able to have some results of this joint initiative by next year's progress report.
University of New Mexico has substantially restricted the ability to develop and maintain interesting websites. While previously we had kept a community website called Healthy Voices which we could develop as a more user-friendly and community—relevant interface, we no longer have the ability to host websites outside of the closely defined, text-heavy structure provided by the institution. This has been extremely challenging, as this format is not community friendly. We have had difficulty even posting center newsletters. We are trying to find creative alternatives, but so far have not been successful. This applies to anything that uses the name UNM and can be accessed through searches. The previously CEC developed website provides a UNM Health Sciences Center link to the Center; see http://pharmacy.unm.edu/research/healthy-voices/equity-map.html, but is difficult to update and keep current.
Finally, the lack of protocols to obtain required limits of detection for analysis of biospecimens delayed generation of analytical results for specimens on hand. This barrier has been overcome with recent changes in equipment and laboratory space provided by the institution and is anticipated to resolve in the coming year. While these analyses have been delayed, we still anticipate completion of these analyses in the coming year, allowing our research results to be completed.
(3) Absence or changes of key personnel involved in the individual projects or Center management.
CDI Joe Hoover, Ph.D., who recently was promoted from postdoctoral fellow to Research Assistant Professor, has taken on the role of co-director of the CEC along with Dr. Gonzales. This change was based on 1) the excellent relationships Dr. Hoover had built with our Crow and Cheyenne River partners, and 2) limitations in time available for Mr. Shuey (former co-director) to meet with those sites. Mr. Shuey remains actively involved in the CEC, with his primary focus on Navajo Nation partners. We believe this change will not only improve the CEC coordination and activities but also will provide Dr. Hoover with crucial experience in management and leadership as part of his professional development as faculty. Dr. Hoover also brings to the CEC established relationships with several NM Pueblo communities -- sites the Center hopes to encourage collaboration with in the coming years.
(4) Results (outputs/outcomes) to date, emphasizing findings and their significance to the field, their relationship to the general goals of the award, their relevance to the Agency’s mission, and their potential practical applications.
Training and professional development:
The Center has a very strong focus on training at all levels. The CDI requirement of the granting agencies is met through inclusion of now 6 CDIs, leveraging on support providing by institutional training grants in addition to Center funding. These CDIs include not only junior Native faculty, but also non-Native faculty interested in working in partnership with Native communities. The success of this choice is illustrated by current invitations of our CDI to work with Native communities on new issues because of the experience they gained working with our Center. These examples are explained in the report on CDI progress in the AC component. Because of the shortage of Native faculty in University programs, we have also intentionally focused on pipeline initiatives. We support undergraduate interns at Cheyenne River Sioux Tribe each summer, provide training, and then data collection opportunities in conjunction with tribal needs and our EC and CEC. In addition, we sponsor undergraduate pipeline positions at UNM for Native students. Also, we currently mentor Emery Three Irons, a Crow Masters student, in collaboration with Montana State University faculty involved in his committee. This joint mentorship is serving to broaden his experience, including bringing him to UNM for a week to work closely with resources here. We also jointly mentor Johnathan Credo in collaboration with NAU colleague Dr. Jani Ingram, building a partnership between the P50 centers at UNM and NAU. Detail on all of these projects is provided within the component reports and will not be itemized here to avoid redundancy.
Future Activities:
Planned activities for the subsequent reporting period.
In the coming year we will:
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Organize and carry-out our third annual Center-wide and External Advisory Committee meeting.
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We will continue with our second phase of Center pilot projects, identify the strategic gaps they might address.
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Continue efforts to integrate historical trauma support into the Center.
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Continue our successful “artist-in-residence” program for community research translation through visual arts.
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Complete sample collection on Crow to complete our population data sets as the foundation for our integrated analyses.
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Implement Center wide methodology for biospecimen analysis.
Journal Articles: 13 Displayed | Download in RIS Format
Other center views: | All 89 publications | 13 publications in selected types | All 13 journal articles |
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Dasher-Titus EJ, Hoover J, Luo L, Lee J-H, Du R, Liu KJ, Traber MG, Ho E, Lewis J, Hudson LG. Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants. Free Radical Biology and Medicine 2018;124:484-492. |
R836157 (2018) R836157 (2019) |
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Doyle JT, Kindness L, Realbird J, Eggers MJ, Camper AK. Challenges and opportunities for tribal waters:addressing disparities in safe public drinking water on the Crow Reservation in Montana, USA. International Journal of Environmental Research and Public Health 2018;15(4):567. |
R836157 (2018) R836157 (2019) R835594 (2018) R835594 (Final) |
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Eggers MJ, Doyle JT, Lefthand MJ, Young SL, Moore-Nall AL, Kindness L, Other Medicine R, Ford TE, Dietrich E, Parker AE, Hoover JH, Camper AK. Community engaged cumulative risk assessment of exposure to inorganic well water contaminants, Crow Reservation, Montana. International Journal of Environmental Research and Public Health 2018;15(1):76. |
R836157 (2019) R835594 (2017) R835594 (2018) R835594 (Final) |
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Eggers MJ, Doyle JT, Lefthand MJ, Young SL, Moore-Nall AL, Kindness L, Other Medicine R, Ford TE, Dietrich E, Parker AE, Hoover JH, Camper AK. Community engaged cumulative risk assessment of exposure to inorganic well water contaminants, Crow Reservation, Montana. International Journal of Environmental Research and Public Health 2018;15(1):76 (34 pp.). |
R836157 (2018) |
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Girlamo C, Lin Y, Hoover J, Beene D, Woldeyohannes T, Liu Z, Campen M, MacKenzie D, Lewis J. Meteorological data source comparison-a case study in geospatial modeling of potential environmental exposure to abandoned uranium mine sites in the Navajo Nation. ENVIRONMENTAL MONITORING AND ASSESSMENT 2023;195(7):834 |
R836157 (2020) |
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Gonzales M, King E, Bobelu J, Ghahate DM, Madrid T, Lesansee S, Shah V. Perspectives on biological monitoring in environmental health research: a focus group study in a Native American community. International Journal of Environmental Research and Public Health 2018;15(6):1129 (8 pp.). |
R836157 (2018) R836157 (2019) |
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Harmon ME, Lewis J, Miller C, Hoover J, Ali AS, Shuey C, Cajero M, Lucas S, Zychowski K, Pacheco B, Erdei E, Ramone S, Nez T, Gonzales M, Campen MJ. Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. Journal of Exposure Science & Environmental Epidemiology 2017;27(4):365-371. |
R836157 (2018) R836157 (2019) |
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Hoover JH, Coker E, Barney Y, Shuey C, Lewis J. Spatial clustering of metal and metalloid mixtures in unregulated water sources on the Navajo Nation – Arizona, New Mexico, and Utah, USA. Science of The Total Environment 2018;633:1667-1678. |
R836157 (2018) R836157 (2019) |
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Hoover J, Gonzales M, Shuey C, Barney Y, Lewis J. Elevated arsenic and uranium concentrations in unregulated water sources on the Navajo Nation, USA. Exposure and Health 2017;9(2):113-124. |
R836157 (2016) R836157 (2017) R836157 (2019) |
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Hoover J, Coker E, Erdei E, Luo L, MacKenzie D, Lewis J. Preterm Birth and Metal Mixture Exposure among Pregnant Women from the Navajo Birth Cohort Study. ENVIRONMENTAL HEALTH PERSPECTIVES 2023;131(12). |
R836157 (Final) |
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Lewis J, Hoover J, MacKenzie D. Mining and environmental health disparities in Native American communities. Current Environmental Health Reports 2017;4(2):130-141. |
R836157 (2017) R836157 (2019) |
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Rodriguez-Freire L, Avasarala S, Ali AS, Agnew D, Hoover JH, Artyushkova K, Latta DE, Peterson EJ, Lewis J, Crossey LJ, Brearley AJ, Cerrato JM. Post Gold King Mine spill investigation of metal stability in water and sediments of the Animas River watershed. Environmental Science & Technology 2016;50(21):11539-11548. |
R836157 (2016) R836157 (2017) R836157 (2019) |
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Saup CM, Williams KH, Rodríguez-Freire L, Cerrato JM, Johnston MD, Wilkins MJ. Anoxia stimulates microbially catalyzed metal release from Animas River sediments. Environmental Science: Processes & Impacts 2017;19(4):578-585. |
R836157 (2017) R836157 (2019) |
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Supplemental Keywords:
metals, uranium, arsenic, DNA repair, mercury, water quality, ICP-OES, ICP-MS, management, resource allocation, communication, career development, community engagement, research dissemination, ANA, immune activity, Native AmericanRelevant Websites:
Southwest Research and Information Center Exit
Native Health Environmental Research - 2016 Exit
The Center for Environmental Health Equity Exit
News 21 - Troubled Waters Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836157C001 Metals and metal mixtures in DNA damage and repair
R836157C002 Development of biomarkers of autoimmunity in 3 tribal communities exposed to mixed metal contaminants
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2020 Progress Report
- 2019 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- Original Abstract
13 journal articles for this center