Grantee Research Project Results
2019 Progress Report: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
EPA Grant Number: R836152Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
Investigators: Hansel, Nadia , Putcha, Nirupama , McCormack, Meredith , Maisonet, Mildred
Current Investigators: Hansel, Nadia , Diette, Greg , McCormack, Meredith , Koehler, Kirsten , Polotsky, Seva
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2021)
Project Period Covered by this Report: June 1, 2018 through May 31,2019
Project Amount: $1,200,000
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
Project 1: Obesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPDObesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPD
The goal of the program is to fully understand the complex interplay between poverty, air pollutants, obesity and diet, in two independent low-income urban and rural cohorts. In particular, Project 1 through an observational study, will focus on low-income adults in an urban setting, aiming to determine whether elevated fat mass and body composition, adverse diet patterns increase susceptibility to indoor pollution in low income adults with COPD.
Project 2: Indoor air pollution and COPD in rural Appalachia
The goal of the program is to fully understand the complex interplay between poverty, air pollutants, obesity and diet, in two independent low-income urban and rural cohorts. In particular, Project 2 will investigate the role of indoor air quality on respiratory health of residents of rural Appalachia.
Progress Summary:
Project 1: Obesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPDObesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPD
To date, we have telephonescreened 569 potential eligible participants, of which 250 were eligible according to the phone screener The mainreasons for telephone screener failure are related to out of catchment area (the percentage of screen failures due to catchment is 54%) the other cause for phone screen failures is current smoker status, which is 21% of the total number of phone screen fails. Currently, from the 237participants eligible based on telephone screening, 47 have declined to participate for various reasons, while 21 were no longer eligible. Of the 156 participants that have signed aconsent form,79 are qualified to actively take part in thestudy based on our clinical screening criteria (exhaled carbon monoxide, pre and postspirometry).
All 79 enrolled subjects have completedscreening questionnaires, exhaled carbon monoxide (eCO) and spirometry testing in order to confirm our casedefinition, which is based upon GOLD guidelines (http://goldcopd.org/wp-content/uploads/2017/11/GOLD-2018-v6.0-FINAL-revised-20-Nov_WMS.pdf). From the79 enrolled and eligible, 69 have completed their baseline clinic and home visit to assess the indoor air quality (PM, nitrogen dioxide and air nicotine), 56 have completed their 3 month follow-up visit and 55 have completed their 6 month follow-up.
Items | Number of Individuals |
Phone-Screened | 569 |
Consented | 156 |
Enrolled & Eligible | 79 |
Baseline home visit completed | 69 |
3 months home visit completed | 56 |
6 months home visit completed | 55 |
To date, participants enrolled were 55.6% black, 57% female, and had an average of age of 67 years. 15.3% of the enrolled participants did not finish high school, 65.3% reported a yearly income lower than $30,000, and 33% report some degree of food insecurity based on the Household Food Insecurity Score.
Participants have a mean BMI of 32.6 (60% obese), and the correlation between BMI and body fat percentage obtained through Densitometry (DEXA) assessment was moderate- high (0.72, p<0.001).
Food Frequency Questionnaires have been completed and analyzed on 68 participants at baseline and during each follow-up clinic visit. Participant's mean total calorie intake was 2236 kcal and they consumed in average a low omega-3 intake (0.5±1.3g) and a high omega-6 intake (19.4±16.4g) suggestive trends towards unhealthy diets.
We have performed preliminary data analysis and results are described in the overall Annual Center Progress Report, Part A Research Project/Core's Activities (Core C: Data Management Core). These results were also shared at the Environmental Health Disparities Centers Grant Meeting in Baltimore, MD on January 24-25, 2019.
Since the last reporting period, we have added, promoted existing, and replaced through attrition, several staff members to the research team to continue the work and help supervise the conduct of the research. Dr. Hansel encourages ongoing training of the staff and field workers, throughout the study.
In addition to the parent study, there are three ancillaries. For Dr. Laura Paulin's career development award (K23ES025781), we have included new data collection instruments and enrolled 22 out of 60 participants into this ancillary study to date.
Corrine Hanson's ancillary study has started to analyze the first 10 stool samples collected as part of the microbiome sub-study.
Dr. Nirupama Putcha is continuing work on her K23 funded by the NIH. The goal of her work is to understand whether allergic sensitization with environmental exposure is associated with worse outcomes in COPD. Her project is nested within the work of CURE COPD, and the progress she has made is reflective of the formidable support of the CURE study.
She has recruited 154 of the 160 planned participants and has completed some preliminary analysis of dust data from the first 90 participants of the study. Preliminary cross-sectional analysis of these data suggests that though allergen sensitization alone may not confer higher risks for exacerbations, but sensitization with exposure status are important to consider and that the home environment may greatly impact risk for outcomes in COPD. A manuscript from part of this work is now in preparation.
Project 2: Indoor air pollution and COPD in rural Appalachia
During the past year, we have continued to have weekly meetings in the form of phone calls or WebEx. We have completed staff training and have conducted retraining for new staff and to ensure adherence to the protocol and collection of high quality data. We have begun enrolling participants and have completed follow-up visits.
Enrollment of study participants and data collection up to date:
Enrollment of study participants and data collection since June 2018.
Items Number of Individuals
Screened for eligibility: 276
Consented: 83
Enrolled: 50
Baseline home visit completed: 44
3 months home visit completed: 41
6 months home visit completed: 36
Participants enrolled were all white, 60% male, and had an average age of 73.6 years, and a mean BMI of 30.7 (45% obese). 26% of the enrolled participants did not finish high school, 40% reported a yearly income lower than $30,000 representing a relatively low-income population with COPD.
The study team continues to actively seek opportunities for community outreach and education. As a result, we have been invited to speak and/or distribute educational materials about household air pollution and ways to minimize it at different events (11 events during the last year).
Drs. Maisonet and McCormack attended the Environmental Health Disparities Centers Grant Meeting in Baltimore, MD on January 24-25, 2019. Dr. McCormack attended the NIH meeting, "COPD and Rural Health: A Dialogue on the National Action Plan" on March 19th.
Dr. McCormack presented "Implementation of a panel exposure and health study in a rural setting" at the International Society of Environmental Epidemiology, Ottawa, Canada in August 2018. She spoke at National Rural Health Institute Rural COPD Stakeholder Meeting in Washington, DC about "Independent Risks for COPD" on February 6, 2019. She will be co-chairing the symposium, "Rurality in COPD: Defining the problem and deploying novel care delivery approaches" at the American Thoracic Society Meeting in May 2019.
Future Activities:
Project 1:Obesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPDObesity and adverse dietary patterns as susceptibility factors to pollutant exposure in urban COPD
During the next reporting period, we plan to finalize the participant recruitment (reaching the 120 enrolled goal), and continue the follow-up of COPD participants enrolled, and data collection.
To accomplish our study goals, we have increased the number of staff dedicated to these activities, reviewed training materials, and increased the frequency of screening visits available in the clinic schedule. We have also increased placement of recruitment materials including in newspapers advertisements.
We have had some success recruiting through the Johns Hopkins Community Physicians (JHCP) and will continue to acquire updated lists of diagnosed COPD patients from this source. We did not find a good return using Baltimore Research (https://www.baltimoreresearch.com/) the national recruiting research service which tracks over 150 medical conditions including COPD, BMI and income and have discontinued that as a recruitment source. Additional plans for the next year include follow-up of COPD participants, QC of the data collected and data analysis and manuscript preparation. Already, interim data analysis (see data core section in Overall Report) supports the hypotheses of the aims of the project as proposed in the original application.
Preliminary data analysis has led to data supporting the role of omega-3 consumption in COPD outcomes and has led to the work of pulmonary fellow, Abigail Koch, to receive a fundable score on her NRSA submission. In addition, in February we initiated a feasibility pilot of a dietary intervention to increase Omega-3 intake. So far we have completed intervention in two participants (goal is 20).
Project 2: Indoor air pollution and COPD in rural Appalachia
We plan to carry out the following tasks during the next reporting period:
During the next reporting period, we plan to continue with participant recruitment, follow up of COPD participants enrolled, and data collection. We will continue preliminary analysis and begin manuscript preparation. In addition, we plan to increase the number and type of outreach and education activities held; identify educational materials on household air pollution that can be adopted or adapted for Regional use; and develop and evaluate a social media platform for dissemination of information on household air pollution risks.
Journal Articles: 48 Displayed | Download in RIS Format
Other center views: | All 73 publications | 48 publications in selected types | All 48 journal articles |
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Belli AJ, Bose S, Aggarwal N, DaSilva C, Thapa S, Grammer L, Paulin LM, Hansel NN. Indoor particulate matter exposure is associated with increased black carbon content in airway macrophages of former smokers with COPD. Environmental Research 2016;150:398-402. |
R836152 (2019) R836152 (2020) R836150 (2017) R836150 (2019) R836150 (2020) |
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Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin M, Jun J, Anokye-Danso F, ahima R, Enquist L, Mendelowitz D, Schwartz A, Polotsky V. Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(6):773-783. |
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Berman JD, McCormack MC, Koehler KA, Connolly F, Clemons-Erby D, Davis MF, Gummerson C, Leaf PJ, Jones TD, Curriero FC. School environmental conditions and links to academic performance and absenteeism in urban, mid-Atlantic public schools. International Journal of Hygiene and Environmental Health 2018;221(5):800-808. |
R836152 (Final) R835639 (2016) R835639 (2017) R835639 (2018) |
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Brigham EP, Matsui EC, Appel LJ, Bull DA, Curtin-Brosnan J, Zhai S, White K, Charleston JB, Hansel NN, Diette GB, McCormack MC. A pilot feeding study for adults with asthma: the healthy eating better breathing trial. PLoS One 2017;12(7):e0180068 (14 pp.). |
R836152 (2018) R836152 (2020) |
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Brigham EP, Steffen LM, London SJ, Boyce D, Diette GB, Hansel NN, Rice J, McCormack MC. Diet pattern and respiratory morbidity in the Atherosclerosis Risk in Communities Study. Annals of the American Thoracic Society 2018;15(6):675-682. |
R836152 (2018) R836152 (2020) |
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Brigham E, Woo H, McCormack M, Rice J, Koehler K, Vulcain T, Wu T, Koch A, Sharma S, Kolandooz F, Bose S, Hanson C, Romero K, Diette G, Hansel N. Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(12):1478-1486. |
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Caballero-Eraso C, Shin M, Pho H, Kim L, Pichard L, Wu Z, Gu C, Berger S, Pham L, Yeung H, Shirahata M, Schwartz A, Tang W, Sham J, Polotsky V. Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response. JOURNAL OF PHYSIOLOGY-LONDON 2019;597(1):151-172. |
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Davis MF, Ludwig S, Brigham EP, McCormack MC, Matsui EC. Effect of home exposure to Staphylococcus aureus on asthma in adolescents. Journal of Allergy and Clinical Immunology 2018;141(1):402-405.e10. |
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Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY. Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Scientific Reports 2017;7:44392. |
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Fleury Curado T, Pho H, Berger S, Caballero-Eraso C, Shin MK, Sennes LU, Pham L, Schwartz AR, Polotsky VY. Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity. Sleep 2018;41(8).zsy089 (9 pp.). |
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Fricke K, Vieira M, Younas H, Shin MK, Bevans-Fonti S, Berger S, Lee R, D’Alessio FR, Zhong Q, Nelson A, Loube J. Sanchez I, Hansel NN, Mitzner W, Polotsky VY. High fat diet induces airway hyperresponsiveness in mice. Scientific Reports 2018;8(1):6404 (6 pp.). |
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Galiatsatos P, Kineza C, Hwang S, Pietri J, Brigham E, Putcha N, Rand CS, McCormack M, Hansel NN. Neighbourhood characteristics and health outcomes:evaluating the association between socioeconomic status, tobacco store density and health outcomes in Baltimore City. Tobacco Control 2018;27(e1):e19-e24. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2018) R836150 (2020) |
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Grant T, McCormack M, Peng R, Keet C, Davis M, Newman M, Balcer-Whaley S, Matsui E. Comprehensive home environmental intervention did not reduce allergen concentrations or controller medication requirements among children in Baltimore. JOURNAL OF ASTHMA 2022;1-10 |
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Grant T, LIlley T, McCormack M, Rathouz P, Pent R, Keeo C, Rule A, Davis M, Balcer-Whaley S, Newman M, Matsui E. Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2023;151(3):716. |
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Gu C, Loube J, Lee R, Bevans-Fonti S, Wu T, Barmine J, Jun J, McCormack M, Hansel N, Mitzner W, Polotsky V. Metformin Alleviates Airway Hyperresponsiveness in a Moe Model of Diet-Induced Obesity. FRONTIERS IN PHYSIOLOGY 2022;13(883275). |
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Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. Journal of the American College of Cardiology 2017;69(7):841-858. |
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Kaviany P, Brighham E, Collaco J, Rice J, Woo H, Wood M, Koehl R, Wu T, Eakin M, koehler K, Hansel N, McCormack M. Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban Households. JOURNAL OF ASTHMA 2022;59(5):946-955 |
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Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN, COPDGene Investigators. Obesity is associated with increased morbidity in moderate to severe COPD. Chest 2017;151(1):68-77. |
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Lemoine S, Brigham E, Woo H, Hanson C, McCormack M, Koch A, Putcha N, hansel N. Omega-3 fatty acid intake and prevalent respiratory symptoms among adults with COPD. BMC PULMONARY MEDICINE 2019;19. |
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Levy JI, Quiros-Alcala L, Fabian MP, Basra K, Hansel NN. Established and emerging environmental contributors to disparities in asthma and chronic obstructive pulmonary disease. Current Epidemiology Reports 2018;5(2):114-124. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) R836156 (2018) R836156 (2019) R836156 (2020) |
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Lu KD, Phipatanakul W, Perzanowski MS, Balcer-Whaley S, Matsui EC. Atopy, but not obesity is associated with asthma severity among children with persistent asthma. Journal of Asthma 2016;53(10):1033-1044. |
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McCormack MC, Belli AJ, Waugh D, Matsui EC, Peng RD, Williams DL, Paulin L, Saha A, Aloe CM, Diette GB, Breysse PN, Hansel NN. Respiratory effects of indoor heat and the interaction with air pollution in chronic obstructive pulmonary disease. Annals of the American Thoracic Society 2016;13(12):2125-2131. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) |
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McCormack MC, Paulin LM, Gummerson CE, Peng RD, Diette GB, Hansel NN. Colder temperature is associated with increased COPD morbidity. European Respiratory Journal 2017;49(6):1601501. |
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McCormack M, Balsubramanian A, Wise R, Keet C, Matsui E, Peng R. Reply by McCormack et al. to Townsend and Cowl, and to Miller et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2022;206(6):795-796. |
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Mesarwi OA, Shin MK, Bevans-Fonti S, Schlesinger C, Shaw J, Polotsky VY. Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease. PLoS One 2016;11(12):e0168572. |
R836152 (2017) R836152 (2020) |
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Nnodum BN, McCormack MC, Putcha N, Hwang S, Paulin LM, Brigham EP, Fawzy A, Romero K, Diette GB, Hansel NN. Impact of physical activity on reporting of childhood asthma symptoms. Lung 2017;195(6):693-698. |
R836152 (2018) R836152 (2020) |
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Paulin LM, Williams DA, Peng R, Diette GB, McCormack MC, Breysse P, Hansel NN. 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma. Environmental Research 2017;159:118-123. |
R836152 (2018) R836152 (2020) |
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Peters KO, Williams AL, Abubaker S, Curtin-Brosnan J, McCormack MC, Peng R, Breysse PN, Matsui EC, Hansel NN, Diette GB, Strickland PT. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. Journal of Exposure Science and Environmental Epidemiology 2017;27(3):290-298. |
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Pham LV, Polotsky VY. Genome-wide association studies in obstructive sleep apnea. Will we catch a black cat in a dark room? American Journal of Respiratory and Critical Care Medicine 2016;194(7):789-791. |
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Pham LV, Miele CH, Schwartz NG, Arias RS, Rattner A, Gilman RH, Miranda JJ, Polotsky VY, Checkley W, Schwartz AR. Cardiometabolic correlates of sleep disordered breathing in Andean highlanders. European Respiratory Journal 2017;49(6):1601705 (20 pp.). |
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Pham LV, Meinzen C, Arias RS, Schwartz NG, Rattner A, Miele CH, Smith PL, Schneider H, Miranda JJ, Gilman RH, Polotsky VY, Checkley W, Schwartz AR. Cross-sectional comparison of sleep-disordered breathing in native Peruvian highlanders and lowlanders. High Altitude Medicine & Biology 2017;18(1):11-19. |
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Rice JL, Brigham E, Dineen R, Muqueeth S, O'Keefe G, Regenold S, Koehler K, Rule A, McCormack M, Hansel NN, Diette GB. The feasibility of an air purifier and secondhand smoke education intervention in homes of inner city pregnant women and infants living with a smoker. Environmental Research 2018;160:524-530. |
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Shin M, Eraso C, Mu Y, Gu C, Yeung B, Kim L, Liu X, Wu Z, Paudel O, Prchard L, Shirahata M, Tang W, Sham J, Polotsky V. Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. CIRCULATION RESEARCH 2019;125(11):989-1002. |
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Shin M-K, Han W, Joo H, Bevans-Fonti S, Shiota M, Stefanovski D, Polotsky VY. Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. Journal of Applied Physiology 2017;122(4):767-774. |
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Stauber CE, Ortiz GM, Loomis DP, Sobsey MD. A randomized controlled trial of the concrete biosand filter and its impact on diarrheal disease in Bonao, Dominican Republic. American Journal of Tropical Medicine and Hygiene 2009;80(2):286-293. |
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Tejwani V, McCormack A, Suresh K, Woo H, Xu N, Davis M, Brigham E, Hansel N, McCormack M, D'Alessio F. Dexamethasone-Induced FKBP51 Expression in CD4+ T-Lymphocytes Is Uniquely Associated With Worse Asthma Control in Obese Children With Asthma. FRONTIERS IN IMMUNOLOGY 2021;12(74482) |
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Wu TD, Brigham EP, Peng R, Koehler K, Rand C, Matsui EC, Diette GB, Hansel NN, McCormack MC. Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. The Journal of Allergy and Clinical Immunology: In Practice 2018;6(6):2157-2159.e5. |
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Wu T, Fawzy A, Brigham E, McCormack M, Rosas I, Villareal D, Hanania N. Association of Triglyceride-Glucose Index and Lung Health A Population-Based Study. CHEST 2021;160(3):1026-1034 |
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Wu T, Zaeh S, Eakin M, Koehler K, Davis M, Wohn C, Diibor I, Psoter K, Cronister C, Connolly F, Stein M, McCormack M. Association of School Infrastructure on Health and Achievement Among Children With Asthma. ACADEMIC PEDIATRICS 2023;23(4):814-820. |
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Zaeh S, McCormack M, Eakin M. Key policies to support asthma medication management for children. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 2019;123(5):428-429 |
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Zaeh S, Koehler K, Eakin M, WOhn C, Diibor I, Eckmann T, Wu T, Clemons-Erby D, Gummerson C, Green T, Wood M, Majid E, Stein M, Rule A, Davis M, McCormack M. Indoor Air Quality Prior to and Following School Building Renovation in a Mid-Atlantic School District. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2021;18(22). |
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Fawzy A, Putcha N, Paulin LM, Aaron CP, Labaki WW, Han MK, Wise RA, Kanner RE, Bowler RP, Barr RG, Hansel NN. Association of thrombocytosis with COPD morbidity:the SPIROMICS and COPDGene cohorts. Respiratory Research 2018;19(1):20. |
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Galiatsatos P, Brigham EP, Pietri J, Littleton K, Hwang S, Grant MC, Hansel NN, Chen ES. The effect of community socioeconomic status on sepsis-attributable mortality. Journal of Critical Care 2018;46:129-133. |
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Younas H, Vieira M, Gu C, Lee R, Shin MK, Berger S, Loube J, Nelson A, Bevans-Fonti S, Zhong Q, D’Alessio FR. Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet. Scientific reports 2019;9(1):1-9. |
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Raju S, Keet CA, Paulin LM, Matsui EC, Peng RD, Hansel NN, McCormack MC. Rural residence and poverty are independent risk factors for chronic obstructive pulmonary disease in the United States. American journal of respiratory and critical care medicine. 2019;199(8):961-969. |
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Tsou PY, McCormack MC, Matsui EC, Peng RD, Diette GB, Hansel NN, Davis MF. The effect of dog allergen exposure on asthma morbidity among inner‐city children with asthma. Pediatric Allergy and Immunology 2020;31(2):210-3. |
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Wu TD, Fawzy A, Kinney GL, Bon J, Neupane M, Tejwani V, Hansel NN, Wise RA, Putcha N, McCormack MC. Metformin use and respiratory outcomes in asthma-COPD overlap. Respiratory research 2021;22(1):1-8. |
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Afshar-Mohajer N, Wu TD, Shade R, Brigham E, Woo H, Wood M, Koehl R, Koehler K, Kirkness J, Hansel NN, Ramchandran G. Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma. European Respiratory Journal 2022;59(3). |
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Supplemental Keywords:
air pollution, obesity, COPD, diet, urban, indoor air pollution, ruralRelevant Websites:
Household Air Pollution and COPD Study Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836152C001 Investigating obesity as a susceptibility factor for air pollution in childhood
R836152C002 Novel exposure metrics for assessing the effects of ultrafine and fine particulate matter on asthma in children
R836152C003 The Role of Obesity in Biological Responses to Particulate Matter in Mice
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2020 Progress Report
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- Original Abstract
48 journal articles for this center