Grantee Research Project Results
2016 Progress Report: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
EPA Grant Number: R836152Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
Investigators: Hansel, Nadia , Diette, Greg
Current Investigators: Hansel, Nadia , Diette, Greg , McCormack, Meredith , Koehler, Kirsten , Polotsky, Seva
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2021)
Project Period Covered by this Report: September 1, 2015 through August 31,2016
Project Amount: $1,200,000
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The long-term goal of this Center is to understand how exposures to indoor and outdoor airborne pollutants and allergens interact with a variety of contextual factors in the inner city to create high asthma morbidity.
Specific Aim 1: Understand the interactive effects of air pollution and obesity to create high asthma morbidity.
Specific Aim 2: Provide causal evidence to support observational findings in a population of inner city African American children.
Progress Summary:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the progress made toward meeting the overall goals of the Center.
Future Activities:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the activities planned in order to meet the overall goals of the Center.
Journal Articles: 48 Displayed | Download in RIS Format
Other center views: | All 73 publications | 48 publications in selected types | All 48 journal articles |
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Belli AJ, Bose S, Aggarwal N, DaSilva C, Thapa S, Grammer L, Paulin LM, Hansel NN. Indoor particulate matter exposure is associated with increased black carbon content in airway macrophages of former smokers with COPD. Environmental Research 2016;150:398-402. |
R836152 (2019) R836152 (2020) R836150 (2017) R836150 (2019) R836150 (2020) |
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Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin M, Jun J, Anokye-Danso F, ahima R, Enquist L, Mendelowitz D, Schwartz A, Polotsky V. Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(6):773-783. |
R836152 (Final) R834510 (Final) |
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Berman JD, McCormack MC, Koehler KA, Connolly F, Clemons-Erby D, Davis MF, Gummerson C, Leaf PJ, Jones TD, Curriero FC. School environmental conditions and links to academic performance and absenteeism in urban, mid-Atlantic public schools. International Journal of Hygiene and Environmental Health 2018;221(5):800-808. |
R836152 (Final) R835639 (2016) R835639 (2017) R835639 (2018) |
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Brigham EP, Matsui EC, Appel LJ, Bull DA, Curtin-Brosnan J, Zhai S, White K, Charleston JB, Hansel NN, Diette GB, McCormack MC. A pilot feeding study for adults with asthma: the healthy eating better breathing trial. PLoS One 2017;12(7):e0180068 (14 pp.). |
R836152 (2018) R836152 (2020) |
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Brigham EP, Steffen LM, London SJ, Boyce D, Diette GB, Hansel NN, Rice J, McCormack MC. Diet pattern and respiratory morbidity in the Atherosclerosis Risk in Communities Study. Annals of the American Thoracic Society 2018;15(6):675-682. |
R836152 (2018) R836152 (2020) |
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Brigham E, Woo H, McCormack M, Rice J, Koehler K, Vulcain T, Wu T, Koch A, Sharma S, Kolandooz F, Bose S, Hanson C, Romero K, Diette G, Hansel N. Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2019;199(12):1478-1486. |
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Caballero-Eraso C, Shin M, Pho H, Kim L, Pichard L, Wu Z, Gu C, Berger S, Pham L, Yeung H, Shirahata M, Schwartz A, Tang W, Sham J, Polotsky V. Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response. JOURNAL OF PHYSIOLOGY-LONDON 2019;597(1):151-172. |
R836152 (Final) R834510 (Final) |
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Davis MF, Ludwig S, Brigham EP, McCormack MC, Matsui EC. Effect of home exposure to Staphylococcus aureus on asthma in adolescents. Journal of Allergy and Clinical Immunology 2018;141(1):402-405.e10. |
R836152 (2018) R836152 (2020) R836152 (Final) R834510 (Final) |
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Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY. Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Scientific Reports 2017;7:44392. |
R836152 (2017) R836152 (2020) |
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Fleury Curado T, Pho H, Berger S, Caballero-Eraso C, Shin MK, Sennes LU, Pham L, Schwartz AR, Polotsky VY. Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity. Sleep 2018;41(8).zsy089 (9 pp.). |
R836152 (2018) R836152 (2020) |
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Fricke K, Vieira M, Younas H, Shin MK, Bevans-Fonti S, Berger S, Lee R, D’Alessio FR, Zhong Q, Nelson A, Loube J. Sanchez I, Hansel NN, Mitzner W, Polotsky VY. High fat diet induces airway hyperresponsiveness in mice. Scientific Reports 2018;8(1):6404 (6 pp.). |
R836152 (2018) R836152 (2020) R834510 (Final) |
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Galiatsatos P, Kineza C, Hwang S, Pietri J, Brigham E, Putcha N, Rand CS, McCormack M, Hansel NN. Neighbourhood characteristics and health outcomes:evaluating the association between socioeconomic status, tobacco store density and health outcomes in Baltimore City. Tobacco Control 2018;27(e1):e19-e24. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2018) R836150 (2020) |
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Grant T, McCormack M, Peng R, Keet C, Davis M, Newman M, Balcer-Whaley S, Matsui E. Comprehensive home environmental intervention did not reduce allergen concentrations or controller medication requirements among children in Baltimore. JOURNAL OF ASTHMA 2022;1-10 |
R836152 (Final) |
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Grant T, LIlley T, McCormack M, Rathouz P, Pent R, Keeo C, Rule A, Davis M, Balcer-Whaley S, Newman M, Matsui E. Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2023;151(3):716. |
R836152 (Final) |
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Gu C, Loube J, Lee R, Bevans-Fonti S, Wu T, Barmine J, Jun J, McCormack M, Hansel N, Mitzner W, Polotsky V. Metformin Alleviates Airway Hyperresponsiveness in a Moe Model of Diet-Induced Obesity. FRONTIERS IN PHYSIOLOGY 2022;13(883275). |
R836152 (Final) R834510 (Final) |
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Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. Journal of the American College of Cardiology 2017;69(7):841-858. |
R836152 (2017) R836152 (2020) |
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Kaviany P, Brighham E, Collaco J, Rice J, Woo H, Wood M, Koehl R, Wu T, Eakin M, koehler K, Hansel N, McCormack M. Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban Households. JOURNAL OF ASTHMA 2022;59(5):946-955 |
R836152 (Final) |
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Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN, COPDGene Investigators. Obesity is associated with increased morbidity in moderate to severe COPD. Chest 2017;151(1):68-77. |
R836152 (2019) R836152 (2020) R836150 (2017) R836150 (2019) R836150 (2020) |
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Lemoine S, Brigham E, Woo H, Hanson C, McCormack M, Koch A, Putcha N, hansel N. Omega-3 fatty acid intake and prevalent respiratory symptoms among adults with COPD. BMC PULMONARY MEDICINE 2019;19. |
R836152 (Final) R834510 (Final) |
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Levy JI, Quiros-Alcala L, Fabian MP, Basra K, Hansel NN. Established and emerging environmental contributors to disparities in asthma and chronic obstructive pulmonary disease. Current Epidemiology Reports 2018;5(2):114-124. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) R836156 (2018) R836156 (2019) R836156 (2020) |
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Lu KD, Phipatanakul W, Perzanowski MS, Balcer-Whaley S, Matsui EC. Atopy, but not obesity is associated with asthma severity among children with persistent asthma. Journal of Asthma 2016;53(10):1033-1044. |
R836152 (2017) R836152 (2020) |
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McCormack MC, Belli AJ, Waugh D, Matsui EC, Peng RD, Williams DL, Paulin L, Saha A, Aloe CM, Diette GB, Breysse PN, Hansel NN. Respiratory effects of indoor heat and the interaction with air pollution in chronic obstructive pulmonary disease. Annals of the American Thoracic Society 2016;13(12):2125-2131. |
R836152 (2018) R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) |
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McCormack MC, Paulin LM, Gummerson CE, Peng RD, Diette GB, Hansel NN. Colder temperature is associated with increased COPD morbidity. European Respiratory Journal 2017;49(6):1601501. |
R836152 (2019) R836152 (2020) R836150 (2018) R836150 (2019) R836150 (2020) |
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McCormack M, Balsubramanian A, Wise R, Keet C, Matsui E, Peng R. Reply by McCormack et al. to Townsend and Cowl, and to Miller et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2022;206(6):795-796. |
R836152 (Final) |
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Mesarwi OA, Shin MK, Bevans-Fonti S, Schlesinger C, Shaw J, Polotsky VY. Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease. PLoS One 2016;11(12):e0168572. |
R836152 (2017) R836152 (2020) |
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Nnodum BN, McCormack MC, Putcha N, Hwang S, Paulin LM, Brigham EP, Fawzy A, Romero K, Diette GB, Hansel NN. Impact of physical activity on reporting of childhood asthma symptoms. Lung 2017;195(6):693-698. |
R836152 (2018) R836152 (2020) |
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Paulin LM, Williams DA, Peng R, Diette GB, McCormack MC, Breysse P, Hansel NN. 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma. Environmental Research 2017;159:118-123. |
R836152 (2018) R836152 (2020) |
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Peters KO, Williams AL, Abubaker S, Curtin-Brosnan J, McCormack MC, Peng R, Breysse PN, Matsui EC, Hansel NN, Diette GB, Strickland PT. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. Journal of Exposure Science and Environmental Epidemiology 2017;27(3):290-298. |
R836152 (2017) R836152 (2020) |
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Pham LV, Polotsky VY. Genome-wide association studies in obstructive sleep apnea. Will we catch a black cat in a dark room? American Journal of Respiratory and Critical Care Medicine 2016;194(7):789-791. |
R836152 (2017) R836152 (2020) |
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Pham LV, Miele CH, Schwartz NG, Arias RS, Rattner A, Gilman RH, Miranda JJ, Polotsky VY, Checkley W, Schwartz AR. Cardiometabolic correlates of sleep disordered breathing in Andean highlanders. European Respiratory Journal 2017;49(6):1601705 (20 pp.). |
R836152 (2018) R836152 (2020) |
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Pham LV, Meinzen C, Arias RS, Schwartz NG, Rattner A, Miele CH, Smith PL, Schneider H, Miranda JJ, Gilman RH, Polotsky VY, Checkley W, Schwartz AR. Cross-sectional comparison of sleep-disordered breathing in native Peruvian highlanders and lowlanders. High Altitude Medicine & Biology 2017;18(1):11-19. |
R836152 (2018) R836152 (2020) |
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Rice JL, Brigham E, Dineen R, Muqueeth S, O'Keefe G, Regenold S, Koehler K, Rule A, McCormack M, Hansel NN, Diette GB. The feasibility of an air purifier and secondhand smoke education intervention in homes of inner city pregnant women and infants living with a smoker. Environmental Research 2018;160:524-530. |
R836152 (2018) R836152 (2020) R834510 (Final) |
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Shin M, Eraso C, Mu Y, Gu C, Yeung B, Kim L, Liu X, Wu Z, Paudel O, Prchard L, Shirahata M, Tang W, Sham J, Polotsky V. Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. CIRCULATION RESEARCH 2019;125(11):989-1002. |
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Shin M-K, Han W, Joo H, Bevans-Fonti S, Shiota M, Stefanovski D, Polotsky VY. Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. Journal of Applied Physiology 2017;122(4):767-774. |
R836152 (2017) R836152 (2020) |
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Stauber CE, Ortiz GM, Loomis DP, Sobsey MD. A randomized controlled trial of the concrete biosand filter and its impact on diarrheal disease in Bonao, Dominican Republic. American Journal of Tropical Medicine and Hygiene 2009;80(2):286-293. |
R836152 (2017) R836152 (2020) SU832463 (Final) |
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Tejwani V, McCormack A, Suresh K, Woo H, Xu N, Davis M, Brigham E, Hansel N, McCormack M, D'Alessio F. Dexamethasone-Induced FKBP51 Expression in CD4+ T-Lymphocytes Is Uniquely Associated With Worse Asthma Control in Obese Children With Asthma. FRONTIERS IN IMMUNOLOGY 2021;12(74482) |
R836152 (Final) |
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Wu TD, Brigham EP, Peng R, Koehler K, Rand C, Matsui EC, Diette GB, Hansel NN, McCormack MC. Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. The Journal of Allergy and Clinical Immunology: In Practice 2018;6(6):2157-2159.e5. |
R836152 (2018) R836152 (2020) |
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Wu T, Fawzy A, Brigham E, McCormack M, Rosas I, Villareal D, Hanania N. Association of Triglyceride-Glucose Index and Lung Health A Population-Based Study. CHEST 2021;160(3):1026-1034 |
R836152 (Final) R836150 (2021) |
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Wu T, Zaeh S, Eakin M, Koehler K, Davis M, Wohn C, Diibor I, Psoter K, Cronister C, Connolly F, Stein M, McCormack M. Association of School Infrastructure on Health and Achievement Among Children With Asthma. ACADEMIC PEDIATRICS 2023;23(4):814-820. |
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Zaeh S, McCormack M, Eakin M. Key policies to support asthma medication management for children. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 2019;123(5):428-429 |
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Zaeh S, Koehler K, Eakin M, WOhn C, Diibor I, Eckmann T, Wu T, Clemons-Erby D, Gummerson C, Green T, Wood M, Majid E, Stein M, Rule A, Davis M, McCormack M. Indoor Air Quality Prior to and Following School Building Renovation in a Mid-Atlantic School District. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2021;18(22). |
R836152 (Final) R835639 (Final) |
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Fawzy A, Putcha N, Paulin LM, Aaron CP, Labaki WW, Han MK, Wise RA, Kanner RE, Bowler RP, Barr RG, Hansel NN. Association of thrombocytosis with COPD morbidity:the SPIROMICS and COPDGene cohorts. Respiratory Research 2018;19(1):20. |
R836152 (2019) R836152 (2020) |
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Galiatsatos P, Brigham EP, Pietri J, Littleton K, Hwang S, Grant MC, Hansel NN, Chen ES. The effect of community socioeconomic status on sepsis-attributable mortality. Journal of Critical Care 2018;46:129-133. |
R836152 (2019) R836152 (2020) |
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Younas H, Vieira M, Gu C, Lee R, Shin MK, Berger S, Loube J, Nelson A, Bevans-Fonti S, Zhong Q, D’Alessio FR. Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet. Scientific reports 2019;9(1):1-9. |
R836152 (Final) R834510 (Final) R836150 (2020) |
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Raju S, Keet CA, Paulin LM, Matsui EC, Peng RD, Hansel NN, McCormack MC. Rural residence and poverty are independent risk factors for chronic obstructive pulmonary disease in the United States. American journal of respiratory and critical care medicine. 2019;199(8):961-969. |
R836152 (2019) R836152 (2020) R836150 (2019) R836150 (2020) |
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Tsou PY, McCormack MC, Matsui EC, Peng RD, Diette GB, Hansel NN, Davis MF. The effect of dog allergen exposure on asthma morbidity among inner‐city children with asthma. Pediatric Allergy and Immunology 2020;31(2):210-3. |
R836152 (Final) R832139 (Final) R834510 (Final) R836150 (2020) |
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Wu TD, Fawzy A, Kinney GL, Bon J, Neupane M, Tejwani V, Hansel NN, Wise RA, Putcha N, McCormack MC. Metformin use and respiratory outcomes in asthma-COPD overlap. Respiratory research 2021;22(1):1-8. |
R836152 (Final) R836150 (2021) |
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Afshar-Mohajer N, Wu TD, Shade R, Brigham E, Woo H, Wood M, Koehl R, Koehler K, Kirkness J, Hansel NN, Ramchandran G. Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma. European Respiratory Journal 2022;59(3). |
R836152 (Final) R836150 (2021) |
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Relevant Websites:
air pollution, obesity, asthma exacerbation, inner city
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836152C001 Investigating obesity as a susceptibility factor for air pollution in childhood
R836152C002 Novel exposure metrics for assessing the effects of ultrafine and fine particulate matter on asthma in children
R836152C003 The Role of Obesity in Biological Responses to Particulate Matter in Mice
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- 2017 Progress Report
- Original Abstract
48 journal articles for this center