National Environmental Respiratory Center

EPA Grant Number: R826442
Center: National Environmental Respiratory Center (NERC)
Center Director: Mauderly, Joe L.
Title: National Environmental Respiratory Center
Investigators: Mauderly, Joe L. , Swenberg, James A. , Belinsky, Steven A. , Barr, E. B. , Seagrave, Jean Clare , McDonald, Jacob D. , Reed, Matthew D. , Barrett, Edward G. , Campen, Matthew J. , Gigliotti, Andrew , Harrod, Kevin , Seilkop, Steven
Institution: Lovelace Biomedical & Environmental Research Institute , University of North Carolina at Chapel Hill
EPA Project Officer: Chung, Serena
Project Period: April 1, 1998 through March 31, 2003
Project Amount: $8,390,600
RFA: Targeted Research Center (1998) RFA Text |  Recipients Lists
Research Category: Targeted Research , Human Health , Particulate Matter


The National Environmental Respiratory Center (NERC) is a laboratory research program sponsored by the U.S. Environmental Protection Agency (EPA), other federal and state agencies, and industry to tackle the difficult problem of disentangling the contributions of myriad man-made and natural air contaminants to the respiratory and cardiac health effects associated with exposures to air pollution. The program was initiated in response to the dilemma that, although population health outcomes are associated statistically with variations in levels of the few routinely measured pollutants and effects of those pollutants can be demonstrated in the laboratory at high doses, no research strategy had been developed to systematically determine the contributory roles of the hundreds of regulated and unregulated, man-made and natural air contaminants that people actually breathe.

Supplemental Keywords:

air pollution, air quality, air toxics, hazardous air pollutants, co-pollutants, multi-pollutant, one atmosphere, particulate matter, PM, aerosols, environment, source emissions, combustion emissions, diesel emissions, gasoline emissions, wood smoke, coal emissions, inhalation, exposure, dose-response, atmospheric chemistry, chemical speciation, health hazards, animal models, respiratory, lung, heart, cardiac, morbidity, inflammation, clotting factors, clinical chemistry, hematology, allergy, immune responses, sensitization, electrocardiogram, heart rate, bacterial infection, viral infection, cancer, carcinogenesis, micronuclei, DNA damage, oxidative injury, DNA methylation, susceptibility,

Progress and Final Reports:

  • 1998
  • 1999
  • 2000
  • 2001
  • Final