Grantee Research Project Results
2014 Progress Report: Children's Environmental Health & Disease Prevention Research Center at Dartmouth
EPA Grant Number: R835442Center: Solutions for Energy, AiR, Climate and Health Center (SEARCH)
Center Director: Bell, Michelle L.
Title: Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Investigators: Karagas, Margaret Rita , Korrick, Susan A. , Enelow, Richard I. , Robbins, David J , Marsit, Carmen J. , Folt, Carol L. , Cottingham, Kathryn L. , Jackson, Brian , Gilbert-Diamond, Diane , Li, Hongzhe , Madan, Juliette , Nadeau, Kari , Punshon, Tracy
Current Investigators: Karagas, Margaret Rita , Cottingham, Kathryn L. , Gilbert-Diamond, Diane , Korrick, Susan A. , Madan, Juliette , Marsit, Carmen J. , Moeschler, John B. , Murray, Carolyn
Institution: Dartmouth College , Stanford University
Current Institution: Dartmouth College
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Period Covered by this Report: July 1, 2013 through June 30,2014
Project Amount: $4,060,713
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Project 1: Childhood Immune Function and Exposure
The primary aims of our project are to test the hypothesis that in utero and early life arsenic (As) and other exposures are related to increased occurrence of childhood: 1) infections (number, type and severity of infections), in particular respiratory infections, in the first 5 years of life; 2) allergy and atopy in the first 5 years of life; and 3) diminished vaccine response (to Diphtheria/Tetanus/Pertussis, Pneumococcus and Polio) at age one. The secondary aim is to investigate the relation between in utero and early life As exposure on the development of the infant intestinal microbiome in the first year of life (based on stool samples taken at 6 weeks and 12 months of age). We hypothesize that As exposure will be associated with decreased diversity of the microbiome (e.g., based on the Simpson Diversity Index (SDI)), and differences in the relative abundance of specific phylotypes (e.g., bacterial genera and species) and/or predominant gene families or metabolic pathways.
Project 2: Water and Dietary Arsenic Exposure Related to Early Growth and Neurodevelopment
The project aims are to: 1) estimate arsenic (As) and other exposure intake from food and water and to relate these intakes to biomarkers of exposure during the first five years of life, a period of rapidly changing diet for most children; 2) quantify the association of biomarkers of early life exposure with physical growth patterns during the first five years of life; and 3) quantify the association of biomarkers of early life exposure with neurodevelopment during the first five years of life.
Project 3: Placental Biomarkers of Exposure and Outcome
The project aims are to: 1) identify regions of variable DNA methylation in the placenta associated with in utero exposure to As by examining the methylation status of relevant candidate genes and regions using quantitative bisulfite pyrosequencing and using genomewide DNA methylation arrays and biomarker-based exposure assessment; 2) identify altered gene expression in the placenta associated with in utero exposure to As by testing the expression of relevant candidate genes, including those identified in Aim 1, and their association with biomarker-based As exposure; and 3) examine if the As-associated variable DNA methylation and altered gene expression in placenta prospectively relates to child weight growth, infection, and neurodevelopmental outcomes.
Progress Summary:
Project 1
Major Activities. Our project builds off the New Hampshire Birth Cohort Study, a longitudinal study of over 1,000 maternal-infant pairs that has collected a wealth of data. These include: maternal health, diet and lifestyle factors, samples of household tap water, maternal blood, urine and toenails (at 24-28 weeks gestation), cord blood and placenta, infant meconium, nails, urine and stool, and maternal toenails at 2 weeks postpartum. Additionally, we have conducted a structured review of prenatal, delivery, and delivery records. During the formative phase of our project, we began collecting more detailed information on maternal and newborn infections and allergies through a review of the medical records, and initiated an interval telephone interview for updated infection allergy/atopy information from the child’s caregiver over the first year of life. As part of our full Center’s project, after refining our protocols and study instruments, we continue this follow-up – both through a review of pediatric records in collaboration with Project 2, and the interval telephone interviews at 18, 24, 30, 36, 42, and 50 months. Through a R21 grant in collaboration with Dr. Kari Nadeau of the Berkeley/Stanford Children’s Center, we have conducted a pilot study to establish a protocol for collecting blood samples from our cohort 5 members at one year of age to test for vaccine response. Another focus of our work is to investigate novel biomarkers of immune function and response. This includes microbiome analysis of infant stool samples beginning at birth and through the first year of life. During the project period, we developed and implemented standard operating procedures for data collection, laboratory operation, quality assurance procedures, and key aspects of the project research.
Specific Objectives. Infectious diseases remain the leading cause of illness in children in the US, and of mortality in children worldwide. Additionally, the prevalence of allergy and atopic diseases have become more widespread among children in recent years, for reasons that are not fully understood. Therefore, our objectives are to assess the relation of environmentally relevant levels of As (and other exposures) with clinical and biologic measures of early childhood immune function (e.g., infection/allergy/atopy, vaccine response and intestinal microbial acquisition). To achieve our objectives, we are leveraging an ongoing US prospective study of women and infants enrolled during pregnancy who are residents of New Hampshire and who obtain household water from private wells, a potential source of arsenic exposure in the region. Understanding whether common levels of exposure during the vulnerable periods of fetal development and early childhood impact immune response have widespread implications for public health and practice change.
Significant Findings. In our initial work, we found maternal urinary As concentrations related to the total number of infections requiring a physician visit or prescription medication (RR=1.6; 95% CI =1.1, 2.4), and specifically lower respiratory infections treated with prescription medication (RR=3.4; 95% CI =1.2, 9.3) in the first four months of life (Farzan, et al., 2013), these findings parallel those reported in highly exposed populations in Bangladesh. Using DNA methylation array data to estimate leukocyte cell proportions in collaboration with Project 3, we found in utero arsenic to be related to the proportion of T cells, in particular CD8+ cells (Koestler, et al., 2013). In placenta, also in collaboration with Project 3, we observed increased expression of the proinflammatory cytokine IL1B in relation to expression of the arsenite transporter gene aquaporin 9 (Fei, et al., 2013). As part of our P01 we are not only continuing to assess childhood infections and allergy/atopy development, but also will determine children’s vaccine response and conduct pilot work on the establishment of their intestinal microbiome on which we have completed methodologic work in the current grant period.
Key Outcomes and Other Achievements. We established Project 1 as part of the Dartmouth Center by building off our work from our formative Center and the New Hampshire Birth Cohort Study. Through this project we will rigorously follow children from our cohort to determine their risk of infection, allergy and atopy. In collaboration with Project 2, we will have available to us detailed information not only on in utero exposures but exposures monitored through dietary sources, questionnaires, and biomarkers taken on infants and children. Additionally, we will have initiated new components of the study to measure infant’s vaccine response and the developing microbiome. We published a number of papers this year, several are under review or revision, and more are in preparation. A number of presentations were made in the past year at regional, national and international meetings. Center Director and Project PI, Dr. Karagas co-chaired two symposia at the 2013 ISEE-ISES-ISAQ Meeting in Basal Switzerland, titled: “Arsenic in Rice” and “Arsenic Poisoning: A Global Perspective."
Project 2
Assessment of dietary exposure to arsenic during the first year of life has continued using the approaches developed during the formative P20 grant phase, and plans for diet assessment at ages three and five are in place. We have created a medical record review protocol and web-based medical record review interface using the REDCap application. We are conducting medical record reviews to abstract physical growth data. In addition to growth assessments, we are performing neurodevelopmental assessments using mailed standardized behavioral assessments at age 3, and will be obtaining more detailed in-person assessments at age 5 years. Given growing public health concern regarding the increasing prevalence of Autism spectrum disorders and the potential for developmental neurotoxicants to play a role, we refined our neurobehavioral assessment protocols to include a standardized instrument for eliciting parental report of autism-related behaviors (e.g., the Social Responsive Scale or SRS). These mailings include the neurobehavioral instruments as well as child dietary questionnaires.
Project 3
Major Activities. In the original project application we proposed to examine a panel of candidate genes for their DNA methylation status and for their expression, and we have worked to design, validate, and implement pyrosequencing assays and a nanostring panel for a number of these genes. We are working on selecting the appropriate samples for analysis using the selection strategy outlined in the original proposal, and are moving forward on processing those samples for molecular analyses.
Specific Objectives. This project is compelled by the hypothesis that environmental exposures encountered by a pregnant woman impact the gene expression of the infant’s placenta via epigenetic and other mechanisms and these functional alterations are associated with developmental outcomes in the children. Our objectives are to identify epigenetic and gene expression alterations in the placenta associated with maternal and infant biomarkers of in utero arsenic exposure, and to examine how these alterations are associated with critical health outcomes in the first few years of life. To accomplish these objectives, we are utilizing the existing and growing resources of the ongoing New Hampshire Birth Cohort Study, and are thus translating key findings from basic research into human populations.
Significant Findings. Using samples from Dr. Marsit’s Rhode Island cohort, we have examined the variability of DNA methylation at a number of candidate loci and the relationship between methylation of the loci across newborn and infant biological samples, including placenta, cord blood and saliva. We identified differential variability in the extent of methylation of these genes, likely reflecting the different functional roles that this methylation has in each of these samples. We also found a general lack of correlation between methylation of these paired tissue samples, reflective of the tissue specific nature of methylation in cells and tissues. These results were reported in our published manuscript (Armstrong, et al., FASEB J 2014). In line with Project 1 goals to better understand the impact of in utero arsenic on immune function and infant infection risk, we examined how in utero arsenic exposure impacted the DNA methylation profiles of infant cord blood. Using advanced statistical techniques, we were able to demonstrate that increased levels of inorganic arsenic in maternal urine collected during the second trimester was significantly associated with elevated proportions of CD8+ T-lymphocytes in infant cord blood. Yet, this change in cord blood cell proportion explained only a small proportion of the variation in DNA methylation associated with arsenic exposure, and so we went on to perform an Epigenome Wide Association Study (EWAS), which identified an over-representation of CpG loci within CpG islands as demonstrating variable methylation associated with maternal urinary arsenic levels, suggesting functional significance to these alterations. These results were reported in Koestler, et al., EHP 2013. Working towards our goals in Aim 2, Dr. Robbins and his team reported on their findings of gene expression of arsenic related genes in the placenta. They found a strong and significant relationship between maternal arsenic exposure and placental expression of the Aquaporin-9 (AQP9) gene, encoding one of the transporters responsible for arsenic transport into cells. They also identified a potential causal pathway from arsenic exposure through AQP9 expression and expression of the phospholipase ENPP2 on infant birthweight. These results were reported in Fei, et al., Environmental Health 2013. We also have begun to develop the use of chick embryos, as a model system to validate and experimentally extend our findings with placental exposure. Our data indicate that chick embryos exhibit genetic responses to arsenic treatment at concentrations that are below the current maximum contaminant level for arsenic in drinking water, and thus these chick embryos are an appropriate and manipulable model for the investigation of genetic responses to arsenic exposure. In support of our work in Aim 3, we also have demonstrated a relationship, using samples and data from Dr. Marsit’s RI cohort, that increased placental DNA methylation of the leptin gene was associated with a newborn neurobehavioral profile characterized by increased lethargy and hypotonicity, reflecting the phenotype of leptin deficient animal models which demonstrate reduced locomoter activity. We also found that this effect was present only in male infants, and that leptin methylation appeared to effect leptin gene expression levels only in male infants, supporting that importance of studies focused on sexual dichotomy, such as those proposed by Dr. Robbins in his supplement application. This has been reported in our publication in Psychoneuroendocrinology (Lesseur, 2014).
Key Outcomes and Other Achievements. The continued analyses of exposures in the cohort are allowing us to best select the appropriate samples for our DNA methylation and gene expression analyses, and we are processing samples for our candidate gene and genome-wide analyses. Dr. Marsit led a symposium at the International Society for Environment Epidemiology Annual Meeting in Basel, Switzerland in August 2013, entitled “Prenatal Environment, Epigenetic Mechanisms and the Developmental Origins of Health and Disease," and presented work from his laboratory during the session. He also presented on preliminary results from 14 methylation and expression analyses related to arsenic and other metals exposure at the Superfund Research Program Annual Meeting in Baton Rouge, LA, in October 2013 on the EPA/NIEHS Children’s Center Webinar Series, and at the recent NIEHS Workshop on “Health effects and mitigation of arsenic: current research efforts and future directions.” Dr. Marsit also presented a plenary talk, “Epigenomics and the Natural Environment,” at the Experimental Biology, Epigenetics in Comparative Physiology Meeting in Banff, British Columbia, Canada. Dr. Robbins presented a seminar to the Cancer Epidemiology and Prevention Program, at the Sylvester Comprehensive Cancer Center in Miami, entitled: "Understanding the role arsenics play in human pathologies," October 2013.
Future Activities:
Project 1: Our focus over the coming grant period will be to obtain follow-up data collection, through interval interviews and medical record review. We will continue collection of one-year blood samples and laboratory analyses of vaccine response, and obtain repeated stool samples for microbiome analyses. One-year plasma samples will be sent in batches to Stanford University to test for antibody response to tetanus and diphtheria toxoid, pertussis, pneumococcus, and polio vaccine. We will continue to develop methods for microbiome analyses including bioinformatical and statistical approaches. We will strive to continue to engage early career investigators and trainees in our research. We plan to present our research findings (e.g., at the upcoming PAS, ISEE, and PPTOXIV/Children’s meetings), publish our initial findings in the scientific literature, and work toward disseminating our findings to relevant communities to implement practice change.
Project 2: In the coming year, we will continue with our dietary assessments and urinary and toenail biomarker collection. We also will continue reviewing pediatric records e.g., for anthropometric data. In addition, we continue to obtain 3-year neurodevelopmental evaluations and dietary information, and begin performing the 5-year in-person evaluations of neurodevelopment and anthropometry.
Project 3: The research team of Drs. Marsit and Robbins has made tremendous progress in moving their analyses forward. Working with the birth cohort biorepository, Drs. Marsit and Robbins will select and obtain the additional samples for examination, and nucleic acids will be isolated from those samples in their respective laboratories. Dr. Marsit’s laboratory, in line with the project’s proposed timeline, plans to complete the genome-wide assessments of DNA methylation during the next funding period, and will begin the analyses of this data. They also will begin to undertake the candidate gene investigations. Dr. Robbins is working to design and implement the Nanostring profiling platform and will be prepared by the end of the next funding period to being the gene expression profiling of candidate genes as well as those that are identified in Dr. Marsit’s genome-wide studies. The research team is on track to complete the goals and objectives as outlined in the proposal.
Journal Articles: 102 Displayed | Download in RIS Format
| Other center views: | All 154 publications | 102 publications in selected types | All 102 journal articles |
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Appleton AA, Lester BM, Armstrong DA, Lesseur C, Marsit CJ. Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. Psychoneuroendocrinology 2015;52:32-42. |
R835442 (2015) R835442 (2016) |
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Armstrong DA, Lesseur C, Conradt E, Lester BM, Marsit CJ. Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. FASEB Journal 2014;28(5):2088-2097. |
R835442 (2014) R835442 (2015) R835442 (2016) |
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Armstrong DA, Green BB, Blair BA, Guerin DJ, Litzky JF, Chavan NR, Pearson KJ, Marsit CJ. Maternal smoking during pregnancy is associated with mitochondrial DNA methylation. Environmental Epigenetics 2016;2(3):dvw020. |
R835442 (2017) |
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Banister CE, Koestler DC, Maccani MA, Padbury JF, Houseman EA, Marsit CJ. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 2011;6(7):920-927. |
R835442 (2014) R835442 (2015) R835442 (2016) |
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Beane Freeman LE, Karagas MR, Baris D, Schwenn M, Johnson AT, Colt JS, Jackson B, Hosain GM, Cantor KP, Silverman DT. Is the inverse association between selenium and bladder cancer due to confounding by smoking? American Journal of Epidemiology 2015;181(7):488-495. |
R835442 (2015) R835442 (2016) |
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Bommarito PA, Martin E, Smeester L, Palys T, Baker ER, Karagas MR, Fry RC. Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reproductive Toxicology 2017;73:184-195. |
R835442 (2018) |
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Braun J, Chen A, Hoofnagle A, Papandonatos G, Jackson-Browne M, Haer R, Romano M, Karagas M, Yolton K, Zoeller R, Lanphear B. Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels. HORMONES AND BEHAVIOR 2018;101:77-84. |
R835442 (Final) |
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Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526. |
R835442 (2017) R835432 (2016) R835432 (2017) |
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Caito SW, Jackson BP, Punshon T, Scrimale T, Grier A, Gill SR, Love TM, Watson GE, van Wijngaarden E, Rand MD. Editor's Highlight: Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicological Sciences 2018;161(2):443-453. |
R835442 (2018) |
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Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics 2015;10(6):508-515. |
R835442 (2015) R835442 (2016) |
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Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environmental Health Perspectives 2015;123(5):500-506. |
R835442 (2015) R835442 (2016) |
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Chen Y, Karagas MR. Arsenic and cardiovascular disease: new evidence from the United States. Annals of Internal Medicine 2013;159(10):713-714. |
R835442 (2014) R835442 (2015) R835442 (2016) |
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Chernikova DA, Koestler DC, Hoen AG, Housman ML, Hibberd PL, Moore JH, Morrison HG, Sogin ML, Zain-Ul-Abideen M, Madan JC. Fetal exposures and perinatal influences on the stool microbiota of premature infants. Journal of Maternal-Fetal and Neonatal Medicine 2016;29(1):99-105. |
R835442 (2017) |
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Chernikova DA, Madan JC, Housman ML, Zain-Ul-Abideen M, Lundgren SN, Morrison HG, Sogin ML, Williams SM, Moore JH, Karagas MR, Hoen AG. The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth. Pediatric Research 2018;84(1):71-79. |
R835442 (2018) |
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Cottingham KL, Karimi R, Gruber JF, Zens MS, Sayarath V, Folt CL, Punshon T, Morris JS, Karagas MR. Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutrition Journal 2013;12:149. |
R835442 (2014) R835442 (2015) R835442 (2016) R834599 (2011) R834599 (Final) R834599C001 (Final) R834599C002 (Final) |
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Davis MA, Gilbert-Diamond D, Karagas MR, Li Z, Moore JH, Williams SM, Frost HR. A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults. PLoS One 2014;9(9):e104768. |
R835442 (2015) R835442 (2016) |
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Davis MA, Li Z, Gilbert-Diamond D, Mackenzie TA, Cottingham KL, Jackson BP, Lee JS, Baker ER, Marsit CJ, Karagas MR. Infant toenails as a biomarker of in utero arsenic exposure. Journal of Exposure Science & Environmental Epidemiology 2014;24(5):467-473. |
R835442 (2015) R835442 (2016) |
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Davis MA, Higgins J, Li Z, Gilbert-Diamond D, Baker ER, Das A, Karagas MR. Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports. Environmental Health 2015;14:12 (11 pp.). |
R835442 (2015) R835442 (2016) |
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Davis MA, Signes-Pastor AJ, Argos M, Slaughter F, Pendergrast C, Punshon T, Gossai A, Ahsan H, Karagas MR. Assessment of human dietary exposure to arsenic through rice. Science of the Total Environment 2017;586:1237-1244. |
R835442 (2017) |
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Demidenko E. Exact and approximate statistical inference for nonlinear regression and the estimating equation approach. Scandinavian Journal of Statistics 2017;44(3):636-665. |
R835442 (2018) |
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Emond JA, Gilbert-Diamond D, Tanski SE, Sargent JD. Energy drink consumption and the risk of alcohol use disorder among a national sample of adolescents and young adults. Journal of Pediatrics 2014;165(6):1194-1200. |
R835442 (2015) R835442 (2016) |
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Emond JA, Sargent JD, Gilbert-Diamond D. Patterns of energy drink advertising over US television networks. Journal of Nutrition Education and Behavior 2015;47(2):120-126.e1. |
R835442 (2015) R835442 (2016) |
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Emond JA, Karagas MR, Baker ER, Gilbert-Diamond D. Better diet quality during pregnancy is associated with a reduced likelihood of an infant born small for gestational age: an analysis of the Prospective New Hampshire Birth Cohort Study. Journal of Nutrition 2018;148(1):22-30. |
R835442 (2018) |
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Everson TM, Armstrong DA, Jackson BP, Green BB, Karagas MR, Marsit CJ. Maternal cadmium, placental PCDHAC1, and fetal development. Reproductive Toxicology 2016;65:263-271. |
R835442 (2017) |
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Everson TM, Kappil M, Hao K, Jackson BP, Punshon T, Karagas MR, Chen J, Marsit CJ. Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes. Environmental Research 2017;158:233-244. |
R835442 (2017) |
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Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ. Cadmium-associated differential methylation throughout the placental genome:epigenome-wide association study of two U.S. birth cohorts. Environmental Health Perspectives 2018;126(1):017010 (13 pp.). |
R835442 (2018) |
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Ezzamouri B, Palys T, Jackson B, Coto S, Madan J, Juliette C, Flohr C, Karagas M, Peacock J. Water hardness and atopic dermatitis in the first year of life in the New Hampshire Birth Cohort Study. CLINICAL AND EXPERIMENTAL ALLERGY 2023; |
R835442 (Final) |
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Farzan SF, Chen Y, Wu F, Jiang J, Liu M, Baker E, Korrick SA, Karagas MR. Blood pressure changes in relation to arsenic exposure in a U.S. pregnancy cohort. Environmental Health Perspectives 2015;123(10):999-1006. |
R835442 (2015) R835442 (2016) |
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Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicology and Applied Pharmacology 2015;287(2):93-97. |
R835442 (2015) R835442 (2016) |
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Farzan SF, Brickley EB, Li Z, Gilbert-Diamond D, Gossai A, Chen Y, Howe CG, Palys T, Karagas MR. Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. Environmental Research 2017;156:426-433. |
R835442 (2017) |
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Fei DL, Koestler DC, Li Z, Giambelli C, Sanchez-Mejias A, Gosse JA, Marsit CJ, Karagas MR, Robbins DJ. Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environmental Health 2013;12:58 (8 pp.). |
R835442 (2014) R835442 (2015) R835442 (2016) R834599 (Final) R834599C001 (Final) R834599C004 (Final) |
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Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Cheng Munthe-Kaas M, Corpeleijn E, Czamara D, Dabelea D, Davey Smith G, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S, Grote V, Gruzieva O, Haberg SE. Cohort profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. International Journal of Epidemiology 2018;47(1):22-23u. |
R835442 (2018) R836159 (2018) R836159 (Final) |
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Fleisch A, Seshasayee S, Garshick E, Chipman J, Koutrakis P, Baker E, Karagas M. Assessment of Maternal Glycemia and Newborn Size Among Pregnant Women Who use Wood Stoves in Northern New England. JAMA NETWORK OPEN 2020;3(5):e206046. |
R835442 (Final) |
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Frediani JK, Naioti EA, Vos MB, Figueroa J, Marsit CJ, Welsh JA. Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environmental Health 2018;17(1):6 (8 pp.). |
R835442 (2018) R836153 (2018) |
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Gilbert-Diamond D, Li Z, Adachi-Mejia AM, McClure AC, Sargent JD. Association of a television in the bedroom with increased adiposity gain in a nationally representative sample of children and adolescents. JAMA Pediatrics 2014;168(5):427-434. |
R835442 (2014) R835442 (2015) R835442 (2016) |
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Gossai A, Lesseur C, Farzan S, Marsit C, Karagas MR, Gilbert-Diamond D. Association between maternal urinary arsenic species and infant cord blood leptin levels in a New Hampshire Pregnancy Cohort. Environmental Research 2015;136:180-186. |
R835442 (2015) R835442 (2016) |
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Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. Life-long implications of developmental exposure to environmental stressors: new perspectives. Endocrinology 2015;156(10):3408-3415. |
R835442 (2017) |
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Green BB, Armstrong DA, Lesseur C, Paquette AG, Guerin DJ, Kwan LE, Marsit CJ. The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight. Biology of Reproduction 2015;92(6):149 (8 pp.). |
R835442 (2015) R835442 (2016) |
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He X, Karagas R, Murray C. Impact of receipt of private well arsenic test results on maternal use of contaminated drinking water in a U.S. population. Science of the Total Environment 2018;643:1055-1012. |
R835442 (2018) |
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Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC. Associations between gut microbial colonization in early life and respiratory outcomes in cystic fibrosis. Journal of Pediatrics 2015;167(1):138-147.e1-3. |
R835442 (2015) R835442 (2016) |
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Hoen AG, Madan JC, Li Z, Coker M, Lundgren SN, Morrison HG, Palys T, Jackson BP, Sogin ML, Cottingham KL, Karagas MR. Sex-specific associations of infants' gut microbiome with arsenic exposure in a US population. Scientific Reports 2018;8(1):12627 (10 pp.). |
R835442 (2018) |
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Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ. Cell-composition effects in the analysis of DNA methylation array data:a mathematical perspective. BMC Bioinformatics 2015;16(1):95 (16 pp.). |
R835442 (2016) |
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Howe C, Armstrong D, Muse M, GIlbert-Diamond D, Gui J, Hoen A, Palys T, Barnaby R, Stanton B, Jackson B. Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk:A Pilot Study. EXPOSURE HEALTH 2022;. |
R835442 (Final) |
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Jackson BP. Fast ion chromatography-ICP-QQQ for arsenic speciation. Journal of Analytical Atomic Spectrometry 2015;30(6):1405-1407. |
R835442 (2015) R835442 (2016) |
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Jackson BP, Punshon T. Recent advances in the measurement of arsenic, cadmium, and mercury in rice and other foods. Current Environmental Health Reports 2015;2(1):15-24. |
R835442 (2015) R835442 (2016) |
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Jackson BP, Liba A, Nelson J. Advantages of reaction cell ICP-MS on doubly charged interferences for arsenic and selenium analysis in foods. Journal of Analytical Atomic Spectrometry 2015;30(5):1179-1183. |
R835442 (2015) R835442 (2016) |
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Karagas MR, Zens MS, Li Z, Stukel TA, Perry AE, Gilbert-Diamond D, Sayarath V, Stephenson RS, Barton D, Nelson HH, Spencer SK. Early-onset basal cell carcinoma and indoor tanning: a population-based study. Pediatrics 2014;134(1):e4-e12. |
R835442 (2015) R835442 (2016) |
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Karagas MR, Gossai A, Pierce B, Ahsan H. Drinking water arsenic contamination, skin lesions and malignancies: a systematic review of the global evidence. Current Environmental Health Reports 2015;2(1):52-68. |
R835442 (2015) R835442 (2016) |
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Kaushal A, Zhang H, Karmaus WJJ, Everson TM, Marsit CJ, Karagas MR, Tsai SF, Wen HJ, Wang SL. Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life. Environmental Health 2017;16(1):50. |
R835442 (2017) |
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Kingsley SL, Deyssenroth MA, Kelsey KT, Awad YA, Kloog I, Schwartz JD, Lambertini L, Chen J, Marsit CJ, Wellenius GA. Maternal residential air pollution and placental imprinted gene expression. Environment International 2017;108:204-211. |
R835442 (2018) |
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Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environmental Health Perspectives 2013;121(8):971-977. |
R835442 (2014) R835442 (2015) R835442 (2016) R834599 (2011) R834599 (Final) R834599C001 (Final) |
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Lansigan RK, Emond JA, Gilbert-Diamond D. Understanding eating in the absence of hunger among young children: a systematic review of existing studies. Appetite 2015;85:36-47. |
R835442 (2015) R835442 (2016) |
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Laue H, Morishi Y, Palys T, Jackson B, Madan J, Karagas M. Contribution of gut bacteria to arsenic metabolism in the first year of life in a prospective birth cohort. ENVIRONMENTAL RESEARCH 2022;214(4):114099. |
R835442 (Final) |
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Laue H, Bauer J, Pathmasiri W, Sumner S, McRichie S, Palys T, Hoen A, Madan J, Kargas M. Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers. PEDIATRIC RESEARCH 2024; |
R835442 (Final) |
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Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology 2014;40:1-9. |
R835442 (2014) R835442 (2015) R835442 (2016) |
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Lesseur C, Paquette AG, Marsit CJ. Epigenetic regulation of infant neurobehavioral outcomes. Medical Epigenetics 2014;2(2):71-79. |
R835442 (2015) R835442 (2016) |
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Lester BM, Marsit CJ. Epigenetic mechanisms in the placenta related to infant neurodevelopment. Epigenomics 2018;10(3):321-333. |
R835442 (2018) |
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Li Z, Frost HR, Tosteson TD, Zhao L, Liu L, Lyons K, Chen H, Cole B, Currow D, Bakitas M. A semiparametric joint model for terminal trend of quality of life and survival in palliative care research. Statistics in Medicine 2017;36(29):4692-4704. |
R835442 (2018) |
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Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. Effect of frozen/thawed embryo transfer on birthweight, macrosomia, and low birthweight rates in US singleton infants. American Journal of Obstetrics Gynecology 2018;218(4):433.e1-433.e10. |
R835442 (2018) |
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Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. Birthweight in infants conceived through in vitro fertilization following blastocyst or cleavage-stage embryo transfer: a national registry study. Journal of Assisted Reproduction and Genetics 2018;35(6):1027-1037. |
R835442 (2018) |
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Litzky JF, Deyssenroth MA, Everson TM, Lester BM, Lambertini L, Chen J, Marsit CJ. Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatric Research 2018;83(5):1075-1083. |
R835442 (2018) |
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Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, Hoen AG. Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner. Microbiome 2018;6(1):109(11 pp.). |
R835442 (2018) |
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Maccani JZ, Koestler DC, Houseman EA, Marsit CJ, Kelsey KT. Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age. Epigenomics 2013;5(6):619-630. |
R835442 (2014) R835442 (2015) R835442 (2016) |
Exit Exit |
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Maccani JZ, Koestler DC, Houseman EA, Armstrong DA, Marsit CJ, Kelsey KT. DNA methylation changes in the placenta are associated with fetal manganese exposure. Reproductive Toxicology 2015;57:43-49. |
R835442 (2016) |
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Maccani JZJ, Koestler DC, Lester B, Houseman EA, Armstrong DA, Kelsey KT, Marsit CJ. Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes. Environmental Health Perspectives 2015;123(7):723-729. |
R835442 (2015) R835442 (2016) |
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Marsit CJ, Brummel SS, Kacanek D, Seage III GR, Spector SA, Armstrong DA, Lester BM, Rich K, Pediatric HIV/AIDS Cohort Studies Network. Infant peripheral blood repetitive element hypomethylation associated with antiretroviral therapy in utero. Epigenetics 2015;10(8):708-716. |
R835442 (2015) R835442 (2016) |
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Marsit CJ. Influence of environmental exposure on human epigenetic regulation. Journal of Experimental Biology 2015;218(Pt 1):71-79. |
R835442 (2015) R835442 (2016) |
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Marsit CJ. Placental epigenetics in children’s environmental health. Seminars in Reproductive Medicine 2016;34(1):36-41. |
R835442 (2016) |
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Martin E, Smeester L, Bommarito PA, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC. Sexual epigenetic dimorphism in the human placenta:implications for susceptibility during the prenatal period. Epigenomics 2017;9(3):267-278. |
R835442 (2017) |
Exit |
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Moroishi Y, Salas L, Zhou J, Baker E, Hoen A, Everson T, Marsit C, Madan J, Gui J, Karagas M. Umbilical cord blood immune cell profiles in relation to the infant gut microbiome. ISCIENCE 2023;26(1):105833 |
R835442 (Final) |
Exit |
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Movassagh H, Halchenko Y, Sampath V, Nygaard U, Jackson B, Robbins D, Li Z, Nadeau K, Karagas M. Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures. ENVIRONMENTAL RESEARCH 2021;201(111385). |
R835442 (Final) |
Exit Exit |
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Muse M, Carroll C, Salas L, Karagas M, Christensen B. Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer- Risk Factors. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2023;32(4):550-560 |
R835442 (Final) |
Exit |
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Nachman KE, Punshon T, Rardin L, Signes-Pastor AJ, Murray CJ, Jackson BP, Guerinot ML, Burke TA, Chen CY, Ahsan H, Argos M, Cottingham KL, Cubadda F, Ginsberg GL, Goodale BC, Kurzius-Spencer M, Meharg AA, Miller MD, Nigra AE, Pendergrast CB, Raab A, Reimer K, Scheckel KG, Schwerdtle T, Taylor VF, Tokar EJ, Warczak TM, Karagas MR. Opportunities and challenges for dietary arsenic intervention. Environmental Health Perspectives 2018;126(8):84503 (6 pp.). |
R835442 (2018) |
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Nadeau KC, Li Z, Farzan S, Koestler D, Robbins D, Fei DL, Malipatlolla M, Maecker H, Enelow R, Korrick S, Karagas MR. In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clinical Immunology 2014;155(2):188-197. |
R835442 (2015) R835442 (2016) R834599 (2011) |
Exit Exit |
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Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One 2017;12(6):e0179606. |
R835442 (2017) |
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Paquette AG, Lester BM, Koestler DC, Lesseur C, Armstrong DA, Marsit CJ. Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort. PLoS One 2014;9(8):e104913 (10 pp.). |
R835442 (2015) R835442 (2016) |
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Paquette AG, Marsit CJ. The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes. Journal of Cellular Biochemistry 2014;115(12):2065-2072. |
R835442 (2015) R835442 (2016) |
Exit Exit |
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Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teiltelbaum SL, Amos CI. Opportunities and challenges for environmental exposure assessment in population-based studies. Cancer Epidemiology, Biomarkers & Prevention 2017;26(9):1370-1380. |
R835442 (2018) |
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Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje F, McMichael AJ, Mclaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby K-C, Olshan AF, Parent M-E, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini AS, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L,Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environmental Health Perspectives 2015;123(6):507-514. |
R835442 (2015) R835442 (2016) |
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Peng S, Deyssenroth MA, Di Narzo AF, Lambertini L, Marsit CJ, Chen J, Hao K. Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases. Human Molecular Genetics 2017;26(17):3432-3441. |
R835442 (2018) |
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Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K. High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy. Analytical and Bioanalytical Chemistry 2015;407(22):6839-6850. |
R835442 (2015) R835442 (2016) |
Exit Exit |
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Punshon T, Jackson BP, Meharg AA, Warczack T, Scheckel K, Guerinot ML. Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Science of the Total Environment 2017;581-582:209-220. |
R835442 (2017) |
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Punshon T, Jackson BP. Essential micronutrient and toxic trace element concentrations in gluten containing and gluten-free foods. Food Chemistry 2018;252:258-264. |
R835442 (2018) |
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Romano ME, Webster GM, Vuong AM, Zoeller RT, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environmental Research 2015;138:453-460. |
R835442 (2015) R835442 (2016) |
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Rothenberg SE, Korrick SA, Fayad R. The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010. Environmental Research 2015;138:173-180. |
R835442 (2015) R835442 (2016) |
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Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, XuZ, Huang RC, Reese SE, Xu CJ, Baiz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Kupers LK, Zhang H, Richmond RC, Page CM, Duijts L, Lie RT, Melton PE, Vonk JM, Nohr EA, Williams-DeVane C, Huen K, Rifas-Shiman SL, Ruiz-Arenas C, Gonseth S, Rezwan FI, Herceg Z, Ekstrom S, Croen L, Falahi F, Perron P, Karagas MR, Quraishi BM, Suderman M, Magnus MC, Jaddoe VWV, Taylor JA, Anderson D, Zhao S, Smit HA, Josey MJ, Bradman A, Baccarelli AA, Bustamante M, Haberg SE, Pershagen G, Hertz-Picciotto I, Newschaffer C, Corpeleijn E, Bouchard L, Lawlor DA, Maguire RL, Barcellos LF, Davey Smith G, Eskenazi B, Karmaus W, Marsit CJ, Hivert MF, Snieder H, Fallin MD, Melen E, Munthe-Kaas MC, Arshad H, Wiemels JL, Annesi-Maesano I, Vrijheid M, Oken E, Holland N, Murphy SK, Sorensen TIA, Koppelman GH, Newnham JP, Wilcox AJ, Nystad W, London SJ, Felix JF, Relton CL. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics 2017;26(20):4067-4085. |
R835442 (2018) R836159 (2018) |
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Shi X, Miller S, Mwenda K, Onda A, Rees J, Onega T, Gui J, Karagas M, Demidenko E, Moeschler J. Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects. International Journal of Environmental Research and Public Health 2013;10(9):4161-4174. |
R835442 (2016) |
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Shi X, Ayotte JD, Onda A, Miller S, Rees J, Gilbert-Diamond D, Onega T, Gui J, Karagas M, Moeschler J. Geospatial association between adverse birth outcomes and arsenic in groundwater in New Hampshire, USA. Environmental Geochemistry and Health 2015;37(2):333-351. |
R835442 (2016) |
Exit Exit |
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Signes-Pastor AJ, Vioque J, Navarrete-Munoz EM, Carey M, García de la Hera M, Sunyer J, Casas M, Riano-Galan I, Tardon A, Llop S, Amoros R, Amiano P, Bilbao JR, Karagas MR, Meharg AA. Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environmental Research 2017;159:69-75. |
R835442 (2018) |
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Signes-Pastor AJ, Cottingham KL, Carey M, Sayarath V, Palys T, Meharg AA, Folt CL, Karagas MR. Infants' dietary arsenic exposure during transition to solid food. Scientific Reports 2018;8(1):7114 (8 pp.). |
R835442 (2018) |
Exit Exit Exit |
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Sverrisson EF, Zens MS, Fei DL, Andrews A, Schned A, Robbins D, Kelsey KT, Li H, DiRenzo J, Karagas MR, Seigne JD. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urologic Oncology 2014;32(5):539-545. |
R835442 (2015) R835442 (2016) |
Exit Exit |
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Yim G, McGee G, Gallagher L, Baker E, Jackson B, Calafat A, Botelho J, Gilbert-Diamond D, Karagas M, Romano M, Howe C. Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches. CHEMOSPHERE 2023;Epub |
R835442 (Final) |
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Carignan CC, Punshon T, Karagas MR, Cottingham KL. Potential exposure to arsenic from infant rice cereal. Annals of Global Health 2016;82(1):221-224. |
R835442 (2017) |
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Karagas MR, Punshon T, Sayarath V, Jackson BP, Folt CL, Cottingham KL. Association of rice and rice product consumption with arsenic exposure early in life. JAMA Pediatrics 2016;170(6):609-616. |
R835442 (2017) |
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Houseman EA, Kile M, Christiani D, Tan I, Kelsey KT, Marsit CJ. Reference-free deconvolution of DNA methylation data and mediation by cell composition effects. BMC Bioinformatics 2016;17:259. |
R835442 (2017) |
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Fried D, Rhyu J, Odata KB, Blunt HB, Karagas MR, Gilbert-Diamond D. Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review. Nutrition Reviews 2016;74(6);387-410. |
R835442 (2017) |
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Appleton AA, Jackson BP, Karagas M, Marsit CJ. Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation. Epigenetics 2017;12(8):607-615. |
R835442 (2017) |
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Cubadda F, Jackson BP, Cottingham KL, Van Horne YO, Kurzius-Spencer M. Human exposure to dietary inorganic arsenic and other arsenic species: state of knowledge, gaps and uncertainties. Science of the Total Environment 2017;579:1228-1239. |
R835442 (2017) |
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Deyssenroth MA, Peng S, Hao K, Lambertini L, Marsit CJ, Chen J. Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth. BMC Genomics 2017;18(1):520. |
R835442 (2017) |
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Rokoff LB, Koutrakis P, Garshick E, Karagas MR, Oken E, Gold DR, Fleisch AF. Wood stove pollution in the developed world: a case to raise awareness among pediatricians. Current Problems in Pediatric and Adolescent Health Care 2017;47(6):123-141. |
R835442 (2017) |
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Nachman KE, Ginsberg GL, Miller MD, Murray CJ, Nigra AE, Pendergrast CB. Mitigating dietary arsenic exposure: current status in the United States and recommendations for an improved path forward. Science of the Total Environment 2017;581-582:221-236. |
R835442 (2017) |
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Bulka CM, Davis MA, Karagas MR, Ahsan H, Argos M. The Unintended Consequences of a Gluten-Free Diet. Epidemiology 2017;28(3):e24-e25. |
R835442 (2017) |
Exit |
Supplemental Keywords:
Relevant Websites:
Children's Environmental Health and Disease Prevention Research Center at Dartmouth Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- 2015 Progress Report
- Original Abstract
102 journal articles for this center