Grantee Research Project Results
2013 Progress Report: Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
EPA Grant Number: R835436Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Investigators: Peterson, Karen E. , Padmanabhan, Vasantha
Institution: University of Michigan
EPA Project Officer: Hahn, Intaek
Project Period: June 1, 2013 through May 31, 2018 (Extended to May 31, 2019)
Project Period Covered by this Report: June 1, 2013 through May 31,2014
Project Amount: $3,651,990
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Aim 1: Assess the impact of in utero and peripubertal exposures to mixtures of EDCs (bisphenol A, phthalates, lead and cadmium) on linear growth and weight status (BMI); sexual maturation and reproductive hormone dynamics.
Aim 2: Determine whether EDC mixtures (BPA, phthalates, lead, cadmium) via epigenetic mechanisms induce oxidative stress (tyrosine oxidation products), disrupt metabolic homeostasis (free fatty acids, amino acids, Acyl-carnitine) and lead to changes in gene transcription and metabolic function.
Aim 3: Conduct tissue- and age-specific unbiased epigenomic analyses (DNA methylation, chromatin structure, transcriptomics) to identify a subset of tissue-independent labile genes to serve as biomarkers of exposure-induced metabolic syndrome.
Aim 4: Examine the role of dietary intake during pregnancy and adolescence in modifying the impact of EDC mixtures on metabolic homeostasis, oxidative stress and risk of metabolic syndrome.
Aim 5: Foster career development by assisting new investigators in the advancement of their research skills and knowledge in translational and children's environmental health research.
Aim 6: Share current research findings on the role that environmental exposures have on children's health in an accurate, relevant way that allows community members, healthcare professionals, and policy-makers to incorporate this new knowledge into practice for the protection of children's _health.
Progress Summary:
Research Projects: Research Projects 1 and 2 examine relationships between toxicant mixtures exposures in utero and peripuberty with physical growth, maturation and metabolic outcomes. The Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) cohorts compromise the primary source of human participants for Projects 1 and 2, building upon work funded through our P20 Formative CEHC. In Year 1 we established subcontracts with Yale School of Public Health and the Instituto Nacional de Salud Pública (INSP) as well as protocols for conducting fieldwork in Mexico City in our research facility at ABC Hospital, including collection of biospecimens, survey data anthropometry and measurement of maturational tempo, and completed relevant amendments to protection of human subjects. The Michigan Mother Infant Pairs (MMIP) cohort is a new US study population established by MPI Padmanabhan that is included in Project 2 of the UM CEHC. In Year 1, we prepared MMIP specimens including isolating RNA and DNA from maternal 1st trimester, maternal term, and infant cord blood samples to pursue DNA methylation and gene transcription studies and will be completing analysis of maternal urine for phthalates at 2 time points (n=80) in Quarter 4.
Project 3 is being implemented in the Agouti mouse model. In Year 1, we have established six cohorts of mating pairs and litters for our mouse model. Mice are being exposed to one of six diets to assess whether in utero high-fat diets modify the effects of perinatal BPA exposure on metabolic, hormonal, and oxidative stress parameters throughout the life-course and to identify if DNA methylation alterations result from these different diets. Additional detail is provided in the Project 3 description.
The Data Management and Modeling Core (DMMC) provides ongoing biostatistical support and database management for the Center to enhance investigators’ and trainees’ study designs and data analysis plans and provide technical consultation in statistical programming, presentation of methods and interpretation of findings for manuscript and poster/presentations at scientific meetings. Additional issues of common interest are discussed at Center-wide meetings.
The Community Outreach and Translation Core (COTC) held bi-monthly meetings with our partners: Head Start for Kent County, Healthy Homes Coalition, Kent County Health Department, and the Children’s Environmental Health Network. These organizations, through educational programs, work to reduce environmental health hazards for children and our partners have indicated an interest in learning about the scientific findings of the U-M CEHC to help bolster their work. As agreed in discussions with our Project Officer, Dr. Karen Peterson as Contact PI is designated as the MPI with primarily responsibility for communicating to key external stakeholders on behalf of the U-M CEHC.
Training and Professional Development: In Year 1, the University of Michigan Children’s Environmental Health and Disease Prevention Center (U-M CEHC) has provided training opportunities for undergraduate, masters, and pre-doctoral trainees to receive mentorship from senior and junior faculty members to enhance their research skills and knowledge in basic and translational research. Students are involved with laboratory work, data analysis, and manuscript preparation. By attending monthly U-M CEHC meetings, students participated in the on-going discussion of scientific and administrative issues, helping to enhance their understanding of the function and structure of the U-M CEHC while also providing them with opportunities to obtain feedback from junior and senior faculty on their own projects.
Future Activities:
As data and biological specimens become available, we will work with the P30 NIEHS Core Center at the University of Michigan to make data and biological specimens available through a searchable web-based kiosk. Additionally, through the Michigan Regional Comprehensive Metabolomics Research Core (MRC)2, metabolomics data from the two human cohorts will also be made available to the public after publication of data, in accordance with NIH guidelines.
Journal Articles: 66 Displayed | Download in RIS Format
Other center views: | All 97 publications | 73 publications in selected types | All 66 journal articles |
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Baek J, Sancehz BN, Berrocal VJ, Sanchez-Vaznaugh EV. Distributed lag models: examining associations between the built environment and health. Epidemiology 2016;27(1):116-124. |
R835436 (2016) R835436 (2017) |
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Baek J, Sanchez-Vaznaugh EV, Sanchez BN. Hierarchial distributed-lag models: exploring varying geographic scale and magnitude in associations between built environment and health. American Journal of Epidemiology 2016;183(6):583-592. |
R835436 (2016) R835436 (2017) |
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Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies:the Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526. |
R835436 (2017) R834515 (Final) R836159 (2018) |
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Buxton M, Perng W, Tellez-Rojo M, Rodriguez-Carmona Y, Cantoral A, Sanchez B, Rivera-Gonzalez L, Gronlund C, Scivappa N, Hebert J, O'Neill M, Peterson K. Particulate matter exposure, dietary inflammatory index and preterm birth in Mexico city, Mexico. ENVIRONMENTAL RESEARCH 2020;189(109852). |
R835436 (Final) |
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Cantonwine DE, Hauser R, Meeker JD. Bisphenol A and human reproductive health. Expert Review of Obstetrics & Gynecology 2013;8(4):329-335. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Cantoral A, Tellez-Rojo MM, Levy TS, Hernandez-Avila M, Schnaas L, Hu H, Peterson KE, Ettinger AS. Differential association of lead on length by zinc status in two-year old Mexican children. Environmental Health 2015;14:95 (7 pp.). |
R835436 (2015) R835436 (2017) |
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Cantoral A, Tellez-Rojo MM, Ettinger AS, Hu H, Hernandez-Avila M, Peterson K. Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age. Pediatric Obesity 2016;11(1):68-74. |
R835436 (2014) R835436 (2015) R835436 (2016) R835436 (2017) |
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Chavarro JE, Watkins DJ, Afeiche MC, Zhang Z, Sanchez BN, Cantonwine D, Mercado-Garcia A, Blank-Goldenberg C, Meeker JD, Tellez-Rojo MM, Peterson KE. Validity of self-assessed sexual maturation against physician assessments and hormone levels. The Journal of Pediatrics 2017;186:172-178.e3. |
R835436 (2016) R835436 (2017) |
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Chen Y-H, Ferguson KK, Meeker JD, McElrath TF, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015;14(1):9 (13 pp.). |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Faulk C, Liu K, Barks A, Goodrich JM, Dolinoy DC. Longitudinal epigenetic drift in mice perinatally exposed to lead. Epigenetics 2014;9(7):934-941. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Ferguson KK, Peterson KE, Lee JM, Mercado-Garcia A, Blank-Goldenberg C, Tellez-Rojo MM, Meeker JD. Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys. Reproductive Toxicology 2014;47:70-76. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Ferguson KK, McElrath TF, Chen Y-H, Loch-Caruso R, Mukherjee B, Meeker JD. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal of Obstetrics & Gynecology 2015;212(2):208.e1-208.e8. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Ferguson KK, McElrath TF, Cantonwine DE, Mukherjee B, Meeker JD. Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy. Placenta 2015;36(6):699-703. |
R835436 (2015) R835436 (2017) |
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Ferguson KK, Meeker JD, Cantonwine DE, Chen Y-H, Mukherjee B, McElrath TF. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016;94:531-537. |
R835436 (2016) R835436 (2017) R834513 (Final) R836155 (2017) R836155 (2020) R836155C003 (2017) |
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Fortenberry GZ, Meeker JD, Sanchez BN, Barr DB, Panuwet P, Bellinger D, Schnaas L, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM. Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City:distribution, temporal variability, and relationship with child attention and hyperactivity. International Journal of Hygiene and Environmental Health 2014; 217(2-3):405-412. |
R835436 (2014) R835436 (2015) R835436 (2017) R834800 (2013) |
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Fossee E, Zamora A, Peterson K, Cantoral A, Perng W, Tellez-Rojo M, Torres-Olascoaga L, Jansen E. Prenatal dietary patterns in relation to adolescent offspring adiposity and adipokines in a Mexico City cohort. JOURNAL OF DEVELOPMENTAL ORIGINA OF HEALTH AND DISEASE 2023;PII S2040174422000678:1-10 |
R835436 (Final) |
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Goodman C, Bashash M, Green R, Song P, Peterson K, Schnass L, Mercado-Garcia A, Martinez-Medina S, Hernandez-Avila M, Martiniz-Mier A, Tellez-Rojo M, Hu H, Till C. Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort. ENVIRONMENTAL RESEARCH 2022;211:112993. |
R835436 (Final) |
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Goodrich JM, Sanchez BN, Dolinoy DC, Zhang Z, Hernandez-Avila M, Hu H, Peterson KE, Tellez-Rojo MM. Quality control and statistical modeling for environmental epigenetics: a study on in utero lead exposure and DNA methylation at birth. Epigenetics 2015;10(1):19-30. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Goodrich JM, Dolinoy DC, Sanchez BN, Zhang Z, Meeker JD, Mercado-Garcia A, Solano-Gonzalez M, Hu H, Tellez-Rojo MM, Peterson KE. Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence. Environmental Epigenetics 2016;2(3):dvw018 (11 pp.). |
R835436 (2016) R835436 (2017) |
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Goodrich JM, Chou HN, Gruninger SE, Fraznblau A, Baus N. Exposures of dental professionals to elemental mercury and methylmercury. Journal of Exposure Science and Environmental Epidemiology 2016;26(1):78-85. |
R835436 (2016) R835436 (2017) |
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Huang S, Hu H, Sanchez BN, Peterson KE, Ettinger AS, Lamadrid-Figueroa H, Schnaas L, Mercado-Garcia A, Wright RO, Basu N, Cantonwine DE, Hernandez-Avila M, Tellez-Rojo MM. Childhood blood lead levels and symptoms of attention deficit hyperactivity disorder (ADHD):a cross-sectional study of Mexican children. Environmental Health Perspectives 2016;124(6):868-874. |
R835436 (2016) R835436 (2017) |
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Jansen EC, Zhou L, Song PXK, Sanchez BN, Mercado A, Hu H, Solano M, Peterson KE, Tellez-Rojo MM. Prenatal lead exposure in relation to age at menarche: results from a longitudinal study in Mexico City. Journal of Developmental Origins of Health and Disease 2018;9(4):467-472. |
R835436 (2017) |
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Jansen EC, Zhou L, Perng W, Song PXK, Tellez-Rojo MM, Mercado A, Peterson KE, Cantoral A. Vegetables and lean proteins-based and processed meats and refined grains-based dietary patterns in early childhood are associated with pubertal timing in a sex-specific manner: a prospective study of children from Mexico City. Nutrition Research 2018;56:41-50. |
R835436 (2017) |
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Jansen E, Burgess H, Chervin R, Dolinoy D, Tellez-Rojo M, Cantoral A, Olasocoaga-Torres L, Lee J, Dunietz G, O'Brien L, Peterson K. Sleep duration and timing are prospectively linked with insulin resistance during late adolescence. OBESITY 2023;31(4):912-922. |
R835436 (Final) |
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Kasper N, Peterson KE, Zhang Z, Ferguson KK, Sanchez BN, Cantoral A, Meeker JD, Tellez-Rojo MM, Pawlowski CM, Ettinger AS. Association of bisphenol A exposure with breastfeeding and perceived insufficient milk supply in Mexican women. Maternal and Child Health Journal 2016;20(8):1713-1719. |
R835436 (2015) R835436 (2016) R835436 (2017) |
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Kochmanski JJ, Marchlewicz EH, Cavalcante RG, Perera BPU, Sartor MA, Dolinoy DC. Longitudinal effects of developmental bisphenol A exposure on epigenome-wide DNA hydroxymethylation at imprinted loci in mouse blood. Environmental Health Perspectives 2018;126(7):077006 (16 pp.). |
R835436 (2017) |
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Kochmanski J, Montrose L, Goodrich JM, Dolinoy DC. Environmental deflection: the impact of toxicant exposures on the aging epigenome. Toxicological Sciences 2017;156(2):325-335. |
R835436 (2016) R835436 (2017) |
Exit Exit |
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Kochmanski J, Marchlewicz EH, Savidge M, Montrose L, Faulk C, Dolinoy DC. Longitudinal effects of perinatal bisphenol A and variable diet exposures on epigenetic drift in mice. Reproductive Toxicology 2017;68:154-163. |
R835436 (2016) R835436 (2017) |
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Kochmanski J, Marchlewicz EH, Dolinoy DC. Longitudinal effects of developmental bisphenol A, variable diet, and physical activity on age-related methylation in blood. Environmental Epigenetics 2018;4(3):dvy017 (10 pp.). |
R835436 (2017) |
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Lewis RC, Meeker JD. Biomarkers of exposure to molybdenum and other metals in relation to testosterone among men from the United States National Health and Nutrition Examination Survey 2011-2012. Fertility and Sterility 2015;103(1):172-178. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012. International Journal of Environmental Research and Public Health 2015;12(6):6098-6114. |
R835436 (2014) R835436 (2015) R835436 (2017) R836155 (2020) R836155C003 (2017) |
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Lewis RC, Johns LE, Meeker JD. Exploratory analysis of the potential relationship between urinary molybdenum and bone mineral density among adult men and women from NHANES 2007-2010. Chemosphere 2016;164:677-682. |
R835436 (2016) R835436 (2017) |
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Liu Y, Peterson KE. Maternal exposure to synthetic chemicals and obesity in the offspring: recent findings. Current Environmental Health Reports 2015;2(4):339-347. |
R835436 (2015) R835436 (2017) |
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Marchlewicz EH, Dolinoy DC, Tang L, Milewski S, Jones TR, Goodrich JM, Soni T, Domino SE, Song PXK, Burant C, Padmanabhan V. Lipid metabolism is associated with developmental epigenetic programming. Scientific Reports 2016;6:34857 (13 pp.). |
R835436 (2016) R835436 (2017) |
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Meeker JD, Ferguson KK. Urinary phthalate metabolites are associated with decreased serum testosterone in men, women, and children from NHANES 2011-2012. The Journal of Clinical Endocrinology and Metabolism 2014;99(11):4346-4352. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Montrose L, Padmanabhan V, Goodrich JM, Domino SE, Treadwell MC, Meeker JD, Watkins DJ, Dolinoy DC. Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation. Epigenetics 2018;13(3):301-309. |
R835436 (2017) |
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Moynihan M, Peterson KE, Cantoral A, Song PXK, Jones A, Solano-Gonzalez M, Meeker JD, Basu N, Tellez-Rojo MM. Dietary predictors of urinary cadmium among pregnant women and children. Science of the Total Environment 2017;575:1255-1262. |
R835436 (2016) R835436 (2017) |
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Neier K, Marchlewicz EH, Dolinoy DC, Padmanabhan V. Assessing human health risk to endocrine disrupting chemicals: a focus on prenatal exposures and oxidative stress. Endocrine Disruptors (Austin);2015;3(1):e1069916 (8 pp.). |
R835436 (2015) R835436 (2017) |
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Omoike OE, Lewis RC, Meeker JD. Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999-2002. Reproductive Toxicology 2015;53:99-104. |
R835436 (2015) R835436 (2017) |
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Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol A and reproductive health: update of experimental and human evidence, 2007-2013. Environmental Health Perspectives 2014;122(8):775-786. |
R835436 (2014) R835436 (2015) R835436 (2017) R834593C001 (Final) R835434 (2013) R835434 (2014) |
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Perng W, Watkins DJ, Cantoral A, Mercado-Garcia A, Meeker JD, Tellez-Rojo MM, Peterson KE. Exposure to phthalates is associated with lipid profile in peripubertal Mexican youth. Environmental Research 2017;154:311-317. |
R835436 (2016) R835436 (2017) |
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Perng W, Fernandez C, Peterson KE, Zhang Z, Cantoral A, Sanchez BN, Solano-Gonzalez M, Tellez-Rojo MM, Baylin A. Dietary patterns exhibit sex-specific associations with adiposity and metabolic risk in a cross-sectional study in urban Mexican adolescents. The Journal of Nutrition 2017;147(10):1977-1985. |
R835436 (2017) |
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Perng W, Hector EC, Song PXK, Tellez Rojo MM, Raskind S, Kachman M, Cantoral A, Burant CF, Peterson KE. Metabolomic determinants of metabolic risk in Mexican adolescents. Obesity (Silver Spring) 2017;25(9):1594-1602. |
R835436 (2017) |
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Sanchez-Vaznaugh EV, Sanchez BN, Crawford PB, Egerter S. Association between competitive food and beverage policies in elementary schools and childhood overweight/obesity trends: differences by neighborhood socioeconomic resources. JAMA Pediatrics 2015;169(5):e150781 (17 pp.). |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Silver MK, Lozoff B, Meeker JD. Blood cadmium is elevated in iron deficient U.S. children: a cross-sectional study. Environmental Health 2013;12(1):117 (9 pp.). |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Somers EC, Monrad SU, Warren JS, Solano M, Schnaas L, Hernandez-Avila M, Tellez-Rojo MM, Hu H. Antinuclear antibody prevalence in a general pediatric cohort from Mexico City: discordance between immunofluorescence and multiplex assays. Clinical Epidemiology 2017;9:1-8. |
R835436 (2016) R835436 (2017) |
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Sun Z, Tao Y, Li S, Ferguson KK, Meeker JD, Park SK, Batterman SA, Mukherjee B. Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons. Environmental Health 2013;12(1):85 (19 pp.). |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Tao Y, Sanchez BN, Mukherjee B. Latent variable models for gene-environment interactions in longitudinal studies with multiple correlated exposures. Statistics in Medicine 2015;34(7):1227-1241. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Trentacosta CJ, Davis-Kean P, Mitchell C, Hyde L, Dolinoy D. Environmental contaminants and child development. Child Developmental Perspectives 2016;10(4):228-233. |
R835436 (2016) R835436 (2017) |
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Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environmental Health 2014;13(1):25 (20 pp.). |
R835436 (2014) R835436 (2015) R835436 (2017) R834678C001 (Final) |
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Veiga-Lopez A, Pennathur S, Kannan K, Patisaul HB, Dolinoy DC, Zeng L, Padmanabhan V. Impact of gestational bisphenol A on oxidative stress and free fatty acids: human association and interspecies animal testing studies. Endocrinology 2015;156(3):911-922. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Veiga-Lopez A, Kannan K, Liao C, Ye W, Domino S, Padmanabhan V. Gender-specific effects on gestational length and birth weight by early pregnancy BPA exposure. Journal of Clinical Endocrinology and Metabolism 2015;100(11):E1394-E1403. |
R835436 (2015) R835436 (2017) |
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Watkins DJ, Tellez-Rojo MM, Ferguson KK, Lee JM, Solano-Gonzalez M, Blank-Goldenberg C, Peterson KE, Meeker JD. In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation. Environmental Research 2014;134:233-241. |
R835436 (2014) R835436 (2015) R835436 (2017) |
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Watkins DJ, Peterson KE, Ferguson KK, Mercado-Garcia A, Tamayo y Ortiz M, Cantoral A, Meeker JD, Tellez-Rojo MM. Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty. Journal of Clinical Endocrinology & Metabolism 2016;101(1):79-88. |
R835436 (2015) R835436 (2016) R835436 (2017) |
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Watkins DJ, Fortenberry GZ, Sanchez BN, Barr DB, Panuwet P, Schnaas L, Osorio-Valencia E, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM, Meeker JD. Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: distribution and relationships with child neurodevelopment. Environmental Research 2016;147:307-313. |
R835436 (2015) R835436 (2016) R835436 (2017) R836155 (2017) R836155 (2020) R836155C003 (2017) |
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Watkins DJ, Milewski S, Domino SE, Meeker JD, Padmanabhan V. Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: a preliminary analysis. Reproductive Toxicology 2016;65:59-66. |
R835436 (2016) R835436 (2017) R834513 (Final) |
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Watkins DJ, Sanchez BN, Tellez-Rojo MM, Lee JM, Mercado-Garcia A, Blank-Goldenberg C, Peterson KE, Meeker JD. Impact of phthalate and BPA exposure during the in utero windows of susceptibility on reproductive hormones and sexual maturation in peripubertal males. Environmental Health 2017;16(1):69 (10 pp.). |
R835436 (2016) R835436 (2017) R835436 (Final) |
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Watkins DJ, Sanchez BN, Tellez-Rojo MM, Lee JM, Mercado-Garcia A, Blank-Goldenberg C, Peterson KE, Meeker JD. Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls. Environmental Research 2017;159:143-151. |
R835436 (2017) |
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Wu J, Wen XW, Faulk C, Boehnke K, Zhang H, Dolinoy DC, Xi C. Perinatal lead exposure alters gut microbiota composition and results in sex-specific body weight increases in adult mice. Toxicological Sciences 2016;151(2):324-333. |
R835436 (2016) R835436 (2017) |
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Yang TC, Peterson KE, Meeker JD, Sanchez BN, Zhang Z, Cantoral A, Solano M, Tellez-Rojo MM. Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity. Environmental Research 2017;156:326-333. |
R835436 (2016) R835436 (2017) |
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Yang TC, Peterson KE, Meeker JD, Sanchez BN, Zhang Z, Cantoral A, Solano M, Tellez-Rojo MM. Exposure to bisphenol A and phthalates metabolites in the third trimester and BMI trajectories. Pediatric Obesity 2018;13(9):550-557. |
R835436 (2017) |
Exit Exit |
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Zamora A, Peterson K, Goodrichy J, Tellez-Roho M, Song P, Meeker J, Dolinoy D, Torres-Olascoaga L, Cantoral A, Jansen E. Associations between exposure to phthalates, phenols, and parabens with objective and subjective measures of sleep health among Mexican women in midlife: a cross-sectional and retrospective analysis. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2023;Epub |
R835436 (Final) |
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Zamora A, Jansen E, Goodrich J, Tellez-Rojo M, Song P, Meeker J, Dolinoy D, Torres O, Cantoral A, Peterson K. Cross-sectional associations between phthalates, phenols, and parabens with metabolic syndrome risk during early-to-mid adolescence among a cohort of Mexican youth. ENVIRONMENTAL SCIENCE 2023;116706 |
R835436 (Final) |
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Zhang K, Buxton M, Rodriguez-Carmona Y, Peterson K, Liu Y, Burgess H, Cantoral A, Tellez-Rojo M, Torres-Olasconaga L, Arboleda-Merino L, Jansen E. Duration, timing, and consistency of sleep in relation to inflammatory cytokines in Mexican adolescents. SLEEP MEDICINE 2022;100:103-111. |
R835436 (Final) |
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Zhang Z, O’Neill MS, Sanchez BN. Using a latent variable model with non-constant factor loadings to examing PM2.5 constituents related to secondary inorganic aerosols. Statistical Modeling 2016;16(2):91-113. |
R835436 (2016) R835436 (2017) |
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Zhou Y, Wang P, Wang X, Zhu J, Song PX. Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis. Genetic Epidemiology 2017;41(1):70-80. |
R835436 (2016) R835436 (2017) |
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Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2017 Progress Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- Original Abstract
66 journal articles for this center