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University of Washington

University of Washington

The theme of the University of Washington based Center for Child Environmental Health Risks Research (CHC) is understanding the biochemical, molecular and exposure mechanisms that define children''''s susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning. The CHC is a multi-disciplinary research center that takes advantage of the established landscape of risk research at the University of Washington; it is administratively housed within the Institute for Risk Analysis and Risk Communication that is in the UW''''s School of Public Health and Community Medicine..

To facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures, center participants include members from multiple institutions, schools, and varied departments and clinics. To achieve tangible effects on the community, the CHC includes a partnership with an eastern Washington community within the Yakima Valley agricultural center of our state, to jointly accomplish pesticide intervention with reduced childhood pesticide exposures.

The CHC is comprised of two laboratory based research projects, two field based projects, and four facility cores. The specific objectives of the laboratory based research projects are to:

  • identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides and
  • identify the impact of genetic polymorphisms for paraoxonase on the developmental neurotoxicity of organophosphate pesticides.

The specific objectives of the two field based projects-a pesticide exposure pathways research project plus the related community based intervention study are to:

  • identify critical pathways of pesticide exposure for children and
  • to develop a culturally-appropriate intervention to break the take-home pathway that will ultimately result in reducing children''''s exposure to pesticides.

The four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) are designed to support the research agenda and to put the research into a child specific risk assessment context. Thus the scientific findings on pesticide toxicity and exposure can be directly incorporated into risk assessment models that are designed to protect child health.

Laboratory Based Projects

The laboratory based projects in this proposal will specifically address two aspects of children''''s susceptibility to pesticides. They will investigate molecular mechanisms of neurotoxicity for pesticides and evaluate the role of paraoxonase in defining sensitivity of children to organophosphate pesticides. Functional assessments for both studies will be performed in the Neurobehavioral Assessment Facility Core. These projects will be closely linked as common organophosphate pesticides will be examined in all projects, animals, and tissues and research results will be readily shared among these researchers.

View Projects in Tabular Format

Main Center Abstract and Reports:

Development of Environmental Indicators of Condition,Integrity, and Sustainability in the Coastal Regions of the US Great Lakes Basin
Atlantic Coast Environmental Indicators Consortium
Research Center for Particulate Air Pollution and Health
Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM)
FRIENDS Children's Environmental Health Center
Center for Hazardous Substances in Urban Environments (CHSUE)
Western Region Hazardous Substance Research Center for Developing In-Situ Processes for VOC Remediation in Groundwater and Soil
Urban Waste Management & Research Center (University of New Orleans)
Hazardous Substance Research Center–South and Southwest
Western Region Hazardous Substance Research Center
The Johns Hopkins University Center For The Asthmatic Child in the Urban Environment
Center for Child Environmental Health Risks Research
CECEHDPR - University of Michigan
HSRC (1989) - South and Southwest HSRC
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
Midwest Hazardous Substance Research Center
Hazardous Substance Research Center/South and Southwest
Center for Hazardous Substances in Urban Environments (CHSUE)
Technical Outreach Services for Communities Support
FDP - Center for Environmental Science
Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States
National Environmental Respiratory Center: Health Hazards of Inhaled Gasoline Engine Emissions and Street Dust
Johns Hopkins Particulate Matter Research Center
Harvard Particle Center
Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
Texas Joint Center for Air Quality
The Center for Advancing Microbial Risk Assessment (CAMRA)
Applying Spatial and Temporal Modeling of Statistical Surveys to Aquatic Resources
Center for Integrating Statistical and Environmental Science
National Research Program on Design-Based/Model-Assisted Survey Methodology for Aquatic Resources
Center for Science and Policy Applications for Coastal Environments (SPACE)
Inner City Toxicants, Child Growth and Development
Center for Children's Environmental Health Research
Center for Child Environmental Health Risks Research
Johns Hopkins Center for Childhood Asthma in the Urban Environment
Center for the Study of Metals in the Environment
Carolina Center for Computational Toxicology
Center for the Study of Metals in the Environment
The Center for Environmental Implications of Nanotechnology (CEINT)
The Texas-Indiana Virtual STAR Center; Data-Generating in vitro and in silico Models of Developmental Toxicity in Embryonic Stem Cells and Zebrafish
Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
Center for Child Environmental Health Risks Research
Berkeley/Stanford Children’s Environmental Health Center
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
University of Washington Center for Clean Air Research (UW CCAR)
Air Pollution Mixtures: Health Effects Across Life Stages
National Environmental Respiratory Center
Environmental Research and Technology Transfer Program of The Consortium for Plant Biotechnology Research, Inc.
Center for Reinventing Aging Infrastructure for Nutrient Management (RAINmgt)
Center for Comprehensive, optimaL, and Effective Abatement of Nutrients
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Novel Methods to Assess the Effects of Chemicals on Child Development
Water Innovation Network for Sustainable Small Systems (WINSSS)
Predictive Toxicology Center for Organotypic Cultures and Assessment ofAOPs for Engineered Nanomaterials
Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments
SEARCH: Solutions to Energy, AiR, Climate, and Health
Comparing Urban and Rural Effects of Poverty on COPD (CURE COPD)
Center for Native American Environmental Health Equity Research
Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
A Sustainable Center for Crowd-Sourced Water Infrastructure Modeling

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023