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Center for Research on Early Childhood Exposure and Development in Puerto Rico

Northeastern University

Exposure to multiple chemicals in the environment during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial risk factors that may modify the effects of these exposures. To address this gap, the Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE) will study the impact of a mixture of environmental exposures and modifying factors on fetal and early childhood health and development in the children of the heavily-contaminated northern coast of Puerto Rico – an underserved, highly-exposed, and low-income population with significant health disparities.

Center Publications:

Views: All publications Selected publication types Journal articles Publications submitted after final report

View Projects in Tabular Format

Main Center Abstract and Reports:

Centers of Excellence in Children's Environmental Health and Disease Prevention Research
Inner City Toxicants and Neurodevelopmental Impairment
CECEHDPR - University of Michigan
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
Harvard Particle Center
The Center for Advancing Microbial Risk Assessment (CAMRA)
Center for Integrating Statistical and Environmental Science
Inner City Toxicants, Child Growth and Development
Center for Children's Environmental Health Research
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
Berkeley/Stanford Children’s Environmental Health Center
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
UC Berkeley/Stanford Children's Environmental Health Center
Water Innovation Network for Sustainable Small Systems (WINSSS)
SEARCH: Solutions to Energy, AiR, Climate, and Health
Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center for Integrative Research on Childhood Leukemia and the Environment

Center Research Projects:

R824834C001 - Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)

R824834C002 - Cardiopulmonary Response to Particulate Exposure

R824834C003 - VOC Exposure in an Industry Impacted Community

R824834C004 - A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)

R824834C005 - Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants

R824834C006 - Relationship Between Indoor, Outdoor and Personal Air (RIOPA)

R824834C007 - Development of the "Leland Legacy" Air Sampling Pump

R824834C008 - Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences

R824834C009 - Development of a Personal Cascade Impactor Sampler (PCIS)

R824834C010 - Testing the Metals Hypothesis in Spokane

R825540C001 - Development and Verification of A Molecular Modeling Approach for Predicting the Sequestration and Bioavailability/Biotoxicity Reduction of Organic Contaminants by Soils and Sediments

R825540C002 - Molecular Modeling of Hydrophobic Organic Contaminants Uptake and Sequestration by Soil Organic Matter

R825540C003 - The Use of Microfiltration and Ultrafiltration Membranes for the Separation, Recovery, and Reuse of Surfactant/Contaminant Solutions

R825540C004 - A Contained Simulation of Field Application of Genetically Engineered Microorganisms (Gems) for the Bioremediation of PCB Contaminated Soils

R826710C001 - Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)

R826710C002 - Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)

R826710C003 - A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)

R827039C001 - Growing Up Healthy in East Harlem

R827039C002 - Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children

R827039C003 - Genetics of Chlorpyrifos Risk in Minority Populations

R827039C004 - Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood

R827039C005 - Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

R828112C042 - Does Inhalation of Methanol Vapor Affect Human Neurobehavior?

R828112C043 - Human Responses to Nitrogen Dioxide

R828112C044 - The Role of Inflammation in Ozone-Induced Lung Injury

R828112C045 - How Does Exercise Affect the Dose of Inhaled Air Pollutants?

R828112C046 - How Do Chemicals in Diesel Engine Exhaust Damage DNA?

R828112C047 - Effect of Nitrogen Dioxide on Bacterial Respiratory infectionin Mice

R828112C048 - Effects of Ozone Exposure on Airway Epithelium

R828112C049 - Inhalation of Aldehydes and Effects on Breathing

R828112C050 - Does Ozone Cause Precancerous Changes in Cells?

R828112C051 - Effects of Formaldehyde on Human Airway Epithelial Cells Exposed in a Novel Culture System

R828112C052 - Carbon Monoxide and Cardiac Arrhythmias

R828112C053 - Effects of Formaldehyde and Particle-Bound Formaldehyde on Lung Macrophage Functions

R828112C054 - Mechanisms for Protecting Lung Epithelial Cells Against Oxidant Injury

R828112C055 - Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis

R828112C056 - Particle Trap Effects on Heavy-Duty Diesel Engine Emissions

R828112C057 - Carbon Monoxide and Atherosclerosis

R828112C058 - Nitrogen Dioxide and Respiratory Illness in Children

R828112C059 - Noninvasive Methods for Measuring Ventilation in Mobile Subjects

R828112C060 - Oxidant Air Pollutants and Lung Cancer: An Animal Model

R828112C061 - Detection of Carcinogen-DNA Adducts: Development of New Methods

R828112C062 - Effects of Carbon Monoxide on Heart Muscle Cells

R828112C063 - Development of Personal Ozone Samplers: Three Approaches

R828112C064 - Development of Biomarkers to Monitor Carcinogen Exposure

R828112C065 - Effects of Prolonged Ozone Inhalation on Collagen Structure and Content in Rat Lungs

R828112C065II - Prolonged Ozone Exposure and the Contractile Properties of Isolated Rat Airways

R828112C065III - Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone Inhalation

R828112C065IV - Genetic Control of Connective Tissue Protein Synthesis After Prolonged Ozone Inhalation

R828112C065V - Pulmonary Function Alterations in Rats After Chronic Ozone Inhalation

R828112C065VII - Prolonged Ozone Exposure Leads to Functional and Structural Changes in the Rat Nose

R828112C065VIII - IX - Studies of Changes in Lung Structure and Enzyme Activitiesin Rats After Prolonged Exposure to Ozone

R828112C065X - An Innovative Approach to Analyzing Multiple Experimental Outcomes: A Case Study of Rats Exposed to Ozone

R828112C065XI - The Consequences of Prolonged Inhalation of Ozone on Rats: An Integrative Summary of the Results of Eight Collaborative Studies

R828112C066 - Interactive Effects of Nitropyrenes in Diesel Exhaust

R828112C067 - Detection of Formaldehyde–DNA Adducts: Development of New Methods

R828112C068I - Comparison of the Carcinogenicity of Diesel Exhaust and Carbon Black in Rat Lungs

R828112C068II - An Investigation of DNA Damage in the Lungs of Rats Exposed to Diesel Exhaust

R828112C068III - No Evidence For Genetic Mutations Found In Lung Tumors From Rats Exposed To Diesel Exhaust or Carbon Black

R828112C069 - Noninvasive Determination of Respiratory Ozone Absorption: The Bolus-Response Method

R828112C070 - The Effects of Inhaled Oxidants and Acid Aerosols on Pulmonary Function

R828112C071 - Biochemical Consequences of Ozone Reacting with Membrane Fatty Acids

R828112C072 - DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust

R828112C073 - Developmental Neurotoxicity of Inhaled Methanol in Rats

R828112C074 - Methanol Distribution in Non Pregnant and Pregnant Rodents

R828112C075 - Is Increased Mortality Associated with Ozone Exposure in Mexico City?

R828112C076 - Effects of Fuel Modification and Emission Control Devices on Heavy-Duty Diesel Engine Emissions

R828112C077 - Metabolic Studies in Monkeys Exposed to Methanol Vapors

R828112C078 - Effects of Ozone on Pulmonary Function and Airway Inflammation in Normal and Potentially Sensitive Human Subjects

R828112C079 - Improvement of a Respiratory Ozone Analyzer

R828112C080 - Mechanism of Oxidative Stress from Low Levels of Carbon Monoxide

R828112C081 - Long-Term Exposure to Ozone: Development of Methods to Estimate Past Exposures and Health Outcomes

R828112C082 - Effects of Ambient Ozone on Healthy, Wheezy, and Asthmatic Children

R828112C083 - Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure

R828112C084 - Evaluation of The Potential Health Effects of the Atmospheric Reaction Products of Polycyclic Aromatic Hydrocarbons

R828112C085 - Mechanisms of Response to Ozone Exposure: The Role of Mast Cells in Mice

R828112C086 - Statistical Methods for Epidemiologic Studies of the Health Effects of Air Pollution

R828112C087 - Development of New Methods to Measure Benzene Biomarkers

R828112C088 - Alveolar Changes in Rat Lungs After Long-Term Exposure to Nitric Oxide

R828112C089 - Effects of Prenatal Exposure to Inhaled Methanol on Nonhuman Primates and Their Infant Offspring

R828112C090 - A Pilot Study of Potential Biomarkers of Ozone Exposure

R828112C091 - Effects of Concentrated Ambient Particles on the Cardiac and Pulmonary Systems of Dogs

R828112C092 - Cancer, Mutations, and Adducts in Rats and Mice Exposed to Butadiene and Its Metabolites

R828112C093 - Effects of Concentrated Ambient Particles in Rats and Hamsters: An Exploratory Study

R828112C094I - The National Morbidity, Mortality, and Air Pollution Study: Methods and Methodologic Issues

R828112C094II - The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the United States

R828112C095 - Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban Populations

R828112C096 - Acute Pulmonary Effects of Ultrafine Particles in Rats and Mice

R828112C097 - Identifying Subgroups of the General Population That May Be Susceptible to Short-Term Increases in Particulate Air Pollution

R828112C098 - Daily Mortality and Fine and Ultrafine Particles in Erfurt, Germany

R828112C099 - A Case-Crossover Analysis of Fine Particulate Matter Air Pollution and Out-of-Hospital Sudden Cardiac Arrest

R828112C100 - Effects of Mexico City Air on Rat Nose

R828112C101 - Penetration of Lung Lining and Clearance of Particles Containing Benzo[a]pyrene

R828112C102 - Metabolism of Ether Oxygenates Added to Gasoline

R828112C103 - Characterization and Mechanisms of Chromosomal Alterations Induced by Benzene in Mice and Humans

R828112C104 - Acute Cardiovascular Effects in Rats from Exposure to Urban Ambient Particles

R828112C105 - Genetic Differences in Induction of Acute Lung Injury and Inflammation in Mice

R828112C106 - Effects on Mice of Exposure to Ozone and Ambient Particle Pollution

R828112C107 - Emissions from Diesel and Gasoline Engines Measured in Highway Tunnels

R828112C108 - Case-Cohort Study of Styrene Exposure and Ischemic Heart Disease Investigators

R828112C110 - Effects of Metals Bound to Particulate Matter on Human Lung Epithelial Cells

R828112C111 - Effect of Concentrated Ambient Particulate Matter on Blood Coagulation Parameters in Rats

R828112C112 - Health Effects of Acute Exposure to Air Pollution

R828112C113 - Benzene Metabolism in Rodents at Doses Relevant to Human Exposure from Urban Air

R828112C114 - A Personal Particle Speciation Sampler

R828112C115 - Validation and Evaluation of Biomarkers in Workers Exposed to Benzene in China

R828112C116 - Biomarkers in Czech Workers Exposed to 1,3-Butadiene: A Transitional Epidemiologic Study

R828112C117 - Peroxides and Macrophages in the Toxicity of Fine Particulate Matter in Rats

R828112C118 - Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los Angeles

R828112C119 - Manganese Toxicokinetics at the Blood-Brain Barrier

R828112C120 - Effects of Exposure to Concentrated Ambient Particles from Detroit Air on Healthy Rats and Rats with Features of Asthma or Mild Bronchitis

R828112C121 - Field Evaluation of Nanofilm Detectors for Measuring Acidic Particles in Indoor and Outdoor Air

R828112C123 - Time-Series Analysis of Air Pollution and Mortality: A Statistical Review

R828112C126 - Effects of Exposure to Ultrafine Carbon Particles in Healthy Subjects and Subjects with Asthma

R828112C128 - Neurogenic Responses of Rat Lung to Diesel Exhaust

R828112C130-I - Relationships of Indoor, Outdoor, and Personal Air (RIOPA). Part I. Collection Methods and Descriptive Analyses

R828112C132 - An Updated Study of Mortality Among North American Synthetic Rubber Industry Workers

R828678C001 - Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)

R828678C002 - Cardiopulmonary Effects of Metal-Containing Particulate Exposure

R828678C003 - VOC Exposure in an Industry Impacted Community

R828678C004 - A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)

R828678C005 - Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)

R828678C006 - Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species

R828678C007 - Development of the “Leland Legacy” Air Sampling Pump

R828678C008 - Source Apportionment of Indoor PAHs in Urban Residences 98-03B

R828678C009 - Development of a Personal Cascade Impactor Sampler (PCIS)

R828678C010 - Testing the Metals Hypothesis in Spokane

R828678C011 - A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas

R828678C012 - Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan

R828678C013 - Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)

R828678C014 - Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs

R828678C015 - RIOPA Database Development

R828678C016 - Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources

R828678C017 - The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children

R829389C001 - Neurobehavioral Effects of Prevalent Toxicants in Children

R829389C002 - Validation of Meconium Markers of Fetal Neurotoxicant Exposures

R829389C003 - Community-Based Research Project Identifying Residential Hazards Using Home Test Kits

R829389C004 - Early Exposure to Lead and Adult Antisocial Outcome

R829389C005 - Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure

R831710C001 - Center for Children’s Environmental Health Research – CHAMACOS Community Based Research Project

R831710C002 - Center for Children’s Environmental Health Research – Pesticide Exposure Assessment Project

R831710C003 - Center for Children’s Environmental Health Research – Mechanisms of Pesticide Neuro- and Immunotoxicity

R831710C004 - Center for Children’s Environmental Health Research – Community Outreach and Translation Core

R831711C001 - Growing Up Healthy in East Harlem (Community-Based Participatory Research)

R831711C002 - Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)

R831711C003 - Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)

R834513C001 - CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty

R834513C002 - Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children

R834513C003 - Epigenetics Project

R834513C004 - Community Outreach and Translation Core

R834797C001 - Cardiometabolic Effects of Exposure to Differing Mixtures and Concentrations of PM2.5 in Obese and Lean Adults

R834797C002 - Cardiometabolic, Autonomic, and Airway Toxicity of Acute Exposures to PM2.5 from Multipollutant Atmospheres in the Great Lakes Region

R834797C003 - Long Term Metabolic Consequences of Exposures to Multipollutant Atmospheres in the Great Lakes Region

R834800C001 - In Utero Lead Exposure: Fetal Epigenetics and Life-Course Physiologic Effects

R834800C002 - Impacts of Life-stage Exposures to BPA and Phthalates on Growth and Development

R835871C001 - Project 1: Modeling Emissions from Energy Transitions

R835871C002 - Project 2: Assessment of Energy-Related Sources, Factors and Transitions Using Novel High-Resolution Ambient Air Monitoring Networks and Personal Monitors

R835871C003 - Project 3: Air Quality and Climate Change Modeling: Improving Projections of the Spatial and Temporal Changes of Multipollutants to Enhance Assessment of Public Health in a Changing World

R835871C004 - Project 4: Human Health Impacts of Energy Transitions: Today and Under a Changing World

R836155C001 - Air Pollution Impacts on Neonatal and Early Childhood Development

R836155C002 - Toxicogenomics-based Mechanistic Multimedia Exposure Assessment and Child Development

R836155C003 - Biomarker Epidemiology of In Utero Environmental Exposures and Child Development

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023