Grantee Research Project Results
Centers of Excellence in Children's Environmental Health and Disease Prevention Research
EPA Grant Number: R826709Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Centers of Excellence in Children's Environmental Health and Disease Prevention Research
Investigators: Eskenazi, Brenda
Institution: University of California - Berkeley
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003
Project Amount: $2,830,746
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The goal of this Center is to establish a forum for the multi-disciplinary approach to understand and reduce the environmental health risks of children. This Center is a joint partnership between the University, the local and State health departments, community clinics, and our community organization, South County Outreach Effort (SCORE). We have brought together a diverse team of specialists representing many disciplines to address the special environmental issues of children.
For this proposal, we have focused on the environmental risks of a largely understudied population of latino farmworkers in Salinas Valley in Monterey County, California. California, with the largest agricultural output of the 50 states, uses 25% of the national total (over 210 million pounds) of pesticides annually, with over 725,000 pounds of organophosphate (OP) pesticides used in the Salinas Valley alone. Furthermore, approximately I million California residents are farmworkers, with Monterey County leading the numbers.
Recently, several studies have demonstrated pesticide contamination in children's homes from agricultural areas. It is estimated that 20-60% of children aged l to 5 years may be exposed to unsafe levels of OP pesticides. Nevertheless, to date, few studies have assessed the extent of children's pesticide exposure, and no studies have examined whether there are adverse health effects of low-level chronic exposure. Farmworker children are exposed by the usual pathways i.e., by ingestion of contaminated foods and from home pest control, as well as through pesticide drift from nearby fields and from the take-home exposures of their parents. Studying this high risk population, we can ascertain whether chronic, low-level exposures may be potentially hazardous.
We will interview and bank biologic and environmental samples from a cohort of 550 pregnant women and their children, who will be followed for 3 years. Our specific aims are: 1) to estimate levels of in utero and postnatal exposures of the child by measuring biologic and ambient samples; 2) to determine whether exposure to pesticides is associated with adverse effects on neurodevelopment and growth, and increased respiratory disease including asthma; and 3) to initiate and evaluate the impact of a 'Healthy Homes' intervention on the reduction of pesticide exposure to children. Our ultimate goal is to translate research findings into a reduction of pesticide exposure to children, and to reduce the incidence of environmentally related childhood disease.
Journal Articles: 38 Displayed | Download in RIS Format
| Other center views: | All 140 publications | 38 publications in selected types | All 38 journal articles |
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Alkon A, Boyce WT, Tran L, Harley KG, Neuhaus J, Eskenazi B. Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLoS One 2014;9(1):e86283. |
R826709 (2002) R831710 (Final) R834513 (2012) R834513 (2014) R834513 (Final) R834513C001 (2012) R834513C001 (2014) R834513C002 (Final) R834513C003 (Final) |
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Alkon A, Harley KG, Neilands TB, Tambellini K, Lustig RH, Boyce WT, Eskenazi B. Latino children's body mass index at 2-3.5 years predicts sympathetic nervous system activity at 5 years. Childhood Obesity 2014;10(3):214-224. |
R826709 (2002) R834513 (2012) R834513 (2014) R834513C001 (2012) R834513C001 (2014) R834513C002 (Final) R834513C003 (Final) |
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Bradman A, Eskenazi B, Sutton P, Athanasoulis M, Goldman LR. Iron deficiency associated with higher blood lead in children living in contaminated environments. Environmental Health Perspectives 2001;109(10):1079-1084. |
R826709 (2001) R826709 (2002) |
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Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti J, Havdahl A, Mulder R. Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular Psychiatry 22;. |
R826709 (2002) R834513 (Final) |
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Castorina R, Bradman A, McKone TE, Barr DB, Harnly ME, Eskenazi B. Cumulative organophosphate pesticide exposure and risk assessment among pregnant women living in an agricultural community: a case study from the CHAMACOS cohort. Environmental Health Perspectives 2003;111(13):1640-1648. |
R826709 (2001) R826709 (2002) R831710 (Final) |
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Daredia S, Huen K, van der Laan L, Collender P, Nwanaji-Enwerem J, Harley K, Deardorff J, Eskenazi B, Holland N, Cardenas A. Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort. EPIGENETICS 2022;842. |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Deardorff J, Borgen N, Rauch S, Kogut K, Eskenazi B. Maternal Adverse Childhood Experiences and Young Adult Latino Children's Mental Health. AMERICAN JOURNAL OF PREVENTATIVE MEDICINE 2024;66(1):119-127 |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Deardorff J, Reeves J, Hayland C, Tilles S, Rauch S, Kogut K, Greenspan L, Shirtcliff E, Lustig R, Eskenazi B. Childhood Overweight and Obesity and Pubertal Onset Among Mexican-American Boys and Girls in the CHAMACOS Longitudinal Study. American Journal of Epidemiology 23;191(1):7-16. |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Engel S, Bradman A, Wolf M, Rauh V. Prenatal Organophosphor Pesticide Exposure and Child Neurodevelopment at 24 Months:An Analysis of Four Birth Cohorts. ENVIRONMENTAL HEALTH PERSPECTIVES 2016;124(6):822-830. |
R826709 (2002) R826886 (2000) R827027 (2002) R827039 (2002) R828609 (Final) R832141 (Final) |
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Eskenazi B, Bradman A, Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environmental Health Perspectives 1999;107(Suppl 3):409-419. |
R826709 (2001) R826709 (2002) R826709C001 (1999) R826709C001 (2000) R826709C002 (1999) R826709C002 (2000) R826709C003 (1999) R826709C003 (2000) |
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Eskenazi B, Bradman A. Longitudinal investigation of pesticides and allergen exposures to children living in agricultural communities in California. Urban Health and Development Bulletin 2001;4(2):33-44. |
R826709 (2001) R826709 (2002) |
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Eskenazi B, Bradman A, Gladstone EA, Jaramillo S, Birch K, Holland N. CHAMACOS, a longitudinal birth cohort study: lessons from the fields. Journal of Children's Health 2003;1(1):3-27. |
R826709 (2002) R831710 (Final) |
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Eskenazi B, Kogut K, Huen K, Harley KG, Bouchard M, Bradman A, Boyd-Barr D, Johnson C, Holland N. Organophosphate pesticide exposure, PON1, and neurodevelopment in school-age children from the CHAMACOS study. Environmental Research 2014;134:149-157. |
R826709 (2002) R832734 (Final) R834513 (2014) R834513 (2015) R834513C001 (2014) R834513C001 (2015) |
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Eskenazi B, Gunier R, Rauch S, Kogut K, Perito E, Mendez X, Limbach C, Holland N, Bradman A, Harley K, Mills P, Mora A. Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study. ENVIRONMENTAL HEATL PERSEPCTIVES 2023;131(3):037001 |
R826709 (2002) |
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Gamba RJ, Eskenazi B, Madsen K, Hubbard A, Harley K, Laraia BA. Changing from a highly food secure household to a marginal or food insecure household is associated with decreased weight and body mass index z-scores among Latino children from CHAMACOS. Pediatric Obesity 2021;. |
R826709 (2002) R831710 (Final) |
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Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environmental Science & Technology 2013;47(19):11249-11257. |
R826709 (2002) R834513 (2013) R834513 (2014) R834513 (Final) R834513C002 (2013) R834513C002 (2014) |
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Gunier RB, Mora AM, Smith D, Arora M, Austin C, Eskenazi B, Bradman A. Biomarkers of manganese exposure in pregnant women and children living in an agricultural community in California. Environmental Science & Technology 2014;48(24):14695-14702. |
R826709 (2002) R834513 (2011) R834513 (2013) R834513 (2014) R834513 (2015) R834513 (Final) R834513C002 (2014) R834513C002 (2015) R834513C004 (2011) |
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Gunier RB, Raanan R, Castorina R, Holland NT, Harley KG, Balmes JR, Fouquette L, Eskenazi B, Bradman A. Residential proximity to agricultural fumigant use and respiratory health in 7-year old children. Environmental Research. 2018;164:93-99. |
R826709 (2002) R831710 (Final) |
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Gunier R, Deardorff J, Rauch S, Bradshaw P, Kogut K, Sagiv S, Hyland C, Mora A, Eskenazi B. Residential proximity to agricultural pesticide use and risk-taking behaviors in young adults from the CHAMACOS study. ENVIRONMENTAL MANAGEMENT 2022;215(2) |
R826709 (2002) R834513 (Final) |
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Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. |
R826709 (2002) R826886 (2000) R827027 (2002) R827039 (2002) R828609 (Final) R831710 (Final) R832141 (Final) R834513C001 (2015) |
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Harley K, Eskenazi B, Block G. The association of time in the US and diet during pregnancy in low-income women of Mexican descent. Paediatric and Perinatal Epidemiology 2005;19(2):125-134. |
R826709 (2001) R826709 (2002) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2004) |
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Heggeseth B, Holland N, Eskenazi B, Harley K. Heterogeneity in childhood body mass trajectories in relation to prenatal phthalate exposure. Environmental Research 2019;175:22-23. |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Holland NT, Smith MT, Eskenazi B, Bastaki M. Biological sample collection and processing for molecular epidemiological studies. Mutation Research-Reviews in Mutation Research 2003;543(3):217-234. |
R826709 (2001) R826709 (2002) R831710 (Final) |
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Huland C, Bradshaw P, Deardorff J, Sagiv S, Bradman A, Eskenzai B. Interactions of agricultural pesticide use near home during pregnancy and adverse childhood experiences on adolescent neurobehavioral development in the CHAMACOS study. Environmental Research 2022;204(2). |
R826709 (2002) R832141 (Final) R834513 (Final) |
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Kalantzi O, Castorina R, Gunier R, Kogut K, Holland N, Eskenazi B, Bradman A. Determinants of organophosphorus pesticide urinary metabolite levels in pregnant women from the CHAMACOS cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2022;854(158551). |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Khodasevich D, Holland N, Harley K, Eskenazi B, Barcellow L, Cardenas A. Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood. ENVIRONMENTAL INTERNATIONAL 2024;190 |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Kokroki J, Kogut K, Harley K, Eskenzai B. Prenatal beta-Hexachlorocyclohexane (beta-HCH) Exposure and 7-Year Child IQ in the CHAMACOS Birth Cohort. NEUROTOXICITY RESEARCH 2020;37(3):533-563. |
R826709 (2002) |
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Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernandez-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Environment International 2015;84:39-54. |
R826709 (2002) R834513 (2014) R834513 (2015) R834513 (2016) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) |
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Nwanaji-Enwerem J, Van der Laan L, Kogut K, Eskenazi B, Holland N, Deardorff J, Cardenas A. Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children. Aging-US 31;13(24):25653-25669. |
R826709 (2002) |
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Raanan R, Harley KG, Balmes JR, Bradman A, Lipsett M, Eskenazi B. Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort. Environmental Health Perspectives 2015;123(2):179-185. |
R826709 (2002) R831710 (Final) R834513 (2010) R834513 (2014) R834513 (2015) R834513 (Final) R834513C001 (2014) R834513C001 (2015) |
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Raanan R, Balmes JR, Harley KG, Gunier RB, Magzamen S, Bradman A, Eskenazi B. Decreased lung function in 7-year-old children with early-life organophosphate exposure. Thorax 2016;71(2):148-153. |
R826709 (2002) R831710 (Final) R834513 (2015) R834513 (2016) R834513 (Final) R834513C001 (2014) R834513C001 (2015) R834513C001 (2016) |
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Raanan R, Gunier RB, Balmes JR, Beltran AJ, Harley KG, Bradman A, Eskenazi B. Elemental sulfur use and associations with pediatric lung function and respiratory symptoms in an agricultural community (California, USA). Environmental Health Perspectives 2017;125(8):087007 (8 pp.). |
R826709 (2002) R831710 (Final) R834513 (Final) R834514 (Final) |
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Rahmani E, Ghenhav L, Schweiger R, Yoefi P, Huen K, Eskenazi B, Eng C, Huntsman S, Hu D, Glanter J, Oh S, Waldenberger M, Strauch K, Grallert H, Meitinger T, Geiger C, Holland N, Burchard E, aetlen N, Halperin E. Genome-wide methylation data mirror ancestry information. EPIGENETICS & CHROMATIN 2017;10(1). |
R826709 (2002) R834513 (Final) |
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Roubinov D, Tein JY, Kogut K, Gunier R, Eskenazi B, Alkon A. Latent profiles of children's autonomic nervous system reactivity early in life predict later externalizing problems. Developmental Phychobiology 2020;00:1-13. |
R826709 (2002) R831710 (Final) |
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Sagiv S, Kogut K, Harley K, Bradman A, Morga N, Eskenazi B. Gestational Exposure to Organophosphate Pesticides and Longitudinally Assessed Behaviors Related to Attention-Deficit/Hyperactivity Disorder and Executive Function. American Journal of Epidemiology 01;190(11):2420-2431. |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Sagiv S, Rauch S, Kogut K, Huland C, Gunier R, Mora A, Bradman A, Deardorff J, Eskenazi B. Prenatal exposure to organophosphate pesticides and risk-taking behaviors in early adulthood. Environmental Health 10;21(1). |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Sagiv S, Mora A, Rauch S, Kogut K, Hyland C, Gunier R, Bradman A, Deardorff J, Eskenazi B. Prenatal and Childhood Exposure to Organophosphate Pesticides and Behavior Problems in Adolescents and Young Adults in the CHAMACOS Study. EMVIRONMENTAL HEALTH PERSPECTIVES 2023;131(6):067008 |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Vernet C, Johnson M, Kogut K, Hyland C, Deardorff J, Bradman A, Eskenazi B. Organophosphate pesticide exposure during pregnancy and childhood and onset of juvenile delinquency by age 16 years:The CHAMACOS cohort. Environmental Research 2021;197. |
R826709 (2002) R831710 (Final) R834513 (Final) |
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Supplemental Keywords:
RFA, Health, Scientific Discipline, Water, Geographic Area, Health Risk Assessment, Epidemiology, State, Risk Assessments, Analytical Chemistry, Biochemistry, Children's Health, Ecological Risk Assessment, Mercury, health effects, pesticide exposure, risk, risk assessment, developmental neurotoxicology, farmworkers, environmental health, community-based intervention, prenatal exposure, developmental neurotoxicity, age-related differences, environmental risks, pesticides, epidemelogy, latino, neurodevelopment, children, Human Health Risk Assessment, neurotoxicity, human exposure, insecticides, children's vulnerablity, neurodevelopmental toxicity, harmful environmental agents, epidemeology, neurobehavioral effects, environmental health hazard, children's environmental health, dietary exposure, growth & development, pregnancy, California (CA), agricultural community, biomedical research, developmental disorders, exposure assessment, human health riskProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826709C001 Community Based Intervention to Reduce Pesticide Exposures to Young Children
R826709C002 The Epidemiological Investigation of the Effects of Pesticide Exposure on Neurodevelopmental, Growth, and Respiratory Health of Farmworker Children
R826709C003 A Comprehensive Assessment of Sources of Pesticide Contamination, Concentrations in Pathways, and Exposure-prone Behavior
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.