Grantee Research Project Results
2016 Progress Report: Center for Integrative Research on Childhood Leukemia and the Environment
EPA Grant Number: R836159Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Center for Integrative Research on Childhood Leukemia and the Environment
Investigators: Metayer, Catherine
Institution: University of California - Berkeley
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2020)
Project Period Covered by this Report: September 1, 2015 through August 31,2016
Project Amount: $2,599,999
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Leukemia is the most common cancer in children and the incidence of acute lymphoblastic leukemia (ALL) in the US has increased by 55% since 1975, disproportionately affecting Latino children. Environmental exposures are important contributing causes of childhood ALL, alone or in combination with genetic and epigenetic factors. Most cases of childhood ALL will be cured, but survivors are at increased risk of debilitating medical and psychosocial complications, thus, elucidating etiologic pathways, with an aim toward prevention, remains an important goal.
To reach its goals, the Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE) is composed of three Cores and three Research Projects. Project 1 (In Utero Chemical Exposures, Immune Status, and Childhood Leukemia), Project 2 (Identifying In Utero Exposures that Are Risk Factors for Childhood Leukemia), Project 3 (Prenatal Exposures, Constitutive Genetics, DNA Methylation and Childhood Leukemia), the Community Outreach and Translation Core, the Administrative Core, and the Mouse Model Service Core. The specific aims for each can be found on the individual project pages.
Progress Summary:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the progress made toward meeting the overall goals of the Center.
Future Activities:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the activities planned in order to meet the overall goals of the Center.
Journal Articles: 35 Displayed | Download in RIS Format
| Other center views: | All 37 publications | 35 publications in selected types | All 35 journal articles |
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Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies:the Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526. |
R836159 (2018) R834515 (Final) R835436 (2017) |
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de Smith AJ, Walsh KM, Morimoto LM, Francis SS, Gonseth S, Jeon S, Chen M, Sun H, Luna-Fineman S, Antillon F, Hansen HM, Kang AY, Smirnov I, Xiao X, Whitehead TP, Barcellos LF, Sender L, Healy J, Laverdière C, Sinnett D, Taub JW, Birch JM, Thompson P, Pombo-de-Oliveira MS, Spector LG , DeWan AT, Mueller BA, Chiang C, Metayer C, Ma X, Wiemels JL (In Press) Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome. Leukemia. |
R836159 (2019) |
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de Smith AJ, Kaur M, Gonseth S, Endicott A, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL. Correlates of prenatal and early-life tobacco smoke exposure and frequency of common gene deletions in childhood acute lymphoblastic leukemia. Cancer Research 2017;77(7):1674-1683. |
R836159 (2017) R836159 (2018) R836159C003 (2017) |
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Edmands WMB, Petrick LM, Barupal DK, Scalbert A, Wilson MJ, Wickliffe JK, Rappaport SM. compMS2Miner:an automatable metabolite identification, visualization, and data-sharing R package for high-resolution LC-MS data sets. Analytical Chemistry 2017;89(7):3919-3928. |
R836159 (2017) R836159C002 (2017) |
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Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Cheng Munthe-Kaas M, Corpeleijn E, Czamara D, Dabelea D, Davey Smith G, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S, Grote V, Gruzieva O, Haberg SE. Cohort profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. International Journal of Epidemiology 2018;47(1):22-23u. |
R836159 (2018) R836159 (Final) R835442 (2018) |
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Giddings BM, Whitehead TP, Metayer C, Miller MD. Childhood leukemia incidence in California: high and rising in the Hispanic population. Cancer 2016;122(18):2867-2875. |
R836159 (2017) R836159 (2018) |
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Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nussle S, Singer AW, Wrensch MR, Metayer C, Wiemels JL. Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes. Epigenetics 2015;10(12):1166-1176. |
R836159 (2017) R836159 (2018) R836159 (2019) R836159C003 (2016) R834511 (2014) |
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Gonseth S, de Smith AJ, Roy R, Zhou M, Lee S-T, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. Epigenetics 2016;11(9):664-673. |
R836159 (2017) R836159 (2018) R836159C003 (2017) |
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Kaur M, de Smith AJ, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Metayer C. Tobacco smoke and Ras mutations among Latino and non-Latino children with acute lymphoblastic leukemia. Archives of Medical Research 2016;47(8):677-683. |
R836159 (2018) |
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McCanlies EC, Fekedulegn D, Mnatsakanova A, Burchfiel CM, Sanderson WT, Charles LE, Hertz-Picciotto I. Parental occupational exposures and autism spectrum disorder. Journal of Autism and Developmental Disorders 2012;42(11):2323-2334. |
R836159 (2019) R833292 (2012) R833292 (Final) |
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Metayer C, Dahl G, Wiemels J, Miller M. Childhood leukemia: a preventable disease. Pediatrics 2016;138 (Suppl 1):S45-S55. |
R836159 (2017) R836159 (2018) |
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Miller MD, Valenti M, Schettler T, Tencza B. A multimedia e-book — A story of health: filling a gap in environmental health literacy for health professionals. Environmental Health Perspectives 2016;124(8):A133-A136. |
R836159 (2017) R836159 (2018) |
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Miller MD, Valenti M, Schettler T, Tencza B. A story of health: filling a gap in environmental health literacy for health professionals. San Francisco Medicine, Journal of San Francisco Medical Society 2016;89(10):20-24 (Reprinted and edited with permission from Environmental Health Perspective). |
R836159 (2018) |
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Milne E, Greenop KR, Petridou E, Bailey HD, Orsi L, Kang AY, Baka M, Bonaventure A, Kourti M, Metayer C, Clavel J. Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: a pooled analysis from the Childhood Leukemia International Consortium. Cancer Causes & Control 2018;29(6):539-550. |
R836159 (2018) R836159 (2019) |
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Orsi L, Magnani C, Petridou ET, Dockerty JD, Metayer C, Milne E, Bailey HD, Dessypris N, Kang AY, Wesseling C, Infante-Rivard C, Wunsch-Filho V, Mora AM, Spector LG, Clavel J. Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium. Cancer Medicine 2018;7(6):2665-2681. |
R836159 (2018) R836159 (2019) |
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Petrick L, Edmands W, Schiffman C, Grigoryan H, Perttula K, Yano Y, Dudoit S, Whitehead T, Metayer C, Rappaport S. An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies. Metabolomics 2017;13(3):27 (19 pp.). |
R836159 (2017) R836159 (2018) R836159C002 (2017) |
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Petridou ET, Georgakis MK, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Ezzat S, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Rashed WM, Dessypris N, Schüz J, Infante-Rivard C, Skalkidou A. Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. European Journal of Epidemiology 2018;33(10):965-976. |
R836159 (2018) R836159 (2019) |
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Rappaport, S.M. Redefining environmental exposure for disease etiology. NPJ Systems Biology and Application. 2018(4):30. |
R836159 (2019) |
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Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, XuZ, Huang RC, Reese SE, Xu CJ, Baiz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Kupers LK, Zhang H, Richmond RC, Page CM, Duijts L, Lie RT, Melton PE, Vonk JM, Nohr EA, Williams-DeVane C, Huen K, Rifas-Shiman SL, Ruiz-Arenas C, Gonseth S, Rezwan FI, Herceg Z, Ekstrom S, Croen L, Falahi F, Perron P, Karagas MR, Quraishi BM, Suderman M, Magnus MC, Jaddoe VWV, Taylor JA, Anderson D, Zhao S, Smit HA, Josey MJ, Bradman A, Baccarelli AA, Bustamante M, Haberg SE, Pershagen G, Hertz-Picciotto I, Newschaffer C, Corpeleijn E, Bouchard L, Lawlor DA, Maguire RL, Barcellos LF, Davey Smith G, Eskenazi B, Karmaus W, Marsit CJ, Hivert MF, Snieder H, Fallin MD, Melen E, Munthe-Kaas MC, Arshad H, Wiemels JL, Annesi-Maesano I, Vrijheid M, Oken E, Holland N, Murphy SK, Sorensen TIA, Koppelman GH, Newnham JP, Wilcox AJ, Nystad W, London SJ, Felix JF, Relton CL. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics 2017;26(20):4067-4085. |
R836159 (2018) R835442 (2018) |
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Wallace AD, Francis SS, Shao X, de Smith AJ, Walsh KM, Mckean-Cowdin R, Ma X, Dahl G, Barcellos LF, Wiemels JL, Metayer C. A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. Haematologica 2018;103(1):e29-e31. |
R836159 (2018) |
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Wallace AD, Francis SS, Ma X, McKean-Cowdin R, Selvin S, Whitehead TP, Barcellos LF, Kang AY, Morimoto L, Moore TB, Wiemels JL, Metayer C. Allergies and childhood acute lymphoblastic leukemia: a case-control study and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention 2018;27(10):1142-1150. |
R836159 (2018) R836159 (2019) |
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Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V, ENGAGE Consortium Telomere Group, Samani NJ, Metayer C, Wiemels JL. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis 2016;37(6):576-582. |
R836159 (2018) |
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Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X. Cesarean section and risk of childhood acute lymphoblastic leukemia in a population-based, record-linkage study in California. American Journal of Epidemiology 2017;185(2):96-105. |
R836159 (2017) R836159 (2018) R836159C001 (2017) |
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Wang R, Metayer C, Morimoto L, Wiemels JL, Yang J, DeWan AT, Kang A, Ma X. Parental age and risk of pediatric cancer in the offspring: a population-based record-linkage study in California. American Journal of Epidemiology 2017;186(7):843-856. |
R836159 (2018) |
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Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood leukemia and primary prevention. Current Problems in Pediatric and Adolescent Health Care 2016;46(10):317-352. |
R836159 (2017) R836159 (2018) |
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Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018;9(1):286 (8 pp.). |
R836159 (2018) |
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Yano Y, Grigoryan H, Schiffman C, Edmands W, Petrick L, Hall K, Whitehead TP, Metayer C, Dudoit S, Rappaport SM. Untargeted adductomics of cys34 modifications to human serum albumin in newborn dried Blood Spots. Analytical and Bioanalytical Chemistry 2019. |
R836159 (2019) |
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Schiffman C, Petrick L, Perttula K, Yano Y, Carlsson H, Whitehead TP, Metayer C, Hayes J, Edmands W, Rappaport SM, Dudoit S. Data-adaptive pipeline for filtering and normalizing metabolomics data. Biorxiv. 2018. |
R836159 (2019) |
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de Smith AJ, Walsh KM, Francis SS, Zhang C, Hansen HM, Smirnov I, Morimoto L, Whitehead TP, Kang A, Shao X, Barcellos LF, McKean-Cowdin R, Zhang L, Fu C, Wang R, Yu H, Hoh J, Dewan AT, Metayer C, Ma X, Wiemels JL. BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. Int J Cancer 2018;143(11):2647-2658. |
R836159 (2019) |
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Panagopoulou P, Skalkidou A, Marcotte E, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Schüz J, Christodoulakis C, Ntzani E, Petridou ET. Parental age and the risk of childhood acute myeloid leukemia:results from the Childhood Leukemia International Consortium. Journal of Cancer Epidemiology. 2019(59):158-165. |
R836159 (2019) |
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Schiffman C, Petrick L, Perttula K, Yano Y, Carlsson H, Whitehead T, Metayer C, Hayes J, Rappaport S, Dudoit S. Filtering procedures for untargeted LC-MS metabolomics data. BMC Bioinformatics. 2019(1):20:334. |
R836159 (2019) |
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Petrick LM, Schiffman C, Edmands WMB, Yano Y, Perttula K, Whitehead T, Metayer C, Wheelock CE, Arora M, Grigoryan H, Carlsson H, Dudoit S, Rappaport SM. Metabolomics of neonatal blood spots reveal distinct phenotypes of pediatric acute lymphoblastic leukemia and potential effects of early-life nutrition. Cancer Letters 2019;452:71-78. |
R836159 (2019) |
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Yano Y, Schiffman C, Grigoryan H, Hayes J, Edmands W, Petrick L, Whitehead T, Metayer C, Dudoit S, Rappaport S. Untargeted adductomics of newborn dried blood spots identifies modifications to juman serum albumin associated with childhood leukemia. Leukemia Research. 2020(8):106268 |
R836159 (2019) |
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Karalexi MA, Dessypris N, Clavel J, Metayer C, Erdmann F, Orsi L, Kang AY, Schüz J, Bonaventure A, Greenop KR, Milne E, Petridou ET. Coffee and tea consumption during pregnancy and risk of childhood acute myeloid leukemia:A Childhood Leukemia International Consortium (CLIC) study. Cancer Epidemiology. 2019(62):101581 |
R836159 (2019) |
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Nielsen AB, Zhou M, de Smith AJ, Want R, McCoy L, Hansen H, Morimoto L, Gronbaech K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in etiology. Haematologica. 2019. |
R836159 (2019) |
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Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836159C001 In Utero Chemical Exposures, Immune Status, and Childhood Leukemia
R836159C002 Identifying In Utero Exposures that are Risk Factors for Childhood Leukemia
R836159C003 Prenatal Exposures, Constitutive Genetics, DNA Methylation & Childhood Leukemia
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.