Grantee Research Project Results
2015 Progress Report: UC Berkeley/Stanford Children's Environmental Health Center
EPA Grant Number: R835435Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: UC Berkeley/Stanford Children's Environmental Health Center
Investigators: Hammond, S. Katharine , Shaw, Gary M. , Balmes, John R.
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Period Covered by this Report: July 1, 2014 through June 30,2015
Project Amount: $4,765,843
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The major goal of the UC Berkeley-Stanford Children’s Environmental Health Center is to study the relationship between air pollution in the San Joaquin Valley of California and children’s health. The health effects upon which we are focused include preterm birth, birth defects, allergic diseases, immunologic impacts, obesity and glucose dysfunction. While the population for preterm births and birth defects will be those who already have given birth, and research based on birth records and the birth defect registry, the studies of allergic diseases, immunologic impacts, obesity and glucose dysfunction will use the same cohorts of children recruited within our piecewise design, the development of which is another major goal.
Supportive Goals:
- Recruiting three cohorts of participants:
- pregnant women and following their children at birth, 1 year, and 2 years of age;
- 7 year olds, who will be followed again at 9 years of age
- teenagers and young adults who already have participated in our previous studies in Fresno.
- Developing exposure estimates for participants in all three projects. The exposure core will collect air samples and air quality data to understand both temporal (on a weekly basis) and spatial variability of exposure, develop models based on these data to predict individual exposures to traffic-related air pollutants, with special focus on polycyclic aromatic hydrocarbons.
- Laying the groundwork for the CAB to translate and use CHAPS research results in their work.
Progress Summary:
- One day retreat of the Center as a whole in late spring 2015 at University California, Berkeley.
- Meeting of the External Advisory Committee on May 26, 2015.
- Biweekly meetings of all investigators held throughout the year.
- Established an Executive Committee consisting of K Hammond, G Shaw, J Balmes, J Mann, K Nadeau, E Eisen, and thus representing each project and each core.
- Began recruiting participants into infant/pregnancy and child cohorts.
- Obtained approval of an IRB protocol by the UC Berkeley Office for the Protection of Human Subjects, Stanford University, and obtained reliance agreement with UCSF; worked with the Human Subjects Research Review Board to clarify that the research funded by the USEPA grant is not human subjects research (rather, this part of the research focuses on Project 4, Transit Exposures during Pregnancy, which has no human subjects, and Core D, the exposure assessment core).
- Programmed interviewer-administered questionnaires into CASIC BUILDER, which enables computer assisted questionnaire administration, and secure transfer of data from Fresno to Berkeley each evening. Program is equivalent to RedCap and Qualtrix.
- Translated screening questionnaires and baseline questionnaires into Spanish for the pregnant women (infant) and child cohorts.
- Presented Webinars.
Accomplishments by projects:
Project 1
- Identified ~1400 sample buccal cells (mother and infant) and bloodspots (infants only) from available birth defect cases and controls. We have sent the samples to the Lammer lab where the DNA will be extracted and genotyped. Our work on this goal is on schedule.
- Analyzed the relationship between PAH during several periods during pregnancy (entire pregnancy, each trimester and last 6 weeks) with categories of gestational age at birth to determine the association between PAH and levels of preterm birth. We found associations between PAH during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR=2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three quartiles. The results were published in Environmental Research (Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM. Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environ Res. 2014;135:221-226).
- Begun analyses on the effects of neighborhood factors and air pollution on preterm birth using causal inference methods (i.e., targeted maximum likelihood estimation). The effects of air pollution appear to be stronger in neighborhoods with greater deprivation. A manuscript is in preparation.
Projects 2 and 3 Combined Field Work (funded by NIEHS)
- Obtained approval of an IRB protocol by the UC Berkeley Office for the Protection of Human Subjects, UCSF MOU for UCSF-Fresno, and Stanford University, and worked with the the U.S. EPA’s Human Subjects Research Review Board to structure the research appropriately.
- Recruited and interviewed the first 100 people in the AYA (adolescent/young adult) cohort, tested their lung function (specific aim 1), and collected their blood and saliva and transported these to Stanford University.
- Began recruitment of pregnant women for infant cohort (n=42 as of 06/30/2015). Transported the blood and saliva collected from UCSF-Fresno to Stanford University. These will be analyzed when more samples have been collected.
- Began recruiting children aged 6 to 8 from Fresno Unified School District beginning in mid-May 2015. The expansion in age range was a recommendation of the EAC. Transported the blood and saliva collected from the first eight children from UCSF-Fresno to Stanford University. These will be analyzed when more samples have been collected.
Project 2
- We currently are in the process of obtaining all the immunophenotyping data and all the epigenetic data for these participants. The associations with PAH exposure will await recruitment of additional subjects in this cohort and assignment of individual exposure data from the Exposure Core.
- No data analysis of key outcomes has been done to date.
Project 3
- Successfully implemented dietary assessments using both a 24-hour recall instrument (ASA-24) and a food frequency instrument (NCI Dietary Screener Questionnaire) to collect covariate data.
- Successfully implemented an anthropometric battery (height, weight, waist circumference), including a bioelectrical impedance method for measuring body fat composition (rather than the Tanita scale as originally proposed).
- Successfully implemented an accelerometry protocol for assessment of adolescent/young adult (n=97/100), child and pregnant women’s physical activity using Actigraph GT3X-BT monitors (n=40/42 pregnant women and 8 children).
- Successfully implemented blood pressure following the NHANES protocol for the child and adolescent/young adult cohorts
- No data analysis of key outcomes has been done to date
Project 4
- Revised goals to correspond to decreased funding (50% of that requested) and EPA regulations on human subjects
- Developed methods to compare the results of structured social observation of indicators of order and disorder adapting the methods of Sampson and Raudenbush (1999) and secondary data measures of neighborhood environment
- Piloted and revised the structured social observation (SSO) tool
- Completed SSO in 3 Fresno neighborhoods with four scales:
- Disorder-Walking considers 16 possible indicators of social disorder and barriers to walking (such as: condoms and syringes on street, abandoned homes, adults being hostile, no safe place to walk). Inter-rater reliability: .96
- Disorder Institutions considers 8 possible indicators of institutional level social disorder (such as liquor stores, auto repair/other business with visible waste, boarded up commercial/industrial properties). Inter-rater reliability: .96
- Order-Walking considers 13 indicators of possible social order and supports for pedestrians (such as: street lights, sidewalks, well-maintained empty lots, clearly marked cross-walks). Inter-rater reliability: .95
- Order-Institutional considers 9 indicators of institutional level social order (such as schools, parks, local businesses, and government services). Inter-rater reliability: .86
- Acquired and analyzed secondary data-based indicators of walkability and neighborhood quality of life. In the table, we provide several examples for comparison, including:
- Walk Score®: uses GPS data to assess neighborhood walkability considering nearby amenities and transportation. The average for Fresno is 42 (and for comparison, Berkeley CA 79). Data set prepared by https://www.walkscore.com.
- CES Deprivation Score: Derived from the California EPA CalEnviroScreen. The score ranks each zip code in state on 11 measures of exposure.
- CES Population Score: Derived from the California EPA CalEnviroScreen, ranks each zip code 7 measures of socio-economic status
- Measured neighborhood exposure concentrations to multiple air pollutants by real-time monitoring study that also collects the time-location data for proximity to traffic emission in 10 neighborhoods corresponding to those with structured social observations.
Core B, COTC
- Held three quarterly meetings of Community Advisory Board.
- Created a factsheet that lists key findings and citations for all CHAPS and FACES (Fresno Asthmatic Children Environment Study) publications.
- Updated study website.
Core D, Exposure Core
- Historical air quality data for the San Joaquin Valley (SJV) in the 1997-2011 time period was acquired and implemented in a database. These include both routine criteria pollutant data from EPA’s Air Quality System (AQS) and the air toxics monitoring network. The data have been subjected to quality checks and compiled as daily average concentrations. Historical ambient concentrations of selected PAHs are available in Fresno, Bakersfield, Modesto, and Stockton starting in 1995. The quality, extent, and trends in these data were examined during the reporting period.
- Continuous PAH and carbon air monitoring data were collected at the four main fixed sites (Garland, Fresno Pacific University, Sierra Sky Park, and Clovis) in our study area during the reporting period.
- Aethalometers were installed at the Sierra Sky Park and Clovis sites in September 2014. A roving PAH analyzer is co-located at each site for 2 month periods in order to generate intercomparison data.
- Data acquisition systems were installed to transmit data from the PAH analyzers and the aethalometers to a project website where the data are automatically displayed graphically. The near-real-time data are reviewed daily to insure analyzers are operating as expected. These systems are designed to maximize data collection rates and minimize labor and travel costs associated with technician monitoring station visits.
- New integrated chilled PAH samplers (CPASS Samplers) were both designed and fabricated by the Exposure Core and installed at two sites. The two CPASS active samplers at Garland and Fresno Pacific University were configured to collect OC/EC and naphthalene in addition to PAHs.
- Following the review of the passive sampler performance evaluation conducted last year, the field sampling campaign for fall/winter 2014/2015 was designed and implemented. The study design consisted of short-term sampling at 50 sites: 14 sites with active and passive sampling and 36 sites with passive-only sampling. The purpose of this campaign was to characterize spatial patterns of individual PAH and other compounds across Fresno.
- 24-hour samples that will subsequently be analyzed for 26 PAHs were collected on EPA’s 1-in-6 day PM sampling schedule starting in October 2014. Pressure and temperature signals from the sampler are transmitted continuously to the project website to remotely assess its operation.
- Twelve FACES MEMS samplers from FACES were refurbished and deployed for active sampling of PAHs using XAD4 coated filters, of naphthalene using XAD2 cartridges, and of EC/OC using quartz filters. The two CPASS active samplers at Garland and Fresno Pacific University were configured to collect OC/EC and naphthalene in addition to PAHs. The passive sampling included Ogawa samplers for NO2/NOx and our newly developed sampler for naphthalene. All passive samples were deployed with shelters to minimize the potential impacts from wind and rain.
- Four 3- to 4-day experiments were conducted where sequential 24-hr active samples were collected starting at noon each day and passive samples were collected as integrated 3- or 4-day samples. The experiments in November, December, and January captured weekday exposures and the experiment in February primarily captured weekend exposures. The field technicians successfully executed the sampling plan and achieved a very high data capture rate. The continuous PAH and BC data collected at four sites during these field campaigns indicate the pollution levels were slightly above the winter average levels. Laboratory analysis of the samples is underway but will continue into Year 3. The NO2 and NOx samples from the first two experiments have been analyzed and the concentrations generally confirm the spatial pattern expected from the study design.
Future Activities:
Project 1
To determine whether exposures to specific air pollutants (identified in our P20 research) are further modified by gene variants in biotransformation enzymes (e.g., NATs, GSTs, CYPH, or NOS3) for risk of selected birth defects.
We will complete genetic assays on a sizable proportion of study subjects and begin statistical analyses of the gene variants and pollution exposure to determine their combined influence on risk of birth defects.
To determine whether ambient exposures to PAHs, during critical periods of organogenesis, are associated with women delivering infants/fetuses with birth defects, and whether relationships are further modified by gene variants in Aim 1.
We plan to assign PAH exposures to the additional data and begin analyzing the relationship between PAH and selected birth defects.
To determine whether ambient exposures to PAHs, during critical periods of gestation, are associated with women delivering preterm.
Work on this goal has been completed.
To determine whether the built environment is associated with preterm birth either directly or indirectly through a joint effect with ambient air pollution.
We will continue to evaluate the data we have on neighborhood deprivation and apply causal inference methods. We also will incorporate additional data on the built environment provided from Project 4.
Project 2
We will continue to recruit and enroll subjects. Our goal is to recruit at least 240 subjects this year.
Project 3
We recently have begun recruiting pregnant women who are 20-weeks pregnant through our UCSF-Fresno field site to populate our infant cohort; we plan to complete recruitment of pregnant women during the third year of the project. We will continue recruiting adolescent/young adults. During the next reporting period, we also will begin recruiting participants for the young children cohort by contacting parents of 7-year olds who attend one of the schools in the Fresno Unified School District.
Project 4
The study plan is to continue structured observation in each of Fresno’s 20 residential zip codes over 3 years of data collection. We also will continue to conduct structured walking routes to measure the real time concentration of PM2.5, ultrafine particle number concentrations, black carbon, and particle-bound PAHs simultaneously. We will add such measurements on other transit modes (e.g., bus, car).
Journal Articles: 44 Displayed | Download in RIS Format
Other center views: | All 126 publications | 45 publications in selected types | All 44 journal articles |
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Alcala E, Cisneros R, Capitman JA. Health care access, concentrated poverty, and pediatric asthma hospital care use in California's San Joaquin Valley: a multilevel approach. Journal of Asthma 2017:1-9. |
R835435 (2018) R835435 (Final) |
Exit Exit |
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Alcala E, Brown P, Capitman JA, Gonzalez M, Cisneros R. Cumulative impact of environmental pollution and population vulnerability on pediatric asthma hospitalizations:a multilevel analysis of CalEnviroScreen. International Journal of Environmental Research and Public Health. 2019;16(15):2683.. |
R835435 (Final) |
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Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research 2018;161:472-478. |
R835435 (Final) R835441 (2018) |
Exit Exit Exit |
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Cossi M, Zuta S, Padula AM, Gould JB, Stevenson DK, Shaw GM. Role of infant sex in the association between air pollution and preterm birth. Annals of Epidemiology 2015;25(11):874-876. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
Exit Exit Exit |
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Gou P, Chang X, Ye Z, Yao Y, Nguyen PK, Hammond SK, Wang J, Liu S. A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China. Environmental Science and Pollution Research 2017;24(28):22579-22586. |
R835435 (Final) |
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Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (Final) R834786 (Final) |
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Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics 2012;4(1):17 (16 pp.). |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
Exit |
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Kwon J, Weisel CP, Morandi MT, Stock TH. Source proximity and meteorological effects on residential outdoor VOCs in urban areas: results from the Houston and Los Angeles RIOPA studies. Science of the Total Environment 2016;573:954-964. |
R835435 (2018) |
Exit Exit Exit |
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Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-related air pollution and telomere length in children and adolescents living in Fresno, CA: a pilot study. Journal of Occupational and Environmental Medicine 2017;59(5):446-452. |
R835435 (2018) R835435 (Final) |
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Lessard LN, Alcala E, Capitman JA. Pollution, poverty, and potentially preventable childhood morbidity in central California. The Journal of Pediatrics 2016;168:198-204. |
R835435 (2014) R835435 (2016) R835435 (Final) |
Exit Exit Exit |
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Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC. Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology 2013;2013:967029. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
Exit |
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Mann JK, Balmes JR, Bruckner TA, Mortimer KM, Margolis HG, Pratt B, Hammond SK, Lurmann FW, Tager IB. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environmental Health Perspectives 2010;118(10):1497-1502. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) |
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Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. Journal of Allergy and Clinical Immunology 2010;126(4):845-852.e10. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596C003 (2010) R834596C003 (2011) R834786 (2011) |
Exit Exit |
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Noth EM, SK Hammond, GS Biging, and IB Tager. 2011. A spatial-temporal regression model to predict daily outdoor residential PAH concentrations in an epidemiologic study in Fresno, CA. Atmospheric Environment 2011;45(14):2394-2403. |
R835435 (Final) R828678C017 (Final) |
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Noth EM, Hammond SK, Biging GS, Tager IB. Mapping and modeling airborne urban phenanthrene distribution using vegetation biomonitoring. Atmospheric Environment 2013;77:518-524. |
R835435 (Final) R834596 (Final) |
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Noth EM, Lurmann F, Northcross A, Perrino C, Vaughn D, Hammond SK. Spatial and temporal distribution of polycyclic aromatic hydrocarbons and elemental carbon in Bakersfield, California. Air Quality, Atmosphere & Health 2016;9(8):899-908. |
R835435 (2016) R835435 (2018) R835435 (Final) |
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Ortega Hinojosa AM, MacLeod K, Balmes JR, Jerrett M. Influence of school environments on childhood obesity in California. Environmental Research 2018;166:100-107. |
R835435 (2018) |
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Padula AM, Mortimer K, Hubbard A, Lurmann F, Jerrett M, Tager IB. Exposure to traffic-related air pollution during pregnancy and term low birth weight:estimation of causal associations in a semiparametric model. American Journal of Epidemiology 2012;176(9):815. |
R835435 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann F, Shaw GM. Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2013;27(4):329-339. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Lurmann F, Shaw GM. The association of ambient air pollution and traffic exposures with selected congenital anomalies in the San Joaquin Valley of California. American Journal of Epidemiology 2013;177(10):1074-1085. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann FW, Shaw GM. Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California. Birth Defects Research, Part A: Clinical and Molecular Teratology 2013;97(11):730-735. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Mortimer KM, Tager IB, Hammond SK, Lurmann FW, Yang W, Stevenson DK, Shaw GM. Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Annals of Epidemiology 2014;24(12):888-895e4. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C001 (Final) |
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Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM. Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environmental Research 2014;135:221-226. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
Exit Exit Exit |
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Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. Journal of Exposure Science & Environmental Epidemiology 2015;25(3):295-302. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) |
Exit Exit |
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Padula AM, Yang W, Carmichael SL, Tager IB, Lurmann FW, Hammond SK, Shaw GM. Air pollution, neighbourhood socioeconomic factors, and neural tube defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2015;29(6):536-545. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
Exit Exit |
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Padula AM, Yang W, Schultz K, Tom L, Lin B, Carmichael SL, Lammer EJ, Shaw GM. Gene variants as risk factors for gastroschisis. American Journal of Medical Genetics Part A 2016;170(11):2788-2802. |
R835435 (2018) R835435 (Final) |
Exit Exit |
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Padula AM, Yang W, Carmichael SL, Lurmann F, Balmes J, Hammond K, Shaw GM. Air pollution, neighborhood acculturation factors and neural tube defects among Hispanic women in California. Birth Defects Research 2017;109(6):403-422. |
R835435 (2017) R835435 (2018) R835435 (Final) |
Exit Exit |
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Padula AM, Yang W, Schultz K, Lurmann F, Hammond SK, Shaw GM. Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. American Journal of Medical Genetics, Part A 2018 May;176(5):1055-1090. |
R835435 (2018) R835435 (Final) |
Exit Exit |
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Prunicki M, Stell L, Dinakarpandian D, de Planell-Saguer M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma. Clinical Epigenetics 2018;10:2. |
R835435 (2018) R835435 (Final) |
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Prunicki, M., et al., Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma (submitted). |
R835435 (2017) |
not available |
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Tager IB, Lurmann FW, Haight T, Alcorn S, Penfold B, Hammond SK. Temporal and spatial patterns of ambient endotoxin concentrations in Fresno, California. Environmental Health Perspectives 2010;118(10):1490-1496. |
R835435 (Final) |
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Zografos K, Krenz V, Yarmo K, Alcala E. College students’ utilization of protective alcohol-use behaviors. Californian Journal of Health Promotion 201;13(1): 49-58. |
R835435 (Final) |
Exit |
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Gale SL, Noth EM, Mann J, Balmes J, Hammond SK, Tager IB. Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA. Journal of Exposure Science and Environmental Epidemiology 2012;22(4):3 86. |
R835435 (Final) |
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Syed A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air pollution and epigenetics. Journal of Environmental Protection 2013;4(08):114. |
R835435 (Final) |
not available |
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Sabounchi S, Bollyky J, Nadeau K. Review of environmental impact on the epigenetic regulation of atopic diseases. Current Allergy and Asthma Reports 2015;15(6):33. |
R835435 (Final) |
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Quinn C, Miller-Lionberg DD, Klunder KJ, Kwon J, Noth EM, Mehaffy J, Leith D, Magzamen S, Hammond SK, Henry CS, Volckens J. Personal exposure to PM2.5 black carbon and aerosol oxidative potential using an automated microenvironmental aerosol sampler (AMAS). Environmental Science & Technology 2018;52(19):11267-11275. |
R835435 (Final) |
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Weber KA, Yang W, Carmichael SL, Padula AM, Shaw GM. A machine learning approach to investigate potential risk factors for gastroschisis in California. Birth Defects Research 2019;111(4):212-221. |
R835435 (Final) |
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Padula AM, Yang W, Lurmann FW, Balmes J, Hammond SK, Shaw GM. Prenatal exposure to air pollution, maternal diabetes and preterm birth. Environmental Research 2019;170:160-167. |
R835435 (Final) |
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Prunicki M, Zhou X, Nadeau K. The impact of a prescribed burn versus a wildfire on the immune and cardiovascular systems of children. Journal of Allergy and Clinical Immunology 2019;143(2):AB80. |
R835435 (Final) |
Exit Exit |
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Padula AM, Yang W, Schultz K, Lee C, Lurmann F, Hammond SK, Shaw GM. Gene–environment interactions between air pollution and biotransformation enzymes and risk of birth defects. Birth Defects Research 2021; 113(9):676-686. |
R835435 (Final) |
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Prunicki, M and Nadeau, K. (2016) The Air We Breathe:How Extreme Weather Conditions Harm Us in Extreme Weather, Health, and Communities:Interdisciplinary Engagement, Springer Publishers. |
R835435 (2017) |
not available |
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Weber KA, Yang W, Lurmann F, Hammond SK, Shaw GM, Padula AM. Air pollution, maternal hypertensive disorders, and preterm birth. Environmental Epidemiology. 2019 Oct 1;3(5):e062. |
R835435 (Final) |
not available |
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Zografos, K; Alcala, E; & Capitman, J. Integrating Research Experiences into Public Health Curricula:Effects on Undergraduate Students’ Overall Educational Experience. To be submitted to:Pedagogy in Health Promotion. |
R835435 (2017) |
not available |
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Zografos K, Alcala E, Capitman J, Khang L. Integrating research experiences into public health curricula:effects on undergraduate students’ knowledge of neighborhood inequalities, perception of research, and motivation to talk about health issues. Pedagogy in Health Promotion 2019:2373379919881469. |
R835435 (Final) |
not available |
Supplemental Keywords:
Ambient air pollution, genetic polymorphisms, epidemiology, infants, pregnancy, health effects, PAHRelevant Websites:
The Children’s Health & Air Pollution Study-San Joaquin Valley (CHAPS) Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- 2014 Progress Report
- Original Abstract
44 journal articles for this center