Grantee Research Project Results
2016 Progress Report: UC Berkeley/Stanford Children's Environmental Health Center
EPA Grant Number: R835435Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: UC Berkeley/Stanford Children's Environmental Health Center
Investigators: Hammond, S. Katharine , Shaw, Gary M. , Balmes, John R.
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Period Covered by this Report: July 1, 2015 through June 30,2016
Project Amount: $4,765,843
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The major goal of the UC Berkeley-Stanford Children’s Environmental Health Center is to study the relationship between air pollution in the San Joaquin Valley of California and children’s health. The health effects upon which we are focused include preterm birth, birth defects, allergic diseases, immunologic impacts, obesity and glucose dysfunction. While the population for preterm births and birth defects will be those who have already given birth, and research based on birth records and the birth defect registry, the studies of allergic diseases, immunologic impacts, obesity and glucose dysfunction will use the same cohorts of children recruited within our piecewise design, the development of which is another major goal.
Specific Aims
- To determine whether exposures to specific air pollutants (identified in our P20 research) are further modified by gene variants in biotransformation enzymes (e.g., NATs, GSTs, CYPH, or NOS3) for risk of selected birth defects.
- To determine whether ambient exposures to polycyclic aromatic hydrocarbons (PAHs), during critical periods of organogenesis, are associated with women delivering infants/fetuses with birth defects, and whether relationships are further modified by gene variants in Aim 1.
- To determine whether ambient exposures to PAHs, during critical periods of gestation, are associated with women delivering preterm.
- To determine whether the built environment is associated with preterm birth either directly or indirectly through a joint effect with ambient air pollution.
Progress Summary:
Specific Aim 1
We have identified ~1,400 samples buccal cells (mother and infant) and bloodspots (infants only) from available birth defect cases and controls. We sent samples to the Lammer lab where the DNA was extracted and genotyping experiments conducted. The genotyping has been completed. We received the genotyping results in April 2016, results on >130 gene polymorphisms. Our work on this goal is on schedule.
Specific Aim 2
We are ready to use the geocodes of the study population and the spatio-temporal model for PAHs to assign exposure to each of the locations during early pregnancy in the Fresno area. We also are in the process of expanding the geographic area of study where we could assign exposure and add to the size of our study sample by including additional geocodes which will be added to our databases in the next month. Our work on this goal is on schedule.
Specific Aim 3
We have published the results of this aim in Environmental Research (Padula AM. Environ Res. 2014). We applied the PAH exposure model to the study population within 20 km of the central site in Fresno, California. We analyzed the relationship between PAH during several periods during pregnancy (entire pregnancy, each trimester and last 6 weeks) with categories of gestational age at birth to determine the association between PAH and levels of preterm birth. We found associations between PAH during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR = 2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three quartiles. When examined for an exposure-response, the association increased across each quartile of PAH exposure. Inverse associations also were observed for exposure to PAH during the entire pregnancy and the first trimester and birth at 28-31 weeks and 20-27 weeks. We have completed this aim.
Specific Aim 4
We have begun analyses on the effects of neighborhood factors and air pollution on preterm birth using causal inference methods (i.e., targeted maximum likelihood estimation). The effects of air pollution appear to be stronger in neighborhoods with greater deprivation. A manuscript is in preparation.
Future Activities:
Specific Aim 1
We will begin analyzing the interaction of air pollution and gene variants with regard to birth defects. We hope to begin drafting a manuscript in the next period.
Specific Aim 2
We plan to assign PAH exposures to the additional data and begin analyzing the relationship between PAH and selected birth defects.
Specific Aim 3
Work on this goal has been completed.
Specific Aim 4
We will continue evaluating the data we have on neighborhood deprivation and apply causal inference methods. We also will incorporate additional data on the built environment provided from Project 4.
References:
Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM.Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environ Res. 2014 Nov;135:221-6. PubMed PMID: 25282280; PubMed Central PMCID: PMC4262545.
Journal Articles: 44 Displayed | Download in RIS Format
| Other center views: | All 126 publications | 45 publications in selected types | All 44 journal articles |
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Alcala E, Cisneros R, Capitman JA. Health care access, concentrated poverty, and pediatric asthma hospital care use in California's San Joaquin Valley: a multilevel approach. Journal of Asthma 2017:1-9. |
R835435 (2018) R835435 (Final) |
Exit Exit |
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Alcala E, Brown P, Capitman JA, Gonzalez M, Cisneros R. Cumulative impact of environmental pollution and population vulnerability on pediatric asthma hospitalizations:a multilevel analysis of CalEnviroScreen. International Journal of Environmental Research and Public Health. 2019;16(15):2683.. |
R835435 (Final) |
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Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research 2018;161:472-478. |
R835435 (Final) R835441 (2018) |
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Cossi M, Zuta S, Padula AM, Gould JB, Stevenson DK, Shaw GM. Role of infant sex in the association between air pollution and preterm birth. Annals of Epidemiology 2015;25(11):874-876. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Gou P, Chang X, Ye Z, Yao Y, Nguyen PK, Hammond SK, Wang J, Liu S. A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China. Environmental Science and Pollution Research 2017;24(28):22579-22586. |
R835435 (Final) |
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Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (Final) R834786 (Final) |
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Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics 2012;4(1):17 (16 pp.). |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
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Kwon J, Weisel CP, Morandi MT, Stock TH. Source proximity and meteorological effects on residential outdoor VOCs in urban areas: results from the Houston and Los Angeles RIOPA studies. Science of the Total Environment 2016;573:954-964. |
R835435 (2018) |
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Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-related air pollution and telomere length in children and adolescents living in Fresno, CA: a pilot study. Journal of Occupational and Environmental Medicine 2017;59(5):446-452. |
R835435 (2018) R835435 (Final) |
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Lessard LN, Alcala E, Capitman JA. Pollution, poverty, and potentially preventable childhood morbidity in central California. The Journal of Pediatrics 2016;168:198-204. |
R835435 (2014) R835435 (2016) R835435 (Final) |
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Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC. Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology 2013;2013:967029. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
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Mann JK, Balmes JR, Bruckner TA, Mortimer KM, Margolis HG, Pratt B, Hammond SK, Lurmann FW, Tager IB. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environmental Health Perspectives 2010;118(10):1497-1502. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) |
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Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. Journal of Allergy and Clinical Immunology 2010;126(4):845-852.e10. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596C003 (2010) R834596C003 (2011) R834786 (2011) |
Exit Exit |
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Noth EM, SK Hammond, GS Biging, and IB Tager. 2011. A spatial-temporal regression model to predict daily outdoor residential PAH concentrations in an epidemiologic study in Fresno, CA. Atmospheric Environment 2011;45(14):2394-2403. |
R835435 (Final) R828678C017 (Final) |
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Noth EM, Hammond SK, Biging GS, Tager IB. Mapping and modeling airborne urban phenanthrene distribution using vegetation biomonitoring. Atmospheric Environment 2013;77:518-524. |
R835435 (Final) R834596 (Final) |
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Noth EM, Lurmann F, Northcross A, Perrino C, Vaughn D, Hammond SK. Spatial and temporal distribution of polycyclic aromatic hydrocarbons and elemental carbon in Bakersfield, California. Air Quality, Atmosphere & Health 2016;9(8):899-908. |
R835435 (2016) R835435 (2018) R835435 (Final) |
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Ortega Hinojosa AM, MacLeod K, Balmes JR, Jerrett M. Influence of school environments on childhood obesity in California. Environmental Research 2018;166:100-107. |
R835435 (2018) |
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Padula AM, Mortimer K, Hubbard A, Lurmann F, Jerrett M, Tager IB. Exposure to traffic-related air pollution during pregnancy and term low birth weight:estimation of causal associations in a semiparametric model. American Journal of Epidemiology 2012;176(9):815. |
R835435 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann F, Shaw GM. Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2013;27(4):329-339. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Lurmann F, Shaw GM. The association of ambient air pollution and traffic exposures with selected congenital anomalies in the San Joaquin Valley of California. American Journal of Epidemiology 2013;177(10):1074-1085. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann FW, Shaw GM. Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California. Birth Defects Research, Part A: Clinical and Molecular Teratology 2013;97(11):730-735. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Mortimer KM, Tager IB, Hammond SK, Lurmann FW, Yang W, Stevenson DK, Shaw GM. Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Annals of Epidemiology 2014;24(12):888-895e4. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C001 (Final) |
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Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM. Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environmental Research 2014;135:221-226. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. Journal of Exposure Science & Environmental Epidemiology 2015;25(3):295-302. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) |
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Padula AM, Yang W, Carmichael SL, Tager IB, Lurmann FW, Hammond SK, Shaw GM. Air pollution, neighbourhood socioeconomic factors, and neural tube defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2015;29(6):536-545. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Schultz K, Tom L, Lin B, Carmichael SL, Lammer EJ, Shaw GM. Gene variants as risk factors for gastroschisis. American Journal of Medical Genetics Part A 2016;170(11):2788-2802. |
R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Carmichael SL, Lurmann F, Balmes J, Hammond K, Shaw GM. Air pollution, neighborhood acculturation factors and neural tube defects among Hispanic women in California. Birth Defects Research 2017;109(6):403-422. |
R835435 (2017) R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Schultz K, Lurmann F, Hammond SK, Shaw GM. Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. American Journal of Medical Genetics, Part A 2018 May;176(5):1055-1090. |
R835435 (2018) R835435 (Final) |
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Prunicki M, Stell L, Dinakarpandian D, de Planell-Saguer M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma. Clinical Epigenetics 2018;10:2. |
R835435 (2018) R835435 (Final) |
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Prunicki, M., et al., Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma (submitted). |
R835435 (2017) |
not available |
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Tager IB, Lurmann FW, Haight T, Alcorn S, Penfold B, Hammond SK. Temporal and spatial patterns of ambient endotoxin concentrations in Fresno, California. Environmental Health Perspectives 2010;118(10):1490-1496. |
R835435 (Final) |
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Zografos K, Krenz V, Yarmo K, Alcala E. College students’ utilization of protective alcohol-use behaviors. Californian Journal of Health Promotion 201;13(1): 49-58. |
R835435 (Final) |
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Gale SL, Noth EM, Mann J, Balmes J, Hammond SK, Tager IB. Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA. Journal of Exposure Science and Environmental Epidemiology 2012;22(4):3 86. |
R835435 (Final) |
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Syed A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air pollution and epigenetics. Journal of Environmental Protection 2013;4(08):114. |
R835435 (Final) |
not available |
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Sabounchi S, Bollyky J, Nadeau K. Review of environmental impact on the epigenetic regulation of atopic diseases. Current Allergy and Asthma Reports 2015;15(6):33. |
R835435 (Final) |
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Quinn C, Miller-Lionberg DD, Klunder KJ, Kwon J, Noth EM, Mehaffy J, Leith D, Magzamen S, Hammond SK, Henry CS, Volckens J. Personal exposure to PM2.5 black carbon and aerosol oxidative potential using an automated microenvironmental aerosol sampler (AMAS). Environmental Science & Technology 2018;52(19):11267-11275. |
R835435 (Final) |
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Weber KA, Yang W, Carmichael SL, Padula AM, Shaw GM. A machine learning approach to investigate potential risk factors for gastroschisis in California. Birth Defects Research 2019;111(4):212-221. |
R835435 (Final) |
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Padula AM, Yang W, Lurmann FW, Balmes J, Hammond SK, Shaw GM. Prenatal exposure to air pollution, maternal diabetes and preterm birth. Environmental Research 2019;170:160-167. |
R835435 (Final) |
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Prunicki M, Zhou X, Nadeau K. The impact of a prescribed burn versus a wildfire on the immune and cardiovascular systems of children. Journal of Allergy and Clinical Immunology 2019;143(2):AB80. |
R835435 (Final) |
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Padula AM, Yang W, Schultz K, Lee C, Lurmann F, Hammond SK, Shaw GM. Gene–environment interactions between air pollution and biotransformation enzymes and risk of birth defects. Birth Defects Research 2021; 113(9):676-686. |
R835435 (Final) |
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Prunicki, M and Nadeau, K. (2016) The Air We Breathe:How Extreme Weather Conditions Harm Us in Extreme Weather, Health, and Communities:Interdisciplinary Engagement, Springer Publishers. |
R835435 (2017) |
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Weber KA, Yang W, Lurmann F, Hammond SK, Shaw GM, Padula AM. Air pollution, maternal hypertensive disorders, and preterm birth. Environmental Epidemiology. 2019 Oct 1;3(5):e062. |
R835435 (Final) |
not available |
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Zografos, K; Alcala, E; & Capitman, J. Integrating Research Experiences into Public Health Curricula:Effects on Undergraduate Students’ Overall Educational Experience. To be submitted to:Pedagogy in Health Promotion. |
R835435 (2017) |
not available |
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Zografos K, Alcala E, Capitman J, Khang L. Integrating research experiences into public health curricula:effects on undergraduate students’ knowledge of neighborhood inequalities, perception of research, and motivation to talk about health issues. Pedagogy in Health Promotion 2019:2373379919881469. |
R835435 (Final) |
not available |
Supplemental Keywords:
Ambient air pollution, genetic polymorphisms, epidemiology, infants, pregnancy, health effects, PAH;Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2018 Progress Report
- 2017 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- Original Abstract
44 journal articles for this center