Grantee Research Project Results
UC Berkeley/Stanford Children's Environmental Health Center
EPA Grant Number: R835435Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: UC Berkeley/Stanford Children's Environmental Health Center
Investigators: Hammond, S. Katharine , Shaw, Gary M. , Balmes, John R.
Institution: University of California - Berkeley
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Amount: $4,765,843
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Children's Health and Air Pollution Study in the San Joaquin Valley (CHAPS-SJV) is a direct descendent of the University of California, UC Berkeley/Stanford Children's Environmental Health Center (CEHC Pre-Center) with the same name. Our proposed Center expands to include research colleagues from California State University Fresno and UCSF-Fresno. The proposed CHAPS-SJV CEHC is innovative in terms of the scientific focus, exposure assessment and methods of data analysis. We have four research projects: 1) Exposures to Air Pollutants, Modifying Genes, and Risk of Birth Defects and Preterm Birth; 2) Mechanisms of Polycyclic Aromatic Hydrocarbon-linked immunopathogenesis in Atopy; 3) Obesity/Glucose Dysregulation; and, 4) Transit Exposures in utero.
Our objectives are to link exposures to air pollutants, particularly polycyclic aromatic hydrocarbons (PAHs), to adverse birth outcomes, regulatory T-cell function and allergic disorders, body weight and fat composition and hemoglobin A1c percentage. Our overarching hypothesis is that inhalational exposure to air pollutants induces oxidative stress which in turn leads to systemic inflammation. Downstream adverse health outcomes can occur throughout childhood and are dependent on both genetic factors and neighborhood contextual factors. In these projects, we will study mechanistic pathways including the potential modifying effects of genes critical in the metabolism of xenobiotics and epigenetic regulation of T-cell function. Extending our work from the P20 [Grant RD834596], we also will evaluate the role of neighborhood and socioeconomic factors as modifiers of the air pollution-adverse health outcome associations. Critical to our proposed work is recruitment of children at multiple age strata, high-quality exposure assessment, and statistical analysis at the cutting edge of an innovative body of causal inference methods. The proposed projects will provide new data on a) the associations between exposures to air pollutants, particularly PAHs, and important health outcomes throughout childhood, from gestation to late adolescence; b) mechanistic pathways by which air pollutants cause adverse outcomes; and c) the modifying role of both genetic and neighborhood contextual factors. The themes of our proposed projects build on our P20 work and the resulting data will allow improved risk assessment in a region characterized by both high air pollution and health disparities related to socioeconomic and minority ethnic status.
Rationale:
The impact of our work stems directly from its innovation. New insights into mechanisms that underlie health effects associated with exposure to ambient pollutants throughout childhood (birth defects and premature birth, allergic diseases, obesity, and diabetes) and the role of neighborhood contextual factors will result from the proposed projects. This information will enable policymakers to formulate regulatory strategies to improve air quality that are targeted to improve children’s health, both in the region of study, the San Joaquin Valley, and the nation as a whole.
Journal Articles: 44 Displayed | Download in RIS Format
| Other center views: | All 126 publications | 45 publications in selected types | All 44 journal articles |
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Alcala E, Cisneros R, Capitman JA. Health care access, concentrated poverty, and pediatric asthma hospital care use in California's San Joaquin Valley: a multilevel approach. Journal of Asthma 2017:1-9. |
R835435 (2018) R835435 (Final) |
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Alcala E, Brown P, Capitman JA, Gonzalez M, Cisneros R. Cumulative impact of environmental pollution and population vulnerability on pediatric asthma hospitalizations:a multilevel analysis of CalEnviroScreen. International Journal of Environmental Research and Public Health. 2019;16(15):2683.. |
R835435 (Final) |
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Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research 2018;161:472-478. |
R835435 (Final) R835441 (2018) |
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Cossi M, Zuta S, Padula AM, Gould JB, Stevenson DK, Shaw GM. Role of infant sex in the association between air pollution and preterm birth. Annals of Epidemiology 2015;25(11):874-876. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Gou P, Chang X, Ye Z, Yao Y, Nguyen PK, Hammond SK, Wang J, Liu S. A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China. Environmental Science and Pollution Research 2017;24(28):22579-22586. |
R835435 (Final) |
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Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (Final) R834786 (Final) |
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Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics 2012;4(1):17 (16 pp.). |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
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Kwon J, Weisel CP, Morandi MT, Stock TH. Source proximity and meteorological effects on residential outdoor VOCs in urban areas: results from the Houston and Los Angeles RIOPA studies. Science of the Total Environment 2016;573:954-964. |
R835435 (2018) |
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Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-related air pollution and telomere length in children and adolescents living in Fresno, CA: a pilot study. Journal of Occupational and Environmental Medicine 2017;59(5):446-452. |
R835435 (2018) R835435 (Final) |
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Lessard LN, Alcala E, Capitman JA. Pollution, poverty, and potentially preventable childhood morbidity in central California. The Journal of Pediatrics 2016;168:198-204. |
R835435 (2014) R835435 (2016) R835435 (Final) |
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Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC. Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology 2013;2013:967029. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C003 (2012) R834596C003 (Final) R834786 (2012) |
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Mann JK, Balmes JR, Bruckner TA, Mortimer KM, Margolis HG, Pratt B, Hammond SK, Lurmann FW, Tager IB. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environmental Health Perspectives 2010;118(10):1497-1502. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) |
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Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. Journal of Allergy and Clinical Immunology 2010;126(4):845-852.e10. |
R835435 (Final) R834596 (2010) R834596 (2011) R834596C003 (2010) R834596C003 (2011) R834786 (2011) |
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Noth EM, SK Hammond, GS Biging, and IB Tager. 2011. A spatial-temporal regression model to predict daily outdoor residential PAH concentrations in an epidemiologic study in Fresno, CA. Atmospheric Environment 2011;45(14):2394-2403. |
R835435 (Final) R828678C017 (Final) |
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Noth EM, Hammond SK, Biging GS, Tager IB. Mapping and modeling airborne urban phenanthrene distribution using vegetation biomonitoring. Atmospheric Environment 2013;77:518-524. |
R835435 (Final) R834596 (Final) |
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Noth EM, Lurmann F, Northcross A, Perrino C, Vaughn D, Hammond SK. Spatial and temporal distribution of polycyclic aromatic hydrocarbons and elemental carbon in Bakersfield, California. Air Quality, Atmosphere & Health 2016;9(8):899-908. |
R835435 (2016) R835435 (2018) R835435 (Final) |
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Ortega Hinojosa AM, MacLeod K, Balmes JR, Jerrett M. Influence of school environments on childhood obesity in California. Environmental Research 2018;166:100-107. |
R835435 (2018) |
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Padula AM, Mortimer K, Hubbard A, Lurmann F, Jerrett M, Tager IB. Exposure to traffic-related air pollution during pregnancy and term low birth weight:estimation of causal associations in a semiparametric model. American Journal of Epidemiology 2012;176(9):815. |
R835435 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann F, Shaw GM. Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2013;27(4):329-339. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Lurmann F, Shaw GM. The association of ambient air pollution and traffic exposures with selected congenital anomalies in the San Joaquin Valley of California. American Journal of Epidemiology 2013;177(10):1074-1085. |
R835435 (Final) R834596 (2011) R834596 (2012) R834596 (Final) R834596C002 (2011) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann FW, Shaw GM. Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California. Birth Defects Research, Part A: Clinical and Molecular Teratology 2013;97(11):730-735. |
R835435 (Final) R834596 (2012) R834596 (Final) R834596C002 (2012) R834596C002 (Final) |
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Padula AM, Mortimer KM, Tager IB, Hammond SK, Lurmann FW, Yang W, Stevenson DK, Shaw GM. Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Annals of Epidemiology 2014;24(12):888-895e4. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) R834596 (2012) R834596 (Final) R834596C001 (2012) R834596C001 (Final) |
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Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM. Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environmental Research 2014;135:221-226. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. Journal of Exposure Science & Environmental Epidemiology 2015;25(3):295-302. |
R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) R834596 (2012) R834596 (Final) |
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Padula AM, Yang W, Carmichael SL, Tager IB, Lurmann FW, Hammond SK, Shaw GM. Air pollution, neighbourhood socioeconomic factors, and neural tube defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2015;29(6):536-545. |
R835435 (2015) R835435 (2016) R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Schultz K, Tom L, Lin B, Carmichael SL, Lammer EJ, Shaw GM. Gene variants as risk factors for gastroschisis. American Journal of Medical Genetics Part A 2016;170(11):2788-2802. |
R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Carmichael SL, Lurmann F, Balmes J, Hammond K, Shaw GM. Air pollution, neighborhood acculturation factors and neural tube defects among Hispanic women in California. Birth Defects Research 2017;109(6):403-422. |
R835435 (2017) R835435 (2018) R835435 (Final) |
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Padula AM, Yang W, Schultz K, Lurmann F, Hammond SK, Shaw GM. Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. American Journal of Medical Genetics, Part A 2018 May;176(5):1055-1090. |
R835435 (2018) R835435 (Final) |
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Prunicki M, Stell L, Dinakarpandian D, de Planell-Saguer M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma. Clinical Epigenetics 2018;10:2. |
R835435 (2018) R835435 (Final) |
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Prunicki, M., et al., Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma (submitted). |
R835435 (2017) |
not available |
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Tager IB, Lurmann FW, Haight T, Alcorn S, Penfold B, Hammond SK. Temporal and spatial patterns of ambient endotoxin concentrations in Fresno, California. Environmental Health Perspectives 2010;118(10):1490-1496. |
R835435 (Final) |
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Zografos K, Krenz V, Yarmo K, Alcala E. College students’ utilization of protective alcohol-use behaviors. Californian Journal of Health Promotion 201;13(1): 49-58. |
R835435 (Final) |
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Gale SL, Noth EM, Mann J, Balmes J, Hammond SK, Tager IB. Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA. Journal of Exposure Science and Environmental Epidemiology 2012;22(4):3 86. |
R835435 (Final) |
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Syed A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air pollution and epigenetics. Journal of Environmental Protection 2013;4(08):114. |
R835435 (Final) |
not available |
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Sabounchi S, Bollyky J, Nadeau K. Review of environmental impact on the epigenetic regulation of atopic diseases. Current Allergy and Asthma Reports 2015;15(6):33. |
R835435 (Final) |
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Quinn C, Miller-Lionberg DD, Klunder KJ, Kwon J, Noth EM, Mehaffy J, Leith D, Magzamen S, Hammond SK, Henry CS, Volckens J. Personal exposure to PM2.5 black carbon and aerosol oxidative potential using an automated microenvironmental aerosol sampler (AMAS). Environmental Science & Technology 2018;52(19):11267-11275. |
R835435 (Final) |
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Weber KA, Yang W, Carmichael SL, Padula AM, Shaw GM. A machine learning approach to investigate potential risk factors for gastroschisis in California. Birth Defects Research 2019;111(4):212-221. |
R835435 (Final) |
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Padula AM, Yang W, Lurmann FW, Balmes J, Hammond SK, Shaw GM. Prenatal exposure to air pollution, maternal diabetes and preterm birth. Environmental Research 2019;170:160-167. |
R835435 (Final) |
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Prunicki M, Zhou X, Nadeau K. The impact of a prescribed burn versus a wildfire on the immune and cardiovascular systems of children. Journal of Allergy and Clinical Immunology 2019;143(2):AB80. |
R835435 (Final) |
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Padula AM, Yang W, Schultz K, Lee C, Lurmann F, Hammond SK, Shaw GM. Gene–environment interactions between air pollution and biotransformation enzymes and risk of birth defects. Birth Defects Research 2021; 113(9):676-686. |
R835435 (Final) |
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Prunicki, M and Nadeau, K. (2016) The Air We Breathe:How Extreme Weather Conditions Harm Us in Extreme Weather, Health, and Communities:Interdisciplinary Engagement, Springer Publishers. |
R835435 (2017) |
not available |
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Weber KA, Yang W, Lurmann F, Hammond SK, Shaw GM, Padula AM. Air pollution, maternal hypertensive disorders, and preterm birth. Environmental Epidemiology. 2019 Oct 1;3(5):e062. |
R835435 (Final) |
not available |
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Zografos, K; Alcala, E; & Capitman, J. Integrating Research Experiences into Public Health Curricula:Effects on Undergraduate Students’ Overall Educational Experience. To be submitted to:Pedagogy in Health Promotion. |
R835435 (2017) |
not available |
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Zografos K, Alcala E, Capitman J, Khang L. Integrating research experiences into public health curricula:effects on undergraduate students’ knowledge of neighborhood inequalities, perception of research, and motivation to talk about health issues. Pedagogy in Health Promotion 2019:2373379919881469. |
R835435 (Final) |
not available |
Supplemental Keywords:
Air pollution, polycyclic aromatic hydrocarbons, birth defects, premature birth, allergies, asthma, immune function, obesity, diabetes, metabolic syndrome, neighborhood environment, socioeconomic status, health disparitiesRelevant Websites:
Children’s Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV) ExitProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2018 Progress Report
- 2017 Progress Report
- 2016 Progress Report
- 2015 Progress Report
- 2014 Progress Report
44 journal articles for this center