Grantee Research Project Results

2005 Progress Report: Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)

EPA Grant Number: R831711C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R831711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
Investigators: Wolff, Mary S.
Current Investigators: Wolff, Mary S. , Engel, Stephanie M.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The objective of this research project is to complete a continuing prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai.

Progress Summary:

This project is a continuing prospective epidemiologic study of an ethnically diverse birth cohort of infants born at Mount Sinai. A total of 482 women have been recruited and 97 enrolled, thus far. We now are conducting neurobehavioral and anthropometric assessments, including percent body fat, at the child’s 4th, 6th, and 7th year. The aim is to assess whether in utero and/or childhood exposure to pesticides and endocrine disruptors, specifically organophosphates, pyrethroids, polychlorinated biphenyls (PCBs), phthalates, and bisphenol A, are associated with childhood growth and neurodevelopment in children in New York City. The possible modulating influences of polymorphisms and enzymatic activity involving paraoxonases (PONs), lipases, and glucuronidases also will be evaluated in collaboration with project R831711C003.

Future Activities:

During the next year, we plan to continue 4- and 6-year follow-up visits and begin administering the 7-year follow-up visits. To date, we have completed a total of 97 visits and are averaging approximately three to four visits per week.

We are finalizing the statistical analyses of birth outcomes in relationship with maternal prenatal exposure to alkylphosphate pesticide metabolites, PCBs and DDT, lead, and PON expression. We have started our analysis of prenatal exposure to pesticide metabolites, PCBs and DDT, lead, and PON expression and the Brazelton Neonatal Behavioral Assessment, which was given within 48 hours of delivery, and the Bayley Scales of Infant Development, which were given at years 1 and 2.

Journal Articles:

No journal articles submitted with this report: View all 94 publications for this subproject

Supplemental Keywords:

lipase, paraoxonase, fast food, obesity, endocrine disruptors, neurodevelopment,, Health, RFA, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, POLLUTANTS/TOXICS, Health Risk Assessment, Environmental Chemistry, Endocrine Disruptors - Human Health, Children's Health, endocrine disruptors, Biochemistry, Endocrine Disruptors - Environmental Exposure & Risk, Chemicals, Risk Assessment, Human Health Risk Assessment, pesticides, neurodevelopmental toxicity, pesticide exposure, phtalates, exposure studies, endocrine disrupting chemicals, children's vulnerablity, environmental health, childhood development, exposure pathways, phthalates

Relevant Websites:

http://www.mssm.edu/cpm/dept_research.shtml Exit
http://www.childenvironment.org Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R831711 Center for Research on Early Childhood Exposure and Development in Puerto Rico

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831711C001 Growing Up Healthy in East Harlem (Community-Based Participatory Research)
R831711C002 Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
R831711C003 Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.