Grantee Research Project Results
Final Report: Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
EPA Grant Number: R829389C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
Investigators: Cecil, Kim
Institution: Children Hospital of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
One hundred sixty one participants were recruited from the Cincinnati Lead Study (CLS), for a magnetic resonance imaging evaluation (n=159 with reportable data). These subjects have been followed from birth through early childhood with extensive documentation of lead exposure, social and medical history, intellectual attainment, neuromotor function, academic achievement, and behavior.
Summary/Accomplishments (Outputs/Outcomes):
Volumetric analyses of whole brain magnetic resonance imaging data revealed significant decreases in brain volume associated with childhood blood lead concentrations. The most affected regions included frontal gray matter, specifically the anterior cingulate cortex. Areas of lead-associated gray matter volume loss were much larger and more significant in men than women.
Conclusions:
Childhood lead exposure is associated with region-specific reductions in adult gray matter volume. Affected regions include the portions of the prefrontal cortex and anterior cingulate cortex responsible for executive function, mood regulation and decision-making. These neuroanatomical findings were more pronounced for males suggesting that lead-related atrophic changes have a disparate impact across genders. This analysis suggests that adverse cognitive, behavioral and motor outcomes may be related to lead’s effect on prefrontal brain development producing persistent alterations in structure.Journal Articles:
No journal articles submitted with this report: View all 6 publications for this subprojectSupplemental Keywords:
toxicology, ADHD, behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants, lead-based paint, lead hazard control, RFA, Scientific Discipline, Health, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Children's Health, Biology, Risk Assessment, magentic resonance, behavioral assessment, lead, neurotoxicity, children, toxicity, behavioral deficits, biological markers, exposure assessment, biomarkerRelevant Websites:
http://www.cincinnatichildrens.org/homestudy/Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R829389 CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
Main Center: R829389
151 publications for this center
111 journal articles for this center