Grantee Research Project Results
Final Report: Neurobehavioral Effects of Prevalent Toxicants in Children
EPA Grant Number: R829389C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Neurobehavioral Effects of Prevalent Toxicants in Children
Investigators: Lanphear, Bruce , Dietrich, Kim
Institution: Children Hospital of Cincinnati , University of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: November 1, 2001 through October 31, 2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The HOME Study is a longitudinal cohort study which examines the effect of low-level exposures (pre- and postnatal) of prevalent toxicants on neurobehavioral outcomes and development disorders, and tests meconium levels as a measure of in utero exposures to numerous toxicants. We are also conducting a nested, randomized controlled trial to test the efficacy of lead hazard controls on blood lead concentrations and developmental conditions and the efficacy of injury hazard controls on injury incidence and severity. Finally, this study provides data that are essential for exposure assessment and risk characterization for prevalent residential pesticides in childhood.
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To examine the effects of low-level exposures to prevalent neurotoxicants in a cohort of 400 children followed from less than 16 weeks gestation to 5 years of age.
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To conduct a nested, randomized controlled trial to test the efficacy of lead hazard controls on children’s blood lead levels and their risk for learning and behavioral problems.
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To determine the efficacy of housing modifications on children’s risk for injuries.
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To provide data that are essential for exposure assessment and risk characterization for prevalent residential pesticides in childhood.
Summary/Accomplishments (Outputs/Outcomes):
Thus far, we have lead, mercury, PCBs, cotinine and pesticides results from maternal blood taken three times during pregnancy and cord blood. We also have preliminary results for organophosphrous and pyrethroid pesticide metabolites from maternal urine during pregnancy for theConclusions:
Data analyses continues. Bruce Lanphear, MD, MPH received funding for an R01, project period ending April 2012, to extend the duration of follow-up of the birth cohort to the age of 5 years.Journal Articles:
No journal articles submitted with this report: View all 19 publications for this subprojectSupplemental Keywords:
toxicology, ADHD, behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants, lead-based paint, lead hazard control,, RFA, Scientific Discipline, Health, ENVIRONMENTAL MANAGEMENT, Toxics, Toxicology, Health Risk Assessment, Chemistry, pesticides, Risk Assessments, Children's Health, Biology, Risk Assessment, pesticide exposure, behavioral assessment, lead, neurotoxicity, children, toxicity, behavioral deficits, biological markers, exposure assessmentRelevant Websites:
www.cincinnatichildrens.org/homestudy/Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R829389 CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
Main Center: R829389
151 publications for this center
111 journal articles for this center