Grantee Research Project Results
2003 Progress Report: Early Exposure to Lead and Adult Antisocial Outcome
EPA Grant Number: R829389C004Subproject: this is subproject number 004 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Early Exposure to Lead and Adult Antisocial Outcome
Investigators: Lanphear, Bruce , Wright, John D. , Ris, Douglas , Dietrich, Kim , Hornung, Richard
Current Investigators: Ris, Douglas
Institution: Children Hospital of Cincinnati , University of Cincinnati
Current Institution: University of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: November 1, 2001 through October 31, 2006
Project Period Covered by this Report: November 1, 2002 through October 31, 2003
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The objective of this research project is to examine the effects of early childhood lead exposure in young adults.
Specific Aim 1
Specific Aim 1 is to ascertain the relationship between early lead exposure and antisocial behavior in young adulthood through a followup of a birth cohort of lead-exposed children into adulthood.
Following covariate adjustment:
Hypothesis 1A. There will be a significant relationship between pre- and postnatal lead levels and criminal activities (official record and self-report).
Hypothesis 1B. There will be a significant relationship between pre- and postnatal lead levels and diagnosis of Substance Abuse Disorder.
Hypothesis 1C. There will be a significant relationship between pre- and postnatal lead levels and diagnosis of Antisocial Personality Disorder.
Specific Aim 2
Employing path analysis procedures, we will determine if academic performance and executive functioning partially mediate the relationship between early lead exposure and adult antisocial behavior.
Hypothesis 2A. Low reading scores during adolescence and low grade attainment will predict adult antisocial behavior.
Hypothesis 2B. Weak executive functioning in adolescence will predict adult antisocial behavior.
Hypothesis 2C. Combined reading and executive weaknesses will predict more severe antisocial outcome.
Progress Summary:
Participation Rate
The participation rate has been excellent. As shown in Table 1, as of this report, 72 subjects have been seen and recruitment continues at the expected rate. Official record searches have been completed for the entire sample.
Adult Antisocial Behavior
American Indian or Alaskan Native |
Asian or Pacific Islander |
Black, not of Hispanic Origin |
Hispanic |
White, not of Hispanic Origin |
Other or Unknown |
TOTAL |
|
Female |
0 |
0 |
36 |
0 |
5 |
0 |
41 |
Male |
0 |
0 |
28 |
0 |
3 |
0 |
31 |
Unknown |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
TOTAL |
0 |
0 |
54 |
0 |
8 |
0 |
72 |
Future Activities:
Within the next year, we plan to run some preliminary data analyses and submit a paper for presentation at a scientific conference.
Journal Articles:
No journal articles submitted with this report: View all 11 publications for this subprojectSupplemental Keywords:
toxicology, ADHD, behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants, lead-based paint, lead hazard control,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Children's Health, Biology, Risk Assessment, behavioral assessment, lead, pesticides, neurotoxicity, children, toxicity, behavioral deficits, biological markers, exposure assessment, biomarkerRelevant Websites:
http://www.healthyhomestoday.com Exit
http://www.cincinnatichildrens.org/research/project/enviro Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R829389 CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
Main Center: R829389
151 publications for this center
111 journal articles for this center