Grantee Research Project Results
2005 Progress Report: Early Exposure to Lead and Adult Antisocial Outcome
EPA Grant Number: R829389C004Subproject: this is subproject number 004 , established and managed by the Center Director under grant R829389
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children
Center Director: Lanphear, Bruce
Title: Early Exposure to Lead and Adult Antisocial Outcome
Investigators: Lanphear, Bruce , Wright, John D. , Ris, Douglas , Dietrich, Kim , Hornung, Richard
Current Investigators: Ris, Douglas
Institution: Children Hospital of Cincinnati , University of Cincinnati
Current Institution: University of Cincinnati
EPA Project Officer: Hahn, Intaek
Project Period: November 1, 2001 through October 31, 2006
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The objective of this research project is to examine the effects of early childhood lead exposure in young adults. The specific aims are listed below.
Specific Aim 1: To ascertain the relationship between early lead exposure and antisocial behavior in young adulthood through a followup of a birth cohort of lead-exposed children into adulthood.
Specific Aim 2: To determine via path analysis procedures if academic performance and executive functioning partially mediate the relationship between early lead exposure and adult antisocial behavior.
Progress Summary:
Participation Rate
The participation rate has been excellent. As shown in Table 1, as of this report, 176 subjects have been seen and recruitment continues at the expected rate. Official record searches have been completed for the entire sample.
Adult Antisocial Outcome
American Indian or Alaskan Native |
Asian or Pacific Islander |
Black, not of Hispanic Origin |
Hispanic |
White, not of Hispanic Origin |
Other or Unknown |
TOTAL |
|
Female |
0 |
0 |
89 |
0 |
6 |
0 |
95 |
Male |
0 |
0 |
75 |
0 |
6 |
0 |
81 |
Unknown |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
TOTAL |
0 |
0 |
164 |
0 |
12 |
0 |
176 |
Significance of Findings
A manuscript has been submitted for publication presenting the analyses of the official record data on the entire sample. Significant relationships were found between indices of early lead exposure and official contacts with the police and judicial system. These relationships still were evident after covariate adjustment and indicate an effect of early lead exposure on increased risk for illegal behaviors in adulthood. Results also were presented recently at an international conference in Dublin, Ireland, showing the relationship between neuropsychological functioning in adolescence and police contacts in early adulthood. This represents our initial attempt to better understand neuropsychological mediators of the relationship between early lead exposure and adult antisocial activities.
Future Activities:
During the next year, we will continue to collect data for the self-report and psychiatric diagnostic interview measures. We also intend to publish one manuscript on the official record data, present some of our findings at a national conference, submit a manuscript on the neuropsychological predictors of adult antisocial behavior, and develop plans for follow-up grants.
Journal Articles:
No journal articles submitted with this report: View all 11 publications for this subprojectSupplemental Keywords:
toxicology, ADHD behavioral assessment, behavioral deficit, genetic susceptibility, pesticides, biomarkers, environmental agents, exposure, exposure assessment, hearing loss, lead, meconium, neurotoxicity, pesticide exposure, risk assessment, toxicants,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Children's Health, Biology, Risk Assessment, behavioral assessment, lead, pesticides, neurotoxicity, children, toxicity, behavioral deficits, biological markers, exposure assessment, biomarkerRelevant Websites:
http://www.healthyhomestoday.com Exit
http://www.cincinnatichildrens.org/research/project/enviro Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R829389 CECEHDPR - University of Cincinnati Center for the Study of Prevalent Neurotoxicants in Children Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829389C001 Neurobehavioral Effects of Prevalent Toxicants in Children
R829389C002 Validation of Meconium Markers of Fetal Neurotoxicant Exposures
R829389C003 Community-Based Research Project Identifying Residential Hazards Using Home Test Kits
R829389C004 Early Exposure to Lead and Adult Antisocial Outcome
R829389C005 Magnetic Resonance Assessment of Brain Function Altered by Lead Exposure
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
Main Center: R829389
152 publications for this center
112 journal articles for this center