Contact Us

Grantee Research Project Results

Research Centers
Carolina Center for Computational Toxicology

University of North Carolina at Chapel Hill

The Carolina Center for Computational Toxicology will advance the field of computational toxicology through the development of new methods and tools, as well as through collaborative efforts. To balance the research needs detailed in the RFA and maximize the interactions within the Center and between the Center and the larger environmental health community, the following sub-disciplines were recognized as critical to the Center:Image displaying the focus of each subproject

  1. Biomedical modeling of chemical-perturbed networks (Project 1, PIs Gomez and Elston),
  2. Toxico-genetic modeling (Project 2, PIs Wright and Rusyn), and
  3. Chem-informatics (Project 3, PI Tropsha).
Overall, we chose a bottom-up approach to predictive computational modeling of adverse effects of toxic agents. Our emphasis spans from the fine-scale predictive simulations of the protein-protein/-chemical interactions in nuclear receptor networks (Project 1), to mapping chemical-perturbed networks and devising modeling tools that can predict the pathobiology of the test compounds based on a limited set of biological data (Project 1), to building tools that will enable toxicologists to understand the role of genetic diversity between individuals in responses to toxicants (Project 2), to unbiased discovery-driven prediction of adverse chronic in vivo outcomes based on statistical modeling of chemical structures, high-throughput screening and the genetic makeup of the organism (Project 3).

In each Project, new computer-based models will be developed and published that represent the state-of-the-art. The tools produced within each project will be widely disseminated, and the emphasis will be placed on their usability by the risk assessment community and the investigative toxicologists alike. The synthesis of data from a variety of sources will move the field of computational toxicology from a hypothesis-driven science toward a predictive science.

Additional information is available on the center website exit EPA

View Projects in Tabular Format

Main Center Abstract and Reports:

Atlantic Coast Environmental Indicators Consortium
Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM)
Center for Hazardous Substances in Urban Environments (CHSUE)
Western Region Hazardous Substance Research Center for Developing In-Situ Processes for VOC Remediation in Groundwater and Soil
Hazardous Substance Research Center–South and Southwest
Western Region Hazardous Substance Research Center
The Johns Hopkins University Center For The Asthmatic Child in the Urban Environment
CECEHDPR - University of Michigan
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
Hazardous Substance Research Center/South and Southwest
Center for Hazardous Substances in Urban Environments (CHSUE)
FDP - Center for Environmental Science
Carolina Environmental Bioinformatics Center
Johns Hopkins Particulate Matter Research Center
Harvard Particle Center
Texas Joint Center for Air Quality
The Center for Advancing Microbial Risk Assessment (CAMRA)
Center for Integrating Statistical and Environmental Science
Inner City Toxicants, Child Growth and Development
Center for Children's Environmental Health Research
Johns Hopkins Center for Childhood Asthma in the Urban Environment
Carolina Center for Computational Toxicology
The Center for Environmental Implications of Nanotechnology (CEINT)
Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
Berkeley/Stanford Children’s Environmental Health Center
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
Air Pollution Mixtures: Health Effects Across Life Stages
National Environmental Respiratory Center
Environmental Research and Technology Transfer Program of The Consortium for Plant Biotechnology Research, Inc.
Center for Reinventing Aging Infrastructure for Nutrient Management (RAINmgt)
Center for Comprehensive, optimaL, and Effective Abatement of Nutrients
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Water Innovation Network for Sustainable Small Systems (WINSSS)
Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments
SEARCH: Solutions to Energy, AiR, Climate, and Health
Comparing Urban and Rural Effects of Poverty on COPD (CURE COPD)
Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
A Sustainable Center for Crowd-Sourced Water Infrastructure Modeling
Initial Annual CEMALB Progress Report: Human Health Effects of Environmental Pollutants

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Site Navigation

Related Information

Contact Us to ask a question, provide feedback, or report a problem.
Last updated April 28, 2023