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Grantee Research Project Results

Research Centers
Michigan Center for the Environment and Children’s Health

University of Michigan

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit is particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children’s Health (MCECH) will engage in coordinated interdisciplinary research aimed at: 1) identifying children with asthma and assess their household, school, and neighborhood environment, 2) increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 3) examining the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, 4) determining the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tree, and 5) developing specific mechanisms for communication and translation of laboratory and community-based research across disciplines and to community partners. The Center will include three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and an Administrative Core, and two new Center Scientists.

The Center is a partnership involving the University of Michigan Schools of Public Health and Medicine, the Detroit Health Department, Henry Ford Health System, community-based organizations based on the southwest and east sides of Detroit, including Butzel Family Center, Community Health and Social Services Center (CHASS), Detroiters Working for Environmental Justice, Friends of Parkside, Kettering/Butzel Health Initiative, Latino Family Services, United Community Housing Coalition, and Warren/Conner Development Coalition, and the Centers for Disease Control and Prevention (CDC.) The Center builds on a partnership established in 1995 by the Detroit Community-Academic Urban Research Center (URC), one of three "Urban Centers for Applied Research" funded by the CDC. The Detroit URC seeks to develop and implement prevention research that improves the health of children and families in selected communities in southwest and east side Detroit. The Detroit URC Board, comprised of representatives of many of the same partners currently participating in the new Center, adopted a set of "Community-Based Research Principles" to guide the development of research projects carried out in conjunction with the URC. These research principles include an emphasis on: the local relevance of public health problems; the involvement of community, practitioner, and academic partners in all major phases of the research process; the conduct of research that is beneficial to the community involved; and the dissemination of research findings to community members in ways that are understandable and useful. In 1996 the URC Board, after a review of relevant data and discussion of interests and needs of partner organizations, identified three overall priority areas for developing new community-based prevention research projects. One of these priorities was the area of environmental health and in particular housing and air quality as it relates to asthma in children. The URC Board enthusiastically and unanimously decided to be involved in submitting a proposal for the new Center that would focus on identifying and reducing environmental exposures considered to be associated with asthma health status in children.

A description of the three core research projects, and an overview of the administrative structure and functions is provided below.

View Projects in Tabular Format

Main Center Abstract and Reports:

Development of Environmental Indicators of Condition,Integrity, and Sustainability in the Coastal Regions of the US Great Lakes Basin
  • Original Abstract
  • 2001 Progress Report
  • 2004 Progress Report
  • Final Report
Atlantic Coast Environmental Indicators Consortium
  • Original Abstract
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • Final Report
Research Center for Particulate Air Pollution and Health
  • Original Abstract
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • Final Report
Consortium for Estuarine Ecoindicator Research for the Gulf of Mexico (CEER-GOM)
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
FRIENDS Children's Environmental Health Center
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
Center for Hazardous Substances in Urban Environments (CHSUE)
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
Western Region Hazardous Substance Research Center for Developing In-Situ Processes for VOC Remediation in Groundwater and Soil
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
Hazardous Substance Research Center–South and Southwest
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • Final Report
Western Region Hazardous Substance Research Center
  • Original Abstract
Centers of Excellence in Children's Environmental Health and Disease Prevention Research
  • Original Abstract
  • 2001 Progress Report
  • 2002 Progress Report
The Johns Hopkins University Center For The Asthmatic Child in the Urban Environment
  • Original Abstract
Center for Child Environmental Health Risks Research
  • Original Abstract
  • 2000 Progress Report
CECEHDPR - University of Michigan
  • Original Abstract
  • 2000 Progress Report
  • 2002 Progress Report
  • Final Report
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
  • Original Abstract
Midwest Hazardous Substance Research Center
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • Final Report
Hazardous Substance Research Center/South and Southwest
  • Original Abstract
  • 2003 Progress Report
  • Final Report
Center for Hazardous Substances in Urban Environments (CHSUE)
  • Original Abstract
  • Final Report
FDP - Center for Environmental Science
  • Original Abstract
  • 2004 Progress Report
  • Final Report
Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States
  • Original Abstract
  • Final Report
Johns Hopkins Particulate Matter Research Center
  • Original Abstract
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • Final Report
Harvard Particle Center
  • Original Abstract
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2010 Progress Report
  • Final Report
Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
  • Original Abstract
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2010 Progress Report
  • 2011 Progress Report
  • Final Report
Texas Joint Center for Air Quality
  • Original Abstract
  • 2006 Progress Report
  • 2007 Progress Report
  • Final Report
The Center for Advancing Microbial Risk Assessment (CAMRA)
  • Original Abstract
  • 2007 Progress Report
  • Final Report
Center for Integrating Statistical and Environmental Science
  • Original Abstract
  • 2004 Progress Report
  • 2006 Progress Report
  • Final Report
National Research Program on Design-Based/Model-Assisted Survey Methodology for Aquatic Resources
  • Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2005 Progress Report
Center for Science and Policy Applications for Coastal Environments (SPACE)
  • Original Abstract
  • 2006 Progress Report
  • 2008 Progress Report
Inner City Toxicants, Child Growth and Development
  • Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • Final Report
Center for Children's Environmental Health Research
  • Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • Final Report
Center for Child Environmental Health Risks Research
  • Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
Johns Hopkins Center for Childhood Asthma in the Urban Environment
  • Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • Final Report
Carolina Center for Computational Toxicology
  • Original Abstract
  • 2008 Progress Report
  • Final Report
The Center for Environmental Implications of Nanotechnology (CEINT)
  • Original Abstract
The Texas-Indiana Virtual STAR Center; Data-Generating in vitro and in silico Models of Developmental Toxicity in Embryonic Stem Cells and Zebrafish
  • Original Abstract
  • 2010 Progress Report
Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • Final Report
Center for Integrative Research on Childhood Leukemia and the Environment (CIRCLE)
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • Final Report
Center for Children’s Environmental Health and DiseasePreventionResearch (P01) (joint EPA and NIEHS) - CHAMACOS
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • Final Report
Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • Final Report
Center for Child Environmental Health Risks Research
  • Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2015 Progress Report
  • Final Report
Berkeley/Stanford Children’s Environmental Health Center
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • Final Report
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
  • Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • Final Report
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
  • Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • Final Report
University of Washington Center for Clean Air Research (UW CCAR)
  • Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • Final Report
Air Pollution Mixtures: Health Effects Across Life Stages
  • Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • Final Report
Environmental Research and Technology Transfer Program of The Consortium for Plant Biotechnology Research, Inc.
  • Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
Center for Reinventing Aging Infrastructure for Nutrient Management (RAINmgt)
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
Center for Comprehensive, optimaL, and Effective Abatement of Nutrients
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
  • Original Abstract
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
UC Berkeley/Stanford Children's Environmental Health Center
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • Final Report
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
  • Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • Final Report
Novel Methods to Assess the Effects of Chemicals on Child Development
  • Original Abstract
  • 2013 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • Final Report
Water Innovation Network for Sustainable Small Systems (WINSSS)
  • Original Abstract
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • Final Report
Predictive Toxicology Center for Organotypic Cultures and Assessment ofAOPs for Engineered Nanomaterials
  • Original Abstract
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • Final Report
Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and in vitro-to-in vivo Extrapolation for High-throughput Hazard, Dose-response and Variability Assessments
  • Original Abstract
  • 2015 Progress Report
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • Final Report
SEARCH: Solutions to Energy, AiR, Climate, and Health
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • 2021 Progress Report
Comparing Urban and Rural Effects of Poverty on COPD (CURE COPD)
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • 2021 Progress Report
Center for Research on Early Childhood Exposure and Development in Puerto Rico
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • 2021 Progress Report
Center for Integrative Research on Childhood Leukemia and the Environment
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • Final Report
Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
  • Original Abstract
  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • Final Report
A Sustainable Center for Crowd-Sourced Water Infrastructure Modeling
  • Original Abstract
  • 2017 Progress Report
  • 2018 Progress Report
  • 2019 Progress Report
  • 2020 Progress Report
  • 2021 Progress Report

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Last updated on October 20, 2022