Research Centers
Michigan Center for the Environment and Children’s Health

University of Michigan

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem. The prevalence of the disease in the city of Detroit is particularly high, reflecting the trends found elsewhere among urban populations and communities of color. The Michigan Center for the Environment and Children’s Health (MCECH) will engage in coordinated interdisciplinary research aimed at: 1) identifying children with asthma and assess their household, school, and neighborhood environment, 2) increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 3) examining the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, 4) determining the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tree, and 5) developing specific mechanisms for communication and translation of laboratory and community-based research across disciplines and to community partners. The Center will include three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and an Administrative Core, and two new Center Scientists.

The Center is a partnership involving the University of Michigan Schools of Public Health and Medicine, the Detroit Health Department, Henry Ford Health System, community-based organizations based on the southwest and east sides of Detroit, including Butzel Family Center, Community Health and Social Services Center (CHASS), Detroiters Working for Environmental Justice, Friends of Parkside, Kettering/Butzel Health Initiative, Latino Family Services, United Community Housing Coalition, and Warren/Conner Development Coalition, and the Centers for Disease Control and Prevention (CDC.) The Center builds on a partnership established in 1995 by the Detroit Community-Academic Urban Research Center (URC), one of three "Urban Centers for Applied Research" funded by the CDC. The Detroit URC seeks to develop and implement prevention research that improves the health of children and families in selected communities in southwest and east side Detroit. The Detroit URC Board, comprised of representatives of many of the same partners currently participating in the new Center, adopted a set of "Community-Based Research Principles" to guide the development of research projects carried out in conjunction with the URC. These research principles include an emphasis on: the local relevance of public health problems; the involvement of community, practitioner, and academic partners in all major phases of the research process; the conduct of research that is beneficial to the community involved; and the dissemination of research findings to community members in ways that are understandable and useful. In 1996 the URC Board, after a review of relevant data and discussion of interests and needs of partner organizations, identified three overall priority areas for developing new community-based prevention research projects. One of these priorities was the area of environmental health and in particular housing and air quality as it relates to asthma in children. The URC Board enthusiastically and unanimously decided to be involved in submitting a proposal for the new Center that would focus on identifying and reducing environmental exposures considered to be associated with asthma health status in children.

A description of the three core research projects, and an overview of the administrative structure and functions is provided below.

Center Publications:

Views: All publications Selected publication types Journal articles Publications submitted after final report

View Projects in List Format

  Identifier Abstract Principal
Investigator
Annual/
Final
Reports
Pubs Count Institution Grant
Representative
Grant
Amount
Project
Period
1 R826710
Centers

- Main center abstract - Michigan Center for the Environment and Children’s Health
CECEHDPR - University of Michigan Israel, Barbara A.
Brown, Randall
Keeler, Gerald J.
Lin, Xihong
Parker, Edith
Philbert, Martin
Remick, Daniel
Robins, Thomas

- Principal Investigators listed are
sub-PIs determined by the center.
 
2000

2002

Final

Total Pubs: 44
Journals: 22
Books: 2
 
University of Michigan Fields, Nigel   $2,830,746   September 1998 -
August 2003
(Extended to August 2005)  
2 R826710C001
Centers

- This is a subproject of the Michigan Center for the Environment and Children’s Health
Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure) Israel, Barbara A.
Robins, Thomas
Brown, Randall
Keeler, Gerald J.
Lin, Xihong
Parker, Edith
Philbert, Martin
Remick, Daniel
Robbins, Tom

- Principal Investigators listed are
sub-PIs determined by the center.
 
1999

2000

2002

Total Pubs: 3
Journals: 1
-- No Books --
 
University of Michigan EPA Project Officer(s) for
Michigan Center for the Environment and Children’s Health

Grant Number R826710:

Saint, Chris  
Refer to main center abstract for funding details.   January 1998 -
January 2002  
3 R826710C002
Centers

- This is a subproject of the Michigan Center for the Environment and Children’s Health
Chemokines in the Pathogenesis of Asthma (Asthma Chemokines) Israel, Barbara A.
Remick, Daniel
Brown, Randall
Keeler, Gerald J.
Lin, Xihong
Parker, Edith
Philbert, Martin
Robins, Thomas

- Principal Investigators listed are
sub-PIs determined by the center.
 
1999

2000

2002

Total Pubs: 3
Journals: 1
-- No Books --
 
University of Michigan EPA Project Officer(s) for
Michigan Center for the Environment and Children’s Health

Grant Number R826710:

Saint, Chris  
Refer to main center abstract for funding details.   January 1998 -
January 2002  
4 R826710C003
Centers

- This is a subproject of the Michigan Center for the Environment and Children’s Health
A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention) Israel, Barbara A.
Parker, Edith
Brown, Randall
Keeler, Gerald J.
Lin, Xihong
Philbert, Martin
Remick, Daniel
Robins, Thomas

- Principal Investigators listed are
sub-PIs determined by the center.
 
1999

2000

2002

Total Pubs: 3
Journals: 1
-- No Books --
 
University of Michigan EPA Project Officer(s) for
Michigan Center for the Environment and Children’s Health

Grant Number R826710:

Saint, Chris  
Refer to main center abstract for funding details.   January 1998 -
January 2002