Grantee Research Project Results
Research Centers
Great Lakes Air Center for Integrative Environmental Research
Michigan State University
GLACIER is a multidisciplinary center with the objective to explore one of the most prevalent and important global health-environment interfaces: the interrelationships between facets of the cardiometabolic syndrome (CMS) and air pollution. CMS is among the leading causes of death and threats to worldwide health. In tandem, exposure to air pollution, most notably fine particle matter (PM2.5), remains highly prevalent and ranks among the leading causes of global mortality. Inter-relationships and health impacts of this burgeoning confluence between these two epidemics are of tremendous importance to elucidate. Our previous research has elucidated that PM2.5 exposure plays a critical, yet under-appreciated, role in eliciting or exacerbating several key facets of the CMS-including elevating blood pressure, impairing vascular function, and even worsening metabolic insulin sensitivity and adiposity over a chronic duration. We have also found that the location of exposure, multipollutant context, and constituents within PM2.5 affect the responses. The full extent and importance of inter-relationships between CMS and air pollution, individual susceptibility, specific pollution components, multipollutant atmospheres, PM2.5 - ozone (O3) coexposures, and underlying mechanisms of toxicity are all key issues remaining to be clarified. Our center’s overall hypothesis is that PM2.5 and O3 are 1) capable of eliciting multiple important adverse cardiometabolic health effects that are dependent on 2) the local multipollutant milieu, 3) an individual’s pre-existing cardiovascular (CV) and metabolic condition (susceptibility), and 4) the interactive toxicity of PM2.5 and O3 coexposure.
Center Publications:
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View Projects in Tabular Format
Main Center Abstract and Reports:
Southern California Particle Center and Supersite (SCPCS)
Ultrafine Particles: Characterization, Health Effects and Pathophysiological Mechanisms
CECEHDPR - University of Southern California
CECEHDPR - University of Michigan
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC
Midwest Hazardous Substance Research Center
Harvard Particle Center
Southern California Particle Center (SCPC)
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
The Center for Advancing Microbial Risk Assessment (CAMRA)
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
Children’s Environmental Health Center
University of California – Center for Environmental Implications of Nanotechnology (UC-CEIN)
Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation
Great Lakes Air Center for Integrative Environmental Research (GLACIER)
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management
- Original Abstract
- 2011 Progress Report
- 2012 Progress Report
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- Final Report
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
- Original Abstract
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
SEARCH: Solutions to Energy, AiR, Climate, and Health
- Original Abstract
- 2013 Progress Report
- 2014 Progress Report
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- Final Report
Center Research Projects:
R826708C001 - Asthma in Children: A Community-based Intervention Project
R826708C002 - Children's Exposure to Environmental Tobacco Smoke: Changes in Allergic Response
R826708C003 - Respiratory Disease and Prevention Center
R829479C001 - Plant Genes and Agrobacterium T-DNA Integration
R829479C002 - Designing Promoters for Precision Targeting of Gene Expression
R829479C003 aka R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C004 - Negative Sense Viral Vectors for Improved Expression of Foreign Genes in Insects and Plants
R829479C005 - Development of Novel Plastics From Agricultural Oils
R829479C006 - Conversion of Paper Sludge to Ethanol
R829479C007 - Enhanced Production of Biodegradable Plastics in Plants
R829479C008 - Engineering Design of Stable Immobilized Enzymes for the Hydrolysis and Transesterification of Triglycerides
R829479C009 - Discovery and Evaluation of SNP Variation in Resistance-Gene Analogs and Other Candidate Genes in Cotton
R829479C010 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals
R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C012 - High Strength Degradable Plastics From Starch and Poly(lactic acid)
R829479C013 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C014 - Identification of Receptors of Bacillus Thuringiensis Toxins in Midguts of the European Corn Borer
R829479C015 - Coordinated Expression of Multiple Anti-Pest Proteins
R829479C016 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C017 - Molecular Improvement of an Environmentally Friendly Turfgrass
R829479C018 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals. II.
R829479C019 - Transgenic Plants for Bioremediation of Atrazine and Related Herbicides
R829479C020 - Root Exudate Biostimulation for Polyaromatic Hydrocarbon Phytoremediation
R829479C021 - Phytoremediation of Heavy Metal Contamination by Metallohistins, a New Class of Plant Metal-Binding Proteins
R829479C022 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C023 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C024 - Development of Vectors for the Stoichiometric Accumulation of Multiple Proteins in Transgenic Crops
R829479C025 - Chemical Induction of Disease Resistance in Trees
R829479C026 - Development of Herbicide-Tolerant Hardwoods
R829479C027 - Environmentally Superior Soybean Genome Development
R829479C028 - Development of Efficient Methods for the Genetic Transformation of Willow and Cottonwood for Increased Remediation of Pollutants
R829479C029 - Development of Tightly Regulated Ecdysone Receptor-Based Gene Switches for Use in Agriculture
R829479C030 - Engineered Plant Virus Proteins for Biotechnology
R832413C001 - Contribution of Primary and Secondary PM Sources to Exposure & Evaluation of Their Relative Toxicity
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C002 - Project 2: The Role of Oxidative Stress in PM-induced Adverse Health Effects
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C003 - The Chemical Properties of PM and their Toxicological Implications
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C004 - Oxidative Stress Responses to PM Exposure in Elderly Individuals With Coronary Heart Disease
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- Final Report
R832413C005 - Ultrafine Particles on and Near Freeways
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.