Research Centers
Great Lakes Air Center for Integrative Environmental Research

Michigan State University

GLACIER is a multidisciplinary center with the objective to explore one of the most prevalent and important global health-environment interfaces: the interrelationships between facets of the cardiometabolic syndrome (CMS) and air pollution. CMS is among the leading causes of death and threats to worldwide health. In tandem, exposure to air pollution, most notably fine particle matter (PM2.5), remains highly prevalent and ranks among the leading causes of global mortality. Inter-relationships and health impacts of this burgeoning confluence between these two epidemics are of tremendous importance to elucidate. Our previous research has elucidated that PM2.5 exposure plays a critical, yet under-appreciated, role in eliciting or exacerbating several key facets of the CMS-including elevating blood pressure, impairing vascular function, and even worsening metabolic insulin sensitivity and adiposity over a chronic duration. We have also found that the location of exposure, multipollutant context, and constituents within PM2.5 affect the responses. The full extent and importance of inter-relationships between CMS and air pollution, individual susceptibility, specific pollution components, multipollutant atmospheres, PM2.5 - ozone (O3) coexposures, and underlying mechanisms of toxicity are all key issues remaining to be clarified. Our center’s overall hypothesis is that PM2.5 and O3 are 1) capable of eliciting multiple important adverse cardiometabolic health effects that are dependent on 2) the local multipollutant milieu, 3) an individual’s pre-existing cardiovascular (CV) and metabolic condition (susceptibility), and 4) the interactive toxicity of PM2.5 and O3 coexposure.

Center Publications:

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View Projects in List Format

  Identifier Abstract Principal
Investigator
Annual/
Final
Reports
Pubs Count Institution Grant
Representative
Grant
Amount
Project
Period
1 R825540
Centers

- Main center abstract - HSRC (1989) - Great Lakes/Mid Atlantic HSRC
HSRC (1989) - Great Lakes/Mid-Atlantic HSRC Hunter, Ray

- Principal Investigators listed are
sub-PIs determined by the center.
 
Total Pubs: 5
Journals: 5
Books: 1
 
University of Michigan Hahn, Intaek   $5,000,000   October 01, 1989 -
September 30, 1999  
2 R826708
Centers

- Main center abstract - CECEHDPR - University of Southern California
CECEHDPR - University of Southern California Gong, Henry
Avol, Edward L.
Peters, John M.
McConnell, Rob Scot
Jones, Craig
Hinds, William C.
Gilliland, Frank D.
Gauderman, William
Diaz-Sanchez, David

- Principal Investigators listed are
sub-PIs determined by the center.
 
2000

2001

2002

Final

Total Pubs: 95
Journals: 95
Books: 2
 
University of California - Los Angeles Hahn, Intaek   $2,895,926   August 01, 1998 -
July 31, 2003  
3 R826710
Centers

- Main center abstract - Michigan Center for the Environment and Children’s Health
CECEHDPR - University of Michigan Israel, Barbara A.
Brown, Randall
Robins, Thomas
Remick, Daniel
Philbert, Martin
Parker, Edith
Lin, Xihong
Keeler, Gerald J.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2000

2002

Final

Total Pubs: 44
Journals: 44
Books: 2
 
University of Michigan Hahn, Intaek   $2,830,746   September 01, 1998 -
August 31, 2003
(Extended to August 31, 2005)  
4 R827352
Centers

- Main center abstract - Southern California Particle Center and Supersite
Southern California Particle Center and Supersite (SCPCS) Froines, John R.
Arey, Janet
Ziemann, Paul J.
Yu, Rong Chun
Winer, Arthur M.
Venkatesan, M. Indira
Turco, Richard
Thomas, Duncan C.
Stram, Dan
Sioutas, Constantinos
Schiestl, Robert H.
Ritz, Beate R.
Que Hee, Shane S.
Phalen, Robert
Peters, John M.
Nel, Andre E.
Miguel, Antonio
McConnell, Rob Scot
Lurmann, Fred
Linn, William S.
Langholz, Brian
Kunzli, Nino
Kumagai, Yoshito
Kleinman, Michael T.
Hinds, William C.
Harkema, Jack
Hankinson, Oliver
Grosser, Stella C.
Gong, Henry
Gauderman, William
Fukuto, Jon
Friedlander, Sheldon
Eldering, Annmarie
Eastmond, David A.
Colome, Steven D.
Cohen, Yoram
Cho, Arthur K.
Charles, Judith M.
Cass, Glen
Berhane, Kiros
Avol, Edward L.
Atkinson, Roger

- Principal Investigators listed are
sub-PIs determined by the center.
 
2003

2004

Final

Total Pubs: 150
Journals: 150
-- No Books --
 
University of California - Los Angeles, Michigan State University, Rancho Los Amigos Medical Center, University of California - Davis, University of California - Irvine, University of California - Riverside, University of Southern California, University of Tsukuba Chung, Serena   $8,715,583   June 01, 1999 -
May 31, 2005
(Extended to May 31, 2006)  
5 R827354
Centers

- Main center abstract - Airborne PM - Rochester PM Center
Ultrafine Particles: Characterization, Health Effects and Pathophysiological Mechanisms Oberdörster, Günter
Beckett, William
Zareba, Wojciech
Yu, C. P.
Wichmann, Heinz-Erich
Utell, Mark J.
Stripp, Barry
Sharp, Zachary
Schwarz, Edward
Prather, Kimberly A.
Phipps, Richard
Peters, Annette
OReilly, Michael
O'Reilly, Michael
Morrow, P. E.
Marder, Victor J.
Looney, John
Heyder, Joachim
Frampton, Mark W.
Finkelstein, Jacob N.
Ensor, David
Cox, Christopher
Cass, Glen

- Principal Investigators listed are
sub-PIs determined by the center.
 
2004

Final

Total Pubs: 102
Journals: 102
Books: 7
 
University of Rochester, GSF- Institute for Epidemiologie, Georgia Institute of Technology, Research Triangle Institute, University of California - Los Angeles, University of California - San Diego Chung, Serena   $8,302,447   June 01, 1999 -
May 31, 2005
(Extended to May 31, 2006)  
6 R828770
Centers

- Main center abstract - HSRC (2001) - Midwest Hazardous Substance Research Center
Midwest Hazardous Substance Research Center Banks, M. Katherine
Blanford, William
Voice, Thomas C.
Reddi, Lakshmi N.
Novak, John T.
Gerba, Charles P.
Brusseau, Mark

- Principal Investigators listed are
sub-PIs determined by the center.
 
2002

2003

Final

Total Pubs: 80
Journals: 80
Books: 1
 
Kansas State University, Central State University, Haskell Indian Nations University, Howard University, Michigan State University, Missouri University of Science and Technology, Purdue University - Main Campus, University of Cincinnati, University of South Carolina at Columbia, Virginia Polytechnic Institute and State University Klieforth, Barbara I     October 01, 2001 -
September 30, 2006  
7 R830117
Centers

- Main center abstract - University of California — Center for Environmental Implications of Nanotechnology (UC—CEIN)
University of California – Center for Environmental Implications of Nanotechnology (UC-CEIN) Nel, Andre E.

- Principal Investigators listed are
sub-PIs determined by the center.
 
  University of California - Los Angeles Hahn, Intaek   $4,000,000   September 01, 2008 -
August 31, 2013  
8 R831861
Centers

- Main center abstract - USC Center for Children’s Environmental Health
Children’s Environmental Health Center Gilliland, Frank D.
Avol, Edward L.
Riedl, Marc A
Peters, John M.
McConnell, Rob Scot
Lurmann, Fred
Linn, William S.
Kuenzli, Nino
Hricko, Andrea M.
Gong, Henry
Gauderman, William
Froines, John R.
Dubeau, Louis
Diaz-Sanchez, David
Berhane, Kiros

- Principal Investigators listed are
sub-PIs determined by the center.
 
2004

2005

2006

Final

Total Pubs: 196
Journals: 196
Books: 1
 
University of Southern California, University of California - Los Angeles Callan, Richard   $3,802,622   November 01, 2003 -
October 31, 2008
(Extended to October 31, 2010)  
9 R832362
Centers

- Main center abstract - Center for Advancing Microbial Risk Assessment
The Center for Advancing Microbial Risk Assessment (CAMRA) Rose, Joan B.
Atwood, Michael
Weber, Rosina
Todd, Ewen
Small, Mitchell J.
S. Eisenberg, Joseph N.
Pepper, Ian L.
Nicas, Mark
Nazaroff, William
Koopman, James
Keim, Paul
Hashsham, Syed
Han, Hyoi
Haas, Charles N.
Gurian, Patrick
Gerba, Charles P.
Downs, Julie
Choi, Christopher Yeonsik
Casman, Elizabeth
Bolin, Carole

- Principal Investigators listed are
sub-PIs determined by the center.
 
2007

Final

Total Pubs: 101
Journals: 101
Books: 2
 
Michigan State University, Carnegie Mellon University, Drexel University, Northern Arizona University, University of Arizona, University of California - Berkeley, University of Michigan Packard, Benjamin H   $10,000,000   September 01, 2005 -
August 31, 2010  
10 R832413
Centers

- Main center abstract - Southern California Particle Center
Southern California Particle Center (SCPC) Froines, John R.
Cho, Arthur K.
Zhu, Yifang
Vaziri, Nostratola
Vaziri, Nosratola D
Stram, Dan
Staimer, Norbert
Sioutas, Constantinos
Shafer, Martin M.
Schauer, James J.
Neuhausen, Susan
Nel, Andre E.
Miguel, Antonio
Lusis, Aldons
Kumagai, Yoshito
Kleinman, Michael T.
Hinds, William C.
Harkema, Jack
Fukuto, Jon
Fine, Philip M.
Delfino, Ralph

- Principal Investigators listed are
sub-PIs determined by the center.
 
2006

2007

2008

2009

2010

Final

Total Pubs: 154
Journals: 154
-- No Books --
 
Michigan State University, University of California - Los Angeles, University of California - Irvine, University of Southern California, University of Tsukuba, University of Wisconsin Chung, Serena   $7,999,994   October 01, 2005 -
September 30, 2010
(Extended to September 30, 2012)  
11 R832416
Centers

- Main center abstract - Harvard Particle Center
Harvard Particle Center Koutrakis, Petros
Brook, Jeffrey R.
Vokonas, Pantel
Suh, Helen H.
Stone, Peter
Speizer, Frank E.
Sparrow, David
Silverman, Frances
Schwartz, Joel
Gonzalez-Flecha, Beatriz
Gold, Diane R.
Godleski, John J.
Dockery, Douglas W.
Demokritou, Philip
Coull, Brent
Brook, Robert D.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2006

2007

2008

2009

2010

Final

Total Pubs: 190
Journals: 190
-- No Books --
 
Harvard University, Boston University, Brigham and Women's Hospital, Inc., University of Michigan, University of Toronto Chung, Serena   $7,999,609   October 01, 2005 -
September 30, 2010
(Extended to September 30, 2011)  
12 R834593
Centers

- Main center abstract - Novel Methods to Assess Effects of Bisphenol A & Phthalates on Child Development
Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development Schantz, Susan L.
Aguiar, Andrea
Yi, Sandra James
Yao, Humphrey
Korrick, Susan A.
Juraska, Janice
Gardnier, Joseph
Flaws, Jodi
Baillargeon, Renee L.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2010

2011

2012

Final

Total Pubs: 35
Journals: 35
-- No Books --
 
University of Illinois at Urbana-Champaign, Harvard T.H. Chan School of Public Health, Michigan State University Hahn, Intaek   $1,094,951   February 15, 2010 -
February 14, 2014  
13 R834797
Centers

- Main center abstract - Great Lakes Air Center for Integrative Environmental Research
Great Lakes Air Center for Integrative Environmental Research (GLACIER) Brook, Robert D.
Brooks, Robert P.
Araujo, Jesus
Oral, Elif
Kaplan, Marianna J.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2011

2012

2013

2014

2015

2016

Final

Total Pubs: 138
Journals: 138
-- No Books --
 
Michigan State University, The Ohio State University - Main Campus, University of California - Los Angeles, University of Michigan - Ann Arbor Chung, Serena   $7,999,875   January 01, 2011 -
December 31, 2015
(Extended to December 31, 2016)  
14 R834797C001
Centers

- This is a subproject of the Great Lakes Air Center for Integrative Environmental Research
Cardiometabolic Effects of Exposure to Differing Mixtures and Concentrations of PM2.5 in Obese and Lean Adults Brook, Robert D.
Araujo, Jesus
Oral, Elif
Kaplan, Marianna J.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2011

2012

2013

2014

2015

2016

Final

Total Pubs: 17
Journals: 17
-- No Books --
 
Michigan State University, University of Michigan - Ann Arbor, University of California - Los Angeles EPA Project Officer(s) for
Great Lakes Air Center for Integrative Environmental Research

Grant Number R834797:

Chung, Serena  
Refer to main center abstract for funding details.   December 01, 2010 -
November 30, 2015
(Extended to December 31, 2016)  
15 R834797C002
Centers

- This is a subproject of the Great Lakes Air Center for Integrative Environmental Research
Cardiometabolic, Autonomic, and Airway Toxicity of Acute Exposures to PM2.5 from Multipollutant Atmospheres in the Great Lakes Region Harkema, Jack
Fink, Greg
Wagner, James

- Principal Investigators listed are
sub-PIs determined by the center.
 
2011

2012

2013

2014

2015

2016

Final

Total Pubs: 73
Journals: 73
-- No Books --
 
Michigan State University EPA Project Officer(s) for
Great Lakes Air Center for Integrative Environmental Research

Grant Number R834797:

Chung, Serena  
Refer to main center abstract for funding details.   December 01, 2010 -
November 30, 2015
(Extended to December 31, 2016)  
16 R834797C003
Centers

- This is a subproject of the Great Lakes Air Center for Integrative Environmental Research
Long Term Metabolic Consequences of Exposures to Multipollutant Atmospheres in the Great Lakes Region Rajagopalan, Sanjay
Sun, Qinghua

- Principal Investigators listed are
sub-PIs determined by the center.
 
2011

2012

2013

2014

2015

2016

Final

Total Pubs: 46
Journals: 46
-- No Books --
 
The Ohio State University - Main Campus, University of Michigan - Ann Arbor EPA Project Officer(s) for
Great Lakes Air Center for Integrative Environmental Research

Grant Number R834797:

Chung, Serena  
Refer to main center abstract for funding details.   December 01, 2010 -
November 30, 2015
(Extended to December 31, 2016)  
17 R834800
Centers

- Main center abstract - Perinatal Exposures, Epigenetics, Child Obesity and Sexual Maturation - University of Michigan
Perinatal Exposures, Epigenetics, Child Obesity & Sexual Maturation Peterson, Karen E.
Dolinoy, Dana
Meeker, John D.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2011

2012

2013

Final

Total Pubs: 103
Journals: 103
Books: 6
 
University of Michigan Hahn, Intaek   $1,335,311   August 09, 2010 -
August 08, 2014  
18 R835436
Centers

- Main center abstract - Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome Peterson, Karen E.
Dolinoy, Dana
Padmanabhan, Vasantha
Meeker, John D.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2013

2014

2015

2016

2017

Final

Total Pubs: 130
Journals: 130
Books: 11
 
University of Michigan Hahn, Intaek   $3,651,990   June 01, 2013 -
May 31, 2018
(Extended to May 31, 2019)  
19 R835871
Centers

- Main center abstract - Solutions for Energy, AiR, Climate and Health Center (SEARCH)
SEARCH: Solutions to Energy, AiR, Climate, and Health Bell, Michelle L.
Anastas, Paul T.
Breysse, Patrick N.
Curriero, Frank
Deziel, Nicole Cardello
Eckelman, Matthew J.
Ellis, J. Hugh
Esty, Daniel C.
Gentner, Drew R.
Gentry, Bradford S.
Gillingham, Ken
Gillingham, Kenneth
Hobbs, Benjamin F.
Katz, Howard
Kerkez, Branko
Koehler, Kirsten
Peccia, Jordan
Peng, Roger D.
Son, Jiyoung
Storelvmo, Trude
Streets, David G.
Wara, Michael W.
Weyant, John P.
Zaitchik, Ben
Zhang, Yang
Zhang, Yawei
Zimmerman, Julie B.

- Principal Investigators listed are
sub-PIs determined by the center.
 
2016

2017

2018

2019

2020

Total Pubs: 114
Journals: 69
-- No Books --
 
Yale University, Argonne National Laboratory, Centers for Disease Control and Prevention, North Carolina State University, Northeastern University, Pacific Northwest National Laboratory, Stanford University, The Johns Hopkins University, University of Chicago, University of Michigan Callan, Richard   $9,999,990   October 01, 2015 -
September 30, 2020
(Extended to September 30, 2022)  
20 RD835567
Centers

- Main center abstract - Water Environment and Reuse Foundation's National Center for Resource Recovery and Nutrient Management
Water Environment and Reuse Foundation (WE&RF)'s National Center for Resource Recovery and Nutrient Management Chandran, Kartik
Pramanik, Amit
Case, Traci L.
Yorgey, Georgine
Wigginton, Krista
Stensel, David
Stack, William
Skerlos, Steven J.
Sedlak, David L.
Radke, Christine
Luthy, Richard G.
Khunjar, Wendell
Frear, Craig

- Principal Investigators listed are
sub-PIs determined by the center.
 
2014

2015

2016

2017

Final

Total Pubs: 86
Journals: 86
-- No Books --
 
Columbia University in the City of New York, Water Environment and Reuse Foundation, Center for Watershed Protection, Hazen and Sawyer, Stanford University, University of California - Berkeley, University of Michigan, University of Washington, Washington State University, Water Research Foundation Packard, Benjamin H   $3,370,298   November 01, 2013 -
October 31, 2018