Grantee Research Project Results
2003 Progress Report: Southern California Particle Center and Supersite (SCPCS)
EPA Grant Number: R827352Center: Southern California Particle Center
Center Director: Froines, John R.
Title: Southern California Particle Center and Supersite (SCPCS)
Investigators: Froines, John R. , Langholz, Brian , Stram, Dan , Gauderman, William
Current Investigators: Froines, John R. , Turco, Richard , Hinds, William C. , Yu, Rong Chun , Nel, Andre E. , Schiestl, Robert H. , Cho, Arthur K. , Avol, Edward L. , Winer, Arthur M. , Peters, John M. , Charles, Judith M. , Ritz, Beate R. , Linn, William S. , McConnell, Rob Scot , Kleinman, Michael T. , Miguel, Antonio , Sioutas, Constantinos , Stram, Dan , Lurmann, Fred , Gong, Henry , Harkema, Jack , Arey, Janet , Fukuto, Jon , Berhane, Kiros , Kunzli, Nino , Phalen, Robert , Atkinson, Roger , Gauderman, William , Kumagai, Yoshito
Institution: University of California - Los Angeles , University of Southern California , Michigan State University , University of California - Irvine
Current Institution: University of California - Los Angeles , Michigan State University , Rancho Los Amigos Medical Center , University of California - Davis , University of California - Irvine , University of California - Riverside , University of Southern California , University of Tsukuba
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
Project Amount: $8,715,583
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Air , Particulate Matter
Objective:
The central hypothesis of the Southern California Particle Center and Supersite (SCPCS) is that organic constituents associated with particulate matter (PM)—including quinones, other organic compounds (polycyclic aromatic hydrocarbons [PAHs], nitro-PAHs, and aldehydes/ketones), and metals—are capable of generating reactive oxygen species and acting as electrophilic agents. They have a central role in allergic airway disease such as asthma and cardiovascular effects through their ability to generate oxidative stress, inflammation, and immunomodulating effects in the lungs and airways.
Progress Summary:
This progress report addresses the activities of the Biostatistical Core. Dr. Daniel Stram continues to provide statistical consultation with projects supported by the SCPCS. Dr. Stram has been providing direct assistance to SCPCS Principal Investigators (PIs) in two main areas: analyses of human exposure studies conducted at Rancho Los Amigos (Dr. H. Gong, PI) and analysis of the data from Dr. Kleinman's freeway exposure study. During his sabbatical leave (June-December 2002), Dr. Brian Langholz served in his stead and mainly focused on the human exposure studies at Los Amigos.
Consultation on SCPCS Projects. Dr. Stram has become closely involved in the analysis and presentation of data from the human exposure studies at Rancho Los Amigos. He has rewritten critical portions of the Rancho Los Amigos analysis code, updating it from BMDP to a much better supported SAS procedure for repeated measures, SAS PROC MIXED, while verifying the reproducibility and appropriateness of the earlier analyses. He has updated the general approach to the graphical display of the data from exposure experiments taking place at Rancho so that plots generated more accurately represent the statistical findings of the repeated measures analyses. This new code now has been extensively used by himself and Dr. Langholz to analyze data from several of the human exposure studies.
Since returning from sabbatical, Dr. Stram has begun working closely with Dr. Kleinman on a cohesive analysis of preliminary data on the immunologic responses of mice to concentrated particles for the first several sites and years of exposure.
A manuscript presently is being written on the results of an exposure study of 40 volunteers at Los Amigos, including normal and chronic obstructive pulmonary disease patients, relating responses of interest to treatment conditions (exposure to particles or filtered air) and to ambient exposures in periods just before the day of the experiment. Dr. Gong has presented results from this analysis. Dr. Kleinman also has presented initial results of the freeway studies.
Future Activities:
Dr. Stram will continue to work closely with SCPCS investigators, especially on the development of manuscripts from the Los Amigos human and freeway mouse exposure studies. He will review all data management plans as well as analytic approaches of the SCPCS investigations.
Journal Articles: 149 Displayed | Download in RIS Format
| Other center views: | All 150 publications | 149 publications in selected types | All 149 journal articles |
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Arellanes C, Paulson SE, Fine PM, Sioutas C. Exceeding of Henry's law by hydrogen peroxide associated with urban aerosols. Environmental Science & Technology 2006;40(16):4859-4866. |
R827352 (Final) R832413 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Arhami M, Kuhn T, Fine PM, Defino RJ, Sioutas C. Effects of sampling artifacts and operating parameters on the performance of a semicontinuous particulate elemental carbon/organic carbon monitor. Environmental Science & Technology 2006;40(3):945-954. |
R827352 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Barone TL, Zhu Y. The morphology of ultrafine particles on and near major freeways. Atmospheric Environment 2008;42(28):6749-6758. |
R827352 (Final) R832413 (Final) R832413C005 (Final) |
Exit Exit Exit |
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Becker S, Soukup JM, Sioutas C, Cassee FR. Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Experimental Lung Research 2003;29(1):29-44. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Biswas S, Fine PM, Geller MD, Hering SV, Sioutas C. Performance evaluation of a recently developed water-based condensation particle counter. Aerosol Science and Technology 2005;39(5):419-427. |
R827352 (Final) R827352C014 (Final) |
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Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M. Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. NeuroToxicology 2005;26(1):133-140. |
R827352 (2004) R827352 (Final) R827352C005 (Final) R827352C014 (Final) |
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Chakrabarti B, Fine PM, Delfino R, Sioutas C. Performance evaluation of the active-flow personal DataRAM PM2.5 mass monitor (Thermo Anderson pDR-1200) designed for continuous personal exposure measurements. Atmospheric Environment 2004;38(20):3329-3340. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Chakrabarti B, Singh M, Sioutas C. Development of a near-continuous monitor for measurement of the sub-150 nm PM mass concentration. Aerosol Science and Technology 2004;38(Suppl 1):239-252. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. Journal of Allergy and Clinical Immunology 2006;118(2):455-465. |
R827352 (Final) R827352C002 (Final) R832413 (2008) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) |
Exit Exit Exit |
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Chang M, Sioutas C, Cassee FR, Fokkens PHB. Field evaluation of a mobile high-capacity particle size classifier (HCPSC) for separate collection of coarse, fine and ultrafine particles. Journal of Aerosol Science 2001;32(1):139-156. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Chang M-C, Geller MD, Sioutas C, Fokkens PHB, Cassee FR. Development and evaluation of a compact, highly efficient coarse particle concentrator for toxicological studies. Aerosol Science and Technology 2002;36(4):492-501. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit |
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Cho AK, Di Stefano E, You Y, Rodriquez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR. Determination of four quinones in diesel exhaust particles, SRM 1649a and atmospheric PM2.5. Aerosol Science and Technology 2004;38(Suppl 1):68-81. |
R827352 (Final) R827352C001 (Final) R827352C009 (Final) R827352C013 (Final) R831861 (2004) R831861 (2005) |
Exit Exit |
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Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environmental Research 2005;99(1):40-47. |
R827352 (Final) R827352C001 (Final) R827352C013 (Final) R827352C014 (Final) R832413C003 (2010) R832413C003 (Final) |
Exit Exit Exit |
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Cui Y, Zhang Z-F, Froines J, Zhao J, Wang H, Yu S-Z, Detels R. Air pollution and case fatality of SARS in the People's Republic of China: an ecologic study. Environmental Health 2003;2(1):15-19. |
R827352 (2004) R827352 (Final) |
Exit Exit |
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de Pereira PA, de Andrade JB, Miguel AH. Determination of 16 priority polycyclic aromatic hydrocarbons in particulate matter by HRGC-MS after extraction by sonication. Analytical Sciences 2001;17(10):1229-1231. |
R827352 (Final) R827352C013 (Final) |
Exit Exit |
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de Pereira PA, de Andrade JB, Miguel AH. Measurements of semivolatile and particulate polycyclic aromatic hydrocarbons in a bus station and an urban tunnel in Salvador, Brazil. Journal of Environmental Monitoring 2002;4(4):558-561. |
R827352 (2004) R827352 (Final) R827352C013 (Final) |
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De Vizcaya-Ruiz A, Gutierrez-Castillo ME, Uribe-Ramirez M, Cebrian ME, Mugica-Alvarez V, Sepulveda J, Rosas I, Salinas E, Garcia-Cuellar C, Martinez F, Alfaro-Moreno E, Torres-Flores V, Osornio-Vargas A, Sioutas C, Fine PM, Singh M, Geller MD, Kuhn T, Miguel AH, Eiguren-Fernandez A, Schiestl RH, Reliene R, Froines J. Characterization and in vitro biological effects of concentrated particulate matter from Mexico City. Atmospheric Environment 2006;40(Suppl 2):583-592. |
R827352 (Final) |
Exit Exit Exit |
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Delfino RJ, Sioutas C, Malik S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environmental Health Perspectives 2005;113(8):934-946. |
R827352 (Final) R827352C014 (Final) |
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Doherty SP, Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Zelikoff JT, Lippmann M, Cohen MD. Detection of changes in alveolar macrophage iron status induced by select PM2.5-associated components using iron-response protein binding activity. Inhalation Toxicology 2007;19(6-7):553-562. |
R827352 (Final) R827351 (Final) R827355 (2004) R827355 (Final) R832413 (Final) R832413C001 (Final) |
Exit |
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Eiguren-Fernandez A, Miguel AH, Jaques PA, Sioutas C. Evaluation of a denuder-MOUDI-PUF sampling system to measure the size distribution of semi-volatile polycyclic aromatic hydrocarbons in the atmosphere. Aerosol Science and Technology 2003;37(3):201-209. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
Exit Exit |
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Eiguren-Fernandez A, Miguel AH. Determination of semivolatile and particulate polycyclic aromatic hydrocarbons in SRM 1649a and PM2.5 samples by HPLC-fluorescence. Polycyclic Aromatic Compounds 2003;23(2):193-205. |
R827352 (2004) R827352 (Final) R827352C013 (Final) |
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Eiguren-Fernandez A, Miguel AH, Froines JR, Thurairatnam S, Avol EL. Seasonal and spatial variation of polycyclic aromatic hydrocarbons in vapor-phase and PM2.5 in Southern California urban and rural communities. Aerosol Science and Technology 2004;38(5):447-455. |
R827352 (2004) R827352 (Final) R827352C009 (Final) R827352C013 (Final) R831861 (2005) |
Exit Exit Exit |
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Eiguren-Fernandez A, Avol EL, Thurairatnam S, Hakami M, Froines JR, Miguel AH. Seasonal influence on vapor-and particle-phase polycyclic aromatic hydrocarbon concentrations in school communities located in Southern California. Aerosol Science & Technology 2007;41(4):438-446. |
R827352 (Final) R827352C009 (Final) R827352C013 (Final) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (Final) |
Exit Exit Exit |
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Eiguren-Fernandez A, Miguel AH, Lu R, Purvis K, Grant B, Mayo P, Di Stefano E, Cho AK, Froines J. Atmospheric formation of 9,10-phenanthraquinone in the Los Angeles air basin. Atmospheric Environment 2008;42(10):2312-2319. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
Exit Exit Exit |
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Eiguren-Fernandez A, Miguel AH, Di Stefano E, Schmitz DA, Cho AK, Thurairatnam S, Avol EL, Froines JR. Atmospheric distribution of gas-and particle-phase quinones in Southern California. Aerosol Science and Technology 2008;42(10):854-861. |
R827352 (Final) R832413 (2008) R832413 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
Exit Exit Exit |
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Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. |
R827352 (Final) R827351 (Final) R827353 (Final) R827354 (Final) R827355 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R832416 (2009) R832416C003 (2009) |
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Fine PM, Jaques PA, Hering SV, Sioutas C. Performance evaluation and use of a continuous monitor for measuring size-fractionated PM2.5 nitrate. Aerosol Science and Technology 2003;37(4):342-354. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit |
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Fine PM, Chakrabarti B, Krudysz M, Schauer JJ, Sioutas C. Diurnal variations of individual organic compound constituents of ultrafine and accumulation mode particulate matter in the Los Angeles Basin. Environmental Science & Technology 2004;38(5):1296-1304. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Fine PM, Shen S, Sioutas C. Inferring the sources of fine and ultrafine particulate matter at downwind receptor sites in the Los Angeles Basin using multiple continuous measurements. Aerosol Science and Technology 2004;38(Suppl 1):182-195. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit |
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Fruin SA, St Denis MJ, Winer AM, Colome SD, Lurmann FW. Reductions in human benzene exposure in the California South Coast Air Basin. Atmospheric Environment 2001;35(6):1069-1077. |
R827352 (2004) R827352 (Final) R827352C015 (Final) |
Exit Exit Exit |
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Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16(6):737-743. |
R827352 (Final) R827352C007 (Final) R827352C009 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2005) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) |
Exit Exit |
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Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet 2007;369(9561):571-577. |
R827352 (Final) R827352C007 (Final) R831861 (2005) R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) |
Exit Exit |
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Geller MD, Kim S, Misra C, Sioutas C, Olson BA, Marple VA. A methodology for measuring size-dependent chemical composition of ultrafine particles. Aerosol Science and Technology 2002;36(6):748-762. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C009 (2002) |
Exit Exit |
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Geller MD, Fine PM, Sioutas C. The relationship between real-time and time-integrated coarse (2.5-10 µm), intermodal (1-2.5 µm), and fine (< 2.5 µm) particulate matter in the Los Angeles Basin. Journal of the Air & Waste Management Association 2004;54(9):1029-1039. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Geller MD, Sardar SB, Phuleria H, Fine PM, Sioutas C. Measurements of particle number and mass concentrations and size distributions in a tunnel environment. Environmental Science & Technology 2005;39(22):8653-8663. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Geller MD, Ntziachristos L, Mamakos A, Samaras Z, Schmitz DA, Froines JR, Sioutas C. Physicochemical and redox characteristics of particulate matter (PM) emitted from gasoline and diesel passenger cars. Atmospheric Environment 2006;40(36):6988-7004. |
R827352 (Final) R832413 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Geller M, Biswas S, Sioutas C. Determination of particle effective density in urban environments with a differential mobility analyzer and aerosol particle mass analyzer. Aerosol Science and Technology 2006;40(9):709-723. |
R827352 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Gong Jr. H, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles:methodology and preliminary health-effect findings. Inhalation Toxicology 2000;12(Suppl 1):107-119. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit |
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Gong Jr. H, Linn WS, Sioutas C, Terrell SL, Clark KW, Anderson KR, Terrell LL. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhalation Toxicology 2003;15(4):305-325. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R831861 (2005) |
Exit |
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Gong Jr. H, Linn WS, Terrell SL, Clark KW, Geller MD, Anderson KR, Cascio WE, Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhalation Toxicology 2004;16(6-7):335-343. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R834797 (2016) |
Exit |
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Gong Jr. H, Linn WS, Terrell SL, Anderson KR, Clark KW, Sioutas C, Cascio WE, Alexis N, Devlin RB. Exposures of elderly volunteers with and without chronic obstructive pulmonary disease (COPD) to concentrated ambient fine particulate pollution. Inhalation Toxicology 2004;16(11-12):731-744. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) R831861 (2005) |
Exit |
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Gong Jr. H, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhalation Toxicology 2005;17(3):123-132. |
R827352 (Final) R827352C012 (Final) R827352C014 (Final) R826708 (Final) R827999 (Final) R831861 (2005) |
Exit Exit |
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Gong Jr. H, Linn WS, Clark KW, Anderson KR, Sioutas C, Alexis NE, Cascio WE, Devlin RB. Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in Los Angeles. Inhalation Toxicology 2008;20(6):533-545. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit |
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Hao M, Comier S, Wang M, Lee JJ, Nel A. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. Journal of Allergy and Clinical Immunology 2003;112(5):905-914. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
Exit Exit |
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Hasson AS, Paulson SE. An investigation of the relationship between gas-phase and aerosol-borne hydroperoxides in urban air. Journal of Aerosol Science 2003;34(4):459-468. |
R827352 (2004) R827352 (Final) |
Exit Exit Exit |
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Hering S, Fine PM, Sioutas C, Jaques PA, Ambs JL, Hogrefe O, Demerjian KL. Field assessment of the dynamics of particulate nitrate vaporization using differential TEOM® and automated nitrate monitors. Atmospheric Environment 2004;38(31):5183-5192. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave J-C, Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. Journal of Immunology 2000;165(5):2703-2711. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
Exit Exit |
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Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Journal of Applied Toxicology 2005;25(1):47-51. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
Exit |
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Houston D, Wu J, Ong P, Winer A. Structural disparities of urban traffic in Southern California: implications for vehicle-related air pollution exposure in minority and high-poverty neighborhoods. Journal of Urban Affairs 2004;26(5):565-592. |
R827352 (2004) R827352 (Final) R827352C015 (Final) |
Exit Exit |
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Houston D, Ong P, Wu J, Winer A. Proximity of licensed child care facilities to near-roadway vehicle pollution. American Journal of Public Health 2006;96(9):1611-1617. |
R827352 (Final) R827352C015 (Final) |
Exit Exit Exit |
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Jaques PA, Ambs JL, Grant WL, Sioutas C. Field evaluation of the differential TEOM monitor for continuous PM2.5 mass concentrations. Aerosol Science and Technology 2004;38(Suppl 1):49-59. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit |
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Khlystov A, Zhang Q, Jimenez JL, Stanier C, Pandis SN, Canagaratna MR, Fine P, Misra C, Sioutas C. In situ concentration of semi-volatile aerosol using water-condensation technology. Journal of Aerosol Science 2005;36(7):866-880. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicology and Applied Pharmacology 2006;210(1-2):47-54. |
R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
Exit Exit Exit |
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Kim HT, Zhu Y, Hinds WC, Lee KW. Experimental study of small cyclones as particle concentrators. Journal of Aerosol Science 2002;33(5):721-733. |
R827352 (Final) R827352C006 (Final) |
Exit Exit Exit |
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Kim S, Chang M-C, Kim D, Sioutas C. A new generation of portable coarse, fine, and ultrafine particle concentrators for use in inhalation toxicology. Inhalation Toxicology 2000;12(Suppl 1):121-137. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit |
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Kim S, Sioutas C, Chang M-C, Gong Jr. H. Factors affecting the stability of the performance of ambient fine-particle concentrators. Inhalation Toxicology 2000;12(Suppl 4):281-298. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R825513C024 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R828598 (Final) R828598C700 (Final) |
Exit |
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Kim S, Jaques PA, Chang M, Froines JR, Sioutas C. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part I:Development and laboratory characterization. Journal of Aerosol Science 2001;32(11):1281-1297. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Kim S, Jaques PA, Chang M, Barone T, Xiong C, Friedlander SK, Sioutas C. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part II:Field evaluation. Journal of Aerosol Science 2001;32(11):1299-1314. |
R827352 (2004) R827352 (Final) R827352C003 (Final) R827352C014 (Final) R826232 (2000) |
Exit Exit Exit |
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Kim S, Shen S, Sioutas C, Zhu Y, Hinds WC. Size distribution and diurnal and seasonal trends of ultrafine particles in source and receptor sites of the Los Angeles Basin. Journal of the Air & Waste Management Association 2002;52(3):297-307. |
R827352 (2004) R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Journal of the Air & Waste Management Association 2005;55(9):1277-1288. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C005 (Final) R827352C014 (Final) R832413C003 (2010) |
Exit Exit |
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Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhalation Toxicology 2007;19(Suppl 1):117-126. |
R827352 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C003 (2007) |
Exit |
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Kuhn T, Biswas S, Fine PM, Geller M, Sioutas C. Physical and chemical characteristics and volatility of PM in the proximity of a light-duty vehicle freeway. Aerosol Science and Technology 2005;39(4):347-357. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Kuhn T, Biswas S, Sioutas C. Diurnal and seasonal characteristics of particle volatility and chemical composition in the vicinity of a light-duty vehicle freeway. Atmospheric Environment 2005;39(37):7154-7166. |
R827352 (Final) |
Exit Exit Exit |
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|
Kuhn T, Krudysz M, Zhu Y, Fine PM, Hinds WC, Froines J, Sioutas C. Volatility of indoor and outdoor ultrafine particulate matter near a freeway. Journal of Aerosol Science 2005;36(3):291-302. |
R827352 (2004) R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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|
Kunzli N, Perez L, Lurmann F, Hricko A, Penfold B, McConnell R. An attributable risk model for exposures assumed to cause both chronic disease and its exacerbations. Epidemiology 2008;19(2):179-185. |
R827352 (Final) R831845 (2005) R831861 (Final) R831861C001 (2007) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
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|
Lall AA, Friedlander SK. On-line measurement of ultrafine aggregate surface area and volume distributions by electrical mobility analysis: I. Theoretical analysis. Journal of Aerosol Science 2006;37(3):260-271. |
R827352 (Final) |
Exit Exit Exit |
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|
Lall AA, Seipenbusch M, Rong W, Friedlander SK. On-line measurement of ultrafine aggregate surface area and volume distributions by electrical mobility analysis: II. Comparison of measurements and theory. Journal of Aerosol Science 2006;37(3):272-282. |
R827352 (Final) |
Exit Exit Exit |
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|
Lee JH, Hopke PK, Holsen TM, Lee D-W, Jaques PA, Sioutas C, Ambs JL. Performance evaluation of continuous PM2.5 mass concentration monitors. Journal of Aerosol Science 2005;36(1):95-109. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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|
Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, Nel A. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. Journal of Immunology 2000;165(6):3393-3401. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C013 (Final) |
Exit Exit |
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|
Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhalation Toxicology 2002;14(5):459-486. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
Exit |
|
|
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 2003;111(4):455-460. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C014 (Final) |
Exit |
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|
Li N, Hao M, Phalen RF, Hinds WC, Nel AE. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clinical Immunology 2003;109(3):250-265. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C006 (Final) R827352C016 (Final) |
Exit Exit |
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|
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. Journal of Immunology 2004;173(5):3467-3481. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C013 (Final) R827352C014 (Final) |
Exit Exit |
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|
Li N, Nel AE. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation:implications for the impact of particulate pollutants on asthma. Antioxidants & Redox Signaling 2006;8(1-2):88-98. |
R827352 (Final) R827352C002 (Final) |
Exit |
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|
Linn WS, Szlachcic Y, Gong Jr. H, Kinney PL, Berhane KT. Air pollution and daily hospital admissions in metropolitan Los Angeles. Environmental Health Perspectives 2000;108(5):427-434. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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Linn WS, Avila M, Gong H Jr. Exhaled nitric oxide: sources of error in offline measurement. Archives of Environmental Health 2004;59(8):385-391. |
R827352 (Final) R827352C011 (Final) R827352C012 (Final) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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|
Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827351 (2002) R827351 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827354 (Final) R827355 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) |
Exit |
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|
Lu R, Wu J, Turco RP, Winer AM, Atkinson R, Arey J, Paulson SE, Lurmann FW, Miguel AH, Eiguren-Fernandez A. Naphthalene distributions and human exposure in Southern California. Atmospheric Environment 2005;39(3):489-507. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C015 (Final) R831861 (2004) R831861 (2005) |
Exit Exit Exit |
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|
Majestic BJ, Schauer JJ, Shafer MM, Turner JR, Fine PM, Singh M, Sioutas C. Development of a wet-chemical method for the speciation of iron in atmospheric aerosols. Environmental Science & Technology 2006;40(7):2346-2351. |
R827352 (Final) R832413C001 (Final) |
Exit Exit Exit |
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|
McConnell R, Jones C, Milam J, Gonzalez P, Berhane K, Clement L, Richardson J, Hanley-Lopez J, Kwong K, Maalouf N, Galvan J, Platts-Mills T. Cockroach counts and house dust allergen concentrations after professional cockroach control and cleaning. Annals of Allergy, Asthma & Immunology 2003;91(6):546-552. |
R827352 (2004) R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) |
Exit Exit |
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|
McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. |
R827352 (2004) R827352 (Final) R827352C007 (Final) R827352C009 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R831861 (2004) R831861 (2005) |
Exit Exit Exit |
|
|
McConnell R, Berhane K, Molitor J, Gilliland F, Kunzli N, Thorne PS, Thomas D, Gauderman WJ, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. |
R827352 (Final) R827352C007 (Final) R826708 (Final) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (2007) R831861C003 (Final) |
|
|
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McConnell R, Berhane K, Yao L, Lurmann FW, Avol E, Peters JM. Predicting residential ozone deficits from nearby traffic. Science of the Total Environment 2006;363(1-3):166-174. |
R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2005) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
|
|
McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. |
R827352 (Final) R827352C007 (Final) R826708 (Final) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (2007) R831861C003 (Final) |
|
|
|
McConnell R, Islam T, Shankardass K, Jerrett M, Lurmann F, Gilliland F, Gauderman J, Avol E, Kunzli N, Yao L, Peters J, Berhane K. Childhood incident asthma and traffic-related air pollution at home and school. Environmental Health Perspectives 2010;118(7):1021-1026. |
R827352 (Final) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
|
|
|
Miguel AH, Eiguren-Fernandez A, Jaques PA, Froines JR, Grant BL, Mayo PR, Sioutas C. Seasonal variation of the particle size distribution of polycyclic aromatic hydrocarbons and of major aerosol species in Claremont, California. Atmospheric Environment 2004;38(20):3241-3251. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Miguel AH, Eiguren-Fernandez A, Sioutas C, Fine PM, Geller M, Mayo PR. Observations of twelve USEPA priority polycyclic aromatic hydrocarbons in the Aitken size range (10-32 nm Dp). Aerosol Science and Technology 2005;39(5):415-418. |
R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
Exit Exit |
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|
Misra C, Geller MD, Shah P, Sioutas C, Solomon PA. Development and evaluation of a continuous coarse (PM10-PM2.5) particle monitor. Journal of the Air & Waste Management Association 2001;51(9):1309-1317. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Misra C, Singh M, Shen S, Sioutas C, Hall PM. Development and evaluation of a personal cascade impactor sampler (PCIS). Journal of Aerosol Science 2002;33(7):1027-1047. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C007 (2001) R828678C007 (2002) R828678C007 (2003) R828678C007 (2004) R828678C007 (Final) R828678C009 (2003) R828678C009 (Final) |
Exit Exit Exit |
|
|
Misra C, Kim S, Shen S, Sioutas C. A high flow rate, very low pressure drop impactor for inertial separation of ultrafine from accumulation mode particles. Journal of Aerosol Science 2002;33(5):735-752. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Misra C, Geller MD, Sioutas C, Solomon PA. Development and evaluation of a PM10 impactor-inlet for a continuous coarse particle monitor. Aerosol Science and Technology 2003;37(3):271-281. |
R827352 (Final) R827352C014 (Final) |
Exit Exit |
|
|
Misra C, Fine PM, Singh M, Sioutas C. Development and evaluation of a compact facility for exposing humans to concentrated ambient ultrafine particles. Aerosol Science and Technology 2004;38(1):27-35. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C009 (2001) R828678C009 (Final) |
Exit Exit Exit |
|
|
Molitor J, Molitor N-T, Jerrett M, McConnell R, Gauderman J, Berhane K, Thomas D. Bayesian modeling of air pollution health effects with missing exposure data. American Journal of Epidemiology 2006;164(1):69-76. |
R827352 (Final) R831845 (2005) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit |
|
|
Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma:evidence for the involvement of organic chemicals and oxidative stress. Current Opinion in Pulmonary Medicine 2001;7(1):20-26. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
Exit |
|
|
Nel AE. Air pollution-related illness: effects of particles. Science 2005;308(5723):804-806. |
R827352 (Final) R827352C002 (Final) |
Exit |
|
|
Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311(5761):622-627. |
R827352 (Final) R832413 (Final) |
Exit |
|
|
Oldham MJ, Phalen RF. Dosimetry implications of upper tracheobronchial airway anatomy in two mouse varieties. The Anatomical Record Part A:Discoveries in Molecular, Cellular, and Evolutionary Biology 2002;268(1):59-65. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
Exit Exit Exit |
|
|
Oldham MJ, Phalen RF, Robinson RJ, Kleinman MT. Performance of a portable whole-body mouse exposure system. Inhalation Toxicology 2004;16(9):657-662. |
R827352 (2004) R827352 (Final) R827352C005 (Final) R827352C016 (Final) |
Exit Exit |
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|
Pan C-JG, Schmitz DA, Cho AK, Froines J, Fukuto JM. Inherent redox properties of diesel exhaust particles: catalysis of the generation of reactive oxygen species by biological reductants. Toxicological Sciences 2004;81(1):225-232. |
R827352 (2004) R827352 (Final) R827352C001 (Final) |
Exit Exit Exit |
|
|
Phalen RF, Oldham MJ. Methods for modeling particle deposition as a function of age. Respiratory Physiology 2001;128(1):119-130. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
Exit Exit Exit |
|
|
Phalen RF. The particulate air pollution controversy. Nonlinearity in Biology, Toxicology, and Medicine 2004;2(1):259-292. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
Exit Exit Exit |
|
|
Phalen RF, Oldham MJ, Nel AE. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicological Sciences 2006;92(1):126-132. |
R827352 (Final) R827352C016 (Final) R832413 (Final) |
Exit Exit Exit |
|
|
Phares DJ, Rhoads KP, Wexler AS, Kane DB, Johnston MV. Application of the ART-2a algorithm to laser ablation aerosol mass spectrometry of particle standards. Analytical Chemistry 2001;73(10):2338-2344. |
R827352 (Final) R826234 (Final) |
Exit Exit Exit |
|
|
Phousongphouang PT, Arey J. Sources of the atmospheric contaminants, 2-nitrobenzanthrone and 3-nitrobenzanthrone. Atmospheric Environment 2003;37(23):3189-3199. |
R827352 (Final) |
Exit Exit Exit |
|
|
Phuleria HC, Fine PM, Zhu Y, Sioutas C. Air quality impacts of the October 2003 Southern California wildfires. Journal of Geophysical Research: Atmospheres 2005;110(D7):D07S20. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Phuleria HC, Geller MD, Fine PM, Sioutas C. Size-resolved emissions of organic tracers from light-and heavy-duty vehicles measured in a California roadway tunnel. Environmental Science & Technology 2006;40(13):4109-4118. |
R827352 (Final) R832413C001 (Final) |
Exit Exit Exit |
|
|
Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Lippmann M, Cohen M. Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and-2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health, Part A:Current Issues 2006;69(10):935-951. |
R827352 (Final) R827352C014 (Final) R827351 (Final) R827351C008 (Final) R827351C010 (Final) R827355 (Final) R827355C008 (Final) R832413C001 (Final) |
Exit |
|
|
Reisen F, Wheeler S, Arey J. Methyl- and dimethyl-/ethyl-nitronaphthalenes measured in ambient air in Southern California. Atmospheric Environment 2003;37(26):3653-3657. |
R827352 (2004) R827352 (Final) |
Exit Exit Exit |
|
|
Reisen F, Arey J. Atmospheric reactions influence seasonal PAH and nitro-PAH concentrations in the Los Angeles Basin. Environmental Science & Technology 2005;39(1):64-73. |
R827352 (Final) |
Exit Exit Exit |
|
|
Rodriguez CE, Shinyashiki M, Froines J, Yu RC, Fukuto JM, Cho AK. An examination of quinone toxicity using the yeast Saccharomyces cerevisiae model system. Toxicology 2004;201(1-3):185-196. |
R827352 (2004) R827352 (Final) R827352C001 (Final) |
Exit Exit Exit |
|
|
Rodriguez CE, Fukuto JM, Taguchi K, Froines J, Cho AK. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Chemico-Biological Interactions 2005;155(1-2):97-110. |
R827352 (Final) R827352C001 (Final) R832413C003 (2010) |
Exit Exit Exit |
|
|
Sardar SB, Fine PM, Yoon H, Sioutas C. Associations between particle number and gaseous co-pollutant concentrations in the Los Angeles Basin. Journal of the Air & Waste Management Association 2004;54(8):992-1005. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit |
|
|
Sardar SB, Fine PM, Sioutas C. Seasonal and spatial variability of the size-resolved chemical composition of particulate matter (PM10) in the Los Angeles Basin. Journal of Geophysical Research: Atmospheres 2005;110(D7):D07S08. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Sardar SB, Fine PM, Mayo PR, Sioutas C. Size-fractionated measurements of ambient ultrafine particle chemical composition in Los Angeles using the NanoMOUDI. Environmental Science & Technology 2005;39(4):932-944. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Sardar SB, Geller MD, Sioutas C, Solomon PA. Development and evaluation of a high-volume dichotomous sampler for chemical speciation of coarse and fine particles. Journal of Aerosol Science 2006;37(11):1455-1466. |
R827352 (Final) R832413C001 (Final) |
Exit Exit Exit |
|
|
Shen S, Jaques PA, Zhu Y, Geller MD, Sioutas C. Evaluation of the SMPS–APS system as a continuous monitor for measuring PM2.5, PM10 and course (PM2.5–10) concentrations. Atmospheric Environment 2002;36(24):3939-3950. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Singh M, Jaques PA, Sioutas C. Size distribution and diurnal characteristics of particle-bound metals in source and receptor sites of the Los Angeles Basin. Atmospheric Environment 2002;36(10):1675-1689. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Singh M, Misra C, Sioutas C. Field evaluation of a personal cascade impactor sampler (PCIS). Atmospheric Environment 2003;37(34):4781-4793. |
R827352 (Final) R827352C014 (Final) R828678C009 (2002) R828678C009 (2003) R828678C009 (Final) |
Exit Exit Exit |
|
|
Sioutas C, Kim S, Chang M, Terrell LL, Gong Jr. H. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmospheric Environment 2000;34(28):4829-4838. |
R827352 (Final) R827352C012 (Final) R827352C014 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
Exit Exit Exit |
|
|
Sioutas C, Pandis SN, Allen DT, Solomon PA. Special issue of Atmospheric Environment on findings from EPA's Particulate Matter Supersites Program (Preface by guest editors). Atmospheric Environment 2004;38(20):3101-3106. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Sioutas C, Delfino RJ, Singh M. Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environmental Health Perspectives 2005;113(8):947-955. |
R827352 (Final) R827352C014 (Final) |
Exit |
|
|
Stolzenburg MR, Dutcher DD, Kirby BW, Hering SV. Automated measurement of the size and concentration of airborne particulate nitrate. Aerosol Science and Technology 2003;37(7):537-546. |
R827352 (2004) R827352 (Final) |
Exit Exit |
|
|
Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biology and Medicine 2007;43(5):789-799. |
R827352 (Final) R832413C003 (2010) |
Exit Exit Exit |
|
|
Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology and Medicine 2008;44(8):1645-1655. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) |
Exit Exit Exit |
|
|
Thach CT, Finkelstein JN. Cationic nanoparticles disrupt cellular signaling in a cholesterol dependent manner. Toxicology in Vitro 2013;27(4):1277-1286. |
R827352 (Final) |
Exit Exit Exit |
|
|
Venkataraman C, Habib G, Eiguren-Fernandez A, Miguel AH, Friedlander SK. Residential biofuels in South Asia:carbonaceous aerosol emissions and climate impacts. Science 2005;307(5714):1454-1456. |
R827352 (Final) R827352C013 (Final) |
Exit Exit |
|
|
Westerdahl D, Fruin S, Sax T, Fine PM, Sioutas C. Mobile platform measurements of ultrafine particles and associated pollutant concentrations on freeways and residential streets in Los Angeles. Atmospheric Environment 2005;39(20):3597-3610. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
|
|
Westerdahl D, Fruin SA, Fine PL, Sioutas C. The Los Angeles International Airport as a source of ultrafine particles and other pollutants to nearby communities. Atmospheric Environment 2008;42(13):3143-3155. |
R827352 (Final) R831861 (2005) R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. Journal of Immunology 2002;168(5):2560-2567. |
R827352 (Final) R827352C002 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) |
Exit Exit |
|
|
Wilhelm M, Ritz B. Residential proximity to traffic and adverse birth outcomes in Los Angeles County, California, 1994–1996. Environmental Health Perspectives 2003;111(2):207-216. |
R827352 (Final) R827352C008 (Final) |
|
|
|
Wilhelm M, Ritz B. Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA. Environmental Health Perspectives 2005;113(9):1212-1221. |
R827352 (Final) R827352C008 (Final) |
Exit Exit |
|
|
Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovascular Toxicology 2006;6(1):69-78. |
R827352 (Final) R831952 (2005) R831952 (Final) R832413 (2008) R832413 (Final) R832413C001 (2007) R832413C001 (Final) |
Exit |
|
|
Wu J, Lurmann F, Winer A, Lu R, Turco R, Funk T. Development of an individual exposure model for application to the Southern California Children's Health Study. Atmospheric Environment 2005;39(2):259-273. |
R827352 (Final) R827352C015 (Final) R828172 (Final) R831845 (2005) R831861 (2004) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit Exit Exit |
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Wu J, Funk T, Lurmann F, Winer A. Improving spatial accuracy of roadway networks and geocoded addresses. Transactions in GIS 2005;9(4):585-601. |
R827352 (Final) R827352C015 (Final) R831845 (2005) R831861 (2005) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
Exit |
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Xia T, Korge P, Weiss JN, Li N, Venkatesan MI, Sioutas C, Nel A. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environmental Health Perspectives 2004;112(14):1347-1358. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
Exit |
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Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Letters 2006;6(8):1794-1807. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2006) R832413C002 (2008) |
Exit Exit Exit |
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Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng C-A, Sioutas C, Borok Z, Kim K-J, Crandall ED. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicology in Vitro 2007;21(8):1373-1381. |
R827352 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
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Yu RC, Teh HW, Jaques PA, Sioutas C, Froines JR. Quality control of semi-continuous mobility size-fractionated particle number concentration data. Atmospheric Environment 2004;38(20):3341-3348. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhang KM, Wexler AS, Zhu YF, Hinds WC, Sioutas C. Evolution of particle number distribution near roadways. Part II:The 'Road-to-Ambient' process. Atmospheric Environment 2004;38(38):6655-6665. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhang KM, Wexler AS, Niemeier DA, Zhu YF, Hinds WC, Sioutas C. Evolution of particle number distribution near roadways. Part III:Traffic analysis and on-road size resolved particulate emission factors. Atmospheric Environment 2005;39(22):4155-4166. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhao Y, Bein KJ, Wexler AS, Misra C, Fine PM, Sioutas C. Field evaluation of the versatile aerosol concentration enrichment system (VACES) particle concentrator coupled to the rapid single-particle mass spectrometer (RSMS-3). Journal of Geophysical Research: Atmospheres 2005;110(D7):D07S02. |
R827352 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhu Y, Hinds WC, Kim S, Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. Journal of the Air & Waste Management Association 2002;52(9):1032-1042. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhu Y, Hinds WC, Kim S, Shen S, Sioutas C. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmospheric Environment 2002;36(27):4323-4335. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhu Y, Hinds WC, Shen S, Sioutas C. Seasonal trends of concentration and size distribution of ultrafine particles near major highways in Los Angeles. Aerosol Science and Technology 2004;38(Suppl 1):5-13. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit |
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Zhu Y, Hinds WC, Krudysz M, Kuhn T, Froines J, Sioutas C. Penetration of freeway ultrafine particles into indoor environments. Journal of Aerosol Science 2005;36(3):303-322. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Zhu Y, Hinds WC. Predicting particle number concentrations near a highway based on vertical concentration profile. Atmospheric Environment 2005;39(8):1557-1566. |
R827352 (Final) R827352C006 (Final) |
Exit Exit Exit |
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Zhu Y, Kuhn T, Mayo P, Hinds WC. Comparison of daytime and nighttime concentration profiles and size distributions of ultrafine particles near a major highway. Environmental Science & Technology 2006;40(8):2531-2536. |
R827352 (Final) R827352C006 (Final) R832413C005 (Final) |
Exit Exit Exit |
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Zhu Y, Yu N, Kuhn T, Hinds WC. Field comparison of P-trak and condensation particle counters. Aerosol Science and Technology 2006;40(6):422-430. |
R827352 (Final) R827352C006 (Final) R832413C005 (Final) |
Exit Exit |
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Zhu Y, Eiguren-Fernandez A, Hinds WC, Miguel AH. In-cabin commuter exposure to ultrafine particles on Los Angeles freeways. Environmental Science & Technology 2007;41(7):2138-2145. |
R827352 (Final) R832413 (2008) R832413 (Final) R832413C005 (2007) R832413C005 (2008) R832413C005 (Final) |
Exit Exit Exit |
Supplemental Keywords:
Particulate matter, quinones, PAHs, aldehydes, ketones, metals, allergic airway disease, human exposure studies, asthma, cardiovascular effects, aerosol sampling, atmospheric aerosol, environmental monitoring, environmental statistics, California., RFA, Health, Scientific Discipline, Air, Geographic Area, particulate matter, Environmental Chemistry, Health Risk Assessment, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Children's Health, genetic susceptability, indoor air, ambient aerosol, asthma, health effects, particulates, sensitive populations, asthma triggers, environmental triggers, air toxics, human health effects, toxicology, airway disease, lead, biological response, outdoor air, air pollution, children, household, Human Health Risk Assessment, PAH, human exposure, bioaerosols, particulate exposure, assessment of exposure, childhood respiratory disease, trajectory modeling, PM, environmentally caused disease, environmental health hazard, indoor air quality, inhaled particles, California (CA), allergens, allergic response, acute exposure, aerosols, air quality, allergen, atmospheric chemistry, dosimetry, exposure assessment, human health risk, particle transport, toxics, particle concentratorRelevant Websites:
http://www.scpcs.ucla.edu/ Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827352C001 The Chemical Toxicology of Particulate Matter
R827352C002 Pro-inflammatory and the Pro-oxidative Effects of Diesel Exhaust Particulate in Vivo and in Vitro
R827352C003 Measurement of the “Effective” Surface Area of Ultrafine and Accumulation Mode PM (Pilot Project)
R827352C004 Effect of Exposure to Freeways with Heavy Diesel Traffic and Gasoline Traffic on Asthma Mouse Model
R827352C005 Effects of Exposure to Fine and Ultrafine Concentrated Ambient Particles near a Heavily Trafficked Freeway in Geriatric Rats (Pilot Project)
R827352C006 Relationship Between Ultrafine Particle Size Distribution and Distance From Highways
R827352C007 Exposure to Vehicular Pollutants and Respiratory Health
R827352C008 Traffic Density and Human Reproductive Health
R827352C009 The Role of Quinones, Aldehydes, Polycyclic Aromatic Hydrocarbons, and other Atmospheric Transformation Products on Chronic Health Effects in Children
R827352C010 Novel Method for Measurement of Acrolein in Aerosols
R827352C011 Off-Line Sampling of Exhaled Nitric Oxide in Respiratory Health Surveys
R827352C012 Controlled Human Exposure Studies with Concentrated PM
R827352C013 Particle Size Distributions of Polycyclic Aromatic Hydrocarbons in the LAB
R827352C014 Physical and Chemical Characteristics of PM in the LAB (Source Receptor Study)
R827352C015 Exposure Assessment and Airshed Modeling Applications in Support of SCPC and CHS Projects
R827352C016 Particle Dosimetry
R827352C017 Conduct Research and Monitoring That Contributes to a Better Understanding of the Measurement, Sources, Size Distribution, Chemical Composition, Physical State, Spatial and Temporal Variability, and Health Effects of Suspended PM in the Los Angeles Basin (LAB)
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.