Grantee Research Project Results
2006 Progress Report: Southern California Particle Center (SCPC)
EPA Grant Number: R832413Center: Southern California Particle Center
Center Director: Froines, John R.
Title: Southern California Particle Center (SCPC)
Investigators: Froines, John R. , Hinds, William C. , Vaziri, Nosratola D , Nel, Andre E. , Schauer, James J. , Cho, Arthur K. , Kleinman, Michael T. , Lusis, Aldons , Miguel, Antonio , Sioutas, Constantinos , Harkema, Jack , Staimer, Norbert , Delfino, Ralph , Neuhausen, Susan , Zhu, Yifang , Kumagai, Yoshito
Current Investigators: Froines, John R. , Sioutas, Constantinos , Cho, Arthur K. , Hinds, William C. , Nel, Andre E. , Kleinman, Michael T. , Harkema, Jack , Stram, Dan , Schauer, James J. , Fukuto, Jon , Kumagai, Yoshito , Lusis, Aldons , Delfino, Ralph , Neuhausen, Susan , Staimer, Norbert , Vaziri, Nostratola , Fine, Philip M.
Institution: University of California - Los Angeles , University of California - Irvine , University of Tsukuba , University of Southern California , University of Wisconsin - Madison , Michigan State University
Current Institution: University of California - Los Angeles , Michigan State University , University of California - Irvine , University of Southern California , University of Wisconsin - Madison , University of Tsukuba
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2012)
Project Period Covered by this Report: October 1, 2005 through September 30, 2006
Project Amount: $7,999,994
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
The overall objective of the Southern California Particle Center (SCPC) is to investigate the mechanisms that produce the health effects associated with exposure to particulate matter (PM), and to understand how toxic mechanisms and resulting health effects vary with the source, chemical composition, and physical characteristics of PM.
The SCPC relies on a team of highly respected researchers committed to developing a strong multidisciplinary program to address the challenging public health issues posed by PM pollution, with a focus on the unique urban setting of the Los Angeles air basin. Our research projects are united by a hypothesis that chemical composition and physical characteristics related to PM sources determine the toxicity and exposure-response of PM. Variations in exposure according to source, season, and location influence the resulting human health responses. The principal mechanistic hypothesis of the SCPC is that many health effects associated with PM exposure including adverse respiratory and cardiovascular outcomes derive from the induction of oxidative stress by reactive chemical species (organic or inorganic) in PM. Oxidative stress and inflammatory responses related to asthma and atherosclerosis are a particular focus. Integral to our toxicological hypothesis is the role of antioxidant defense pathways that protect against the pro-inflammatory effects of PM.
The studies undertaken by the SCPC address research priorities in source linkages, susceptibility to PM, biological mechanisms for PM, and exposure-response relationships as identified by the U.S. Environmental Protection Agency (EPA). Our research to address these priorities is integrated across a wide variety of disciplines, including aerosol formation and characterization, advanced analytical chemistry, exposure assessment, chemical toxicology, genetic toxicology and immunology, animal toxicology, epidemiology and biostatistics. Linking the diverse research efforts into a coordinated whole is an overarching theme, as illustrated in the pictorial diagram of the five SCPC projects (Figure 1).
Figure 1.
Progress Summary:
The first months of the new Southern California Particle Center (SCPC) have been quite successful with all projects initiating their planned research. A major freeway sampling campaign was completed, which included high volume filter collections of coarse, fine, and ultrafine PM; analysis of polycyclic aromatic hydrocarbon (PAH) and tracer concentrations for emission factor calculations; collection of coarse, fine, and ultrafine PM to be used for chemical toxicology and in vitro studies; tandem differential mobility analyzer measurements of particle diameter/volatility; particle surface area measurements; and ultrafine mass chemical composition analyses. All of the above analyses resulting from the freeway campaign are completed or underway, and Project 1 has produced three manuscripts for publication. In Project 2, two in vivo animal studies of mice with genetic susceptibility to atherosclerosis (ApoE null and LDL receptor knockout mice) have been performed. ApoE null mice exposed to fine and ultrafine PM displayed increased atherosclerotic lesional area in the aorta compared to control animals, while PM exposure did not enhance lesions in mice that lack LDL receptors and were maintained on a Western Diet. Brain tissues from the ApoE mice displayed elevated expression levels of a key transcription factor. Further analyses of the biological samples collected from exposed and control mice in these experiments are underway. In vitro studies of particles have also advanced during year 1 of the SCPC, with a study from Project 2 that compared ambient ultrafines to a variety of commercial nanoparticles in cell-free and cellular assays designed to detect production of reactive oxygen species and oxidative toxicity in test cells. Project 3 completed the analysis of quinone species in particle and gaseous samples collected across the Los Angeles Basin, and reports that the concentration of some of the assayed species increases as the air mass ages, suggesting that these redox active compounds are photochemically produced. Two assays for reactive oxygen species were performed on a wide range of indoor and outdoor samples collected at retirement homes. Analysis of the freeway samples in redox and other assays is underway in the laboratories of Projects 2 and 3. Progress was reported on deciphering the mechanisms by which quinones may promote cellular changes, in a study showing increased activation of a key protein tyrosine kinase receptor in treated cells. Project 4 has followed 32 elderly people with coronary artery disease, with weekly blood draws. Glutathione Peroxidase-1, superoxide dismutase, hemoglobin and myeloperoxidase assays are underway. The protocols for determination of 8-isoprostane and the ratio of glutathione to reduced glutathione are being refined for successful application to the collected biological samples. A new Project 5 has been added to the SCPC. Project 5 developed a proposal and conducted preliminary measurements to support the design of a planned high volume sampling system for capturing both the particulate and vapor phase contaminants in a 500 m3 air sample. An instrumented van was used in studies of changes in ultrafine particles near freeways by taking Transmission Electron Microscopy (TEM) samples for morphological analysis of 50 nm mobility diameter particles. Results suggest that the aerosols were internally mixed. Year 1 summaries for the individual projects, containing results and findings, will follow.
Research Challenges. The SCPC did not experience any significant difficulties during the reporting period.
Individual Research Project Goals/Hypotheses Changes and Rationale. A new Project 5 has been added to the organization of the SCPC. In the original SCPC proposal, Dr. William Hinds had a role within Project 1, with Dr. Sioutas. Since that time, Dr. Hinds has introduced a proposal to take advantage of an opportunity for a jointly funded project with the SCPC and the California Air Resources Board. In Project 5, Dr. Hinds proposes to collect large scale samples of fine particles and volatile air components at three different locations: on a freeway to collect fresh traffic emissions of particles and gases; an urban source site not directly on a freeway, and an urban receptor site that will reflect photochemical aging of source emissions. The project utilizes a van equipped with a two person exposure chamber and instruments including CPC, SMPS, aethelometer, particle-bound PAH, PM-10, PM-2.5, NOx, CO2, CO, temperature, relative humidity, and GPS, and is jointly funded with the CARB study that seeks to evaluate a variety of short term measures of exposure and response including heart rate variability, and 26 cytokines and other blood factors before, after, and 20 hours after exposure to freeway or filtered air. The large scale samples will be evaluated in a variety of assays by Dr. Cho and his staff (Project 3). The Project 5 description will be submitted to EPA as a separate report.
The rationale underlying additional sample collections and expansion of scope for Project 3 is that SCPC studies completed during this first year of funding have shown that four quinone species are present in both particle and gaseous fractions of ambient air samples across the Los Angeles Basin, and are in fact at higher concentrations in the gaseous phase (please see the report for Project 3). Since quinone compounds contribute to the redox capacity of polluted air, an assessment of total exposure to redox active species requires simultaneous monitoring of both the particulate and gaseous phases at a location of interest. The expanded scope of Project 3 will enable total redox exposure assessment by collecting a set samples dedicated to redox assays, and large enough to meet the needs of the multiple redox and biological assays the SCPC has developed.
Year-1 Center Expenditure. There was a re-budget in the Administrative Core and Project 2. Pursuant to EPA guidelines, a detailed review of the Year-1 financials will be submitted on November 1, 2006.
Research Quality Assurance Requirement. In March 2006, Quality Management Project Plans (QMPP) were submitted to Dr. John Froines, SCPC Principal Investigator, by individual project leads. The documents are filed at the SCPC central management office at UCLA.
Future Activities:
Planned Year-2 Sampling Campaigns
Projects’ Year-2 efforts are in accord with the overall proposed sampling schedule, namely:
Year 2:
Winter: Long Beach - LA Harbor
Summer: 110 freeway (road dust, volatility, gasoline)
Fall: Animal CAP studies at USC
Journal Articles: 157 Displayed | Download in RIS Format
| Other center views: | All 241 publications | 157 publications in selected types | All 157 journal articles |
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Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circulation Research 2008;102(5):589-596. |
R832413 (2008) R832413 (2009) R832413 (2010) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) R832413C002 (Final) R832413C003 (Final) |
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Araujo JA, Nel AE. Particulate matter and atherosclerosis:role of particle size, composition and oxidative stress. Particle and Fibre Toxicology 2009;6:24. |
R832413 (Final) R832413C002 (2010) R832413C002 (Final) |
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Arellanes C, Paulson SE, Fine PM, Sioutas C. Exceeding of Henry's law by hydrogen peroxide associated with urban aerosols. Environmental Science & Technology 2006;40(16):4859-4866. |
R832413 (Final) R832413C001 (Final) R827352 (Final) |
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Arhami M, Kuhn T, Fine PM, Defino RJ, Sioutas C. Effects of sampling artifacts and operating parameters on the performance of a semicontinuous particulate elemental carbon/organic carbon monitor. Environmental Science & Technology 2006;40(3):945-954. |
R832413C001 (Final) R827352 (Final) |
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Arhami M, Polidori A, Delfino RJ, Tjoa T, Sioutas C. Associations between personal, indoor, and residential outdoor pollutant concentrations:implications for exposure assessment to size-fractionated particulate matter. Journal of the Air & Waste Management Association 2009;59(4):392-404. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) |
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Arhami M, Sillanpaa M, Hu S, Olson MR, Schauer JJ, Sioutas C. Size-segregated inorganic and organic components of PM in the communities of the Los Angeles harbor. Aerosol Science and Technology 2009;43(2):145-160. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
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Arhami M, Minguillon MC, Polidori A, Schauer JJ, Delfino RJ, Sioutas C. Organic compound characterization and source apportionment of indoor and outdoor quasi-ultrafine particulate matter in retirement homes of the Los Angeles Basin. Indoor Air 2010;20(1):17-30. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) |
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Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential—a workshop report and consensus statement. Inhalation Toxicology 2008;20(1):75-99. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2008) R832413C003 (2008) R832413C003 (2009) |
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Barone TL, Zhu Y. The morphology of ultrafine particles on and near major freeways. Atmospheric Environment 2008;42(28):6749-6758. |
R832413 (Final) R832413C005 (Final) R827352 (Final) |
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Biswas S, Ntziachristos L, Moore KF, Sioutas C. Particle volatility in the vicinity of a freeway with heavy-duty diesel traffic. Atmospheric Environment 2007;41(16):3479-3493. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2006) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
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Biswas S, Verma V, Schauer JJ, Sioutas C. Chemical speciation of PM emissions from heavy-duty diesel vehicles equipped with diesel particulate filter (DPF) and selective catalytic reduction (SCR) retrofits. Atmospheric Environment 2009;43(11):1917-1925. |
R832413 (2008) R832413 (Final) |
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Biswas S, Verma V, Schauer JJ, Cassee FR, Cho AK, Sioutas C. Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies. Environmental Science & Technology 2009;43(10):3905-3912. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) |
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Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. |
R832413 (Final) R832414 (Final) R832415 (Final) R832416 (Final) R834798 (2013) R834798 (2014) R834798 (2015) R834798 (Final) R834798C001 (2013) R834798C001 (2014) |
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Campbell A, Araujo JA, Li H, Sioutas C, Kleinman M. Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. Journal of Nanoscience and Nanotechnology 2009;9(8):5099-5104. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
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Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. Journal of Allergy and Clinical Immunology 2006;118(2):455-465. |
R832413 (2008) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) R827352 (Final) R827352C002 (Final) |
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Chang J, Delfino RJ, Gillen D, Tjoa T, Nickerson B, Cooper D. Repeated respiratory hospital encounters among children with asthma and residential proximity to traffic. Occupational and Environmental Medicine 2009;66(2):90-98. |
R832413 (2008) R832413 (Final) |
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Chatila TA, Li N, Garcia-Lloret M, Kim H-J, Nel AE. T-cell effector pathways in allergic diseases:transcriptional mechanisms and therapeutic targets. Journal of Allergy and Clinical Immunology 2008;121(4):812-823. |
R832413 (2007) R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) |
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Cheung KL, Polidori A, Ntziachristos L, Tzamkiozis T, Samaras Z, Cassee FR, Gerlofs M, Sioutas C. Chemical characteristics and oxidative potential of particulate matter emissions from gasoline, diesel, and biodiesel cars. Environmental Science & Technology 2009;43(16):6334-6340. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
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Cheung KL, Ntziachristos L, Tzamkiozis T, Schauer JJ, Samaras Z, Moore KF, Sioutas C. Emissions of particulate trace elements, metals and organic species from gasoline, diesel, and biodiesel passenger vehicles and their relation to oxidative potential. Aerosol Science and Technology 2010;44(7):500-513. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) |
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Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environmental Research 2005;99(1):40-47. |
R832413C003 (2010) R832413C003 (Final) R827352 (Final) R827352C001 (Final) R827352C013 (Final) R827352C014 (Final) |
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Daher N, Ning Z, Cho AK, Shafer M, Schauer JJ, Sioutas C. Comparison of the chemical and oxidative characteristics of particulate matter (PM) collected by different methods:filters, impactors, and biosamplers. Aerosol Science and Technology 2011;45(11):1294-1304. |
R832413 (Final) R832413C001 (Final) R832413C003 (Final) |
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Delfino RJ, Staimer N, Gillen D, Tjoa T, Sioutas C, Fung K, George SC, Kleinman MT. Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environmental Health Perspectives 2006;114(11):1736-1743. |
R832413 (Final) R832413C001 (Final) |
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Delfino RJ, Staimer N, Tjoa T, Gillen D, Kleinman MT, Sioutas C, Cooper D. Personal and ambient air pollution exposures and lung function decrements in children with asthma. Environmental Health Perspectives 2008;116(4):550-558. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
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Delfino RJ, Staimer N, Tjoa T, Polidori A, Arhami M, Gillen DL, Kleinman MT, Vaziri ND, Longhurst J, Zaldivar F, Sioutas C. Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environmental Health Perspectives 2008;116(7):898-906. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C004 (2007) R832413C004 (2008) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Staimer N, Tjoa T, Gillen DL, Polidori A, Arhami M, Kleinman MT, Vaziri ND, Longhurst J, Sioutas C. Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms. Environmental Health Perspectives 2009;117(8):1232-1238. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Chang J, Wu J, Ren C, Tjoa T, Nickerson B, Cooper D, Gillen DL. Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the home. Annals of Allergy, Asthma & Immunology 2009;102(2):138-144. |
R832413 (2008) R832413 (Final) |
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Delfino RJ, Brummel S, Wu J, Stern H, Ostro B, Lipsett M, Winer A, Street DH, Zhang L, Tjoa T, Gillen DL. The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003. Occupational and Environmental Medicine 2009;66(3):189-197 |
R832413 (2008) |
not available |
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Delfino RJ, Staimer N, Tjoa T, Arhami M, Polidori A, Gillen DL, Kleinman MT, Schauer JJ, Sioutas C. Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles. Environmental Health Perspectives 2010;118(6):756-762. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Tjoa T, Gillen DL, Staimer N, Polidori A, Arhami M, Jamner L, Sioutas C, Longhurst J. Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease. Epidemiology 2010;21(3):396-404. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (2010) R832413C001 (Final) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Staimer N, Tjoa T, Arhami M, Polidori A, Gillen DL, George SC, Shafer MM, Schauer JJ, Sioutas C. Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort. Epidemiology 2010;21(6):892-902. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Gillen DL, Tjoa T, Staimer N, Polidori A, Arhami M, Sioutas C, Longhurst J. Electrocardiographic ST-segment depression and exposure to traffic-related aerosols in elderly subjects with coronary artery disease. Environmental Health Perspectives 2011;119(2):196-202. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C004 (2010) R832413C004 (Final) |
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Delfino RJ, Staimer N, Vaziri ND. Air pollution and circulating biomarkers of oxidative stress. Air Quality, Atmosphere & Health 2011;4(1):37-52. |
R832413 (Final) R832413C004 (2010) R832413C004 (Final) |
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DiStefano E, Eiguren-Fernandez A, Delfino RJ, Sioutas C, Froines JR, Cho AK. Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles. Inhalation Toxicology 2009;21(9):731-738. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2009) R832413C003 (2010) R832413C004 (2010) |
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Doherty SP, Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Zelikoff JT, Lippmann M, Cohen MD. Detection of changes in alveolar macrophage iron status induced by select PM2.5-associated components using iron-response protein binding activity. Inhalation Toxicology 2007;19(6-7):553-562. |
R832413 (Final) R832413C001 (Final) R827351 (Final) R827352 (Final) R827355 (2004) R827355 (Final) |
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Eiguren-Fernandez A, Avol EL, Thurairatnam S, Hakami M, Froines JR, Miguel AH. Seasonal influence on vapor-and particle-phase polycyclic aromatic hydrocarbon concentrations in school communities located in Southern California. Aerosol Science & Technology 2007;41(4):438-446. |
R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (Final) R827352 (Final) R827352C009 (Final) R827352C013 (Final) |
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Eiguren-Fernandez A, Miguel AH, Lu R, Purvis K, Grant B, Mayo P, Di Stefano E, Cho AK, Froines J. Atmospheric formation of 9,10-phenanthraquinone in the Los Angeles air basin. Atmospheric Environment 2008;42(10):2312-2319. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) R827352 (Final) |
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Eiguren-Fernandez A, Miguel AH, Di Stefano E, Schmitz DA, Cho AK, Thurairatnam S, Avol EL, Froines JR. Atmospheric distribution of gas-and particle-phase quinones in Southern California. Aerosol Science and Technology 2008;42(10):854-861. |
R832413 (2008) R832413 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) R827352 (Final) |
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Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, DiStefano E, Hinds W, Kumagai Y, Cho AK, Froines JR. Redox and electrophilic properties of vapor-and particle-phase components of ambient aerosols. Environmental Research 2010;110(3):207-212. |
R832413 (Final) R832413C003 (2010) R832413C003 (Final) R832413C005 (2010) R832413C005 (Final) |
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Eiguren-Fernandez A, Di Stefano E, Schmitz DA, Guarieiro ALN, Salinas EM, Nasser E, Froines JR, Cho AK. Chemical reactivities of ambient air samples in three Southern California communities. Journal of the Air & Waste Management Association 2015;65(3):270-277. |
R832413 (Final) |
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Ferris DP, Lu J, Gothard C, Yanes R, Thomas CR, Olsen JC, Stoddart JF, Tamanoi F, Zink JI. Synthesis of Biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells. Small 2011;7(13):1816-1826. |
R832413 (Final) |
Exit Exit |
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Fine PM, Sioutas C, Solomon PA. Secondary particulate matter in the United States: insights from the Particulate Matter Supersites Program and related studies. Journal of the Air & Waste Management Association 2008;58(2):234-253. |
R832413 (2008) R832413 (Final) R832413C001 (Final) |
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Fruin SA, Hudda N, Sioutas C, Delfino RJ. Predictive model for vehicle air exchange rates based on a large, representative sample. Environmental Science & Technology 2011;45(8):3569-3575. |
R832413 (Final) R832413C001 (Final) |
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Fruin S, Westerdahl D, Sax T, Sioutas C, Fine PM. Measurements and predictors of on-road ultrafine particle concentrations and associated pollutants in Los Angeles. Atmospheric Environment 2008;42(2):207-219. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
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Fung DC, Zhang QF, Hinds WC, Zhy YF. Particle concentration on freeways: affecting factors and a simple model development. Aerosol and Air Quality Research 2013;13(6):1693-1701. |
R832413C005 (2010) |
Exit Exit |
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Geller MD, Ntziachristos L, Mamakos A, Samaras Z, Schmitz DA, Froines JR, Sioutas C. Physicochemical and redox characteristics of particulate matter (PM) emitted from gasoline and diesel passenger cars. Atmospheric Environment 2006;40(36):6988-7004. |
R832413 (Final) R832413C001 (Final) R827352 (Final) |
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Geller M, Biswas S, Sioutas C. Determination of particle effective density in urban environments with a differential mobility analyzer and aerosol particle mass analyzer. Aerosol Science and Technology 2006;40(9):709-723. |
R832413C001 (Final) R827352 (Final) |
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George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Madler L, Nel AE. Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano 2010;4(1):15-29. |
R832413 (Final) R832413C002 (2010) |
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Gerlofs-Nijland ME, Totlandsdal AI, Kilinc E, Boere AJ, Fokkens PH, Leseman DL, Sioutas C, Schwarze PE, Spronk HM, Hadoke PW, Miller MR, Cassee FR. Pulmonary and cardiovascular effects of traffic-related particulate matter:4-week exposure of rats to roadside and diesel engine exhaust particles. Inhalation Toxicology 2010;22(14):1162-1173. |
R832413 (Final) R832413C001 (Final) |
Exit |
|
|
Gong Jr. H, Linn WS, Clark KW, Anderson KR, Sioutas C, Alexis NE, Cascio WE, Devlin RB. Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in Los Angeles. Inhalation Toxicology 2008;20(6):533-545. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R827352 (Final) |
Exit |
|
|
Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biology 2007;8(7):R149 (13 pp.). |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) |
Exit Exit Exit |
|
|
Gorham KA, Sulbaek Andersen MP, Meinardi S, Delfino RJ, Staimer N, Tjoa T, Rowland FS, Blake DR. Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect. Biomarkers 2009;14(1):17-25. |
R832413 (Final) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) |
Exit Exit |
|
|
Han B, Kim H-J, Kim Y-J, Sioutas C. Unipolar charging of fine and ultra-fine particles using carbon fiber ionizers. Aerosol Science and Technology 2008;42(10):793-800. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
|
|
Han B, Hudda N, Ning Z, Sioutas C. Enhanced unipolar charging of concentration-enriched particles using water-based condensational growth. Journal of Aerosol Science 2008;39(9):770-784. |
R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Han B, Hudda N, Ning Z, Kim H-J, Kim Y-J, Sioutas C. A novel bipolar charger for submicron aerosol particles using carbon fiber ionizers. Journal of Aerosol Science 2009;40(4):285-294. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
|
|
Han B, Hudda N, Ning Z, Kim Y-J, Sioutas C. Efficient collection of atmospheric aerosols with a particle concentrator-electrostatic precipitator sampler. Aerosol Science and Technology 2009;43(8):757-766. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
|
|
Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Journal of Applied Toxicology 2005;25(1):47-51. |
R832413C003 (2010) R827352 (2004) R827352 (Final) R827352C001 (Final) |
Exit |
|
|
Hsu A, Mendez L, Shah J, Sioutas C, Kleinman M, Campbell A. Nanoparticles in air pollution and innate immune responses within the CNS. International Journal of Neuroprotection and Neuroregeneration 2007;3(2):107-113. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit |
|
|
Hu S, Polidori A, Arhami M, Shafer MM, Schauer JJ, Cho A, Sioutas C. Redox activity and chemical speciation of size fractioned PM in the communities of the Los Angeles-Long Beach harbor. Atmospheric Chemistry and Physics 2008;8(21):6439-6451. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C003 (2010) R832413C003 (Final) |
Exit Exit |
|
|
Hudda N, Cheung K, Moore KF, Sioutas C. Inter-community variability in total particle number concentrations in the eastern Los Angeles air basin. Atmospheric Chemistry and Physics 2010;10(23):11385-11399. |
R832413 (Final) R832413C001 (Final) |
Exit Exit |
|
|
Hudda N, Eckel SP, Knibbs LD, Sioutas C, Delfino RJ, Fruin SA. Linking in-vehicle ultrafine particle exposures to on-road concentrations. Atmospheric Environment 2012;59:578-586. |
R832413 (Final) |
Exit Exit Exit |
|
|
Hudda N, Fruin S, Delfino RJ, Sioutas C. Efficient determination of vehicle emission factors by fuel use category using on-road measurements: downward trends on Los Angeles freight corridor I-710. Atmospheric Chemistry and Physics 2013;13(1):347-357. |
R832413 (Final) |
Exit Exit |
|
|
Inoue K-I, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Cho AK, Hiyoshi K, Kumagai Y. Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. Archives of Toxicology 2007;81(8):575-581. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) |
Exit |
|
|
Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y. Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. Journal of Biological Chemistry 2007;282(46):33396-33404. |
R832413 (2008) R832413 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) R832413C003 (Final) |
Exit Exit Exit |
|
|
Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M. Biochemical and cellular effects of electrophiles present in ambient air samples. Atmospheric Environment 2010;44(12):1483-1489. |
R832413 (Final) R832413C003 (2010) R832413C003 (Final) R832413C005 (2010) R832413C005 (Final) |
Exit Exit Exit |
|
|
Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, Nel AE. Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. Proteomics 2007;7(21):3906-3918. |
R832413 (Final) R832413C002 (Final) |
Exit |
|
|
Kam W, Liacos JW, Schauer JJ, Delfino RJ, Sioutas C. Size-segregated composition of particulate matter (PM) in major roadways and surface streets. Atmospheric Environment 2012;55:90-97. |
R832413 (Final) |
Exit Exit Exit |
|
|
Kang X, Li N, Wang M, Boontheung P, Sioutas C, Harkema JR, Bramble LA, Nel AE, Loo JA. Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid. Proteomics 2010;10(3):520-531. |
R832413 (Final) R832413C002 (2010) R832413C002 (Final) |
Exit |
|
|
Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicology and Applied Pharmacology 2006;210(1-2):47-54. |
R832413C003 (2010) R827352 (Final) R827352C001 (Final) |
Exit Exit Exit |
|
|
Kim YH, Sioutas C, Fine P, Shing KS. Effect of albumin on physical characteristics of drug particles produced by supercritical fluid technology. Powder Technology 2008;182(3):354-363. |
R832413C001 (Final) |
Exit Exit |
|
|
Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Journal of the Air & Waste Management Association 2005;55(9):1277-1288. |
R832413C003 (2010) R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C005 (Final) R827352C014 (Final) |
Exit Exit |
|
|
Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhalation Toxicology 2007;19(Suppl 1):117-126. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C003 (2007) R827352 (Final) |
Exit |
|
|
Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC. Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicology Letters 2008;178(2):127-130. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R831952 (Final) |
Exit Exit Exit |
|
|
Krudysz MA, Froines JR, Fine PM, Sioutas C. Intra-community spatial variation of size-fractionated PM mass, OC, EC, and trace elements in the Long Beach, CA area. Atmospheric Environment 2008;42(21):5374-5389. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C001 (2007) R832413C001 (Final) R832413C003 (2007) R832157 (2007) R832157 (Final) |
Exit Exit Exit |
|
|
Krudysz MA, Dutton SJ, Brinkman GL, Hannigan MP, Fine PM, Sioutas C, Froines JR. Intra-community spatial variation of size-fractionated organic compounds in Long Beach, California. Air Quality, Atmosphere & Health 2009;2(2):69-88. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832157 (Final) |
Exit Exit |
|
|
Krudysz M, Moore K, Geller M, Sioutas C, Froines J. Intra-community spatial variability of particulate matter size distributions in Southern California/Los Angeles. Atmospheric Chemistry and Physics 2009;9(3):1061-1075. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832157 (Final) |
Exit Exit |
|
|
Kumagai Y, Shinkai Y, Miura T, Cho AK. The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology 2012;52:221-247. |
R832413 (Final) |
Exit |
|
|
Lee ES, Xu B, Zhu Y. Measurements of ultrafine particles carrying different number of charges in on-and near-freeway environments. Atmospheric Environment 2012;60:564-572. |
R832413 (Final) R832413C005 (Final) |
Exit Exit Exit |
|
|
Lee ES, Polidori A, Koch M, Fine PM, Mehadi A, Hammond D, Wright JN, Miguel AH, Ayala A, Zhu Y. Water-based condensation particle counters comparison near a major freeway with significant heavy-duty diesel traffic. Atmospheric Environment 2013;68:151-161. |
R832413 (Final) R832413C005 (Final) |
Exit Exit Exit |
|
|
Li N, Nel AE. The cellular impacts of diesel exhaust particles:beyond inflammation and death. European Respiratory Journal 2006;27(4):667-668. |
R832413 (2008) R832413 (Final) R832413C002 (2006) R832413C002 (2008) |
Exit Exit Exit |
|
|
Li N, Xia T, Nel AE. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radical Biology and Medicine 2008;44(9):1689-1699. |
R832413 (2007) R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2007) R832413C002 (2008) R832413C002 (2009) |
Exit Exit Exit |
|
|
Li N, Wang M, Bramble LA, Schmitz DA, Schauer JJ, Sioutas C, Harkema JR, Nel AE. The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential. Environmental Health Perspectives 2009;117(7):1116-1123. |
R832413 (2009) R832413 (2010) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C002 (2009) R832413C002 (Final) |
|
|
|
Li N, Harkema JR, Lewandowski RP, Wang M, Bramble LA, Gookin GR, Ning Z, Kleinman MT, Sioutas C, Nel AE. Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response:implication for traffic-related asthma flares. American Journal of Physiology 2010;299(3):L374-L383. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C002 (2010) R832413C002 (Final) |
Exit Exit Exit |
|
|
Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T. Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. Free Radical Biology and Medicine 2009;46(6):775-782. |
R832413 (Final) |
Exit Exit Exit |
|
|
Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C, Hsiai T. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses:implication of chemical components and NF-κB signaling. Particle and Fibre Toxicology 2010;7:6. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) |
Exit Exit Exit |
|
|
Li R, Ning Z, Cui J, Yu F, Sioutas C, Hsiai T. Diesel exhaust particles modulate vascular endothelial cell permeability:implication of ZO-1 expression. Toxicology Letters 2010;197(3):163-168. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) |
Exit Exit Exit |
|
|
Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng C-H, Araujo JA, Fogelman AM, Sioutas C, Navab M, Hsiai T. Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine. Environmental Health Perspectives 2015;123(1):34-41. |
R832413 (Final) |
|
|
|
Liacos JW, Kam W, Delfino RJ, Schauer JJ, Sioutas C. Characterization of organic, metal and trace element PM2.5 species and derivation of freeway-based emission rates in Los Angeles, CA. Science of the Total Environment 2012;435-436:159-166. |
R832413 (Final) |
Exit Exit Exit |
|
|
Lin P, Yu JZ. Generation of reactive oxygen species mediated by humic-like substances in atmospheric aerosols. Environmental Science & Technology 2011;45(24):10362-10368. |
R832413C003 (Final) |
Exit |
|
|
Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2008;2(5):889-896. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
Exit Exit Exit |
|
|
Majestic BJ, Schauer JJ, Shafer MM, Turner JR, Fine PM, Singh M, Sioutas C. Development of a wet-chemical method for the speciation of iron in atmospheric aerosols. Environmental Science & Technology 2006;40(7):2346-2351. |
R832413C001 (Final) R827352 (Final) |
Exit Exit Exit |
|
|
Majestic BJ, Schauer JJ, Shafer MM, Fine PM, Singh M, Sioutas C. Trace metal analysis of atmospheric particulate matter: a comparison of personal and ambient samplers. Journal of Environmental Engineering and Science 2008;7(4):289-298. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit |
|
|
Melega WP, Jorgensen MJ, Lacan G, Way BM, Pham J, Morton G, Cho AK, Fairbanks LA. Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: Brain neurotoxicity and behavioral profiles. Neuropsychopharmacology 2008;33(6):1441-1452. |
R832413 (2008) |
Exit Exit |
|
|
Minguillon MC, Arhami M, Schauer JJ, Sioutas C. Seasonal and spatial variations of sources of fine and quasi-ultrafine particulate matter in neighborhoods near the Los Angeles-Long Beach harbor. Atmospheric Environment 2008;42(32):7317-7328. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
|
|
Moore KF, Ning Z, Ntziachristos L, Schauer JJ, Sioutas C. Daily variation in the properties of urban ultrafine aerosol—Part I:physical characterization and volatility. Atmospheric Environment 2007;41(38):8633-8646. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Moore K, Krudysz M, Pakbin P, Hudda N, Sioutas C. Intra-community variability in total particle number concentrations in the San Pedro harbor area (Los Angeles, California). Aerosol Science and Technology 2009;43(6):587-603. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832157 (Final) |
Exit Exit |
|
|
Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, Kam W, Hsu YT, Winkler JW, Chen JC, Petasis NA, Baudry M, Sioutas C, Finch CE. Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environmental Health Perspectives 2011;119(7):1003-1009. |
R832413 (Final) R832413C001 (Final) |
Exit |
|
|
Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials 2009;8(7):543-557. |
R832413 (Final) R832413C002 (2010) |
Exit |
|
|
Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311(5761):622-627. |
R832413 (Final) R827352 (Final) |
Exit |
|
|
Ngo MA, Pinkerton KE, Freeland S, Geller M, Ham W, Cliff S, Hopkins LE, Kleeman MJ, Kodavanti UP, Meharg E, Plummer L, Recendez JJ, Schenker MB, Sioutas C, Smiley-Jewell S, Haas C, Gutstein J, Wexler AS. Airborne particles in the San Joaquin Valley may affect human health. California Agriculture 2010;64(1):12-16. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R826246 (Final) R832414 (2010) R832414C003 (2010) R832414C003 (Final) |
Exit Exit |
|
|
Ning Z, Moore KF, Polidori A, Sioutas C. Field validation of the new miniature Versatile Aerosol Concentration Enrichment System (mVACES). Aerosol Science and Technology 2006;40(12):1098-1110. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ning Z, Geller MD, Moore KF, Sheesley R, Schauer JJ, Sioutas C. Daily variation in chemical characteristics of urban ultrafine aerosols and inference of their sources. Environmental Science & Technology 2007;41(17):6000-6006. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ning Z, Polidori A, Schauer JJ, Sioutas C. Emission factors of PM species based on freeway measurements and comparison with tunnel and dynamometer studies. Atmospheric Environment 2008;42(13):3099-3114. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ning Z, Sillanpaa M, Pakbin P, Sioutas C. Field evaluation of a new particle concentrator-electrostatic precipitator system for measuring chemical and toxicological properties of particulate matter. Particle and Fibre Technology 2008;5:15. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ning Z, Hudda N, Daher N, Kam W, Herner J, Kozawa K, Mara S, Sioutas C. Impact of roadside noise barriers on particle size distributions and pollutants concentrations near freeways. Atmospheric Environment 2010;44(26):3118-3127. |
R832413 (Final) |
Exit Exit Exit |
|
|
Ning Z, Sioutas C. Atmospheric processes influencing aerosols generated by combustion and the inference of their impact on public exposure:a review. Aerosol and Air Quality Research 2010;10(1):43-58. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) |
Exit Exit |
|
|
Ntziachristos L, Ning Z, Geller MD, Sioutas C. Particle concentration and characteristics near a major freeway with heavy-duty diesel traffic. Environmental Science & Technology 2007;41(7):2223-2230. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2006) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ntziachristos L, Froines JR, Cho AK, Sioutas C. Relationship between redox activity and chemical speciation of size-fractionated particulate matter. Particle and Fibre Toxicology 2007;4:5 (12 pp.). |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C003 (2008) R832413C003 (2010) |
Exit Exit Exit |
|
|
Ntziachristos L, Ning Z, Geller MD, Sheesley RJ, Schauer JJ, Sioutas C. Fine, ultrafine and nanoparticle trace element compositions near a major freeway with a high heavy-duty diesel fraction. Atmospheric Environment 2007;41(27):5684-5696. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Ntziachristos L, Polidori A, Phuleria H, Geller MD, Sioutas C. Application of a diffusion charger for the measurement of particle surface concentration in different environments. Aerosol Science and Technology 2007;41(6):571-580. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2006) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Pakbin P, Ning Z, Schauer JJ, Sioutas C. Characterization of particle bound organic carbon from diesel vehicles equipped with advanced emission control technologies. Environmental Science & Technology 2009;43(13):4679-4686. |
R832413 (Final) R835172 (Final) |
Exit Exit Exit |
|
|
Pakbin P, Ning Z, Eiguren-Fernandez A, Sioutas C. Modification of the Versatile Aerosol Concentration Enrichment System (VACES) for conducting inhalation exposures to semi-volatile vapor phase pollutants. Journal of Aerosol Science 2011;42(9):555-566. |
R832413 (Final) R832413C001 (Final) |
Exit Exit Exit |
|
|
Phalen RF, Oldham MJ, Nel AE. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicological Sciences 2006;92(1):126-132. |
R832413 (Final) R827352 (Final) R827352C016 (Final) |
Exit Exit Exit |
|
|
Phuleria HC, Geller MD, Fine PM, Sioutas C. Size-resolved emissions of organic tracers from light-and heavy-duty vehicles measured in a California roadway tunnel. Environmental Science & Technology 2006;40(13):4109-4118. |
R832413C001 (Final) R827352 (Final) |
Exit Exit Exit |
|
|
Phuleria HC, Sheesley RJ, Schauer JJ, Fine PM, Sioutas C. Roadside measurements of size-segregated particulate organic compounds near gasoline and diesel-dominated freeways in Los Angeles, CA. Atmospheric Environment 2007;41(22):4653-4671. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
|
|
Polidori A, Arhami M, Sioutas C, Delfino RJ, Allen R. Indoor/outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles Basin. Journal of the Air & Waste Management Association 2007;57(3):366-379. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit |
|
|
Polidori A, Hu S, Biswas S, Delfino RJ, Sioutas C. Real-time characterization of particle-bound polycyclic aromatic hydrocarbons in ambient aerosols and from motor-vehicle exhaust. Atmospheric Chemistry and Physics 2008;8(5):1277-1291. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit |
|
|
Polidori A, Cheung KL, Arhami M, Delfino RJ, Schauer JJ, Sioutas C. Relationships between size-fractionated indoor and outdoor trace elements at four retirement communities in southern California. Atmospheric Chemistry and Physics 2009;9(14):4521-4536. |
R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) R832413C004 (2009) R832413C004 (2010) R832413C004 (Final) R833743 (Final) |
Exit Exit |
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Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Lippmann M, Cohen M. Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and-2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health, Part A:Current Issues 2006;69(10):935-951. |
R832413C001 (Final) R827351 (Final) R827351C008 (Final) R827351C010 (Final) R827352 (Final) R827352C014 (Final) R827355 (Final) R827355C008 (Final) |
Exit |
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Quiros DC, Zhang Q, Choi W, He M, Paulson SE, Winer AM, Wang R, Zhu Y. Air quality impacts of a scheduled 36-h closure of a major highway. Atmospheric Environment 2013;67:404-414. |
R832413 (Final) R832413C005 (Final) |
Exit Exit Exit |
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Riedl MA, Nel AE. Importance of oxidative stress in the pathogenesis and treatment of asthma. Current Opinion in Allergy and Clinical Immunology 2008;8(1):49-56. |
R832413 (Final) |
Exit |
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Rodriguez CE, Fukuto JM, Taguchi K, Froines J, Cho AK. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Chemico-Biological Interactions 2005;155(1-2):97-110. |
R832413C003 (2010) R827352 (Final) R827352C001 (Final) |
Exit Exit Exit |
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Saffari A, Daher N, Shafer MM, Schauer JJ, Sioutas C. Global perspective on the oxidative potential of airborne particulate matter: a synthesis of research findings. Environmental Science & Technology 2014;48(13):7576-7583. |
R832413 (Final) R833743 (Final) |
Exit Exit Exit |
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Sardar SB, Geller MD, Sioutas C, Solomon PA. Development and evaluation of a high-volume dichotomous sampler for chemical speciation of coarse and fine particles. Journal of Aerosol Science 2006;37(11):1455-1466. |
R832413C001 (Final) R827352 (Final) |
Exit Exit Exit |
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Shinkai Y, Nakajima S, Eiguren-Fernandez A, Di Stefano E, Schmitz DA, Froines JR, Cho AK, Kumagai Y. Ambient vapor samples activate the Nrf2-ARE pathway in human bronchial epithelial BEAS-2B cells. Environmental Toxicology 2014;29(11):1292-1300. |
R832413 (Final) |
Exit |
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Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK. On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles:evidence for electrophilic species. Atmospheric Environment 2008;42(3):517-529. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) R832413C003 (2007) R832413C003 (2008) R832413C003 (2010) R832413C003 (Final) R832413C004 (2009) R832413C004 (2010) |
Exit Exit Exit |
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Shinyashiki M, Eiguren-Fernandez A, Schmitz DA, Di Stefano E, Li N, Linak WP, Cho S-H, Froines JR, Cho AK. Electrophilic and redox properties of diesel exhaust particles. Environmental Research 2009;109(3):239-244. |
R832413 (2008) R832413 (Final) R832413C003 (2009) R832413C003 (2010) R832413C003 (Final) R832413C004 (2010) |
Exit Exit Exit |
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Sillanpaa M, Geller MD, Phuleria HC, Sioutas C. High collection efficiency electrostatic precipitator for in vitro cell exposure to concentrated ambient particulate matter (PM). Journal of Aerosol Science 2008;39(4):335-347. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) |
Exit Exit Exit |
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Singh M, Phuleria HC, Bowers K, Sioutas C. Seasonal and spatial trends in particle number concentrations and size distributions at the Children’s Health Study sites in southern California. Journal of Exposure Science and Environmental Epidemiology 2006;16(1):3-18. |
R832413 (Final) |
Exit Exit Exit |
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Snyder DC, Dallmann TR, Schauer JJ, Holloway T, Kleeman MJ, Geller MD, Sioutas C. Direct observation of the break-up of a nocturnal inversion layer using elemental mercury as a tracer. Geophysical Research Letters 2008;35(17):L17812. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2008) R832413C001 (Final) |
Exit Exit |
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Solomon PA, Hopke PK, Froines J, Scheffe R. Key scientific findings and policy-and health-relevant insights from the U.S. Environmental Protection Agency's Particulate Matter Supersites Program and related studies:an integration and synthesis of results. Journal of the Air & Waste Management Association 2008;58(13 SI):S3-S92. |
R832413 (2008) R832413 (Final) |
Exit Exit |
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Solomon PA, Sioutas C. Continuous and semicontinuous monitoring techniques for particulate matter mass and chemical components:a synthesis of findings from EPA's Particulate Matter Supersites Program and related studies. Journal of the Air & Waste Management Association 2008;58(2):164-195. |
R832413 (2008) R832413 (Final) R832413C001 (Final) |
Exit Exit |
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Staimer N, Nguyen TB, Nizkorodov SA, Delfino RJ. Glutathione peroxidase inhibitory assay for electrophilic pollutants in diesel exhaust and tobacco smoke. Analytical and Bioanalytical Chemistry 2012;403(2):431-441. |
R832413 (Final) R832413C004 (Final) |
Exit |
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Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biology and Medicine 2007;43(5):789-799. |
R832413C003 (2010) R827352 (Final) |
Exit Exit Exit |
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Taguchi K, Shimada M, Fujii S, Sumi D, Pan X, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology and Medicine 2008;44(8):1645-1655. |
R832413 (2007) R832413 (2008) R832413C003 (2007) R832413C003 (2008) R832413C003 (2009) R832413C003 (2010) R827352 (Final) |
Exit Exit Exit |
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Tzamkiozis T, Stoeger T, Cheung K, Ntziachristos L, Sioutas C, Samaras Z. Monitoring the inflammatory potential of exhaust particles from passenger cars in mice. Inhalation Toxicology 2010;22(Suppl 2):59-69. |
R832413 (Final) R832413C001 (Final) |
Exit |
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Verma V, Ning Z, Cho AK, Schauer JJ, Shafer MM, Sioutas C. Redox activity of urban quasi-ultrafine particles from primary and secondary sources. Atmospheric Environment 2009;43(40):6360-6368. |
R832413 (Final) R832413C001 (2010) R832413C001 (Final) R832413C003 (Final) |
Exit Exit Exit |
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Verma V, Polidori A, Schauer JJ, Shafer MM, Cassee FR, Sioutas C. Physicochemical and toxicological profiles of particulate matter in Los Angeles during the October 2007 Southern California wildfires. Environmental Science & Technology 2009;43(3):954-960. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2009) R832413C001 (Final) |
Exit Exit Exit |
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Verma V, Shafer MM, Schauer JJ, Sioutas C. Contribution of transition metals in the reactive oxygen species activity of PM emissions from retrofitted heavy-duty vehicles. Atmospheric Environment 2010;44(39):5165-5173. |
R832413 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Verma V, Pakbin P, Cheung KL, Cho AK, Schauer JJ, Shafer MM, Kleinman MT, Sioutas C. Physicochemical and oxidative characteristics of semi-volatile components of quasi-ultrafine particles in an urban atmosphere. Atmospheric Environment 2011;45(4):1025-1033. |
R832413 (Final) R832413C001 (Final) |
Exit Exit Exit |
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Wang Y, Zhu Y, Salinas R, Ramirez D, Karnae S, John K. Roadside measurements of ultrafine particles at a busy urban intersection. Journal of the Air & Waste Management Association 2008;58(11):1449-1457. |
R832413 (Final) R832413C005 (Final) |
Exit Exit |
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Westerdahl D, Fruin SA, Fine PL, Sioutas C. The Los Angeles International Airport as a source of ultrafine particles and other pollutants to nearby communities. Atmospheric Environment 2008;42(13):3143-3155. |
R832413 (2007) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R827352 (Final) R831861 (2005) |
Exit Exit Exit |
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Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovascular Toxicology 2006;6(1):69-78. |
R832413 (2008) R832413 (Final) R832413C001 (2007) R832413C001 (Final) R827352 (Final) R831952 (2005) R831952 (Final) |
Exit |
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Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Letters 2006;6(8):1794-1807. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2006) R832413C002 (2008) R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
Exit Exit Exit |
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Xia T, Kovochich M, Nel A. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clinics in Occupational and Environmental Medicine 2006;5(4):817-836. |
R832413 (2008) R832413 (Final) R832413C002 (2007) R832413C002 (2008) |
Exit |
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Xia T, Kovochich M, Nel AE. Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease. Frontiers in Bioscience 2007;12(4):1238-1246. |
R832413 (2008) R832413 (Final) R832413C002 (2007) R832413C002 (2008) |
Exit Exit |
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Xia T, Kovochich M, Liong M, Zink JI, Nel AE. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano 2008;2(1):85-96. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
Exit Exit Exit |
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Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008;2(10):2121-2134. |
R832413 (2010) R832413 (Final) R832413C002 (2009) |
Exit Exit Exit |
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Xia T, Li N, Nel AE. Potential health impact of nanoparticles. Annual Review of Public Health 2009;30:137-150. |
R832413 (2008) R832413 (2010) R832413 (Final) R832413C002 (2009) |
Exit Exit |
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Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009;3(10):3273-3286. |
R832413 (Final) |
Exit Exit Exit |
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Xiao GG, Wang M, Li N, Loo JHA, Nel AE. Use of proteomics to demonstrate a heirarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. Journal of Biological Chemistry 2003;278(50):50781-50790. |
R832413C002 (Final) |
Exit Exit Exit |
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Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng C-A, Sioutas C, Borok Z, Kim K-J, Crandall ED. Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicology in Vitro 2007;21(8):1373-1381. |
R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R827352 (Final) |
Exit Exit Exit |
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Zhang L, Wang M, Kang X, Boontheung P, Li N, Nel AE, Loo JA. Oxidative stress and asthma:proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid. Journal of Proteome Research 2009;8(4):1631-1638. |
R832413 (2008) R832413 (Final) R832413C002 (Final) |
Exit Exit Exit |
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Zhu Y, Kuhn T, Mayo P, Hinds WC. Comparison of daytime and nighttime concentration profiles and size distributions of ultrafine particles near a major highway. Environmental Science & Technology 2006;40(8):2531-2536. |
R832413C005 (Final) R827352 (Final) R827352C006 (Final) |
Exit Exit Exit |
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Zhu Y, Yu N, Kuhn T, Hinds WC. Field comparison of P-trak and condensation particle counters. Aerosol Science and Technology 2006;40(6):422-430. |
R832413C005 (Final) R827352 (Final) R827352C006 (Final) |
Exit Exit |
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Zhu Y, Eiguren-Fernandez A, Hinds WC, Miguel AH. In-cabin commuter exposure to ultrafine particles on Los Angeles freeways. Environmental Science & Technology 2007;41(7):2138-2145. |
R832413 (2008) R832413 (Final) R832413C005 (2007) R832413C005 (2008) R832413C005 (Final) R827352 (Final) |
Exit Exit Exit |
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Zhu Y, Fung DC, Kennedy N, Hinds WC, Eiguren-Fernandez A. Measurements of ultrafine particles and other vehicular pollutants inside a mobile exposure system on Los Angeles freeways. Journal of the Air & Waste Management Association 2008;58(3):424-434. |
R832413 (2007) R832413 (2008) R832413 (Final) R832413C005 (2007) R832413C005 (2008) R832413C005 (Final) |
Exit Exit |
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Zhu Y, Fanning E, Yu RC, Zhang Q, Froines JR. Aircraft emissions and local air quality impacts from takeoff activities at a large international airport. Atmospheric Environment 2011;45(36):6526-6533. |
R832413 (Final) R832413C005 (Final) |
Exit Exit Exit |
Supplemental Keywords:
RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Ecological Risk Assessment, cardiopulmonary responses, chemical characteristics, human health effects, toxicology, airborne particulate matter, cardiovascular vulnerability, animal model, biological mechanism , biological mechanisms, chemical composition, ambient particle health effects, human exposure, respiratory impact, PM, cardiotoxicity, oxidative stress, cardiovascular diseaseRelevant Websites:
http://www.scpcs.ucla.edu/ Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832413C001 Contribution of Primary and Secondary PM Sources to Exposure & Evaluation of Their Relative Toxicity
R832413C002 Project 2: The Role of Oxidative Stress in PM-induced Adverse Health Effects
R832413C003 The Chemical Properties of PM and their Toxicological Implications
R832413C004 Oxidative Stress Responses to PM Exposure in Elderly Individuals With Coronary Heart Disease
R832413C005 Ultrafine Particles on and Near Freeways
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.