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Reference Type Citation Progress Report Year Document Sources
Abstract Allen KM, Brooks P, Dereski M, Lewandowski R, Hotchkiss I, Jackson-Humbles D, Brandenberger C, Bramble L, Wagner JG, Harkema J. Inhaled ozone induces metabolic abnormalities in mice fed a high-fructose diet. The Toxicologist 2013;132(1):12. R834797 (2013)
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Abstract Allen K, Kopec AK, Zacharewski TR, Wagner JG, Morishita M, Dvonch JT, Harkema JR. Metabolic changes from high-fructose feeding are altered by air pollutant exposure. The Toxicologist 2012;126(1):49. R834797 (2012)
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Abstract Allen K, Lewandowski R, Wagner JG, Harkema JR. Inhalation exposures to ozone induce insulin resistance and pulmonary pathology in Type II diabetes-prone mice. The Toxicologist 2014;138(1):623. R834797 (2014)
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Abstract Baker GL, McKinney WJ, Phalen RF, Oldham M, Harkema JR, Higuchi MA. Inhalation studies: challenges and complexities. The Toxicologist 2014;138(1):1. R834797 (2014)
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Abstract Harkema JR. Site-specific airway pathology and dosimetry of inhaled toxicants. The Toxicologist 2014;138(1):200. R834797 (2014)
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Abstract Hotchkiss IP, Allen K, Wagner JG, Morishita M, Lewandowski RP, Bramble LA, Dvonch JT, Harkema JR. Effects of high-fructose diet on nasal epithelial and inflammatory responses to inhaled ozone and ambient fine particles in rats. The Toxicologist 2012;126(1):48. R834797 (2012)
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Abstract Liu C, Desikan R, Ying Z, Gushchina L, Kampfrath T, Deiuliis J, Wang A, Xu X, Zhong J, Rao X, Sun Q, Maiseyeu A, Parthasarathy S, Rajagopalan S. Antiatherosclerotic effects of a novel pharmacologic inhibitor of myeloperoxidase in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2012; 32(Suppl 5):A155. R834797 (Final)
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Abstract Liu C, Xu X, Bai Y, Wang T-Y, Rao X, Sun L, Ying Z, Maiseyeu A, Sun Q, Rajagopalan S. Air-pollution mediated susceptibility to inflammation and insulin resistance via CCR2 dependent and independent effects (P6246). Journal of Immunology 2013;190(Meeting Abstract Suppl):115.19. R834797 (2013)
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Abstract Ong C, Allen K, Brandenberger C, Jackson-Humbles D, Bramble L, Lewandowski R, Wagner JG, Harkema JR. Development of eosinophilic rhinitis and nasal tissue remodeling in mice episodically exposed to ozone. The Toxicologist 2014;138(1):624. R834797 (2014)
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Abstract Rao X, Maiseye A, Zhong J, Gopalakrishnan B, Ying Z, Liu C, Guschina L, Villamena F, Harkema J, Sun Q, Rajagopalan S. 7-ketocholesterol-mediated alterations in vascular function:a link between vascular and metabolic complications of chronic particulate matter exposure. Arteriosclerosis, Thrombosis, and Vascular Biology 2012;32(Suppl 5)A547. R834797 (Final)
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Abstract Rao X, Zhong J, Maiseyeu A, Harkema JR, Sun Q, Rajagopalan S. Air pollution promotes CD36-dependent accumulation of oxidized lipids. Arteriosclerosis, Thrombosis, and Vascular Biology 2014;34(Suppl 1):A469. R834797 (2014)
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Abstract Rao X, Zhong J, Maiseyeu A, Harkema J, Sun Q, Rajagopalan S. Air pollution promotes CD36-dependent accumulation of oxidized lipids. Arteriosclerosis, Thrombosis, and Vascular Biology 2018;34(Suppl 1):A469 R834797 (Final)
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Abstract Wagner JG, Kamal AS, Allen K, Morishita M, Dvonch JT, Lewandowski RP, Fink G, Harkema JR. Hypotensive and bradycardic responses to inhaled O3 and ambient fine particles are enhanced in rats on a high-fructose diet. The Toxicologist 2012;126(1):185. R834797 (2012)
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Abstract Wagner JG, Yang H, Allen KM, Morishita M, Nan B, Mukherjee B, Fink GD, Harkema JR. Suppressed responses in heart rate variability during inhalation exposure to ozone and ambient fine particles in rats on a high-fructose diet. The Toxicologist 2013;132(1):12. R834797 (2013)
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Abstract Wagner JG, Allen K, Nan B, Lewandowski R, Fink G, Harkema JR. Role of transient receptor potential (TRP) channels in ozone-induced decreases in blood pressure and heart rate in rats on a high fructose diet. American Journal of Respiratory and Critical Care 2013;187:A5093. R834797 (2013)
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Abstract Wagner JG. Cardiometabolic interactions of diet and air pollution: field studies with multipollutant atmospheres. The Toxicologist 2014;138(1):545. R834797 (2014)
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Abstract Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC. PM2.5-induced tachycardia and hypertension in rats are linked to elemental carbon and specific temperature-resolved carbon subfractions. The Toxicologist 2014;138(1):328-329. R834797 (2014)
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Abstract Wagner JG, Das R, Allen K, Morishita M, Nan B, Mukherjee B, Harkema JR. Cardiovascular depression during inhalation exposure to a mixture of ozone and rural ambient fine particles (PM2.5) in rats on a high fructose diet. American Journal of Respiratory and Critical Care Medicine 2014;189:A1668. R834797 (2014)
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Journal Article Balasubramanian P, Sirivelu MP, Weiss KA, Wagner JG, Harkema JR, Morishita M, Mohankumar PS, Mohankumar SM. Differential effects of inhalation exposure to PM 2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. NeuroToxicology 2013;36:106-111. R834797 (2013)
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Journal Article Blazek A, Rutsky J, Osei K, Maiseyeu A, Rajagopalan S. Exercise-mediated changes in high-density lipoprotein: impact on form and function. American Heart Journal 2013;166(3):392-400. R834797 (2013)
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Journal Article Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR. Enhanced allergic airway disease in old mice is associated with a Th17 response. Clinical & Experimental Allergy 2014;44(10):1282-1292. R834797 (2014)
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Journal Article Brook RD, Rajagopalan S, Pope III CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 2010;121(21):2331-2378. EM833367 (Final)
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Journal Article Brook RD, Rajagopalan S. Can what you breathe trigger a stroke within hours? Comment on "ambient air pollution and the risk of acute ischemic stroke". Archives of Internal Medicine 2012;172(3):235-236. R834797 (2014)
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Journal Article Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L, Yang H-Y, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013;25(10):587-592. R833740 (2012)
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Journal Article Brook RD, Xu X, Bard RL, Dvonch JT, Morishita M, Kaciroti N, Sun Q, Harkema J, Rajagopalan S. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. The Science of the Total Environment 2013;448:66-71. R834797 (2012)
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Journal Article Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S. Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environmental Health Perspectives 2014;122(6):624-630. R833740 (2012)
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Journal Article Byrd JB, Morishita M, Bard RL, Das R, Wang L, Sun Z, Spino C, Harkema J, Dvonch JT, Rajagopalan S, Brook RD. Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location. Journal of the American Society of Hypertension 2016;10(2):133-139. R834797 (2016)
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Journal Article Carey SA, Ballinger CA, Plopper CG, McDonald RJ, Bartolucci AA, Postlethwait EM, Harkema JR. Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. American Journal of Physiology:Lung Cellular and Molecular Physiology 2011;300(2):L242-L254. R834797 (2014)
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Journal Article Deiuliis JA, Kampfrath T, Zhong J, Oghumu S, Maiseyeu A, Chen LC, Sun Q, Satoskar AR, Rajagopalan S. Pulmonary T cell activation in response to chronic particulate air pollution. American Journal of Physiology:Lung Cellular and Molecular Physiology 2012;302(4):L399-L409. R834797 (2014)
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Journal Article Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, Nelson RJ. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Molecular Psychiatry 2011;16(10):987-995. R834797 (2014)
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Journal Article Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Higher fine particulate matter and temperature levels impair exercise capacity in cardiac patients. Heart 2015;101(16):1293-1301. R834797 (2014)
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Journal Article Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Particulate matter air pollution and ambient temperature: opposing effects on blood pressure in high-risk cardiac patients. Journal of Hypertension 2015;33(10):2032-2038. R834797 (2014)
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Journal Article Gong Jr. H, Linn WS, Terrell SL, Clark KW, Geller MD, Anderson KR, Cascio WE, Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhalation Toxicology 2004;16(6-7):335-343. R827352 (2004)
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Journal Article Harkema J, Wagner J. Innate Lymphoid Cell-Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone:A New Paradigm in Pathogenesis. TOXICOLOGY PATHOLOGY 2019;47(8):993-1003. R834797 (Final)
Journal Article Huang W, Wang L, Li J, Liu M, Xu H, Liu S, Chen J, Zhang Y, Morishita M, Bard RL, Harkema JR, Rajagopalan S, Brook RD. Short-term blood pressure responses to ambient fine particulate matter exposures at the extremes of global air pollution concentrations. American Journal of Hypertension 2018;31(5):590-599. R834797 (Final)
Journal Article Hubbs AF, Mercer RR, Benkovic SA, Harkema J, Sriram K, Schwegler-Berry D, Goravanahally MP, Nurkiewicz TR, Castranova V, Sargent LM. Nanotoxicology--a pathologist's perspective. Toxicologic Pathology 2011;39(2):301-324. R834797 (2014)
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Journal Article Kamal AS, Rohr AC, Mukherjee B, Morishita M, Keeler GJ, Harkema JR, Wagner JG. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011;23(7):417-430. R834797 (2014)
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Journal Article Kumagai K, Lewandowski R, Jackson-Humbles D, Buglak N, Li N, White K, Van Dyken S, Wagner J, Harkema J. Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Muco Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone. TOXICOLOGIC PATHOLOGY 2017;45(6):692-704. R834797 (Final)
Journal Article Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicologic Pathology 2013;41(2):361-373. R834797 (2013)
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Journal Article Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. Air pollution-mediated susceptibility to inflammation and insulin resistance:influence of CCR2 pathways in mice. Environmental Health Perspectives 2014;122(1):17-26. R834797 (2013)
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Journal Article Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, Maurya SK, Periasamy M, Morishita M, Harkema J, Ying Z, Sun Q, Rajagopalan S. Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Particle and Fibre Toxicology 2014;11:27. R834797 (2014)
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Journal Article Liu C, Fonken LK, Wang A, Maiseyeu A, Bai Y, Wang T-Y, Maurya S, Ko Y-A, Periasamy M, Dvonch T, Morishita M, Brook RD, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson RJ, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle and Fibre Toxicology 2014;11:53. R834797 (2014)
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Journal Article Maiseyeu A, Yang H-Y, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014;26(1):23-29. R833740 (Final)
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Journal Article Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. American Journal of Physiology:Lung Cellular and Molecular Physiology 2011;300(3):L462-L471. R834797 (2014)
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Journal Article Mathew AV, Yu J, Guo Y, Byun J, Chen YE, Wang L, Liu M, Bard RL, Morishita M, Huang W, Li J, Harkema JR, Rajagopalan S, Pennathur S, Brook RD. Effect of ambient fine particulate matter air pollution and colder outdoor temperatures on high-density lipoprotein function. The American Journal of Cardiology 2018;122(4):565-570. R834797 (Final)
Journal Article Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American Journal of Translational Research 2013;5(2):224-234. R834797 (2016)
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Journal Article Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Source identification of ambient PM2.5 for inhalation exposure studies in Steubenville, Ohio using highly time-resolved measurements. Atmospheric Environment 2011;45(40):7688-7697. R834797 (2014)
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Journal Article Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Identification of ambient PM2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements. Atmospheric Environment 2011;45(8):1627-1637. R834797 (2014)
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Journal Article Morishita M, Bard RL, Kaciroti N, Fitzner CA, Dvonch T, Harkema JR, Rajagopalan S, Brook RD. Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):145-152. R834797 (2014)
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Journal Article Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):153-159. R833740 (Final)
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Journal Article Munzel T, Sorensen M, Gori T, Schmidt FP, Rao X, Brook FR, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part II–mechanistic insights. European Heart Journal 2017;38(8):557-564. R834797 (Final)
Journal Article Munzel T, Sorensen M, Gori T, Schmidt FP, Rao X, Brook J, Chen LC, Brook RD, Rajagopalan S. Environmental stressors and cardio-metabolic disease: part I–epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies. European Heart Journal 2017;38(8):550-556. R834797 (Final)
Journal Article Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, Forastiere F, Franchini M, Franco OH, Graham I, Hoek G, Hoffmann B, Hoylaerts MF, Kunzli N, Mills N, Pekkanen J, Peters A, Piepoli MF, Rajagopalan S, Storey RF, ESC Working Group on Thrombosis, European Association for Cardiovascular Prevention and Rehabilitation, ESC Heart Failure Association. Expert position paper on air pollution and cardiovascular disease. European Heart Journal 2015;36(2):83-93b. R834797 (2014)
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Journal Article Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-HumblesDN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. (2016) Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. American Journal of Respiratory Cell and Molecular Biology 2016;54(3):331-340. R834797 (Final)
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Journal Article Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-induced type 2 immunity in nasal airways. Development and lymphoid cell dependence in mice. American Journal of Respiratory Cell and Molecular Biology 2016;54(3):331-340. R834797 (2014)
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Journal Article Pancras JP, Landis MS, Norris GA, Vedantham R, Dvonch JT. Source apportionment of ambient fine particulate matter in Dearborn, Michigan, using hourly resolved PM chemical composition data. The Science of the Total Environment 2013;448:2-13. R834797 (2013)
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Journal Article Rajagopalan S, Brook RD. Personalizing your airspace and your health. Journal of the American College of Cardiology 2015;65(21):2288-2290. R834797 (2014)
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Journal Article Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR, Sun Q, Rajagopalan S. CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circulation Research 2014;115(9):770-780. R834797 (2014)
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Journal Article Rao X, Patel P, Puett R, Rajagopalan S. Air pollution as a risk factor for type 2 diabetes. Toxicological Sciences 2015;143(2):231-241. R834797 (2014)
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Journal Article Rao X, Montresor-Lopez J, Puett R, Rajagopalan S, Brook RD. Ambient air pollution:an emerging risk factor for diabetes mellitus. Current Diabetes Reports 2015;15(6):603. R834797 (2014)
R834797 (2015)
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Journal Article Rohr AC, Kamal A, Morishita M, Mukherjee B, Keeler GJ, Harkema JR, Wagner JG. Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan. Environmental Health Perspectives 2011;119(4):474-480. R834797 (2014)
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Journal Article Sarnat SE, Suh HH, Coull BA, Schwartz J, Stone PH, Gold DR. Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio. Occupational and Environmental Medicine 2006;63(10):700-706. R826780 (Final)
R827353 (Final)
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R832416 (2008)
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Journal Article Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR, Sun Q, Fan Z. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Particle and Fibre Toxicology 2013;10:43. R834797 (2013)
R834797 (2014)
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Journal Article Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C. Alterations of the murine gut microbiome with age and allergic airway disease. Journal of Immunology Research 2015;2015:892568 (8 pp.). R834797 (2015)
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Journal Article Wagner JG, Morishita M, Keeler GJ, Harkema JR. Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma:a comparison of field exposure studies. Environmental Health 2012;11:45 (13 pp.). R834797 (2014)
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Journal Article Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR. Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome. Environmental Health Perspectives 2014;122(1):27-33. R834797 (2013)
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Journal Article Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC. PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions. Particle and Fibre Toxicology 2014;11:25 (10 pp.). R834797 (2014)
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Journal Article Wang Y, Eliot MN, Kuchel GA, Schwartz J, Coull BA, Mittleman MA, Lipsitz LA, Wellenius GA. Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston Study. Journal of Occupational and Environmental Medicine 2014;56(9):e73-e77. R834797 (2016)
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Journal Article Wellenius GA, Boyle LD, Wilker EH, Sorond FA, Coull BA, Koutrakis P, Mittleman MA, Lipsitz LA. Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke 2013;44(6):1532-1536. R834797 (2016)
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R834798 (2013)
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Journal Article Wold LE, Ying Z, Hutchinson KR, Velten M, Gorr MW, Velten C, Youtz DJ, Wang A, Lucchesi PA, Sun Q, Rajagopalan S. Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution. Circulation:Heart Failure 2012;5(4):452-461. R834797 (2014)
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Journal Article Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S, Sun Q. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicological Sciences 2011;124(1):88-98. R831697 (Final)
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Journal Article Xu X, Liu C, Xu Z, Tzan K, Wang A, Rajagopalan S, Sun Q. Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice. Life Sciences 2012;90(25-26):1001-1009. R834797 (2014)
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Journal Article Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen L-C, Sun Q. Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues. Particle and Fibre Toxicology 2011;8:20 (14 pp.). R834797 (2014)
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Journal Article Ying Z, Xu X, Chen M, Liu D, Zhong M, Chen L-C, Sun Q, Rajagopalan S. A synergistic vascular effect of airborne particulate matter and nickel in a mouse model. Toxicological Sciences 2013;135(1):72-80. R834797 (2013)
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Journal Article Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S. Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of sympathetic nervous system:a role for hypothalamic inflammation. Environmental Health Perspectives 2014;122(1):79-86. R834797 (2013)
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Journal Article Ying Z, Xie X, Bai Y, Chen M, Wang X, Zhang X, Morishita M, Sun Q, Rajagopalan S. Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats. Particle and Fibre Toxicology 2015;12:15 (10 pp.). R834797 (2014)
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Journal Article Yue W, Stolzel M, Cyrys J, Pitz M, Heinrich J, Kreyling WG, Wichmann H-E, Peters A, Wang S, Hopke PK. Source apportionment of ambient fine particle size distribution using positive matrix factorization in Erfurt, Germany. Science of the Total Environment 2008;398(1-3):133-144. R827354 (Final)
R832415 (2007)
R832415 (2008)
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Journal Article Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Huttemann M, Grossman LI, Chen LC, Rajagopalan S, Sun Q, Zhang K. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. Journal of Hepatology 2013;58(1):148-154. R834797 (2014)
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Journal Article Zhong J, Allen K, Rao X, Ying Z, Braunstein Z, Kankanala SR, Xia C, Wang X, Bramble LA, Wagner JG, Lewandowski R, Sun Q, Harkema JR, Rajagopalan S. (2016) Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice. Inhalation Toxicology 2016;28(9):383-392. R834797 (Final)
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Journal Article Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG, Harkema JR (2016). Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells. American Journal of Respiratory Cell and Molecular Biology 2016;54(6):782-791. R834797 (Final)
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Journal Article Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR. Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model. Inhalation Toxicology 2016;28(4):155-163. R834797 (Final)
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Journal Article Harkema JR, Hotchkiss LA, Vetter NA, Jackson-Humbles DN, Lewandowski RP, Wagner JG. Strain Differences in a Murine Model of Air Pollutant-induced Nonatopic Asthma and Rhinitis. Toxicologic Pathology 2017;45(1):161-171. R834797 (Final)
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Presentation Allen K, Kopec AK, Zacharewski TR, Wagner JG, Morishita M, Dvonch JT, Harkema JR. Metabolic changes from high-fructose feeding are altered by air pollutant exposure. Presented at the Society of Toxicology 51st Annual Meeting and ToxExpo, San Francisco, CA, March 11-15, 2012. R834797 (2015)
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Presentation Allen K, Lewandowski R, Wagner JG, Harkema JR. Inhalation exposures to ozone induce insulin resistance and pulmonary pathology in type II diabetes-prone mice. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014 (invited, abstract 2324). R834797 (2015)
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Presentation Baker GL, McKinney WJ, Phalen RF, Oldham M, Harkema JR, Higuchi MA. Inhalation studies: challenges and complexities. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014 (invited, abstract 5). R834797 (2015)
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Presentation Bard RL, Morishita M, Dvonch JT, Wang L, Das R, Spino C, Mukherjee B, Sun Q, Harkema J, Rajagopalan S, BrookRD. The associations of coarse particulate matter air pollution components with elevations in blood pressure and heart rate during controlled exposures. Presented at the American Society of Hypertension Annual Scientific Meeting and Exposition, New York, NY, May 16-20, 2014. R834797 (2014)
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Presentation Brook RD. GLACIER Project 1 update. Presented at the Clean Air Research Centers Annual Meeting, Cambridge, MA, June 21-22, 2012. R834797 (2013)
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Presentation Brook RD, Bard RL. The hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution in a rural location. Presented at the American Society of Hypertension (ASH) Annual Scientific Meeting and Exposition, San Francisco, CA, May 15-18, 2013. R833740 (2012)
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Presentation Brook RD. Air pollution exposures and the cardiometabolic syndrome. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. R834797 (2014)
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Presentation Brook RD. The components of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Poster presented at the American Society of Hypertension (ASH) Annual Scientific Meeting and Exposition, New York, NY, May 16-20, 2014. R833740 (Final)
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Presentation Cuiqing L, Wang A, Fonken L, Xu X, Wang TY, Maurya SK, Rao X, Ying Z, Bai Y, Gushchina L, Weil Z, Nelson R, Periasamy M, Sun Q, Rajagopala S. Effect of regional cap exposure in a model of genetic type II DM. Poster presented at the Clean Air Research Centers Annual Meeting, Cambridge, MA, June 21-22, 2012. R834797 (Final)
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Presentation Harkema JR, Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, and Wagner JG. Innate Lymphoid Cells Mediate Type-2 Immunity in the Lungs of Ozone-Exposed Mice. American Thoracic Society International Conference, San Francisco, CA, May 16, 2016. R834797 (Final)
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Presentation Harkema JR, Jackson-Humbles DN, Lewandowski RP, Wagner JG, and Tighe RM. Rapid Onset of Ozone-Induced Pulmonary Fibrosis in Diabetic KKAy Mice. American Thoracic Society International Conference, San Francisco, CA, May 15, 2016. R834797 (Final)
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Presentation Harkema JR. GLACIER Center and project 2 update. Presented at the U.S. EPA Clean Air Research Centers (CLARC) Annual Meeting, Cambridge, MA, June 21-22, 2012. R834797 (2015)
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Presentation Harkema JR. Interface of health effects caused by the CardioMetabolic Syndrome and exposures to air pollutant mixtures. Presented at the Society of Toxicology Webinar sponsored by the Risk Assessment and Mixtures Specialty Sections, April 10, 2013. R834797 (2013)
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Presentation Harkema JR. The interface of health effects caused by the cardiometabolic syndrome and exposures to air pollutants. Presented at the IEHS & Center for Urban Responses to Environmental Stressors Seminar Series, Wayne State University, Detroit, MI, December 5, 2013 (invited). R834797 (2014)
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Presentation Harkema JR, Brook RD. GLACIER Center update. Presented at the U.S. EPA Clean Air Research Centers (CLARC) Annual Meeting, Seattle, WA, July 25-26, 2013. R834797 (2014)
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Presentation Harkema JR. Investigating the health effects of air pollution: inhalation toxicology and animal models of chronic human disease. Presented at the Henan University of Traditional Chinese Medicine, Zhengzhou, China, October 29, 2013. R834797 (2014)
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Presentation Harkema JR. The interface of health effects caused by air pollution and the metabolic syndrome. Presented at the Fall 2013 Ohio Valley Society of Environmental Toxicology and Chemistry and the Michigan Society of Toxicology Regional Meeting, East Lansing, MI, September 20, 2013. R834797 (2014)
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Presentation Harkema JR. Toxicology pathology of the respiratory system. Presented at the Annual Meeting of the Latin American Society of Toxicologic Pathology, São Paulo, Brazil, April 13, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Interface of health effects caused by air pollution and the metabolic syndrome. Presented at the Biology Department Seminar, Calvin College, Grand Rapids, MI, April 25, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Nasal toxicity of inhaled chemical irritants. Presented at the 8th Annual CounterACT Network Research Symposium, Denver, CO, June 19, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Inhalation toxicology studies in air pollution research. Presented at the Annual Meeting of the Alleghany-Erie Regional Chapter of the Society of Toxicology, Morgantown, WV, May 15, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. The intersection of two global health problems: air pollution and the metabolic syndrome. Presented at the West Michigan Clean Air Action Meeting, Grand Rapids, MI, May 2, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Mouse granulocytes: neutrophils and eosinophils in health and disease. Presented at the Understanding the Mouse Immune System: Relevance for the Study of Human Disease Workshop, Annual Conference of the American College of Veterinary Pathology, Atlanta, GA, November 8, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Toxicology exploring the health effects interface between air pollution and the metabolic syndrome. Presented at the 2014 Annual Conference of the Central States Society of Toxicology, Kansas City, MO, October 17, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Ozone, diabetes, and innate lymphoid cells: what’s the connection? Presented at the Lovelace Respiratory Research Institute, Albuquerque, NM, September 29, 2014 (invited). R834797 (2014)
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Presentation Harkema JR. GLACIER Center update. Presented at the U.S. EPA Clean Air Research Centers (CLARC) Annual Meeting, Atlanta, GA, September 2014 (invited). R834797 (2014)
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Presentation Harkema JR. Inhaled air pollutants and the respiratory and metabolic system response. Presented at the Experimental Biology Meeting, Boston, MA, March 29, 2015 (invited). R834797 (2014)
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Presentation Harkema JR, Allen KM, Williams KM, Jackson-Humbles DN, Lewandowski RP, Wagner JG. Inhaled ozone causes more severe lung lesions in hyperglycemic, insulin-resistant KKAy mice as compared to normoglycemic, insulin-sensitive C57BL/6 mice. Presented at the American Thoracic Society International Conference, Denver, CO, May 19, 2015. R834797 (2014)
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Presentation Hotchkiss IP, Allen K, Wagner JG, Morishita M, Lewandowski RP, Bramble LA, Dvonch JT, Harkema JR. Effects of high-fructose diet on nasal epithelial and inflammatory responses to inhaled ozone and ambient fine particles in rats. Presented at the Society of Toxicology 51st Annual Meeting and ToxExpo, San Francisco, CA, March 11-15, 2012. R834797 (2015)
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Presentation Kumagai K, Ong CB, Jackson-Humbles DN, Lewandowski RP, Wagner JG, Harkema JR. Ozone-induced eosinophilic rhinitis and nasal epithelial remodeling are dependent on innate lymphoid cells in mice. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. R834797 (2014)
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Presentation Liu C, Xu X, Bai Y, Wang TY, Wang A, Gushchina L, Rao X, Sun Q, Rajagopalan S. Effects of regional CAP exposure on insulin resistance in diet induced obesity. Poster presented at the U.S. EPA Clean Air Research Centers (CLARC) Annual Meeting, Cambridge, MA, June 21-22, 2012. R834797 (2015)
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Presentation Liu C, et al. Central IKKb inhibition prevents particulate matter mediated peripheral inflammation and exaggeration of type II diabetes. Presented at the Annual EPA Clean Air Research Centers (CLARC) Meeting, Seattle, WA, July 25-26, 2013. R834797 (2013)
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Presentation Morishita M, Wagner J, Dvonch T, Keeler G, Harkema J, Rohr A. Source identification of ambient PM2.5 for inhalation exposure studies in Dearborn, Michigan using highly time-resolved measurements. Presented at the International Society of Exposure Science: 21st Annual Conference-Advancing Exposure Science for Environmental Health, Baltimore, MD, October 23-27, 2011. R834797 (2012)
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Presentation Morishita M, Dvonch T. Source identification of ambient PM2.5 for inhalation exposure studies in Dearborn, Michigan using highly time-resolved measurements. Presented at the Clean Air Research Centers Annual Meeting, Cambridge, MA, June 21-22, 2012. R834797 (2012)
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Presentation Nathan PM, Rickard AH, Dvonch JT. Fine bioaerosols in outdoor air – method development and associations with chemical co-pollutants in urban and rural airsheds. Presented at the University of Michigan Early Career Scientists Symposium, Ecosystems within Organisms: Ecology and Evolution of the Microbiome, Ann Arbor, MI, March 28, 2015. R834797 (2014)
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Presentation Ong Chee B, et al. Development of ozone-induced eosinophilic rhinitis in mice. Presented at the Annual Meeting of the Society of Toxicologic Pathology, Portland, OR, June 16-20, 2013. R834797 (2013)
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Presentation Ong C, Allen K, Brandenberger C, Jackson-Humbles D, Bramble L, Lewandowski R, Wagner JG, Harkema JR. Development of eosinophilic rhinitis and nasal tissue remodeling in mice episodically exposed to ozone. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014 (invited, abstract 2328). R834797 (2015)
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Presentation Sun L. Ambient fine particulate pollution and ozone exposure induces inflammation in epicardial and perirenal adipose tissues in a rat model. Presented at the Annual EPA Clean Air Research Centers (CLARC) Meeting, Seattle, WA, July 25-26, 2013. R834797 (2013)
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Presentation Wagner JG, Kamal AS, Allen K, Morishita M, Dvonch JT, Lewandowski RP, Fink GD, Harkema JR. Hypotensive and bradycardic responses to inhaled O3 and ambient fine particles are enhanced in rats on a high-fructose diet. Presented at the Society of Toxicology 51st Annual Meeting & ToxExpo, San Francisco, CA, March 11-15, 2012. R834797 (2015)
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Presentation Wagner JG, Kamal, AS, Allen K, Morishita M, Dvonch JT, Brook RD and JR Harkema. Decreases in blood pressure, heart rate, and heart rate variability in response to inhaled O3 and/or ambient fine particles are enhanced in rats on a high fructose diet. Presented at the American Thoracic Society Annual Meeting, San Francisco, CA, May 18-23, 2012. R834797 (Final)
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Presentation Wagner JG, Kamal, AS, Allen K, Morishita M, Dvonch JT, Brook RD, Harkema JR. Decreases in blood pressure, heart rate, and heart rate variability in response to inhaled O3 and/or ambient fine particles are enhanced in rats on a high fructose diet. Presented at the American Thoracic Society International Conference, Moscone Convention Center, San Francisco, CA, May 18-23, 2012. R834797 (2015)
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Presentation Wagner JG. Cardiovascular toxicity of acute exposures to multipollutant atmospheres: results from field studies using a rodent model of the CardioMetabolic Syndrome. Presented at the EPA Work-In-Progress Webinar for the Clean Air Research Centers, January 2013. R834797 (2013)
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R834797C002 (Final)
 not available
Presentation Wagner JG. Interface of cardiovascular health effects and exposures to air pollutant mixtures caused by the metabolic syndrome. Presented at the University of Washington Environmental and Occupational Health Sciences Seminar Series, Seattle, WA, June 5, 2014 (invited). R834797 (2014)
R834797 (Final)
R834797C002 (2014)
R834797C002 (Final)
 not available
Presentation Wagner JG. Interface of cardiovascular health effects and exposures to air pollutant mixtures caused by the metabolic syndrome. Presented at the Environmental and Occupational Health Sciences Seminar Series, University of Washington, Seattle, WA, June 5, 2014 (invited). R834797 (2015)
 not available
Presentation Wagner JG. Cardiometabolic interactions of diet and air pollution: field studies with multipollutant atmospheres. Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014 (invited, abstract 2071). R834797 (2015)
R834797 (Final)
R834797C002 (2014)
R834797C002 (Final)
Presentation Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC. PM2.5-induced tachycardia and hypertension in rats are linked to elemental carbon and specific temperature-resolved carbon fractions. Poster presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014 (abstract 1240). R834797 (2015)
R834797 (Final)
R834797C002 (2014)
R834797C002 (Final)
Presentation Wagner JG, Das R, Allen K, Morishita M, Nan B, Mukherjee B, Harkema JR. Cardiovascular depression during inhalation exposure to a mixture of ozone and rural ambient fine particles (PM2.5) in rats on a high fructose diet. Poster presented at the American Thoracic Society 2014 International Conference, San Diego, CA, May 16-21, 2014 (abstract 1668). R834797 (2015)
R834797 (Final)
R834797C002 (2014)
R834797C002 (Final)
Presentation Wagner JG. Diet matters: cardiometabolic susceptibility to air pollution. Presented at the Institute for Risk Assessment Sciences, Center for Environmental Health Research, Utrecht University, Utrecht, The Netherlands, October 17, 2014 (invited). R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C002 (2015)
R834797C002 (Final)
 not available
Presentation Wagner JG. Source matters: cardiopulmonary and metabolic susceptibility to air pollution. Presented at the Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV, April 23, 2015 (invited). R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C002 (2015)
R834797C002 (Final)
 not available
Presentation Wagner JG, Das R, Morishita M, Nan B, Mukherjee B, Harkema JR. Distinct cardiovascular responses to traffic and urban industrial sources of ambient fine particulate matter in rats on a high fructose diet. Presented at the Society of Toxicology 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C002 (2015)
R834797C002 (Final)
 not available
Presentation Wagner JG, Das R, Lewandowski R, Morishita M, Nan B, Mukherjee B, Harkema JR. Cardiovascular responses in high fructose-fed rats exposed to mixtures of ozone and ambient fine particles (PM2.5) derived from urban and rural airsheds. Presented at the American Thoracic Society International Conference, Denver, CO, May 19, 2015. R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C002 (2015)
R834797C002 (Final)
 not available
Presentation Wagner JG, Kamal AS, Allen K, Morishita M, Dvonch JT, Lewandowski RP, Fink GD and JR Harkema (2012). Hypotensive and Bradycardic Responses to Inhaled O3 and Ambient Fine Particles are Enhanced in Rats on a High-Fructose Diet. Annual Meeting of the Society of Toxicology, The Toxicologist 126(S2):A863. R834797 (Final)
 not available
Presentation White K, Kumagai K and Harkema J. Innate Lymphoid Cells Mediate Type 2 Immunity in the Lungs of Mice Repeatedly Exposed to Ozone. Society of Toxicology Annual Meeting, March 14, 2016. R834797 (Final)
R834797C002 (2016)
R834797C002 (Final)
 not available
Presentation Ying Z.The effects of inhalation exposure to ozone on systemic inflammation and vascular functions. Presented at the Annual EPA Clean Air Research Centers (CLARC) Meeting, Seattle, WA, July 25-26, 2013. R834797 (2013)
R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C003 (2013)
R834797C003 (Final)
 not available
Presentation Zhong J. Ozone exposure promotes adipose inflammation in mice. Presented at the Annual EPA Clean Air Research Centers (CLARC) Meeting, Seattle, WA, July 25-26, 2013. R834797 (2013)
R834797 (2014)
R834797 (2015)
R834797 (Final)
R834797C003 (2013)
R834797C003 (Final)
 not available
Presentation Harkema JR (2012). GLACIER Center and Project2 update. EPA CLARC Annual Meeting. Boston, MA. R834797 (Final)
 not available
Presentation Jackson-Humbles DN, Allen KM, Williams KM, Lewandowski RP, Wagner JG, Harkema JR. Inhaled ozone causes exaggerated pulmonary pathology in insulin-resistant, diabetes prone mice exposed to ozone. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 14, 2016. R834797 (Final)
R834797C002 (2016)
R834797C002 (Final)
 not available
Presentation Harkema JR (invited). Strain-and Environment-Related Factors in Murine Models of Allergic Airway Disease. Society of Toxicologic Pathology Annual Symposium, San Diego, CA, June 29, 2016. R834797 (Final)
R834797C002 (2016)
R834797C002 (Final)
 not available

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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