Grantee Research Project Results
Research Centers
Center for Air, Climate, and Energy Solutions
Carnegie Mellon University
We propose a multidisciplinary, multi-institutional research center to address critical questions at the nexus of air, climate, and energy. The center design addresses overarching themes of regional differences, multiple pollutants, and development and dissemination of tools for air quality impact assessment. Novel measurement and modeling approaches will be applied to understand spatial and temporal differences in human exposures and health outcomes. We will investigate a range of technology and policy scenarios for addressing our nation’s air, climate, and energy challenges, and test their potential ability to meet policy goals such as improved health outcomes and cost-effectiveness.
Center Publications:
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View Projects in Tabular Format
Main Center Abstract and Reports:
Development of Environmental Indicators of Condition,Integrity, and Sustainability in the Coastal Regions of the US Great Lakes Basin
Rochester PM Center: Source-Specific Health Effects of Ultrafine/Fine Particles
Center for Air, Climate, and Energy Solutions (CACES)
- Original Abstract
- 2006 Progress Report
- 2007 Progress Report
- 2008 Progress Report
- 2009 Progress Report
- 2010 Progress Report
- 2011 Progress Report
- Final Report
A Sustainable Center for Crowd-Sourced Water Infrastructure Modeling
- Original Abstract
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
- 2019 Progress Report
- 2020 Progress Report
- Final Report
Center Research Projects:
R825370C032 - Means for Producing an Entirely New Generation of Lignin-Based Plastics
- Original Abstract
- 1996 Progress Report
- 1997 Progress Report
- 1998 Progress Report
- 1999 Progress Report
R825370C042 - Environmentally Conscious Design for Construction
R825370C046 - Clean Process Advisory System (CPAS) Core Activities
R825370C048 - Investigation of the Partial Oxidation of Methane to Methanol in a Simulated Countercurrent Moving Bed Reactor
R825370C054 - Predictive Tool for Ultrafiltration Performance
R825370C055 - Heuristic Reactor Design for Clean Synthesis and Processing - Separative Reactors
R825370C056 - Characterization of Selective Solid Acid Catalysts Towards the Rational Design of Catalytic Reactions
R825370C057 - Environmentally Conscious Manufacturing: Prediction of Processing Waste Streams for Discrete Products
R825370C064 - The Physical Properties Management System (PPMS™): A P2 Engineering Aid to Support Process Design and Analysis
R825370C065 - Development and Testing of Pollution Prevention Design Aids for Process Analysis and Decision Making
R825370C066 - Design Tools for Chemical Process Safety: Accident Probability
R825370C067 - Environmentally Conscious Manufacturing: Design for Disassembly (DFD) in De-Manufacturing of Products
R825370C068 - An Economic Comparison of Wet and Dry Machining
R825370C069 - In-Line Copper Recovery Technology
R825370C070 - Selective Catalytic Hydrogenation of Lactic Acid
R825370C071 - Biosynthesis of Polyhydroxyalkanoate Polymers from Industrial Wastewater
R825370C072 - Tin Zeolites for Partial Oxidation Catalysis
R825370C073 - Development of a High Performance Photocatalytic Reactor System for the Production of Methanol from Methane in the Gas Phase
R825370C074 - Recovery of Waste Polymer Generated by Lost Foam Technology in the Metal Casting Industry
R825370C075 - Industrial Implementation of the P2 Framework
R825370C076 - Establishing Automated Linkages Between Existing P2-Related Software Design Tools
R825370C077 - Integrated Applications of the Clean Process Advisory System to P2-Conscious Process Analysis and Improvement
R825370C078 - Development of Environmental Indices for Green Chemical Production and Use
R826371C001 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Cal Tech, UC-Riverside, UC-San Diego, UC-Davis Report
R826371C002 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Cal Tech, Carnegie Mellon, Georgia Institute, NJIT, Oregon Institute, UC-Irvine, UC-Riverside Report
R826371C003 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Cal Tech Report
R826371C004 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: California - Irvine Report
R826371C005 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Carnegie Mellon Report
R826371C006 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Carnegie Mellon Report
R826371C007 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: UC-Riverside
R826371C008 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: Oregon Health and Science Report
R826371C009 - Research Consortium on Ozone and Fine Particle Formation in California and in the Northeastern United States: NJIT Report
R826886C001 - Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R826886C002 - Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
R826886C003 - Community-Based Participatory Research Project
R826886C004 - Pesticide Exposure Pathways Research Project
R827355C001 - Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
- Original Abstract
- 1999 Progress Report
- 2000 Progress Report
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- Final Report
R827355C002 - Health Effects
- Original Abstract
- 1999 Progress Report
- 2000 Progress Report
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- Final Report
R827355C003 - Personal PM Exposure Assessment
- Original Abstract
- 1999 Progress Report
- 2000 Progress Report
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- Final Report
R827355C004 - Characterization of Fine Particulate Matter
- Original Abstract
- 1999 Progress Report
- 2000 Progress Report
- 2001 Progress Report
- 2003 Progress Report
- Final Report
R827355C005 - Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
- Original Abstract
- 1999 Progress Report
- 2000 Progress Report
- 2001 Progress Report
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- Final Report
R827355C006 - Toxicology Project -- Controlled Exposure Facility
R827355C007 - Health Effects Research Core
R827355C008 - Exposure Core
R827355C009 - Statistics and Data Core
R827355C010 - Biomarker Core
R827355C011 - Oxidation Stress Makers
R828112C042 - Does Inhalation of Methanol Vapor Affect Human Neurobehavior?
R828112C043 - Human Responses to Nitrogen Dioxide
R828112C044 - The Role of Inflammation in Ozone-Induced Lung Injury
R828112C045 - How Does Exercise Affect the Dose of Inhaled Air Pollutants?
R828112C046 - How Do Chemicals in Diesel Engine Exhaust Damage DNA?
R828112C047 - Effect of Nitrogen Dioxide on Bacterial Respiratory infectionin Mice
R828112C048 - Effects of Ozone Exposure on Airway Epithelium
R828112C049 - Inhalation of Aldehydes and Effects on Breathing
R828112C050 - Does Ozone Cause Precancerous Changes in Cells?
R828112C051 - Effects of Formaldehyde on Human Airway Epithelial Cells Exposed in a Novel Culture System
R828112C052 - Carbon Monoxide and Cardiac Arrhythmias
R828112C053 - Effects of Formaldehyde and Particle-Bound Formaldehyde on Lung Macrophage Functions
R828112C054 - Mechanisms for Protecting Lung Epithelial Cells Against Oxidant Injury
R828112C055 - Relationship of Nitropyrene-Derived DNA Adducts to Carcinogenesis
R828112C056 - Particle Trap Effects on Heavy-Duty Diesel Engine Emissions
R828112C057 - Carbon Monoxide and Atherosclerosis
R828112C058 - Nitrogen Dioxide and Respiratory Illness in Children
R828112C059 - Noninvasive Methods for Measuring Ventilation in Mobile Subjects
R828112C060 - Oxidant Air Pollutants and Lung Cancer: An Animal Model
R828112C061 - Detection of Carcinogen-DNA Adducts: Development of New Methods
R828112C062 - Effects of Carbon Monoxide on Heart Muscle Cells
R828112C063 - Development of Personal Ozone Samplers: Three Approaches
R828112C064 - Development of Biomarkers to Monitor Carcinogen Exposure
R828112C065 - Effects of Prolonged Ozone Inhalation on Collagen Structure and Content in Rat Lungs
R828112C065II - Prolonged Ozone Exposure and the Contractile Properties of Isolated Rat Airways
R828112C065III - Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone Inhalation
R828112C065IV - Genetic Control of Connective Tissue Protein Synthesis After Prolonged Ozone Inhalation
R828112C065V - Pulmonary Function Alterations in Rats After Chronic Ozone Inhalation
R828112C065VII - Prolonged Ozone Exposure Leads to Functional and Structural Changes in the Rat Nose
R828112C065VIII - IX - Studies of Changes in Lung Structure and Enzyme Activitiesin Rats After Prolonged Exposure to Ozone
R828112C065X - An Innovative Approach to Analyzing Multiple Experimental Outcomes: A Case Study of Rats Exposed to Ozone
R828112C065XI - The Consequences of Prolonged Inhalation of Ozone on Rats: An Integrative Summary of the Results of Eight Collaborative Studies
R828112C066 - Interactive Effects of Nitropyrenes in Diesel Exhaust
R828112C067 - Detection of Formaldehyde–DNA Adducts: Development of New Methods
R828112C068I - Comparison of the Carcinogenicity of Diesel Exhaust and Carbon Black in Rat Lungs
R828112C068II - An Investigation of DNA Damage in the Lungs of Rats Exposed to Diesel Exhaust
R828112C068III - No Evidence For Genetic Mutations Found In Lung Tumors From Rats Exposed To Diesel Exhaust or Carbon Black
R828112C069 - Noninvasive Determination of Respiratory Ozone Absorption: The Bolus-Response Method
R828112C070 - The Effects of Inhaled Oxidants and Acid Aerosols on Pulmonary Function
R828112C071 - Biochemical Consequences of Ozone Reacting with Membrane Fatty Acids
R828112C072 - DNA Mutations in Rats Treated with a Carcinogen Present in Diesel Exhaust
R828112C073 - Developmental Neurotoxicity of Inhaled Methanol in Rats
R828112C074 - Methanol Distribution in Non Pregnant and Pregnant Rodents
R828112C075 - Is Increased Mortality Associated with Ozone Exposure in Mexico City?
R828112C076 - Effects of Fuel Modification and Emission Control Devices on Heavy-Duty Diesel Engine Emissions
R828112C077 - Metabolic Studies in Monkeys Exposed to Methanol Vapors
R828112C078 - Effects of Ozone on Pulmonary Function and Airway Inflammation in Normal and Potentially Sensitive Human Subjects
R828112C079 - Improvement of a Respiratory Ozone Analyzer
R828112C080 - Mechanism of Oxidative Stress from Low Levels of Carbon Monoxide
R828112C081 - Long-Term Exposure to Ozone: Development of Methods to Estimate Past Exposures and Health Outcomes
R828112C082 - Effects of Ambient Ozone on Healthy, Wheezy, and Asthmatic Children
R828112C083 - Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure
R828112C084 - Evaluation of The Potential Health Effects of the Atmospheric Reaction Products of Polycyclic Aromatic Hydrocarbons
R828112C085 - Mechanisms of Response to Ozone Exposure: The Role of Mast Cells in Mice
R828112C086 - Statistical Methods for Epidemiologic Studies of the Health Effects of Air Pollution
R828112C087 - Development of New Methods to Measure Benzene Biomarkers
R828112C088 - Alveolar Changes in Rat Lungs After Long-Term Exposure to Nitric Oxide
R828112C089 - Effects of Prenatal Exposure to Inhaled Methanol on Nonhuman Primates and Their Infant Offspring
R828112C090 - A Pilot Study of Potential Biomarkers of Ozone Exposure
R828112C091 - Effects of Concentrated Ambient Particles on the Cardiac and Pulmonary Systems of Dogs
R828112C092 - Cancer, Mutations, and Adducts in Rats and Mice Exposed to Butadiene and Its Metabolites
R828112C093 - Effects of Concentrated Ambient Particles in Rats and Hamsters: An Exploratory Study
R828112C094I - The National Morbidity, Mortality, and Air Pollution Study: Methods and Methodologic Issues
R828112C094II - The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the United States
R828112C095 - Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban Populations
R828112C096 - Acute Pulmonary Effects of Ultrafine Particles in Rats and Mice
R828112C097 - Identifying Subgroups of the General Population That May Be Susceptible to Short-Term Increases in Particulate Air Pollution
R828112C098 - Daily Mortality and Fine and Ultrafine Particles in Erfurt, Germany
R828112C099 - A Case-Crossover Analysis of Fine Particulate Matter Air Pollution and Out-of-Hospital Sudden Cardiac Arrest
R828112C100 - Effects of Mexico City Air on Rat Nose
R828112C101 - Penetration of Lung Lining and Clearance of Particles Containing Benzo[a]pyrene
R828112C102 - Metabolism of Ether Oxygenates Added to Gasoline
R828112C103 - Characterization and Mechanisms of Chromosomal Alterations Induced by Benzene in Mice and Humans
R828112C104 - Acute Cardiovascular Effects in Rats from Exposure to Urban Ambient Particles
R828112C105 - Genetic Differences in Induction of Acute Lung Injury and Inflammation in Mice
R828112C106 - Effects on Mice of Exposure to Ozone and Ambient Particle Pollution
R828112C107 - Emissions from Diesel and Gasoline Engines Measured in Highway Tunnels
R828112C108 - Case-Cohort Study of Styrene Exposure and Ischemic Heart Disease Investigators
R828112C110 - Effects of Metals Bound to Particulate Matter on Human Lung Epithelial Cells
R828112C111 - Effect of Concentrated Ambient Particulate Matter on Blood Coagulation Parameters in Rats
R828112C112 - Health Effects of Acute Exposure to Air Pollution
R828112C113 - Benzene Metabolism in Rodents at Doses Relevant to Human Exposure from Urban Air
R828112C114 - A Personal Particle Speciation Sampler
R828112C115 - Validation and Evaluation of Biomarkers in Workers Exposed to Benzene in China
R828112C116 - Biomarkers in Czech Workers Exposed to 1,3-Butadiene: A Transitional Epidemiologic Study
R828112C117 - Peroxides and Macrophages in the Toxicity of Fine Particulate Matter in Rats
R828112C118 - Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los Angeles
R828112C119 - Manganese Toxicokinetics at the Blood-Brain Barrier
R828112C120 - Effects of Exposure to Concentrated Ambient Particles from Detroit Air on Healthy Rats and Rats with Features of Asthma or Mild Bronchitis
R828112C121 - Field Evaluation of Nanofilm Detectors for Measuring Acidic Particles in Indoor and Outdoor Air
R828112C123 - Time-Series Analysis of Air Pollution and Mortality: A Statistical Review
R828112C126 - Effects of Exposure to Ultrafine Carbon Particles in Healthy Subjects and Subjects with Asthma
R828112C128 - Neurogenic Responses of Rat Lung to Diesel Exhaust
R828112C130-I - Relationships of Indoor, Outdoor, and Personal Air (RIOPA). Part I. Collection Methods and Descriptive Analyses
R828112C132 - An Updated Study of Mortality Among North American Synthetic Rubber Industry Workers
R828675C001 - Great Lakes Diatom and Water Quality Indicators
R828675C002 - Vegetative Indicators of Condition, Integrity, and Sustainability of Great Lakes Coastal Wetlands
R828675C003 - Testing Indicators of Coastal Ecosystem Integrity Using Fish and Macroinvertebrates
R828675C004 - Development and Assessment of Environmental Indicators Based on Birds and Amphibians in the Great Lakes Basin
R828675C005 - Development and Evaluation of Chemical Indicators for Monitoring Ecological Risk
R828770C001 - Technical Outreach Services for Communities
R828770C002 - Technical Outreach Services for Native American Communities
R828770C003 - Sustainable Remediation
R828770C004 - Incorporating Natural Attenuation Into Design and Management Strategies For Contaminated Sites
R828770C005 - Metals Removal by Constructed Wetlands
R828770C006 - Adaptation of Subsurface Microbial Biofilm Communities in Response to Chemical Stressors
R828770C007 - Dewatering, Remediation, and Evaluation of Dredged Sediments
R828770C008 - Interaction of Various Plant Species with Microbial PCB-Degraders in Contaminated Soils
R828770C009 - Microbial Indicators of Bioremediation Potential and Success
R829458C001 - Remote Sensing of Water Quality
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C002 - Microbial Biofilms as Indicators of Estuarine Ecosystem Condition
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C003 - Individual Level Indicators: Molecular Indicators of Dissolved Oxygen Stress in Crustaceans
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C004 - Data Management and Analysis
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C005 - Individual Level Indicators: Reproductive Function in Estuarine Fishes
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C006 - Collaborative Efforts Between CEER-GOM and U.S. Environmental Protection Agency (EPA)-Gulf Ecology Division (GED)
R829458C007 - GIS and Terrestrial Remote Sensing
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C008 - Macrobenthic Process Indicators of Estuarine Condition for the Northern Gulf of Mexico
- Original Abstract
- 2002 Progress Report
- 2003 Progress Report
- 2004 Progress Report
- 2005 Progress Report
R829458C009 - Modeling and Integration
R829479C001 - Plant Genes and Agrobacterium T-DNA Integration
R829479C002 - Designing Promoters for Precision Targeting of Gene Expression
R829479C003 aka R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C004 - Negative Sense Viral Vectors for Improved Expression of Foreign Genes in Insects and Plants
R829479C005 - Development of Novel Plastics From Agricultural Oils
R829479C006 - Conversion of Paper Sludge to Ethanol
R829479C007 - Enhanced Production of Biodegradable Plastics in Plants
R829479C008 - Engineering Design of Stable Immobilized Enzymes for the Hydrolysis and Transesterification of Triglycerides
R829479C009 - Discovery and Evaluation of SNP Variation in Resistance-Gene Analogs and Other Candidate Genes in Cotton
R829479C010 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals
R829479C011 - Biological Effects of Epoxy Fatty Acids
R829479C012 - High Strength Degradable Plastics From Starch and Poly(lactic acid)
R829479C013 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C014 - Identification of Receptors of Bacillus Thuringiensis Toxins in Midguts of the European Corn Borer
R829479C015 - Coordinated Expression of Multiple Anti-Pest Proteins
R829479C016 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C017 - Molecular Improvement of an Environmentally Friendly Turfgrass
R829479C018 - Woody Biomass Crops for Bioremediating Hydrocarbons and Metals. II.
R829479C019 - Transgenic Plants for Bioremediation of Atrazine and Related Herbicides
R829479C020 - Root Exudate Biostimulation for Polyaromatic Hydrocarbon Phytoremediation
R829479C021 - Phytoremediation of Heavy Metal Contamination by Metallohistins, a New Class of Plant Metal-Binding Proteins
R829479C022 - Development of Herbicide-Tolerant Energy and Biomass Crops
R829479C023 - A Novel Fermentation Process for Butyric Acid and Butanol Production from Plant Biomass
R829479C024 - Development of Vectors for the Stoichiometric Accumulation of Multiple Proteins in Transgenic Crops
R829479C025 - Chemical Induction of Disease Resistance in Trees
R829479C026 - Development of Herbicide-Tolerant Hardwoods
R829479C027 - Environmentally Superior Soybean Genome Development
R829479C028 - Development of Efficient Methods for the Genetic Transformation of Willow and Cottonwood for Increased Remediation of Pollutants
R829479C029 - Development of Tightly Regulated Ecdysone Receptor-Based Gene Switches for Use in Agriculture
R829479C030 - Engineered Plant Virus Proteins for Biotechnology
R831709C001 - Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
R831709C002 - Genetic Susceptibility to Pesticides
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
R831709C003 - Community-Based Participatory Research Project
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
R831709C004 - Pesticide Exposure Pathways Research Project
- Original Abstract
- 2004 Progress Report
- 2005 Progress Report
- 2006 Progress Report
- 2007 Progress Report
R834514C001 - Community-Based Participatory Research
R834514C002 - Pesticide Exposure Pathways
R834514C003 - Molecular Mechanisms
R834514C004 - Genetic Susceptibility
R835738C001 - Airway Epithelium Organotypic Culture as a Platform forAdverseOutcomesPathway Assessment of Engineered Nanomaterials
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
R835738C002 - Organotypic Model of Human Kidney as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
R835738C003 - Organotypic Models of Mammalian Liver as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
R835738C004 - Organotypic Model of Testis as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
R835738C005 - Integrating Liver, Kidney and Testis Nanomaterial Toxicity using the Adverse Outcome Pathway Approach
- Original Abstract
- 2015 Progress Report
- 2016 Progress Report
- 2017 Progress Report
- 2018 Progress Report
R835873C001 - Mechanistic Air Quality Impact Models for Assessment of Multiple Pollutants at High Spatial Resolution
R835873C002 - Air Quality Observatory
R835873C003 - Next Generation LUR Models: Development of Nationwide Modeling Tools for Exposure Assessment and Epidemiology
R835873C004 - Air Pollutant Control Strategies in a Changing World
R835873C005 - Health Effects of Air Pollution and Mitigation Scenarios
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.